CAS 81131-70-6 | 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)- | CAS Number 81131-70-6

Title	Journal
A transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20181001
Functional characterization of rainbow trout (Oncorhynchus mykiss) Abcg2a (Bcrp) transporter.	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20161201
Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.	The Journal of pharmacology and experimental therapeutics 20160801
Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice.	Toxicology 20160217
Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice.	PloS one 20160101
Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.	Chemical research in toxicology 20150518
Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes.	Toxicology in vitro : an international journal published in association with BIBRA 20140901
Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.	Toxicological sciences : an official journal of the Society of Toxicology 20130701
ATP-dependent transport of statins by human and rat MRP2/Mrp2.	Toxicology and applied pharmacology 20130601
Simvastatin-lnduced nocturnal leg pain disappears with pravastatin substitution.	Srpski arhiv za celokupno lekarstvo 20130101
Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.	Journal of clinical pharmacology 20121101
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.	Pharmaceutical research 20121001
Development and validation of a simple and fast HPLC method for determination of lovastatin, pravastatin and simvastatin.	Journal of chromatographic science 20121001
Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.	American journal of physiology. Heart and circulatory physiology 20121001
Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function.	Human reproduction (Oxford, England) 20121001
Association of cholesteryl ester transfer protein mass with peripheral leukocyte count following statin therapy: a pilot study.	American journal of cardiovascular drugs : drugs, devices, and other interventions 20121001
Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease.	Clinical nephrology 20121001
Effects of rosuvastatin versus pravastatin on low-density lipoprotein diameter in HIV-1-infected patients receiving ritonavir-boosted protease inhibitor.	AIDS (London, England) 20120910
Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.	Molecular pharmaceutics 20120904
Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.	Journal of cellular and molecular medicine 20120901
Pravastatin reverses the membrane cholesterol reorganization induced by myocardial infarction within lipid rafts in CD14(+)/CD16(-) circulating monocytes.	Biochimica et biophysica acta 20120901
Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.	European heart journal 20120901
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.	Drug metabolism and disposition: the biological fate of chemicals 20120901
Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β.	Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20120901
Impacts of estimated glomerular filtration rate on coronary atherosclerosis and plaque composition before and during statin therapy in patients with normal to mild renal dysfunction: subanalysis of the TRUTH study.	Nephrology (Carlton, Vic.) 20120901
Can statins reduce the inflammatory response associated with preterm birth in an animal model?	American journal of obstetrics and gynecology 20120901
Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance.	Transplantation 20120815
Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.	Metabolism: clinical and experimental 20120801
Pravastatin and simvastatin improves acetylsalicylic acid-mediated in vitro blood platelet inhibition.	European journal of clinical investigation 20120801
Elevated concentration of placental growth factor (PlGF) and long term risk in patients with acute coronary syndrome in the PROVE IT-TIMI 22 trial.	Journal of thrombosis and thrombolysis 20120801
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance.	Journal of applied physiology (Bethesda, Md. : 1985) 20120801
Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis.	Journal of molecular and cellular cardiology 20120801
Erythrocyte-mediated delivery of pravastatin: in vitro study of effect of hypotonic lysis on biochemical parameters and loading efficiency.	Archives of pharmacal research 20120801
Prospective, randomized, single-blind comparison of effects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease.	Heart and vessels 20120701
Comparative efficacy and safety of fenofibrate/pravastatin plus ezetimibe triple therapy and simvastatin/ezetimibe dual therapy in type 2 diabetic patients with mixed hyperlipidaemia and cardiovascular disease.	Diabetes & vascular disease research 20120701
Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy.	Diabetes, obesity & metabolism 20120701
Effects of bile salts on gastrointestinal absorption of pravastatin.	Journal of pharmaceutical sciences 20120701
Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice.	Pharmacotherapy 20120701
Role of non-high-density lipoprotein cholesterol in predicting cerebrovascular events in patients following myocardial infarction.	The American journal of cardiology 20120615
Blood pressure control status and effects of pravastatin on cardiovascular events occurrence in patients with dyslipidaemia.	Journal of human hypertension 20120601
Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.	Acta physiologica (Oxford, England) 20120601
Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress.	Cardiovascular research 20120601
A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter.	American journal of physiology. Cell physiology 20120601
The effect of low-dose pravastatin in metabolic syndrome for primary prevention of cardiovascular disease in Japan: a post hoc analysis of the MEGA study.	Journal of cardiovascular pharmacology and therapeutics 20120601
Effects of pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of diabetic nephropathy in an experimental model of diabetic renal disease.	Saudi medical journal 20120601
The evaluation of analgesic effects of simvastatin, pravastatin and atorvastatin in hot plate test.	European review for medical and pharmacological sciences 20120601
Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis.	Medical mycology 20120501
Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.	British journal of clinical pharmacology 20120501
EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.	Molecular and cellular biochemistry 20120501
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.	Drug metabolism and disposition: the biological fate of chemicals 20120501
Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells.	Clinical and experimental immunology 20120501
Pravastatin and fenofibrate in combination (Pravafenix(®)) for the treatment of high-risk patients with mixed hyperlipidemia.	Expert review of cardiovascular therapy 20120501
Pravastatin attenuates noise-induced cochlear injury in mice.	Neuroscience 20120419
Mechanisms involved in cardioprotective effects of pravastatin administered during reoxygenation in human myocardium in vitro.	Anesthesiology 20120401
Safety of a fixed-dose combination of fenofibrate/pravastatin 160 mg/40 mg in patients with mixed hyperlipidaemia: a pooled analysis from a database of clinical trials.	Clinical drug investigation 20120401
Targeting HDL-cholesterol to reduce residual cardiovascular risk.	Current opinion in lipidology 20120401
Development of a model for prediction of coronary atherosclerotic regression: evaluation of high-density lipoprotein cholesterol level and peripheral blood monocyte count.	Heart and vessels 20120301
In vitro evaluation of phototoxic properties of proton pump inhibitors, H2-receptor antagonists and statins.	Acta dermato-venereologica 20120301
Effect of dalcetrapib plus pravastatin on lipoprotein metabolism and high-density lipoprotein composition and function in dyslipidemic patients: results of a phase IIb dose-ranging study.	American heart journal 20120301
Determination of pravastatin and pravastatin lactone in rat plasma and urine using UHPLC-MS/MS and microextraction by packed sorbent.	Talanta 20120215
Pravastatin for thioacetamide-induced hepatic failure and encephalopathy.	European journal of clinical investigation 20120201
The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.	British journal of clinical pharmacology 20120201
Pravastatin inhibits C-reactive protein generation induced by fibrinogen, fibrin and FDP in isolated rat vascular smooth muscle cells.	Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120201
Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction.	International journal of epidemiology 20120201
Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.	Atherosclerosis 20120201
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.	Atherosclerosis 20120201
HMG-CoA reductase inhibitors (statins) reduce hypertrophic scar formation in a rabbit ear wounding model.	Plastic and reconstructive surgery 20120201
Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis.	American heart journal 20120201
Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats.	Acta orthopaedica 20120201
Statin therapy in the elderly: might there be uncertainty in the majority?	European journal of preventive cardiology 20120201
Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability.	The Journal of physiology 20120115
Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients: Justification for Atherosclerosis Regression Treatment (JART) study.	Circulation journal : official journal of the Japanese Circulation Society 20120101
Galectin-3 and the development of heart failure after acute coronary syndrome: pilot experience from PROVE IT-TIMI 22.	Clinical chemistry 20120101
Usefulness of LDL-C-related parameters to predict cardiovascular risk and effect of pravastatin in mild-to-moderate hypercholesterolemia.	Journal of atherosclerosis and thrombosis 20120101
Bilayered transmucosal drug delivery system of pravastatin sodium: statistical optimization, in vitro, ex vivo, in vivo and stability assessment.	Drug delivery 20120101
The differential effect of statins on oxidative stress and endothelial function: atorvastatin versus pravastatin.	Journal of clinical lipidology 20120101
Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.	Circulation journal : official journal of the Japanese Circulation Society 20120101
Double-dose pravastatin versus add-on ezetimibe with low-dose pravastatin - effects on LDL cholesterol, cholesterol absorption, and cholesterol synthesis in Japanese patients with hypercholesterolemia (PEAS study).	Journal of atherosclerosis and thrombosis 20120101
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.	PloS one 20120101
Selected statins produce rapid spinal motor neuron loss in vitro.	BMC musculoskeletal disorders 20120101
Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.	PloS one 20120101
[Equivalence studies of pravastatin original and generic drugs by dissolution test].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101
Effect of pravastatin on endothelial function and endothelial progenitor cells in healthy postmenopausal women.	Clinical and experimental obstetrics & gynecology 20120101
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.	PloS one 20120101
A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.	PloS one 20120101
Adherence to preferable behavior for lipid control by high-risk dyslipidemic Japanese patients under pravastatin treatment: the APPROACH-J study.	Journal of atherosclerosis and thrombosis 20120101
Angiotensin converting enzyme inhibitor and HMG-CoA reductase inhibitor as adjunct treatment for persons with HIV infection: a feasibility randomized trial.	PloS one 20120101
Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: possible role of CYP3A4 inhibition by pravastatin.	Indian journal of pharmacology 20120101
Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat: role of vitamin D metabolites.	Atherosclerosis 20111201
HMG-CoA reductase inhibitor (Statin) therapy and coronary atherosclerosis in Japanese subjects: role of high-density lipoprotein cholesterol.	American journal of cardiovascular drugs : drugs, devices, and other interventions 20111201
[Achievement of therapeutic target in subjects on statin treatment in clinical practice. Results of the STAR (Statins Target Assessment in Real practice) study].	Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20111201
Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats.	Life sciences 20111107
Low-dosage statins reduce choroidal damage in hypercholesterolemic rabbits.	Acta ophthalmologica 20111101
Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study.	Critical care medicine 20111101
The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.	Journal of neural transmission (Vienna, Austria : 1996) 20111101
Differential effect of statins on diabetic nephropathy in db/db mice.	International journal of molecular medicine 20111101
Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation.	Journal of experimental botany 20111101
Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high risk patients with mixed hyperlipidemia not controlled by pravastatin monotherapy.	Current medical research and opinion 20111101
Efficient bioconversion of compactin to pravastatin by the quinoline-degrading microorganism Pseudonocardia carboxydivorans isolated from petroleum-contaminated soil.	Bioresource technology 20111101
Statins in preventing ventilator-associated pneumonia and death: still only a hope*.	Critical care medicine 20111101
Apolipoprotein B100 is a better treatment target than calculated LDL and non-HDL cholesterol in statin-treated patients.	Annals of clinical biochemistry 20111101
Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells.	The Journal of thoracic and cardiovascular surgery 20111101
High-sensitivity C-reactive protein levels do not decrease with the use of statins in all persons with HIV infection.	AIDS (London, England) 20111023
Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis.	Journal of gastroenterology and hepatology 20111001
Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk.	Arteriosclerosis, thrombosis, and vascular biology 20111001
Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study.	Clinical pharmacology and therapeutics 20111001
Role of complement component C1q in the onset of preeclampsia in mice.	Hypertension (Dallas, Tex. : 1979) 20111001
Effects of statins on cholestasis: good, bad or indifferent?	Journal of gastroenterology and hepatology 20111001
Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia.	American journal of obstetrics and gynecology 20111001
Pravastatin reduces Marfan aortic dilation.	Circulation 20110913
Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.	American journal of physiology. Heart and circulatory physiology 20110901
Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.	Drug metabolism and disposition: the biological fate of chemicals 20110901
Low-dose pravastatin and age-related differences in risk factors for cardiovascular disease in hypercholesterolaemic Japanese: analysis of the management of elevated cholesterol in the primary prevention group of adult Japanese (MEGA study).	Drugs & aging 20110901
[Prediction of the pharmacokinetic drug-drug interaction of pravastatin and pitavastatin with cyclosporine by a digital liver model based on metabolism and transporter].	Yao xue xue bao = Acta pharmaceutica Sinica 20110901
Graft-protective effects of the HMG-CoA reductase inhibitor pravastatin after lung transplantation--a propensity score analysis with 23 years of follow-up.	Transplantation 20110827
HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits.	Biochemical and biophysical research communications 20110819
Long-term follow-up of statin treatment in a cohort of children with familial hypercholesterolemia: efficacy and tolerability.	Paediatric drugs 20110801
Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats.	Stroke 20110801
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.	Atherosclerosis 20110801
The complex interplay between cholesterol and prostate malignancy.	The Urologic clinics of North America 20110801
Data mining approach shows promise in detecting unexpected drug interactions.	JAMA 20110713
Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.	Human & experimental toxicology 20110701
The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes.	Xenobiotica; the fate of foreign compounds in biological systems 20110701
HMG CoA reduction in patients with average cholesterol concentrations.	Clinical chemistry 20110701
Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.	Clinical pharmacology and therapeutics 20110701
[Pharmaco-economic optimization of cholesterol-lowering treatment with statins].	Medicina clinica 20110625
Intravenous administration of pravastatin immediately after middle cerebral artery occlusion reduces cerebral oedema in spontaneously hypertensive rats.	European journal of pharmacology 20110625
Effect of statins on cholesterol crystallization and atherosclerotic plaque stabilization.	The American journal of cardiology 20110615
Statins and prostate cancer diagnosis and grade in a veterans population.	Journal of the National Cancer Institute 20110608
Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.	Fundamental & clinical pharmacology 20110601
High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome.	The pharmacogenomics journal 20110601
Prognostic utility of neopterin and risk of heart failure hospitalization after an acute coronary syndrome.	European heart journal 20110601
Treatment with pravastatin attenuates progression of chronic pancreatitis in rat.	Laboratory investigation; a journal of technical methods and pathology 20110601
Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.	Drug metabolism and disposition: the biological fate of chemicals 20110601
Effects of statins on matrix metalloproteinases and their endogenous inhibitors in human endothelial cells.	Naunyn-Schmiedeberg's archives of pharmacology 20110601
Design and in vitro performance evaluation of purified microparticles of pravastatin sodium for intestinal delivery.	AAPS PharmSciTech 20110601
Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22).	American heart journal 20110601
Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria:Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT).	American heart journal 20110601
High-sensitivity C-reactive protein levels fall during statin therapy in HIV-infected patients receiving ritonavir-boosted protease inhibitors.	AIDS (London, England) 20110515
Effect of statin therapy on disease progression in pediatric ADPKD: design and baseline characteristics of participants.	Contemporary clinical trials 20110501
The incidence and risk factors for new onset atrial fibrillation in the PROSPER study.	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110501
Pravastatin therapy fails to suppress post-PCI inflammatory response measured by serum neopterin and CRP levels.	Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110501
Benefit of intensive statin therapy in women: results from PROVE IT-TIMI 22.	Circulation. Cardiovascular quality and outcomes 20110501
Treatment of indeterminate cell histiocytosis with pravastatin.	Journal of the American Academy of Dermatology 20110501
The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention.	JACC. Cardiovascular interventions 20110501
Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation.	Heart (British Cardiac Society) 20110401
Statins utilisation pattern: a retrospective evaluation in a tertiary care hospital in Thailand.	The International journal of pharmacy practice 20110401
Treatment with pravastatin attenuates oxidative stress and protects osteoblast cell viability from indoxyl sulfate.	Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20110401
Pravastatin activates PPARalpha/PPARgamma expression in the liver and gallbladder epithelium of hamsters.	Hepatobiliary & pancreatic diseases international : HBPD INT 20110401
Rosuvastatin and primary cardiovascular prevention. Continue to use pravastatin or simvastatin.	Prescrire international 20110401
Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice.	Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110301
Variation in the CBP gene involved in epigenetic control associates with cognitive function.	Neurobiology of aging 20110301
Differential metabolic effects of distinct statins.	Atherosclerosis 20110301
Influence of long-term treatment with pravastatin on the survival, evolution of cutaneous lesion and weight of animals infected by Leishmania amazonensis.	Experimental parasitology 20110301
Mannose binding lectin 2 haplotypes do not affect the progression of coronary atherosclerosis in men with proven coronary artery disease treated with pravastatin.	Atherosclerosis 20110301
A novel use of oxidative coupling reactions for determination of some statins (cholesterol-lowering drugs) in pharmaceutical formulations.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110301
[Effect of pravastatin on transportation of scutellarin in mouse liver and its mechanism].	Yao xue xue bao = Acta pharmaceutica Sinica 20110301
Low-density lipoprotein cholesterol goal attainment among Malaysian dyslipidemic patients.	The Southeast Asian journal of tropical medicine and public health 20110301
Efficacy and safety of more intensive lowering of LDL cholesterol.	Lancet (London, England) 20110226
Effect of niacin on preβ-1 high-density lipoprotein levels in diabetes.	Metabolism: clinical and experimental 20110201
Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions.	Thrombosis and haemostasis 20110201
Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation.	Thrombosis research 20110201
[Pravastatin and rosiglitazone combination therapy upgrades the expression of ABCA1 in THP-1 macrophages].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110201
[Retention behavior of statins in microemulsion liquid chromatography].	Se pu = Chinese journal of chromatography 20110201
The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.	European journal of pharmacology 20110125
Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data.	BMJ (Clinical research ed.) 20110121
Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.	Biochemical and biophysical research communications 20110107
Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.	Journal of molecular and cellular cardiology 20110101
Differential effects of statins on endogenous H2S formation in perivascular adipose tissue.	Pharmacological research 20110101
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.	Journal of atherosclerosis and thrombosis 20110101
Paradoxical decrease in HDL-cholesterol and apolipoprotein A1 with simvastatin and atorvastatin in a patient with type 2 diabetes.	Annals of clinical biochemistry 20110101
Colchicine-induced rhabdomyolysis in a heart/lung transplant patient with concurrent use of cyclosporin, pravastatin, and azithromycin.	Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20110101
Statins have an early antiplatelet effect in patients with acute myocardial infarction.	Platelets 20110101
[Anti-atherosclerotic and anti-inflammatory effects of statin on cardiovascular disease and their mechanisms].	Nihon rinsho. Japanese journal of clinical medicine 20110101
Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin.	Journal of clinical lipidology 20110101
Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).	BMC geriatrics 20110101
Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia.	Endocrine journal 20110101
Pravastatin versus simvastatin for prevention of contrast-induced nephropathy.	Journal of cardiovascular pharmacology and therapeutics 20110101
Fixed-dose combination fenofibrate/pravastatin 160/40 mg versus simvastatin 20 mg monotherapy in adults with type 2 diabetes and mixed hyperlipidemia uncontrolled with simvastatin 20 mg: a double-blind, randomized comparative study.	Clinical therapeutics 20110101
Statins as modulators of colon cancer cells induced cytokine secretion by human PBMC.	Vascular pharmacology 20110101
Characterization of human erythrocytes as potential carrier for pravastatin: an in vitro study.	International journal of medical sciences 20110101
Acute modulation of vasoconstrictor responses by pravastatin in small vessels.	Circulation journal : official journal of the Japanese Circulation Society 20110101
Cardioprotective effects of pravastatin against lethal ventricular arrhythmias induced by reperfusion in the rat heart.	Circulation journal : official journal of the Japanese Circulation Society 20110101
Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.	Journal of biomedicine & biotechnology 20110101
Relationship between hemoglobin A1c and cardiovascular disease in mild-to-moderate hypercholesterolemic Japanese individuals: subanalysis of a large-scale randomized controlled trial.	Cardiovascular diabetology 20110101
Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains.	Lipids in health and disease 20110101
No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis.	Journal of biomedicine & biotechnology 20110101
APPROACH-J study: design, rationale, and baseline data of the affirmation primary prevention with pravastatin in reduction of occlusive atherosclerotic complications in hypercholesterolemia--Japan study.	Journal of atherosclerosis and thrombosis 20110101
Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart.	PloS one 20110101
Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses.	BMC medical genetics 20110101
Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.	Respiratory research 20110101
[Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial].	Revista medica del Instituto Mexicano del Seguro Social 20110101
Long-term efficacy of upstream therapy with lipophilic or hydrophilic statins on antiarrhythmic drugs in patients with paroxysmal atrial fibrillation: comparison between atorvastatin and pravastatin.	International heart journal 20110101
Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites.	PloS one 20110101
Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit.	Cirugia y cirujanos 20110101
Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans.	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101223
Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation.	Journal of controlled release : official journal of the Controlled Release Society 20101220
Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo.	Cardiovascular research 20101201
Lifibrol as a model compound for a novel lipid-lowering mechanism of action.	Journal of cardiovascular pharmacology and therapeutics 20101201
The addition of pravastatin to chemotherapy in advanced gastric carcinoma: a randomised phase II trial.	European journal of cancer (Oxford, England : 1990) 20101201
Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin.	Arteriosclerosis, thrombosis, and vascular biology 20101201
Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin.	International journal of clinical pharmacology and therapeutics 20101201
Pitavastatin - results from phase III & IV.	Atherosclerosis. Supplements 20101201
What is the optimal blood pressure in patients after acute coronary syndromes?: Relationship of blood pressure and cardiovascular events in the PRavastatin OR atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction (PROVE IT-TIMI) 22 trial.	Circulation 20101123
Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity.	Current drug targets 20101101
Effect of pravastatin on bleomycin-induced acute lung injury and pulmonary fibrosis.	Clinical and experimental pharmacology & physiology 20101101
The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-κB activation while enhancing PPARγ expression in human monocyte/macrophages.	Pharmacological research 20101101
Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.	Arteriosclerosis, thrombosis, and vascular biology 20101101
Pravastatin potentiates increases in serum adiponectin concentration in dyslipidemic patients receiving thiazolidinedione: the DOLPHIN study.	Journal of atherosclerosis and thrombosis 20101027
Effects of pravastatin on murine chronic graft-versus-host disease.	Transplantation 20101027
Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015
Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: no clinically relevant drug-drug interactions.	Journal of clinical pharmacology 20101001
Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.	Pharmaceutical research 20101001
Use of statins in patients with chronic hepatitis C.	Southern medical journal 20101001
Acceptable incremental cost effectiveness ratio for use of new drugs, cases in statin therapies.	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001
[Indications for statin therapy in patients with acute coronary syndrome of ischemic origin].	Giornale italiano di cardiologia (2006) 20101001
Efficacy and safety of adding fenofibrate 160 mg in high-risk patients with mixed hyperlipidemia not controlled by pravastatin 40 mg monotherapy.	The American journal of cardiology 20100915
Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up.	Neurology 20100914
No significant effect of uridine or pravastatin treatment for HIV lipoatrophy in men who have ceased thymidine analogue nucleoside reverse transcriptase inhibitor therapy: a randomized trial.	HIV medicine 20100901
Drug-drug interactions between raltegravir and pravastatin in healthy volunteers.	Journal of acquired immune deficiency syndromes (1999) 20100901
Reduction of endoplasmic reticulum stress--a novel mechanism of action of statins in the protection against atherosclerosis.	Atherosclerosis 20100901
On the combined effect of statins and lycopene on cytokine production by human peripheral blood cells.	Heart and vessels 20100901
Office-based global cardiometabolic risk assessment: a simple tool incorporating nontraditional markers.	Critical pathways in cardiology 20100901
Association between lowering low-density lipoprotein cholesterol with pravastatin and primary prevention of cardiovascular disease in mild to moderate hypercholesterolemic Japanese.	Journal of atherosclerosis and thrombosis 20100831
Pravastatin attenuates cardiac dysfunction induced by lysophosphatidylcholine in isolated rat hearts.	European journal of pharmacology 20100825
On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study).	The American journal of cardiology 20100815
KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study.	European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20100801
Effect of combining ACE inhibitor and statin in lupus-prone mice.	Clinical immunology (Orlando, Fla.) 20100801
Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43.	Journal of applied physiology (Bethesda, Md. : 1985) 20100801
Unusual pattern of dyslipidemia in children receiving steroid minimization immunosuppression after renal transplantation.	Clinical journal of the American Society of Nephrology : CJASN 20100801
Comparative study of bezafibrate and pravastatin in patients with coronary artery disease and high levels of remnant lipoprotein.	Circulation journal : official journal of the Japanese Circulation Society 20100801
Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.	Translational research : the journal of laboratory and clinical medicine 20100801
Pravastatin administration does not induce detrimental effects on hemodynamics and collaterals of portal hypertensive rats.	Journal of gastroenterology and hepatology 20100801
The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse.	Microcirculation (New York, N.Y. : 1994) 20100801
Switching to aggressive statin improves vascular endothelial function in patients with stable coronary artery disease.	Journal of atherosclerosis and thrombosis 20100730
Association between percutaneous coronary intervention and long-term C-reactive protein levels in patients with acute coronary syndromes.	Journal of thrombosis and thrombolysis 20100701
Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1.	Molecular pharmacology 20100701
Lipid-lowering drugs and heart failure: where do we go after the statin trials?	Current opinion in cardiology 20100701
Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia.	Obstetrics and gynecology 20100701
Effects of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor pravastatin on membrane lipids and membrane associated functions of Methanothermobacter thermautotrophicus.	Folia microbiologica 20100701
Treatment with pravastatin and fenofibrate improves atherogenic lipid profiles but not inflammatory markers in ACTG 5087.	Journal of clinical lipidology 20100701
Effect of pravastatin on experimental diabetic wound healing.	The Journal of surgical research 20100615
Mitochondrial K(ATP) channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection.	Apoptosis : an international journal on programmed cell death 20100601
Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601
Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells.	Chinese medical journal 20100601
Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.	Journal of cellular and molecular medicine 20100501
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.	Journal of lipid research 20100501
Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs.	Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100501
Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology.	European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20100501
Coronary plaque regression and lifestyle modification in patients treated with pravastatin. - Assessment mainly by daily aerobic exercise and an increase in the serum level of high-density lipoprotein cholesterol -.	Circulation journal : official journal of the Japanese Circulation Society 20100501
Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.	The American journal of cardiology 20100501
[Pravastatin inhibits the expression of syndecan-4 protein in tumor necrosis factor-alpha-induced rat vascular smooth muscle cells in vitro].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501
[Effects of pravastatin on the expression of transforming growth factor-beta 1 in cardiac fibroblasts].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100501
Long-term efficacy of pravastatin therapy in diabetic patients undergoing complete coronary revascularization.	Journal of atherosclerosis and thrombosis 20100430
Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study.	Journal of atherosclerosis and thrombosis 20100430
Differential effects of statins (pravastatin or simvastatin) on ventricular ectopic complexes: Galpha(i2), a possible molecular marker for ventricular irritability.	The American journal of cardiology 20100415
Statins improve visual field alterations related to hypercholesterolemia.	Atherosclerosis 20100401
Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans.	Journal of pediatric hematology/oncology 20100401
[Effects of pravastatin on the proliferation and invasion of human hepatocarcinoma HepG2 cell line].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100401
Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats.	Brain research 20100331
In vitro antioxidant activity of pravastatin provides vascular protection.	European journal of pharmacology 20100325
Statins in acute coronary syndromes and genetic insight.	Journal of the American College of Cardiology 20100323
Letter by Superko and King regarding article, 'Lipid Treatment Assessment Project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals'.	Circulation 20100309
Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial.	Atherosclerosis 20100301
Statins for the treatment of obstetric complications in antiphospholipid syndrome?	Journal of reproductive immunology 20100301
Distribution of traditional and novel risk factors and their relation to subsequent cardiovascular events in patients with acute coronary syndromes (from the PROVE IT-TIMI 22 trial).	The American journal of cardiology 20100301
Buccal drug delivery of pravastatin sodium.	AAPS PharmSciTech 20100301
Pravastatin treatment before coronary artery bypass grafting for reduction of postoperative atrial fibrillation.	General thoracic and cardiovascular surgery 20100301
Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.	Brain research 20100226
Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2?	European journal of clinical pharmacology 20100201
Pravastatin use and cancer risk: a meta-analysis of individual patient data from long-term prospective controlled trials in Japan.	Pharmacoepidemiology and drug safety 20100201
The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.	The pharmacogenomics journal 20100201
Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells.	American journal of physiology. Endocrinology and metabolism 20100201
[A negative first-line work-up of Raynaud's phenomenon: And what if it were cancer?].	Journal des maladies vasculaires 20100201
Pravastatin counteracts angiotensin II-induced upregulation and activation of NADPH oxidase at plasma membrane of human endothelial cells.	Journal of cardiovascular pharmacology 20100201
Effect of pravastatin on kidney function and urinary protein excretion in autosomal dominant polycystic kidney disease.	Scandinavian journal of urology and nephrology 20100201
Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III.	British journal of anaesthesia 20100201
Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3.	British journal of pharmacology 20100201
Commentary on pravastatin and cancer: need for individual patient data meta-analyses.	Pharmacoepidemiology and drug safety 20100201
Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease.	The American journal of cardiology 20100115
Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance.	The American journal of cardiology 20100115
Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial.	AIDS (London, England) 20100102
Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes.	Angiology 20100101
Survival analysis using inverse probability of treatment weighted methods based on the generalized propensity score.	Pharmaceutical statistics 20100101
Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial.	Journal of lipid research 20100101
Pravastatin and cognitive function in the elderly. Results of the PROSPER study.	Journal of neurology 20100101
HPLC and mass spectrometry analysis of dolichol-phosphates at the cell culture scale.	Analytical biochemistry 20100101
Biotechnological production and applications of statins.	Applied microbiology and biotechnology 20100101
Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.	Drug metabolism and disposition: the biological fate of chemicals 20100101
HIV-associated dyslipidaemia among HIV antibody-positive patients in Ireland: prevalence and management strategies.	International journal of STD & AIDS 20100101
Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis.	American journal of physiology. Gastrointestinal and liver physiology 20100101
Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis.	Diabetes research and clinical practice 20100101
Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat.	British journal of pharmacology 20100101
Does higher usage of low-cost statins correlate with a poorer achievement in cholesterol quality markers for secondary prevention?	The British journal of general practice : the journal of the Royal College of General Practitioners 20100101
The disposition of pravastatin in a rat model of streptozotocin-induced diabetes and organic anion transporting polypeptide 2 and multidrug resistance-associated protein 2 expression in the liver.	Biological & pharmaceutical bulletin 20100101
Efficacy and safety of ezetimibe for Japanese patients with dyslipidaemia: The ESSENTIAL Study.	Clinical drug investigation 20100101
Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial.	BMJ (Clinical research ed.) 20100101
Genome-wide association of lipid-lowering response to statins in combined study populations.	PloS one 20100101
Semi-parametric risk prediction models for recurrent cardiovascular events in the LIPID study.	BMC medical research methodology 20100101
Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.	Arthritis research & therapy 20100101
Pitavastatin: the newest HMG-CoA reductase inhibitor.	Reviews in cardiovascular medicine 20100101
The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides.	Drug metabolism and pharmacokinetics 20100101
Clinical implications of the cytokine hypothesis of depression: the association between use of statins and aspirin and the risk of major depression.	Psychotherapy and psychosomatics 20100101
Effects of pravastatin on cellular ultrastructure and hemorheology in rats after traumatic head injury.	Clinical hemorheology and microcirculation 20100101
Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis.	Arthritis research & therapy 20100101
A new mouse model to explore therapies for preeclampsia.	PloS one 20100101
Pravastatin provides antioxidant activity and protection of erythrocytes loaded Primaquine.	International journal of medical sciences 20100101
Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome.	Nucleus (Austin, Tex.) 20100101
Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial.	Journal of the American College of Cardiology 20091215
Cardiovascular outcomes in randomized trials: should time to first event for 'hard' end points remain the standard approach?	Journal of the American College of Cardiology 20091215
Effect of intensive statin therapy on clinical outcomes among patients undergoing percutaneous coronary intervention for acute coronary syndrome. PCI-PROVE IT: A PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) Substudy.	Journal of the American College of Cardiology 20091208
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201
The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome.	Metabolic syndrome and related disorders 20091201
Coronary heart disease in moderately hypercholesterolemic, hypertensive black and non-black patients randomized to pravastatin versus usual care: the antihypertensive and lipid lowering to prevent heart attack trial (ALLHAT-LLT).	American heart journal 20091201
Atrial fibrillation at baseline and during follow-up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).	Journal of the American College of Cardiology 20091124
In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids.	The journal of physical chemistry. B 20091112
Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice.	Journal of reproductive immunology 20091101
Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expression.	Arteriosclerosis, thrombosis, and vascular biology 20091101
The impact of pravastatin therapy on long-term outcome in patients with metabolic syndrome undergoing complete coronary revascularization.	Circulation journal : official journal of the Japanese Circulation Society 20091101
Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic Information on SLCO1B1 and ABCC2 polymorphisms.	Journal of clinical pharmacology 20091101
Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hypertensive rats.	Journal of hypertension 20091101
Efficacy of aggressive lipid controlling therapy for preventing saphenous vein graft disease.	The Annals of thoracic surgery 20091101
Statins and colorectal cancer: the jury is still out.	The American journal of gastroenterology 20091101
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20091028
The SLCO1B1*5 genetic variant is associated with statin-induced side effects.	Journal of the American College of Cardiology 20091020
New highly sensitive enzyme immunoassay for the determination of pravastatin in human plasma.	Talanta 20091015
Skin ulcers and myopathy associated with pravastatin therapy.	Clinical and experimental dermatology 20091001
Pravastatin and cardiovascular risk in moderate chronic kidney disease.	Atherosclerosis 20091001
Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells.	Journal of lipid research 20091001
Prevention of contrast-induced nephropathy by chronic pravastatin treatment in patients with cardiovascular disease and renal insufficiency.	Journal of cardiology 20091001
Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.	Pharmacogenomics 20091001
Risk factors for stroke and lipid-lowering effect of pravastatin on the risk of stroke in Japanese patients with hypercholesterolemia: analysis of data from the MEGA Study, a large randomized controlled trial.	Journal of the neurological sciences 20090915
Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin.	British journal of pharmacology 20090901
Chronic treatment with pravastatin prevents early cardiovascular changes in spontaneously hypertensive rats.	British journal of pharmacology 20090901
Identification of genetic variants associated with response to statin therapy.	Arteriosclerosis, thrombosis, and vascular biology 20090901
Seasonal variation in lipids: should we consider it more?	The American journal of cardiology 20090901
Rhabdomyolysis a result of azithromycin and statins: an unrecognized interaction.	British journal of clinical pharmacology 20090901
[Comparison on long-term effects of atorvastatin or pravastatin combined with clopidogrel for patients undergoing coronary stenting: a randomized controlled trial].	Zhonghua yi xue za zhi 20090825
Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment.	The American journal of cardiology 20090815
A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.	Journal of lipid research 20090801
Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin.	Journal of hypertension 20090801
Improvement of glucose intolerance by combination of pravastatin and olmesartan in type II diabetic KK-A(y) mice.	Hypertension research : official journal of the Japanese Society of Hypertension 20090801
Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase.	Hypertension research : official journal of the Japanese Society of Hypertension 20090801
Rationale and design of assessment of lipophilic vs. hydrophilic statin therapy in acute myocardial infarction (the ALPS-AMI) study.	Journal of cardiology 20090801
Effects of Xuezhikang and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension.	Chinese journal of integrative medicine 20090801
No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.	British journal of clinical pharmacology 20090801
[Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090801
Rosuvastatin for cardiovascular prevention: too many uncertainties.	Prescrire international 20090801
A randomized, multicentre, open-label, parallel-group trial to compare the efficacy and safety profile of daming capsule in patients with hypercholesterolemia.	Phytotherapy research : PTR 20090701
Oral pravastatin prolongs survival time of scrapie-infected mice.	The Journal of general virology 20090701
Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model.	Hypertension research : official journal of the Japanese Society of Hypertension 20090701
Combination treatment to prevent atherosclerosis.	Hypertension (Dallas, Tex. : 1979) 20090701
Long-term efficacy of upstream therapy using angiotensin-converting enzyme inhibitors and statins in combination with antiarrhythmic agents for the treatment of paroxysmal atrial fibrillation.	International heart journal 20090701
Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.	Atherosclerosis 20090601
Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy.	The pharmacogenomics journal 20090601
Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease.	Neurobiology of disease 20090601
Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.	Genes to cells : devoted to molecular & cellular mechanisms 20090601
Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?	PLoS medicine 20090601
Association of body mass index with coronary plaque regression: 6-month prospective study.	Journal of atherosclerosis and thrombosis 20090601
Effects of a concomitant single oral dose of rifampicin on the pharmacokinetics of pravastatin in a two-phase, randomized, single-blind, placebo-controlled, crossover study in healthy Chinese male subjects.	Clinical therapeutics 20090601
Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease.	Clinical science (London, England : 1979) 20090501
Pravastatin limits radiation-induced vascular dysfunction in the skin.	The Journal of investigative dermatology 20090501
Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease.	European journal of clinical investigation 20090501
The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.	Pharmacogenetics and genomics 20090501
Re: Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.	Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090501
Rhabdomyolysis in an HIV-infected patient on anti-retroviral therapy precipitated by high-dose pravastatin.	Current drug safety 20090501
Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease.	Clinical and experimental pharmacology & physiology 20090501
Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury.	Blood 20090423
Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes.	Bioscience, biotechnology, and biochemistry 20090423
Seasonal variation in lipids in patients following acute coronary syndrome on fixed doses of Pravastatin (40 mg) or Atorvastatin (80 mg) (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 [PROVE IT-TIMI 22] Study).	The American journal of cardiology 20090415
Statins for the prevention of dementia.	The Cochrane database of systematic reviews 20090415
Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E-knockout mice.	Clinical and experimental pharmacology & physiology 20090401
The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).	Journal of lipid research 20090401
Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors.	Pharmacoepidemiology and drug safety 20090401
Preoperative statin use and infection after cardiac surgery: a cohort study.	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090401
Statins may not protect against vasospasm in subarachnoid haemorrhage.	Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090401
Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.	Melanoma research 20090401
Rosuvastatin in patients with elevated C-reactive protein.	The New England journal of medicine 20090305
Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension.	Clinical science (London, England : 1979) 20090301
Role of pravastatin in pulmonary hypertension in chronic obstructive pulmonary disease.	Clinical science (London, England : 1979) 20090301
Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22.	Arteriosclerosis, thrombosis, and vascular biology 20090301
Metabolic syndrome abating the beneficial effect of pravastatin treatment on adhesion of endothelium by monocytes in subjects with hypercholesterolemia.	Metabolism: clinical and experimental 20090301
[Statin therapy and muscle disorders].	Orvosi hetilap 20090208
[Comment from the cardiologic viewpoint].	Praxis 20090204
3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.	Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090204
Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans.	The Journal of pharmacology and experimental therapeutics 20090201
Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.	Diabetologia 20090201
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.	Circulation journal : official journal of the Japanese Circulation Society 20090201
Pravastatin for cardiovascular event primary prevention in patients with mild-to-moderate hypertension in the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study.	Hypertension (Dallas, Tex. : 1979) 20090201
Treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH Study): rationale and design.	Circulation journal : official journal of the Japanese Circulation Society 20090201
Effects of pravastatin on the function of dendritic cells in patients with coronary heart disease.	Basic & clinical pharmacology & toxicology 20090201
Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?	Metabolism: clinical and experimental 20090201
[Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090201
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.	Circulation research 20090130
The cornucopia of 'pleiotropic' actions of statins: myogenesis as a new mechanism for statin-induced benefits?	Circulation research 20090130
Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.	Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090101
Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.	Cardiovascular research 20090101
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.	American journal of kidney diseases : the official journal of the National Kidney Foundation 20090101
Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung.	Thorax 20090101
Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?	Journal of leukocyte biology 20090101
Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.	Biomedical chromatography : BMC 20090101
Complete assignment of 1H and 13C NMR data of pravastatin derivatives.	Magnetic resonance in chemistry : MRC 20090101
Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study.	International journal of obesity (2005) 20090101
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.	Anesthesia and analgesia 20090101
[Effect of the brand and generic medicine of pravastatin on dyslipidemia in rabbits fed a high cholesterol diet].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090101
Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.	Journal of pharmacological sciences 20090101
Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis.	PLoS medicine 20090101
[Primary prevention trial by lowering hyperlipidemia on the cardiovascular disease (MEGA Study)].	Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20090101
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.	Drug metabolism and pharmacokinetics 20090101
Effects of statins on the secretion of human serum albumin in cultured HepG2 cells.	Journal of biomedical science 20090101
Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.	Molecular pharmaceutics 20090101
Impact of ezetimibe on cholesterol subfractions in dyslipidemic cardiac transplant recipients receiving statin therapy.	Clinical transplantation 20090101
Mood stabilizer therapy and pravastatin: higher risk for adverse skin reactions?	Acta medica (Hradec Kralove) 20090101
Effects of increasing the dose of pravastatin on serum adiponectin level in Japanese mild hypercholesterolemic and hypertensive patients.	Arzneimittel-Forschung 20090101
Norepinephrine transporter is involved in down-regulation of beta1-adrenergic receptors caused by adjuvant arthritis.	Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101
Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation.	Transplantation 20081227
Reduction of charge-modified LDL by statin therapy in patients with CHD or CHD risk factors and elevated LDL-C levels: the SPECIAL Study.	Atherosclerosis 20081201
Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: results from two open-label extension studies in hypercholesterolemic patients.	Clinical therapeutics 20081201
Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	Circulation. Cardiovascular genetics 20081201
Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.	Journal of the American College of Cardiology 20081125
Statins and blood pressure.	Archives of internal medicine 20081124
The influence of statin medications on prostate-specific antigen levels.	Journal of the National Cancer Institute 20081105
Impact of adherence to statins on chronic heart failure in primary prevention.	British journal of clinical pharmacology 20081101
CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction.	European heart journal 20081101
Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins.	Biopharmaceutics & drug disposition 20081101
Rosuvastatin, pravastatin, and atorvastatin for the treatment of hypercholesterolaemia in HIV-infected patients receiving protease inhibitors.	Current HIV research 20081101
The efficacy and safety of ezetimibe for treatment of dyslipidemia after heart transplantation.	Transplantation proceedings 20081101
Transition of psoriasiform drug eruption to psoriasis de novo evidenced by histopathology.	The Journal of dermatology 20081101
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice.	International journal of molecular sciences 20081101
Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin.	European journal of pharmacology 20081010
Lovastatin, but not pravastatin, limits in vitro infection due to Coxiella burnetii.	The Journal of antimicrobial chemotherapy 20081001
Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes.	Drug metabolism and disposition: the biological fate of chemicals 20081001
Statins limit Rickettsia conorii infection in cells.	International journal of antimicrobial agents 20081001
Ptosis, diplopia and statins: an association?	European journal of neurology 20081001
The relationship between the effect of pravastatin and risk factors for coronary heart disease in Japanese patients with hypercholesterolemia.	Circulation journal : official journal of the Japanese Circulation Society 20081001
Statins: under investigation for increasing bone mineral density and augmenting fracture healing.	Expert opinion on investigational drugs 20081001
A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions.	Journal of biomolecular screening 20081001
Comparison of the effect of lipophilic and hydrophilic statins on serum adiponectin levels in patients with mild hypertension and dyslipidemia: Kinki Adiponectin Interventional (KAI) Study.	Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001
Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus.	Journal of atherosclerosis and thrombosis 20081001
Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress.	Hypertension research : official journal of the Japanese Society of Hypertension 20081001
Baseline low-density lipoprotein cholesterol is an important predictor of the benefit of intensive lipid-lowering therapy: a PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) analysis.	Journal of the American College of Cardiology 20080909
Phytosterols dissolved in diacylglycerol oil reinforce the cholesterol-lowering effect of low-dose pravastatin treatment.	Nutrition, metabolism, and cardiovascular diseases : NMCD 20080901
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.	Atherosclerosis 20080901
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.	Atherosclerosis 20080901
Statin therapy increases carotid plaque echogenicity in hypercholesterolemic patients.	Ultrasound in medicine & biology 20080901
Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients.	Clinical and experimental pharmacology & physiology 20080901
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.	Kidney international 20080901
Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.	International journal of cancer 20080901
Progression of kidney disease in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin versus usual care: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).	American journal of kidney diseases : the official journal of the National Kidney Foundation 20080901
Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.	Pharmacogenetics and genomics 20080901
Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function.	Kidney international 20080901
Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials).	The American journal of cardiology 20080901
Statins for slowing kidney disease progression: an as yet unproven indication.	American journal of kidney diseases : the official journal of the National Kidney Foundation 20080901
Pharmacogenomic importance of pravastatin.	Pharmacogenomics 20080901
Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model.	Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20080901
[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina].	Zhonghua xin xue guan bing za zhi 20080901
Effects of pravastatin on obesity, diabetes, and adiponectin in diet-induced obese mice.	Obesity (Silver Spring, Md.) 20080901
Increased adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: a role of the attenuation of oxidative stress.	Atherosclerosis 20080801
Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy.	Atherosclerosis 20080801
Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801
Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.	Clinical pharmacology and therapeutics 20080801
Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.	Molecular pharmacology 20080801
Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.	British journal of pharmacology 20080801
Impact of a combined treatment of angiotensin II type 1 receptor blockade and 3-hydroxy-3-methyl-glutaryl-CoA-reductase inhibition on secretory phospholipase A2-type IIA and low density lipoprotein oxidation in patients with coronary artery disease.	European heart journal 20080801
Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway.	The American journal of pathology 20080801
Pravastatin-induced colitis.	European journal of gastroenterology & hepatology 20080801
Pravastatin reduces the risk for cardiovascular disease in Japanese hypercholesterolemic patients with impaired fasting glucose or diabetes: diabetes subanalysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study.	Atherosclerosis 20080801
Lipophilicity and cardiovascular outcome in patients with CHF.	American heart journal 20080801
LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products.	Journal of pharmaceutical and biomedical analysis 20080715
Re: The association between statins and cancer incidence in a veterans population.	Journal of the National Cancer Institute 20080702
Gender-specific regulation of pancreatic islet blood flow, insulin levels and glycaemia in spontaneously diabetic Goto-Kakizaki rats.	Clinical science (London, England : 1979) 20080701
On-line extraction coupled with liquid chromatography tandem mass spectrometry for quantitation of pravastatin and its metabolite in human serum.	Biomedical chromatography : BMC 20080701
Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis.	Apoptosis : an international journal on programmed cell death 20080701
Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study.	Journal of the American College of Cardiology 20080701
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.	Nature medicine 20080701
Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker: a pilot study.	Journal of cardiovascular pharmacology 20080701
Rejuvenating premature aging.	Nature medicine 20080701
Lipid management: considerations in acute coronary syndrome.	Current cardiology reports 20080701
Pravastatin increases the expression of the tissue inhibitor of matrix metalloproteinase-1 and the oncogene Bax in human aortic abdominal aneurysms.	Canadian journal of physiology and pharmacology 20080701
Cost-effectiveness analysis of rosuvastatin versus atorvastatin, simvastatin, and pravastatin from a Canadian health system perspective.	Clinical therapeutics 20080701
Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.	Lancet (London, England) 20080607
Neuroprotection by pravastatin in acute ischemic stroke in rats.	Brain research reviews 20080601
Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.	Diabetes 20080601
Association of circulating leukocyte count with coronary atherosclerosis regression after pravastatin treatment.	Atherosclerosis 20080601
Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.	American journal of physiology. Heart and circulatory physiology 20080601
Efficacy of lipid-lowering medications in patients treated with clozapine: a naturalistic study.	Journal of clinical psychopharmacology 20080601
Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia.	The Journal of pediatrics 20080601
The relation between extent of coronary artery disease measured by quantitative coronary angiography and changes in lipid profile: insights from trials of atherosclerosis regression.	The Journal of invasive cardiology 20080601
Pravastatin: an evidence-based statin?	Expert opinion on drug metabolism & toxicology 20080601
Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass.	European cytokine network 20080601
[Pleiotropic effects of statins].	Revista medica de Chile 20080601
Repression of BK virus infection of human renal proximal tubular epithelial cells by pravastatin.	Transplantation 20080515
Estimation of treatment effect adjusting for treatment changes using the intensity score method: application to a large primary prevention study for coronary events (MEGA study).	Statistics in medicine 20080510
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.	American journal of human genetics 20080509
Monitoring cholesterol levels: measurement error or true change?	Annals of internal medicine 20080506
An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection.	Journal of chromatography. A 20080502
Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.	Arteriosclerosis, thrombosis, and vascular biology 20080501
Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis.	Clinical immunology (Orlando, Fla.) 20080501
Atorvastatin monotherapy vs. combination therapy in the management of patients with combined hyperlipidemia.	European journal of internal medicine 20080501

Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Chemical research in toxicology 20150518

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes.

Toxicology in vitro : an international journal published in association with BIBRA 20140901

Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.

Toxicological sciences : an official journal of the Society of Toxicology 20130701

ATP-dependent transport of statins by human and rat MRP2/Mrp2.

Toxicology and applied pharmacology 20130601

Simvastatin-lnduced nocturnal leg pain disappears with pravastatin substitution.

Srpski arhiv za celokupno lekarstvo 20130101

Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.

Journal of clinical pharmacology 20121101

Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.

Pharmaceutical research 20121001

Development and validation of a simple and fast HPLC method for determination of lovastatin, pravastatin and simvastatin.

Journal of chromatographic science 20121001

Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.

American journal of physiology. Heart and circulatory physiology 20121001

Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function.

Human reproduction (Oxford, England) 20121001

Association of cholesteryl ester transfer protein mass with peripheral leukocyte count following statin therapy: a pilot study.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20121001

Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease.

Clinical nephrology 20121001

Effects of rosuvastatin versus pravastatin on low-density lipoprotein diameter in HIV-1-infected patients receiving ritonavir-boosted protease inhibitor.

AIDS (London, England) 20120910

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

Molecular pharmaceutics 20120904

Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.

Journal of cellular and molecular medicine 20120901

Pravastatin reverses the membrane cholesterol reorganization induced by myocardial infarction within lipid rafts in CD14(+)/CD16(-) circulating monocytes.

Biochimica et biophysica acta 20120901

Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.

European heart journal 20120901

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20120901

Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20120901

Impacts of estimated glomerular filtration rate on coronary atherosclerosis and plaque composition before and during statin therapy in patients with normal to mild renal dysfunction: subanalysis of the TRUTH study.

Nephrology (Carlton, Vic.) 20120901

Can statins reduce the inflammatory response associated with preterm birth in an animal model?

American journal of obstetrics and gynecology 20120901

Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance.

Transplantation 20120815

Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.

Metabolism: clinical and experimental 20120801

Pravastatin and simvastatin improves acetylsalicylic acid-mediated in vitro blood platelet inhibition.

European journal of clinical investigation 20120801

Elevated concentration of placental growth factor (PlGF) and long term risk in patients with acute coronary syndrome in the PROVE IT-TIMI 22 trial.

Journal of thrombosis and thrombolysis 20120801

Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance.

Journal of applied physiology (Bethesda, Md. : 1985) 20120801

Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis.

Journal of molecular and cellular cardiology 20120801

Erythrocyte-mediated delivery of pravastatin: in vitro study of effect of hypotonic lysis on biochemical parameters and loading efficiency.

Archives of pharmacal research 20120801

Prospective, randomized, single-blind comparison of effects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease.

Heart and vessels 20120701

Comparative efficacy and safety of fenofibrate/pravastatin plus ezetimibe triple therapy and simvastatin/ezetimibe dual therapy in type 2 diabetic patients with mixed hyperlipidaemia and cardiovascular disease.

Diabetes & vascular disease research 20120701

Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy.

Diabetes, obesity & metabolism 20120701

Effects of bile salts on gastrointestinal absorption of pravastatin.

Journal of pharmaceutical sciences 20120701

Cholesterol level goal attainment with statins: clinical management guideline recommendations versus management in actual clinical practice.

Pharmacotherapy 20120701

Role of non-high-density lipoprotein cholesterol in predicting cerebrovascular events in patients following myocardial infarction.

The American journal of cardiology 20120615

Blood pressure control status and effects of pravastatin on cardiovascular events occurrence in patients with dyslipidaemia.

Journal of human hypertension 20120601

Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.

Acta physiologica (Oxford, England) 20120601

Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress.

Cardiovascular research 20120601

A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter.

American journal of physiology. Cell physiology 20120601

The effect of low-dose pravastatin in metabolic syndrome for primary prevention of cardiovascular disease in Japan: a post hoc analysis of the MEGA study.

Journal of cardiovascular pharmacology and therapeutics 20120601

Effects of pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of diabetic nephropathy in an experimental model of diabetic renal disease.

Saudi medical journal 20120601

The evaluation of analgesic effects of simvastatin, pravastatin and atorvastatin in hot plate test.

European review for medical and pharmacological sciences 20120601

Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis.

Medical mycology 20120501

Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.

British journal of clinical pharmacology 20120501

EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.

Molecular and cellular biochemistry 20120501

Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.

Drug metabolism and disposition: the biological fate of chemicals 20120501

Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells.

Clinical and experimental immunology 20120501

Pravastatin and fenofibrate in combination (Pravafenix(®)) for the treatment of high-risk patients with mixed hyperlipidemia.

Expert review of cardiovascular therapy 20120501

Pravastatin attenuates noise-induced cochlear injury in mice.

Neuroscience 20120419

Mechanisms involved in cardioprotective effects of pravastatin administered during reoxygenation in human myocardium in vitro.

Anesthesiology 20120401

Safety of a fixed-dose combination of fenofibrate/pravastatin 160 mg/40 mg in patients with mixed hyperlipidaemia: a pooled analysis from a database of clinical trials.

Clinical drug investigation 20120401

Targeting HDL-cholesterol to reduce residual cardiovascular risk.

Current opinion in lipidology 20120401

Development of a model for prediction of coronary atherosclerotic regression: evaluation of high-density lipoprotein cholesterol level and peripheral blood monocyte count.

Heart and vessels 20120301

In vitro evaluation of phototoxic properties of proton pump inhibitors, H2-receptor antagonists and statins.

Acta dermato-venereologica 20120301

Effect of dalcetrapib plus pravastatin on lipoprotein metabolism and high-density lipoprotein composition and function in dyslipidemic patients: results of a phase IIb dose-ranging study.

American heart journal 20120301

Determination of pravastatin and pravastatin lactone in rat plasma and urine using UHPLC-MS/MS and microextraction by packed sorbent.

Talanta 20120215

Pravastatin for thioacetamide-induced hepatic failure and encephalopathy.

European journal of clinical investigation 20120201

The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.

British journal of clinical pharmacology 20120201

Pravastatin inhibits C-reactive protein generation induced by fibrinogen, fibrin and FDP in isolated rat vascular smooth muscle cells.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120201

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction.

International journal of epidemiology 20120201

Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly.

Atherosclerosis 20120201

KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.

Atherosclerosis 20120201

HMG-CoA reductase inhibitors (statins) reduce hypertrophic scar formation in a rabbit ear wounding model.

Plastic and reconstructive surgery 20120201

Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis.

American heart journal 20120201

Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats.

Acta orthopaedica 20120201

Statin therapy in the elderly: might there be uncertainty in the majority?

European journal of preventive cardiology 20120201

Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability.

The Journal of physiology 20120115

Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients: Justification for Atherosclerosis Regression Treatment (JART) study.

Circulation journal : official journal of the Japanese Circulation Society 20120101

Galectin-3 and the development of heart failure after acute coronary syndrome: pilot experience from PROVE IT-TIMI 22.

Clinical chemistry 20120101

Usefulness of LDL-C-related parameters to predict cardiovascular risk and effect of pravastatin in mild-to-moderate hypercholesterolemia.

Journal of atherosclerosis and thrombosis 20120101

Bilayered transmucosal drug delivery system of pravastatin sodium: statistical optimization, in vitro, ex vivo, in vivo and stability assessment.

Drug delivery 20120101

The differential effect of statins on oxidative stress and endothelial function: atorvastatin versus pravastatin.

Journal of clinical lipidology 20120101

Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.

Circulation journal : official journal of the Japanese Circulation Society 20120101

Double-dose pravastatin versus add-on ezetimibe with low-dose pravastatin - effects on LDL cholesterol, cholesterol absorption, and cholesterol synthesis in Japanese patients with hypercholesterolemia (PEAS study).

Journal of atherosclerosis and thrombosis 20120101

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

PloS one 20120101

Selected statins produce rapid spinal motor neuron loss in vitro.

BMC musculoskeletal disorders 20120101

Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

PloS one 20120101

[Equivalence studies of pravastatin original and generic drugs by dissolution test].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Effect of pravastatin on endothelial function and endothelial progenitor cells in healthy postmenopausal women.

Clinical and experimental obstetrics & gynecology 20120101

Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.

PloS one 20120101

A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.

PloS one 20120101

Adherence to preferable behavior for lipid control by high-risk dyslipidemic Japanese patients under pravastatin treatment: the APPROACH-J study.

Journal of atherosclerosis and thrombosis 20120101

Angiotensin converting enzyme inhibitor and HMG-CoA reductase inhibitor as adjunct treatment for persons with HIV infection: a feasibility randomized trial.

PloS one 20120101

Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: possible role of CYP3A4 inhibition by pravastatin.

Indian journal of pharmacology 20120101

Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat: role of vitamin D metabolites.

Atherosclerosis 20111201

HMG-CoA reductase inhibitor (Statin) therapy and coronary atherosclerosis in Japanese subjects: role of high-density lipoprotein cholesterol.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20111201

[Achievement of therapeutic target in subjects on statin treatment in clinical practice. Results of the STAR (Statins Target Assessment in Real practice) study].

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20111201

Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats.

Life sciences 20111107

Low-dosage statins reduce choroidal damage in hypercholesterolemic rabbits.

Acta ophthalmologica 20111101

Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study.

Critical care medicine 20111101

The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.

Journal of neural transmission (Vienna, Austria : 1996) 20111101

Differential effect of statins on diabetic nephropathy in db/db mice.

International journal of molecular medicine 20111101

Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation.

Journal of experimental botany 20111101

Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high risk patients with mixed hyperlipidemia not controlled by pravastatin monotherapy.

Current medical research and opinion 20111101

Efficient bioconversion of compactin to pravastatin by the quinoline-degrading microorganism Pseudonocardia carboxydivorans isolated from petroleum-contaminated soil.

Bioresource technology 20111101

Statins in preventing ventilator-associated pneumonia and death: still only a hope*.

Critical care medicine 20111101

Apolipoprotein B100 is a better treatment target than calculated LDL and non-HDL cholesterol in statin-treated patients.

Annals of clinical biochemistry 20111101

Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells.

The Journal of thoracic and cardiovascular surgery 20111101

High-sensitivity C-reactive protein levels do not decrease with the use of statins in all persons with HIV infection.

AIDS (London, England) 20111023

Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis.

Journal of gastroenterology and hepatology 20111001

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk.

Arteriosclerosis, thrombosis, and vascular biology 20111001

Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study.

Clinical pharmacology and therapeutics 20111001

Role of complement component C1q in the onset of preeclampsia in mice.

Hypertension (Dallas, Tex. : 1979) 20111001

Effects of statins on cholestasis: good, bad or indifferent?

Journal of gastroenterology and hepatology 20111001

Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia.

American journal of obstetrics and gynecology 20111001

Pravastatin reduces Marfan aortic dilation.

Circulation 20110913

Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.

American journal of physiology. Heart and circulatory physiology 20110901

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20110901

Low-dose pravastatin and age-related differences in risk factors for cardiovascular disease in hypercholesterolaemic Japanese: analysis of the management of elevated cholesterol in the primary prevention group of adult Japanese (MEGA study).

Drugs & aging 20110901

[Prediction of the pharmacokinetic drug-drug interaction of pravastatin and pitavastatin with cyclosporine by a digital liver model based on metabolism and transporter].

Yao xue xue bao = Acta pharmaceutica Sinica 20110901

Graft-protective effects of the HMG-CoA reductase inhibitor pravastatin after lung transplantation--a propensity score analysis with 23 years of follow-up.

Transplantation 20110827

HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits.

Biochemical and biophysical research communications 20110819

Long-term follow-up of statin treatment in a cohort of children with familial hypercholesterolemia: efficacy and tolerability.

Paediatric drugs 20110801

Statins promote the growth of experimentally induced cerebral aneurysms in estrogen-deficient rats.

Stroke 20110801

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Atherosclerosis 20110801

The complex interplay between cholesterol and prostate malignancy.

The Urologic clinics of North America 20110801

Data mining approach shows promise in detecting unexpected drug interactions.

JAMA 20110713

Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.

Human & experimental toxicology 20110701

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes.

Xenobiotica; the fate of foreign compounds in biological systems 20110701

HMG CoA reduction in patients with average cholesterol concentrations.

Clinical chemistry 20110701

Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.

Clinical pharmacology and therapeutics 20110701

[Pharmaco-economic optimization of cholesterol-lowering treatment with statins].

Medicina clinica 20110625

Intravenous administration of pravastatin immediately after middle cerebral artery occlusion reduces cerebral oedema in spontaneously hypertensive rats.

European journal of pharmacology 20110625

Effect of statins on cholesterol crystallization and atherosclerotic plaque stabilization.

The American journal of cardiology 20110615

Statins and prostate cancer diagnosis and grade in a veterans population.

Journal of the National Cancer Institute 20110608

Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease.

Fundamental & clinical pharmacology 20110601

High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome.

The pharmacogenomics journal 20110601

Prognostic utility of neopterin and risk of heart failure hospitalization after an acute coronary syndrome.

European heart journal 20110601

Treatment with pravastatin attenuates progression of chronic pancreatitis in rat.

Laboratory investigation; a journal of technical methods and pathology 20110601

Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.

Drug metabolism and disposition: the biological fate of chemicals 20110601

Effects of statins on matrix metalloproteinases and their endogenous inhibitors in human endothelial cells.

Naunyn-Schmiedeberg's archives of pharmacology 20110601

Design and in vitro performance evaluation of purified microparticles of pravastatin sodium for intestinal delivery.

AAPS PharmSciTech 20110601

Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22).

American heart journal 20110601

Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria:Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT).

American heart journal 20110601

High-sensitivity C-reactive protein levels fall during statin therapy in HIV-infected patients receiving ritonavir-boosted protease inhibitors.

AIDS (London, England) 20110515

Effect of statin therapy on disease progression in pediatric ADPKD: design and baseline characteristics of participants.

Contemporary clinical trials 20110501

The incidence and risk factors for new onset atrial fibrillation in the PROSPER study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110501

Pravastatin therapy fails to suppress post-PCI inflammatory response measured by serum neopterin and CRP levels.

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110501

Benefit of intensive statin therapy in women: results from PROVE IT-TIMI 22.

Circulation. Cardiovascular quality and outcomes 20110501

Treatment of indeterminate cell histiocytosis with pravastatin.

Journal of the American Academy of Dermatology 20110501

The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention.

JACC. Cardiovascular interventions 20110501

Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation.

Heart (British Cardiac Society) 20110401

Statins utilisation pattern: a retrospective evaluation in a tertiary care hospital in Thailand.

The International journal of pharmacy practice 20110401

Treatment with pravastatin attenuates oxidative stress and protects osteoblast cell viability from indoxyl sulfate.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20110401

Pravastatin activates PPARalpha/PPARgamma expression in the liver and gallbladder epithelium of hamsters.

Hepatobiliary & pancreatic diseases international : HBPD INT 20110401

Rosuvastatin and primary cardiovascular prevention. Continue to use pravastatin or simvastatin.

Prescrire international 20110401

Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110301

Variation in the CBP gene involved in epigenetic control associates with cognitive function.

Neurobiology of aging 20110301

Differential metabolic effects of distinct statins.

Atherosclerosis 20110301

Influence of long-term treatment with pravastatin on the survival, evolution of cutaneous lesion and weight of animals infected by Leishmania amazonensis.

Experimental parasitology 20110301

Mannose binding lectin 2 haplotypes do not affect the progression of coronary atherosclerosis in men with proven coronary artery disease treated with pravastatin.

Atherosclerosis 20110301

A novel use of oxidative coupling reactions for determination of some statins (cholesterol-lowering drugs) in pharmaceutical formulations.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110301

[Effect of pravastatin on transportation of scutellarin in mouse liver and its mechanism].

Yao xue xue bao = Acta pharmaceutica Sinica 20110301

Low-density lipoprotein cholesterol goal attainment among Malaysian dyslipidemic patients.

The Southeast Asian journal of tropical medicine and public health 20110301

Efficacy and safety of more intensive lowering of LDL cholesterol.

Lancet (London, England) 20110226

Effect of niacin on preβ-1 high-density lipoprotein levels in diabetes.

Metabolism: clinical and experimental 20110201

Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions.

Thrombosis and haemostasis 20110201

Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation.

Thrombosis research 20110201

[Pravastatin and rosiglitazone combination therapy upgrades the expression of ABCA1 in THP-1 macrophages].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110201

[Retention behavior of statins in microemulsion liquid chromatography].

Se pu = Chinese journal of chromatography 20110201

The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.

European journal of pharmacology 20110125

Monitoring adherence to drug treatment by using change in cholesterol concentration: secondary analysis of trial data.

BMJ (Clinical research ed.) 20110121

Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor.

Biochemical and biophysical research communications 20110107

Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.

Journal of molecular and cellular cardiology 20110101

Differential effects of statins on endogenous H2S formation in perivascular adipose tissue.

Pharmacological research 20110101

Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.

Journal of atherosclerosis and thrombosis 20110101

Paradoxical decrease in HDL-cholesterol and apolipoprotein A1 with simvastatin and atorvastatin in a patient with type 2 diabetes.

Annals of clinical biochemistry 20110101

Colchicine-induced rhabdomyolysis in a heart/lung transplant patient with concurrent use of cyclosporin, pravastatin, and azithromycin.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20110101

Statins have an early antiplatelet effect in patients with acute myocardial infarction.

Platelets 20110101

[Anti-atherosclerotic and anti-inflammatory effects of statin on cardiovascular disease and their mechanisms].

Nihon rinsho. Japanese journal of clinical medicine 20110101

Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin.

Journal of clinical lipidology 20110101

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

BMC geriatrics 20110101

Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia.

Endocrine journal 20110101

Pravastatin versus simvastatin for prevention of contrast-induced nephropathy.

Journal of cardiovascular pharmacology and therapeutics 20110101

Fixed-dose combination fenofibrate/pravastatin 160/40 mg versus simvastatin 20 mg monotherapy in adults with type 2 diabetes and mixed hyperlipidemia uncontrolled with simvastatin 20 mg: a double-blind, randomized comparative study.

Clinical therapeutics 20110101

Statins as modulators of colon cancer cells induced cytokine secretion by human PBMC.

Vascular pharmacology 20110101

Characterization of human erythrocytes as potential carrier for pravastatin: an in vitro study.

International journal of medical sciences 20110101

Acute modulation of vasoconstrictor responses by pravastatin in small vessels.

Circulation journal : official journal of the Japanese Circulation Society 20110101

Cardioprotective effects of pravastatin against lethal ventricular arrhythmias induced by reperfusion in the rat heart.

Circulation journal : official journal of the Japanese Circulation Society 20110101

Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.

Journal of biomedicine & biotechnology 20110101

Relationship between hemoglobin A1c and cardiovascular disease in mild-to-moderate hypercholesterolemic Japanese individuals: subanalysis of a large-scale randomized controlled trial.

Cardiovascular diabetology 20110101

Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains.

Lipids in health and disease 20110101

No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis.

Journal of biomedicine & biotechnology 20110101

APPROACH-J study: design, rationale, and baseline data of the affirmation primary prevention with pravastatin in reduction of occlusive atherosclerotic complications in hypercholesterolemia--Japan study.

Journal of atherosclerosis and thrombosis 20110101

Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart.

PloS one 20110101

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses.

BMC medical genetics 20110101

Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells.

Respiratory research 20110101

[Therapeutic use Hibiscus sabadariffa extract in the treatment of hypercholesterolemia. A randomized clinical trial].

Revista medica del Instituto Mexicano del Seguro Social 20110101

Long-term efficacy of upstream therapy with lipophilic or hydrophilic statins on antiarrhythmic drugs in patients with paroxysmal atrial fibrillation: comparison between atorvastatin and pravastatin.

International heart journal 20110101

Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites.

PloS one 20110101

Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit.

Cirugia y cirujanos 20110101

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101223

Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation.

Journal of controlled release : official journal of the Controlled Release Society 20101220

Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo.

Cardiovascular research 20101201

Lifibrol as a model compound for a novel lipid-lowering mechanism of action.

Journal of cardiovascular pharmacology and therapeutics 20101201

The addition of pravastatin to chemotherapy in advanced gastric carcinoma: a randomised phase II trial.

European journal of cancer (Oxford, England : 1990) 20101201

Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin.

Arteriosclerosis, thrombosis, and vascular biology 20101201

Atorvastatin-induced acute elevation of hepatic enzymes and the absence of cross-toxicity of pravastatin.

International journal of clinical pharmacology and therapeutics 20101201

Pitavastatin - results from phase III & IV.

Atherosclerosis. Supplements 20101201

What is the optimal blood pressure in patients after acute coronary syndromes?: Relationship of blood pressure and cardiovascular events in the PRavastatin OR atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction (PROVE IT-TIMI) 22 trial.

Circulation 20101123

Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity.

Current drug targets 20101101

Effect of pravastatin on bleomycin-induced acute lung injury and pulmonary fibrosis.

Clinical and experimental pharmacology & physiology 20101101

The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-κB activation while enhancing PPARγ expression in human monocyte/macrophages.

Pharmacological research 20101101

Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

Arteriosclerosis, thrombosis, and vascular biology 20101101

Pravastatin potentiates increases in serum adiponectin concentration in dyslipidemic patients receiving thiazolidinedione: the DOLPHIN study.

Journal of atherosclerosis and thrombosis 20101027

Effects of pravastatin on murine chronic graft-versus-host disease.

Transplantation 20101027

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

Coadministration of dalcetrapib with pravastatin, rosuvastatin, or simvastatin: no clinically relevant drug-drug interactions.

Journal of clinical pharmacology 20101001

Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.

Pharmaceutical research 20101001

Use of statins in patients with chronic hepatitis C.

Southern medical journal 20101001

Acceptable incremental cost effectiveness ratio for use of new drugs, cases in statin therapies.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001

[Indications for statin therapy in patients with acute coronary syndrome of ischemic origin].

Giornale italiano di cardiologia (2006) 20101001

Efficacy and safety of adding fenofibrate 160 mg in high-risk patients with mixed hyperlipidemia not controlled by pravastatin 40 mg monotherapy.

The American journal of cardiology 20100915

Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up.

Neurology 20100914

No significant effect of uridine or pravastatin treatment for HIV lipoatrophy in men who have ceased thymidine analogue nucleoside reverse transcriptase inhibitor therapy: a randomized trial.

HIV medicine 20100901

Drug-drug interactions between raltegravir and pravastatin in healthy volunteers.

Journal of acquired immune deficiency syndromes (1999) 20100901

Reduction of endoplasmic reticulum stress--a novel mechanism of action of statins in the protection against atherosclerosis.

Atherosclerosis 20100901

On the combined effect of statins and lycopene on cytokine production by human peripheral blood cells.

Heart and vessels 20100901

Office-based global cardiometabolic risk assessment: a simple tool incorporating nontraditional markers.

Critical pathways in cardiology 20100901

Association between lowering low-density lipoprotein cholesterol with pravastatin and primary prevention of cardiovascular disease in mild to moderate hypercholesterolemic Japanese.

Journal of atherosclerosis and thrombosis 20100831

Pravastatin attenuates cardiac dysfunction induced by lysophosphatidylcholine in isolated rat hearts.

European journal of pharmacology 20100825

On-statin cholesteryl ester transfer protein mass and risk of recurrent coronary events (from the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 [PROVE IT-TIMI 22] study).

The American journal of cardiology 20100815

KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20100801

Effect of combining ACE inhibitor and statin in lupus-prone mice.

Clinical immunology (Orlando, Fla.) 20100801

Effect of pravastatin on ventricular arrhythmias in infarcted rats: role of connexin43.

Journal of applied physiology (Bethesda, Md. : 1985) 20100801

Unusual pattern of dyslipidemia in children receiving steroid minimization immunosuppression after renal transplantation.

Clinical journal of the American Society of Nephrology : CJASN 20100801

Comparative study of bezafibrate and pravastatin in patients with coronary artery disease and high levels of remnant lipoprotein.

Circulation journal : official journal of the Japanese Circulation Society 20100801

Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.

Translational research : the journal of laboratory and clinical medicine 20100801

Pravastatin administration does not induce detrimental effects on hemodynamics and collaterals of portal hypertensive rats.

Journal of gastroenterology and hepatology 20100801

The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse.

Microcirculation (New York, N.Y. : 1994) 20100801

Switching to aggressive statin improves vascular endothelial function in patients with stable coronary artery disease.

Journal of atherosclerosis and thrombosis 20100730

Association between percutaneous coronary intervention and long-term C-reactive protein levels in patients with acute coronary syndromes.

Journal of thrombosis and thrombolysis 20100701

Pravastatin attenuates carboplatin-induced nephrotoxicity in rodents via peroxisome proliferator-activated receptor alpha-regulated heme oxygenase-1.

Molecular pharmacology 20100701

Lipid-lowering drugs and heart failure: where do we go after the statin trials?

Current opinion in cardiology 20100701

Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia.

Obstetrics and gynecology 20100701

Effects of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor pravastatin on membrane lipids and membrane associated functions of Methanothermobacter thermautotrophicus.

Folia microbiologica 20100701

Treatment with pravastatin and fenofibrate improves atherogenic lipid profiles but not inflammatory markers in ACTG 5087.

Journal of clinical lipidology 20100701

Effect of pravastatin on experimental diabetic wound healing.

The Journal of surgical research 20100615

Mitochondrial K(ATP) channels-derived reactive oxygen species activate pro-survival pathway in pravastatin-induced cardioprotection.

Apoptosis : an international journal on programmed cell death 20100601

Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Aspirin and pravastatin reduce lectin-like oxidized low density lipoprotein receptor-1 expression, adhesion molecules and oxidative stress in human coronary artery endothelial cells.

Chinese medical journal 20100601

Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.

Journal of cellular and molecular medicine 20100501

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.

Journal of lipid research 20100501

Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20100501

Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20100501

Coronary plaque regression and lifestyle modification in patients treated with pravastatin. - Assessment mainly by daily aerobic exercise and an increase in the serum level of high-density lipoprotein cholesterol -.

Circulation journal : official journal of the Japanese Circulation Society 20100501

Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.

The American journal of cardiology 20100501

[Pravastatin inhibits the expression of syndecan-4 protein in tumor necrosis factor-alpha-induced rat vascular smooth muscle cells in vitro].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501

[Effects of pravastatin on the expression of transforming growth factor-beta 1 in cardiac fibroblasts].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100501

Long-term efficacy of pravastatin therapy in diabetic patients undergoing complete coronary revascularization.

Journal of atherosclerosis and thrombosis 20100430

Can intensive lipid-lowering therapy with statins ameliorate atherosclerosis in Japanese patients? Rationale and design of the JART study.

Journal of atherosclerosis and thrombosis 20100430

Differential effects of statins (pravastatin or simvastatin) on ventricular ectopic complexes: Galpha(i2), a possible molecular marker for ventricular irritability.

The American journal of cardiology 20100415

Statins improve visual field alterations related to hypercholesterolemia.

Atherosclerosis 20100401

Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans.

Journal of pediatric hematology/oncology 20100401

[Effects of pravastatin on the proliferation and invasion of human hepatocarcinoma HepG2 cell line].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100401

Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats.

Brain research 20100331

In vitro antioxidant activity of pravastatin provides vascular protection.

European journal of pharmacology 20100325

Statins in acute coronary syndromes and genetic insight.

Journal of the American College of Cardiology 20100323

Letter by Superko and King regarding article, 'Lipid Treatment Assessment Project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals'.

Circulation 20100309

Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial.

Atherosclerosis 20100301

Statins for the treatment of obstetric complications in antiphospholipid syndrome?

Journal of reproductive immunology 20100301

Distribution of traditional and novel risk factors and their relation to subsequent cardiovascular events in patients with acute coronary syndromes (from the PROVE IT-TIMI 22 trial).

The American journal of cardiology 20100301

Buccal drug delivery of pravastatin sodium.

AAPS PharmSciTech 20100301

Pravastatin treatment before coronary artery bypass grafting for reduction of postoperative atrial fibrillation.

General thoracic and cardiovascular surgery 20100301

Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition.

Brain research 20100226

Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2?

European journal of clinical pharmacology 20100201

Pravastatin use and cancer risk: a meta-analysis of individual patient data from long-term prospective controlled trials in Japan.

Pharmacoepidemiology and drug safety 20100201

The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.

The pharmacogenomics journal 20100201

Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells.

American journal of physiology. Endocrinology and metabolism 20100201

[A negative first-line work-up of Raynaud's phenomenon: And what if it were cancer?].

Journal des maladies vasculaires 20100201

Pravastatin counteracts angiotensin II-induced upregulation and activation of NADPH oxidase at plasma membrane of human endothelial cells.

Journal of cardiovascular pharmacology 20100201

Effect of pravastatin on kidney function and urinary protein excretion in autosomal dominant polycystic kidney disease.

Scandinavian journal of urology and nephrology 20100201

Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III.

British journal of anaesthesia 20100201

Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3.

British journal of pharmacology 20100201

Commentary on pravastatin and cancer: need for individual patient data meta-analyses.

Pharmacoepidemiology and drug safety 20100201

Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease.

The American journal of cardiology 20100115

Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance.

The American journal of cardiology 20100115

Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial.

AIDS (London, England) 20100102

Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes.

Angiology 20100101

Survival analysis using inverse probability of treatment weighted methods based on the generalized propensity score.

Pharmaceutical statistics 20100101

Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial.

Journal of lipid research 20100101

Pravastatin and cognitive function in the elderly. Results of the PROSPER study.

Journal of neurology 20100101

HPLC and mass spectrometry analysis of dolichol-phosphates at the cell culture scale.

Analytical biochemistry 20100101

Biotechnological production and applications of statins.

Applied microbiology and biotechnology 20100101

Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.

Drug metabolism and disposition: the biological fate of chemicals 20100101

HIV-associated dyslipidaemia among HIV antibody-positive patients in Ireland: prevalence and management strategies.

International journal of STD & AIDS 20100101

Synergistic antifibrotic efficacy of statin and protein kinase C inhibitor in hepatic fibrosis.

American journal of physiology. Gastrointestinal and liver physiology 20100101

Differing effect of statins on insulin sensitivity in non-diabetics: a systematic review and meta-analysis.

Diabetes research and clinical practice 20100101

Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat.

British journal of pharmacology 20100101

Does higher usage of low-cost statins correlate with a poorer achievement in cholesterol quality markers for secondary prevention?

The British journal of general practice : the journal of the Royal College of General Practitioners 20100101

The disposition of pravastatin in a rat model of streptozotocin-induced diabetes and organic anion transporting polypeptide 2 and multidrug resistance-associated protein 2 expression in the liver.

Biological & pharmaceutical bulletin 20100101

Efficacy and safety of ezetimibe for Japanese patients with dyslipidaemia: The ESSENTIAL Study.

Clinical drug investigation 20100101

Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial.

BMJ (Clinical research ed.) 20100101

Genome-wide association of lipid-lowering response to statins in combined study populations.

PloS one 20100101

Semi-parametric risk prediction models for recurrent cardiovascular events in the LIPID study.

BMC medical research methodology 20100101

Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.

Arthritis research & therapy 20100101

Pitavastatin: the newest HMG-CoA reductase inhibitor.

Reviews in cardiovascular medicine 20100101

The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides.

Drug metabolism and pharmacokinetics 20100101

Clinical implications of the cytokine hypothesis of depression: the association between use of statins and aspirin and the risk of major depression.

Psychotherapy and psychosomatics 20100101

Effects of pravastatin on cellular ultrastructure and hemorheology in rats after traumatic head injury.

Clinical hemorheology and microcirculation 20100101

Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis.

Arthritis research & therapy 20100101

A new mouse model to explore therapies for preeclampsia.

PloS one 20100101

Pravastatin provides antioxidant activity and protection of erythrocytes loaded Primaquine.

International journal of medical sciences 20100101

Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome.

Nucleus (Austin, Tex.) 20100101

Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial.

Journal of the American College of Cardiology 20091215

Cardiovascular outcomes in randomized trials: should time to first event for 'hard' end points remain the standard approach?

Journal of the American College of Cardiology 20091215

Effect of intensive statin therapy on clinical outcomes among patients undergoing percutaneous coronary intervention for acute coronary syndrome. PCI-PROVE IT: A PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) Substudy.

Journal of the American College of Cardiology 20091208

Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201

The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome.

Metabolic syndrome and related disorders 20091201

Coronary heart disease in moderately hypercholesterolemic, hypertensive black and non-black patients randomized to pravastatin versus usual care: the antihypertensive and lipid lowering to prevent heart attack trial (ALLHAT-LLT).

American heart journal 20091201

Atrial fibrillation at baseline and during follow-up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).

Journal of the American College of Cardiology 20091124

In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids.

The journal of physical chemistry. B 20091112

Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice.

Journal of reproductive immunology 20091101

Statins block calcific nodule formation of valvular interstitial cells by inhibiting alpha-smooth muscle actin expression.

Arteriosclerosis, thrombosis, and vascular biology 20091101

The impact of pravastatin therapy on long-term outcome in patients with metabolic syndrome undergoing complete coronary revascularization.

Circulation journal : official journal of the Japanese Circulation Society 20091101

Quantitative population pharmacokinetic analysis of pravastatin using an enterohepatic circulation model combined with pharmacogenomic Information on SLCO1B1 and ABCC2 polymorphisms.

Journal of clinical pharmacology 20091101

Effect of pravastatin on nephroprotection in deoxycorticosterone acetate-salt hypertensive rats.

Journal of hypertension 20091101

Efficacy of aggressive lipid controlling therapy for preventing saphenous vein graft disease.

The Annals of thoracic surgery 20091101

Statins and colorectal cancer: the jury is still out.

The American journal of gastroenterology 20091101

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20091028

The SLCO1B1*5 genetic variant is associated with statin-induced side effects.

Journal of the American College of Cardiology 20091020

New highly sensitive enzyme immunoassay for the determination of pravastatin in human plasma.

Talanta 20091015

Skin ulcers and myopathy associated with pravastatin therapy.

Clinical and experimental dermatology 20091001

Pravastatin and cardiovascular risk in moderate chronic kidney disease.

Atherosclerosis 20091001

Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells.

Journal of lipid research 20091001

Prevention of contrast-induced nephropathy by chronic pravastatin treatment in patients with cardiovascular disease and renal insufficiency.

Journal of cardiology 20091001

Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.

Pharmacogenomics 20091001

Risk factors for stroke and lipid-lowering effect of pravastatin on the risk of stroke in Japanese patients with hypercholesterolemia: analysis of data from the MEGA Study, a large randomized controlled trial.

Journal of the neurological sciences 20090915

Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin.

British journal of pharmacology 20090901

Chronic treatment with pravastatin prevents early cardiovascular changes in spontaneously hypertensive rats.

British journal of pharmacology 20090901

Identification of genetic variants associated with response to statin therapy.

Arteriosclerosis, thrombosis, and vascular biology 20090901

Seasonal variation in lipids: should we consider it more?

The American journal of cardiology 20090901

Rhabdomyolysis a result of azithromycin and statins: an unrecognized interaction.

British journal of clinical pharmacology 20090901

[Comparison on long-term effects of atorvastatin or pravastatin combined with clopidogrel for patients undergoing coronary stenting: a randomized controlled trial].

Zhonghua yi xue za zhi 20090825

Association of leukocyte subtype counts with coronary atherosclerotic regression following pravastatin treatment.

The American journal of cardiology 20090815

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Journal of lipid research 20090801

Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin.

Journal of hypertension 20090801

Improvement of glucose intolerance by combination of pravastatin and olmesartan in type II diabetic KK-A(y) mice.

Hypertension research : official journal of the Japanese Society of Hypertension 20090801

Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase.

Hypertension research : official journal of the Japanese Society of Hypertension 20090801

Rationale and design of assessment of lipophilic vs. hydrophilic statin therapy in acute myocardial infarction (the ALPS-AMI) study.

Journal of cardiology 20090801

Effects of Xuezhikang and pravastatin on circulating endothelial progenitor cells in patients with essential hypertension.

Chinese journal of integrative medicine 20090801

No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

British journal of clinical pharmacology 20090801

[Effects of pravastatin and granulocyto-colony stimulating factor in mobilizing endothelial progenitor cells in mice with myocardial ischemia].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090801

Rosuvastatin for cardiovascular prevention: too many uncertainties.

Prescrire international 20090801

A randomized, multicentre, open-label, parallel-group trial to compare the efficacy and safety profile of daming capsule in patients with hypercholesterolemia.

Phytotherapy research : PTR 20090701

Oral pravastatin prolongs survival time of scrapie-infected mice.

The Journal of general virology 20090701

Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model.

Hypertension research : official journal of the Japanese Society of Hypertension 20090701

Combination treatment to prevent atherosclerosis.

Hypertension (Dallas, Tex. : 1979) 20090701

Long-term efficacy of upstream therapy using angiotensin-converting enzyme inhibitors and statins in combination with antiarrhythmic agents for the treatment of paroxysmal atrial fibrillation.

International heart journal 20090701

Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.

Atherosclerosis 20090601

Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy.

The pharmacogenomics journal 20090601

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease.

Neurobiology of disease 20090601

Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Genes to cells : devoted to molecular & cellular mechanisms 20090601

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?

PLoS medicine 20090601

Association of body mass index with coronary plaque regression: 6-month prospective study.

Journal of atherosclerosis and thrombosis 20090601

Effects of a concomitant single oral dose of rifampicin on the pharmacokinetics of pravastatin in a two-phase, randomized, single-blind, placebo-controlled, crossover study in healthy Chinese male subjects.

Clinical therapeutics 20090601

Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease.

Clinical science (London, England : 1979) 20090501

Pravastatin limits radiation-induced vascular dysfunction in the skin.

The Journal of investigative dermatology 20090501

Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease.

European journal of clinical investigation 20090501

The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

Pharmacogenetics and genomics 20090501

Re: Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090501

Rhabdomyolysis in an HIV-infected patient on anti-retroviral therapy precipitated by high-dose pravastatin.

Current drug safety 20090501

Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease.

Clinical and experimental pharmacology & physiology 20090501

Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury.

Blood 20090423

Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes.

Bioscience, biotechnology, and biochemistry 20090423

Seasonal variation in lipids in patients following acute coronary syndrome on fixed doses of Pravastatin (40 mg) or Atorvastatin (80 mg) (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 [PROVE IT-TIMI 22] Study).

The American journal of cardiology 20090415

Statins for the prevention of dementia.

The Cochrane database of systematic reviews 20090415

Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E-knockout mice.

Clinical and experimental pharmacology & physiology 20090401

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).

Journal of lipid research 20090401

Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors.

Pharmacoepidemiology and drug safety 20090401

Preoperative statin use and infection after cardiac surgery: a cohort study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090401

Statins may not protect against vasospasm in subarachnoid haemorrhage.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090401

Potentiated cytotoxic effects of statins and ajoene in murine melanoma cells.

Melanoma research 20090401

Rosuvastatin in patients with elevated C-reactive protein.

The New England journal of medicine 20090305

Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension.

Clinical science (London, England : 1979) 20090301

Role of pravastatin in pulmonary hypertension in chronic obstructive pulmonary disease.

Clinical science (London, England : 1979) 20090301

Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22.

Arteriosclerosis, thrombosis, and vascular biology 20090301

Metabolic syndrome abating the beneficial effect of pravastatin treatment on adhesion of endothelium by monocytes in subjects with hypercholesterolemia.

Metabolism: clinical and experimental 20090301

[Statin therapy and muscle disorders].

Orvosi hetilap 20090208

[Comment from the cardiologic viewpoint].

Praxis 20090204

3-Hydroxy-3-methylglutaryl (HMG)-COA reductase inhibitors and phosphodiesterase type V inhibitors attenuate right ventricular pressure and remodeling in a rat model of pulmonary hypertension.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090204

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans.

The Journal of pharmacology and experimental therapeutics 20090201

Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly.

Diabetologia 20090201

Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

Circulation journal : official journal of the Japanese Circulation Society 20090201

Pravastatin for cardiovascular event primary prevention in patients with mild-to-moderate hypertension in the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study.

Hypertension (Dallas, Tex. : 1979) 20090201

Treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH Study): rationale and design.

Circulation journal : official journal of the Japanese Circulation Society 20090201

Effects of pravastatin on the function of dendritic cells in patients with coronary heart disease.

Basic & clinical pharmacology & toxicology 20090201

Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?

Metabolism: clinical and experimental 20090201

[Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090201

Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.

Circulation research 20090130

The cornucopia of 'pleiotropic' actions of statins: myogenesis as a new mechanism for statin-induced benefits?

Circulation research 20090130

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090101

Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.

Cardiovascular research 20090101

Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20090101

Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung.

Thorax 20090101

Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

Journal of leukocyte biology 20090101

Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.

Biomedical chromatography : BMC 20090101

Complete assignment of 1H and 13C NMR data of pravastatin derivatives.

Magnetic resonance in chemistry : MRC 20090101

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study.

International journal of obesity (2005) 20090101

Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.

Anesthesia and analgesia 20090101

[Effect of the brand and generic medicine of pravastatin on dyslipidemia in rabbits fed a high cholesterol diet].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090101

Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.

Journal of pharmacological sciences 20090101

Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis.

PLoS medicine 20090101

[Primary prevention trial by lowering hyperlipidemia on the cardiovascular disease (MEGA Study)].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20090101

In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.

Drug metabolism and pharmacokinetics 20090101

Effects of statins on the secretion of human serum albumin in cultured HepG2 cells.

Journal of biomedical science 20090101

Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.

Molecular pharmaceutics 20090101

Impact of ezetimibe on cholesterol subfractions in dyslipidemic cardiac transplant recipients receiving statin therapy.

Clinical transplantation 20090101

Mood stabilizer therapy and pravastatin: higher risk for adverse skin reactions?

Acta medica (Hradec Kralove) 20090101

Effects of increasing the dose of pravastatin on serum adiponectin level in Japanese mild hypercholesterolemic and hypertensive patients.

Arzneimittel-Forschung 20090101

Norepinephrine transporter is involved in down-regulation of beta1-adrenergic receptors caused by adjuvant arthritis.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation.

Transplantation 20081227

Reduction of charge-modified LDL by statin therapy in patients with CHD or CHD risk factors and elevated LDL-C levels: the SPECIAL Study.

Atherosclerosis 20081201

Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: results from two open-label extension studies in hypercholesterolemic patients.

Clinical therapeutics 20081201

Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.

Circulation. Cardiovascular genetics 20081201

Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.

Journal of the American College of Cardiology 20081125

Statins and blood pressure.

Archives of internal medicine 20081124

The influence of statin medications on prostate-specific antigen levels.

Journal of the National Cancer Institute 20081105

Impact of adherence to statins on chronic heart failure in primary prevention.

British journal of clinical pharmacology 20081101

CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction.

European heart journal 20081101

Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins.

Biopharmaceutics & drug disposition 20081101

Rosuvastatin, pravastatin, and atorvastatin for the treatment of hypercholesterolaemia in HIV-infected patients receiving protease inhibitors.

Current HIV research 20081101

The efficacy and safety of ezetimibe for treatment of dyslipidemia after heart transplantation.

Transplantation proceedings 20081101

Transition of psoriasiform drug eruption to psoriasis de novo evidenced by histopathology.

The Journal of dermatology 20081101

Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice.

International journal of molecular sciences 20081101

Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin.

European journal of pharmacology 20081010

Lovastatin, but not pravastatin, limits in vitro infection due to Coxiella burnetii.

The Journal of antimicrobial chemotherapy 20081001

Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20081001

Statins limit Rickettsia conorii infection in cells.

International journal of antimicrobial agents 20081001

Ptosis, diplopia and statins: an association?

European journal of neurology 20081001

The relationship between the effect of pravastatin and risk factors for coronary heart disease in Japanese patients with hypercholesterolemia.

Circulation journal : official journal of the Japanese Circulation Society 20081001

Statins: under investigation for increasing bone mineral density and augmenting fracture healing.

Expert opinion on investigational drugs 20081001

A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions.

Journal of biomolecular screening 20081001

Comparison of the effect of lipophilic and hydrophilic statins on serum adiponectin levels in patients with mild hypertension and dyslipidemia: Kinki Adiponectin Interventional (KAI) Study.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001

Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus.

Journal of atherosclerosis and thrombosis 20081001

Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress.

Hypertension research : official journal of the Japanese Society of Hypertension 20081001

Baseline low-density lipoprotein cholesterol is an important predictor of the benefit of intensive lipid-lowering therapy: a PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) analysis.

Journal of the American College of Cardiology 20080909

Phytosterols dissolved in diacylglycerol oil reinforce the cholesterol-lowering effect of low-dose pravastatin treatment.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20080901

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.

Atherosclerosis 20080901

Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

Atherosclerosis 20080901

Statin therapy increases carotid plaque echogenicity in hypercholesterolemic patients.

Ultrasound in medicine & biology 20080901

Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients.

Clinical and experimental pharmacology & physiology 20080901

Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.

Kidney international 20080901

Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.

International journal of cancer 20080901

Progression of kidney disease in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin versus usual care: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

American journal of kidney diseases : the official journal of the National Kidney Foundation 20080901

Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.

Pharmacogenetics and genomics 20080901

Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function.

Kidney international 20080901

Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials).

The American journal of cardiology 20080901

Statins for slowing kidney disease progression: an as yet unproven indication.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20080901

Pharmacogenomic importance of pravastatin.

Pharmacogenomics 20080901

Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20080901

[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina].

Zhonghua xin xue guan bing za zhi 20080901

Effects of pravastatin on obesity, diabetes, and adiponectin in diet-induced obese mice.

Obesity (Silver Spring, Md.) 20080901

Increased adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: a role of the attenuation of oxidative stress.

Atherosclerosis 20080801

Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy.

Atherosclerosis 20080801

Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801

Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.

Clinical pharmacology and therapeutics 20080801

Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.

Molecular pharmacology 20080801

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.

British journal of pharmacology 20080801

Impact of a combined treatment of angiotensin II type 1 receptor blockade and 3-hydroxy-3-methyl-glutaryl-CoA-reductase inhibition on secretory phospholipase A2-type IIA and low density lipoprotein oxidation in patients with coronary artery disease.

European heart journal 20080801

Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway.

The American journal of pathology 20080801

Pravastatin-induced colitis.

European journal of gastroenterology & hepatology 20080801

Pravastatin reduces the risk for cardiovascular disease in Japanese hypercholesterolemic patients with impaired fasting glucose or diabetes: diabetes subanalysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study.

Atherosclerosis 20080801

Lipophilicity and cardiovascular outcome in patients with CHF.

American heart journal 20080801

LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products.

Journal of pharmaceutical and biomedical analysis 20080715

Re: The association between statins and cancer incidence in a veterans population.

Journal of the National Cancer Institute 20080702

Gender-specific regulation of pancreatic islet blood flow, insulin levels and glycaemia in spontaneously diabetic Goto-Kakizaki rats.

Clinical science (London, England : 1979) 20080701

On-line extraction coupled with liquid chromatography tandem mass spectrometry for quantitation of pravastatin and its metabolite in human serum.

Biomedical chromatography : BMC 20080701

Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis.

Apoptosis : an international journal on programmed cell death 20080701

Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study.

Journal of the American College of Cardiology 20080701

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Nature medicine 20080701

Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker: a pilot study.

Journal of cardiovascular pharmacology 20080701

Rejuvenating premature aging.

Nature medicine 20080701

Lipid management: considerations in acute coronary syndrome.

Current cardiology reports 20080701

Pravastatin increases the expression of the tissue inhibitor of matrix metalloproteinase-1 and the oncogene Bax in human aortic abdominal aneurysms.

Canadian journal of physiology and pharmacology 20080701

Cost-effectiveness analysis of rosuvastatin versus atorvastatin, simvastatin, and pravastatin from a Canadian health system perspective.

Clinical therapeutics 20080701

Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.

Lancet (London, England) 20080607

Neuroprotection by pravastatin in acute ischemic stroke in rats.

Brain research reviews 20080601

Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

Diabetes 20080601

Association of circulating leukocyte count with coronary atherosclerosis regression after pravastatin treatment.

Atherosclerosis 20080601

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.

American journal of physiology. Heart and circulatory physiology 20080601

Efficacy of lipid-lowering medications in patients treated with clozapine: a naturalistic study.

Journal of clinical psychopharmacology 20080601

Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia.

The Journal of pediatrics 20080601

The relation between extent of coronary artery disease measured by quantitative coronary angiography and changes in lipid profile: insights from trials of atherosclerosis regression.

The Journal of invasive cardiology 20080601

Pravastatin: an evidence-based statin?

Expert opinion on drug metabolism & toxicology 20080601

Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass.

European cytokine network 20080601

[Pleiotropic effects of statins].

Revista medica de Chile 20080601

Repression of BK virus infection of human renal proximal tubular epithelial cells by pravastatin.

Transplantation 20080515

Estimation of treatment effect adjusting for treatment changes using the intensity score method: application to a large primary prevention study for coronary events (MEGA study).

Statistics in medicine 20080510

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

American journal of human genetics 20080509

Monitoring cholesterol levels: measurement error or true change?

Annals of internal medicine 20080506

An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection.

Journal of chromatography. A 20080502

Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.

Arteriosclerosis, thrombosis, and vascular biology 20080501

Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis.

Clinical immunology (Orlando, Fla.) 20080501

Atorvastatin monotherapy vs. combination therapy in the management of patients with combined hyperlipidemia.

European journal of internal medicine 20080501

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

Pharmacogenetics and genomics 20080501

High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients--a Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis.

American heart journal 20080501

Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes.

Journal of pharmacological sciences 20080501

HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation.

Transplant immunology 20080501

The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans.

Journal of the American College of Cardiology 20080429

Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080423

Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial.

Archives of internal medicine 20080414

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

The Journal of biological chemistry 20080411

Granulocytic sarcoma with massive scalp involvement.

American journal of hematology 20080401

The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.

Atherosclerosis 20080401

Regulation of the PTEN promoter by statins and SREBP.

Human molecular genetics 20080401

Early Improvements in insulin sensitivity and inflammatory markers are induced by pravastatin in nondiabetic subjects with hypercholesterolemia.

Clinica chimica acta; international journal of clinical chemistry 20080401

'Real-life' reduction in cholesterol with statins, 1993 to 2002.

British journal of clinical pharmacology 20080401

Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring.

Hypertension (Dallas, Tex. : 1979) 20080401

The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study.

European heart journal 20080401

Initiating statins in the elderly: the evolving challenge.

Current opinion in endocrinology, diabetes, and obesity 20080401

Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.

Pharmacogenetics and genomics 20080401

Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care.

Expert opinion on pharmacotherapy 20080401

Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells.

The American journal of gastroenterology 20080401

Statins in esophageal cancer cell lines: promising lead?

The American journal of gastroenterology 20080401

Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion.

Retina (Philadelphia, Pa.) 20080401

Can cheap generic statins achieve national cholesterol lowering targets?

Journal of health services research & policy 20080401

Adjunctive interventions in myocardial infarction: the role of statin therapy.

Current atherosclerosis reports 20080401

A case of vasospastic angina showing resolution of coronary vasospasm in acetylcholine provocation test corresponding to regression of coronary atherosclerosis.

International journal of cardiology 20080328

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.

FEBS letters 20080319

Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy.

Arteriosclerosis, thrombosis, and vascular biology 20080301

Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis.

Pharmacoepidemiology and drug safety 20080301

The Food and Drug Administration and over-the-counter statins: an opportunity lost?

Journal of clinical hypertension (Greenwich, Conn.) 20080301

Inhibition of macrophage phagocytotic activity by a receptor-targeted polymer vesicle-based drug delivery formulation of pravastatin.

Journal of cardiovascular pharmacology 20080301

Metabolic myopathies discovered during investigations of statin myopathy.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20080301

[Effects of pravastatin in prevention of diabetes and mechanism thereof: experiment with non-obese diabetic mice].

Zhonghua yi xue za zhi 20080226

Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial.

Journal of the American College of Cardiology 20080219

Cardiovascular health in New Zealand: areas of concern and targets for improvement in 2008 and beyond.

The New Zealand medical journal 20080215

Differences in cardiovascular mortality between Australia and New Zealand according to socioeconomic status: findings from the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study.

The New Zealand medical journal 20080215

Usefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatin.

The American journal of cardiology 20080215

Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study.

Biomedical chromatography : BMC 20080201

Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C.

Molecular genetics and genomics : MGG 20080201

Phospholipid chlorohydrin induces leukocyte adhesion to ApoE-/- mouse arteries via upregulation of P-selectin.

Free radical biology & medicine 20080201

Effect of statin dose on incidence of atrial fibrillation: data from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) and Aggrastat to Zocor (A to Z) trials.

American heart journal 20080201

Class effects of statins in elderly patients with congestive heart failure: a population-based analysis.

American heart journal 20080201

Direct effect of statins on homocysteine-induced endothelial adhesiveness: potential impact to human atherosclerosis.

European journal of clinical investigation 20080201

Usefulness of statin pretreatment to prevent contrast-induced nephropathy and to improve long-term outcome in patients undergoing percutaneous coronary intervention.

The American journal of cardiology 20080201

Impact of systemic hypertension on the cardiovascular benefits of statin therapy--a meta-analysis.

The American journal of cardiology 20080201

The mechanism of carrier-mediated transport of folates in BeWo cells: the involvement of heme carrier protein 1 in placental folate transport.

Bioscience, biotechnology, and biochemistry 20080201

What is the evidence in favor of low-dose statin therapy in 2008?

Current atherosclerosis reports 20080201

Usefulness of pravastatin in primary prevention of cardiovascular events in women: analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA study).

Circulation 20080129

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.

Journal of the American College of Cardiology 20080129

Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.

Journal of the American College of Cardiology 20080129

The association between statins and cancer incidence in a veterans population.

Journal of the National Cancer Institute 20080116

Long-term follow-up of the West of Scotland Coronary Prevention Study.

The New England journal of medicine 20080110

Long-term follow-up of the West of Scotland Coronary Prevention Study.

The New England journal of medicine 20080110

Long-term follow-up of the West of Scotland Coronary Prevention Study.

The New England journal of medicine 20080110

[Influence of pravastatin on blood lipids and serum high sensitive C-reactive protein in patients undergoing conventional coronary artery bypass grafting under on-pump: a clinical study of 81 cases].

Zhonghua yi xue za zhi 20080108

Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects.

Atherosclerosis 20080101

Effect of pravastatin on the development of diabetes and adiponectin production.

Atherosclerosis 20080101

Hydrophobic but not hydrophilic statins enhance phagocytosis and decrease apoptosis of human peripheral blood cells in vitro.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080101

Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial.

American heart journal 20080101

Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction: the OACIS-LIPID Study.

Circulation journal : official journal of the Japanese Circulation Society 20080101

Contribution of multidrug resistance-associated protein 2 to secretory intestinal transport of organic anions.

Biological & pharmaceutical bulletin 20080101

Lowering LDL-C for optimal protection in high-risk patients.

The American journal of managed care 20080101

Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice.

Journal of cardiovascular pharmacology 20080101

Incidence of adverse events with HMG-CoA reductase inhibitors in liver transplant patients.

Clinical transplantation 20080101

[Classification of Streptomyces strain Z314 and purification of its product pravastatin].

Wei sheng wu xue bao = Acta microbiologica Sinica 20080101

Lipid-altering therapy and atrial fibrillation.

Cardiology in review 20080101

Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.

Clinical pharmacokinetics 20080101

Statin potentiates human platelet eNOS activity without enhancing eNOS mRNA and protein levels.

Cerebrovascular diseases (Basel, Switzerland) 20080101

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism.

Journal of human genetics 20080101

Treatment of altered body composition in HIV-associated lipodystrophy: comparison of rosiglitazone, pravastatin, and recombinant human growth hormone.

HIV clinical trials 20080101

Risk factors for cerebral microbleeds in the elderly.

Cerebrovascular diseases (Basel, Switzerland) 20080101

Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma.

Digestion 20080101

Practical management of dyslipidemia with elevated lipoprotein(a).

Journal of the American Pharmacists Association : JAPhA 20080101

Parametric conditional frailty models for recurrent cardiovascular events in the lipid study.

Clinical trials (London, England) 20080101

[Effects of pravastatin on myocardial connexin 43, IFN-gamma and IL-10 expressions in a murine model of viral myocarditis induced by Coxsackievirus B3].

Zhonghua xin xue guan bing za zhi 20080101

Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071201

The effects of high dose pravastatin and low dose pravastatin and ezetimibe combination therapy on lipid, glucose metabolism and inflammation.

Inflammation 20071201

Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.

Lipids 20071201

Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.

American journal of physiology. Heart and circulatory physiology 20071201

Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNF-alpha-treated cardiomyocytes in association with improved glucose uptake.

American journal of physiology. Heart and circulatory physiology 20071201

The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems.

Biopharmaceutics & drug disposition 20071201

Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter.

Pharmaceutical research 20071201

Effects of initiation and acute withdrawal of statins on the neurovascular coupling mechanism in healthy, normocholesterolemic humans.

Stroke 20071201

Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice.

Journal of hypertension 20071201

Importance of intensive lipid lowering in acute coronary syndrome and percutaneous coronary intervention.

Journal of interventional cardiology 20071201

Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling.

Journal of pharmacological sciences 20071201

A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.

International journal of STD & AIDS 20071201

Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial.

Journal of neurosurgery 20071201

Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats.

Drug metabolism and pharmacokinetics 20071201

Postischemic administration of HMG CoA reductase inhibitor inhibits infarct expansion after transient middle cerebral artery occlusion.

Brain research 20071121

Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol.

The American journal of cardiology 20071115

Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial.

Hepatology (Baltimore, Md.) 20071101

Decreased plasma soluble RAGE in patients with hypercholesterolemia: effects of statins.

Free radical biology & medicine 20071101

Bilateral pleural effusions associated with pravastatin sodium treatment.

The European respiratory journal 20071101

Association between apolipoprotein E4 and cognitive decline in elderly adults.

Journal of the American Geriatrics Society 20071101

A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.

Calcified tissue international 20071101

Long-term follow-up of the West of Scotland Coronary Prevention Study.

The New England journal of medicine 20071011

Primary prevention of coronary artery disease.

The New England journal of medicine 20071011

Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease.

Atherosclerosis 20071001

Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice.

Digestive diseases and sciences 20071001

P-glycoprotein has differential effects on the disposition of statin acid and lactone forms in mdr1a/b knockout and wild-type mice.

Drug metabolism and disposition: the biological fate of chemicals 20071001

Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials).

The American journal of cardiology 20071001

Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits.

Circulation journal : official journal of the Japanese Circulation Society 20071001

A meta-analysis to evaluate the efficacy of statins in children with familial hypercholesterolemia.

International journal of clinical pharmacology and therapeutics 20071001

Inhibition of balloon injury-induced neointimal formation by olmesartan and pravastatin in rats with insulin resistance.

Hypertension research : official journal of the Japanese Society of Hypertension 20071001

Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.

Journal of cardiovascular pharmacology 20071001

Effective uptake of N-acetylglucosamine-conjugated liposomes by cardiomyocytes in vitro.

Journal of controlled release : official journal of the Controlled Release Society 20070926

Pravastatin Inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats.

Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

In vivo coronary plaque histology in patients with stable and acute coronary syndromes: relationships with hyperlipidemic status and statin treatment.

Atherosclerosis 20070901

A pravastatin dose-escalation study in systemic lupus erythematosus.

Rheumatology international 20070901

SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients.

British journal of clinical pharmacology 20070901

Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.

The Journal of pharmacology and experimental therapeutics 20070901

Physiogenomic association of statin-related myalgia to serotonin receptors.

Muscle & nerve 20070901

Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts.

Clinical and experimental pharmacology & physiology 20070901

Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes.

Free radical research 20070901

Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.

The American journal of geriatric pharmacotherapy 20070901

[The antiplatelet effect of clopidogrel is not attenuated by statin treatment in patients with acute coronary syndromes undergone coronary stenting].

Zhonghua xin xue guan bing za zhi 20070901

Use of lipid-modulating drugs in complicated course of coronary heart disease.

Bulletin of experimental biology and medicine 20070901

The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin.

Journal of pharmaceutical and biomedical analysis 20070815

Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice.

Heart (British Cardiac Society) 20070801

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

Drug metabolism and disposition: the biological fate of chemicals 20070801

Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study.

European heart journal 20070801

Cholesterol lowering with statins: how WOSCOPS confounded the skeptics.

Atherosclerosis. Supplements 20070801

Primary prevention of cardiovascular diseases among hypercholesterolemic Japanese with a low dose of pravastatin.

Atherosclerosis. Supplements 20070801

Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants.

Pharmacogenetics and genomics 20070801

Low HDL-C predicts the onset of transplant vasculopathy in pediatric cardiac recipients on pravastatin therapy.

Pediatric transplantation 20070801

On the factors modulating the effect of statins on malignant cell proliferation.

Cancer investigation 20070801

Successful mitigation of delayed intestinal radiation injury using pravastatin is not associated with acute injury improvement or tumor protection.

International journal of radiation oncology, biology, physics 20070801

Impact of statin dosing intensity on transaminase and creatine kinase.

The American journal of medicine 20070801

[Case report of cholesterol crystal embolism 1 month after carotid stenting].

No shinkei geka. Neurological surgery 20070801

PROactive 07: pioglitazone in the treatment of type 2 diabetes: results of the PROactive study.

Vascular health and risk management 20070801

[Effects of pravastatin on the expression of endothelin induced by aldosterone in rat cardiac fibroblasts].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801

Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.

Journal of the American College of Cardiology 20070731

Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial.

Journal of the American College of Cardiology 20070724

Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.

The Journal of biological chemistry 20070720

Effect of statin withdrawal on frequency of cardiac events after vascular surgery.

The American journal of cardiology 20070715

A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels.

Atherosclerosis 20070701

RhoA-dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling.

Atherosclerosis 20070701

Statins and cancer.

Epidemiology (Cambridge, Mass.) 20070701

Effects of Pravastatin on neuroprotection and neurogenesis after cerebral ischemia in rats.

Neuroscience bulletin 20070701

[The primary observation on the effect of pravastatin to non-ischemic heart failure].

Zhonghua xin xue guan bing za zhi 20070701

Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study.

Archives of internal medicine 20070625

Long-term prognostic value of neopterin: a novel marker of monocyte activation in patients with acute coronary syndrome.

Circulation 20070619

Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.

Journal of cellular biochemistry 20070601

Effect of pravastatin treatment on Chlamydia pneumoniae infection, inflammation and serum lipids in NIH/S mice.

International journal of antimicrobial agents 20070601

Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia.

Endocrine journal 20070601

Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction.

Clinical immunology (Orlando, Fla.) 20070601

Effect of pravastatin on markers of endothelial activation in dialysis patients.

Nephrology (Carlton, Vic.) 20070601

Difference in early effects of statin therapy on coronary and forearm flow reserve in postmenopausal hypercholesterolemic women.

Circulation journal : official journal of the Japanese Circulation Society 20070601

The effects of statin and fibrate on lowering small dense LDL- cholesterol in hyperlipidemic patients with type 2 diabetes.

Journal of atherosclerosis and thrombosis 20070601

Effects of pravastatin in murine collagen-induced arthritis.

Rheumatology international 20070501

Synergistic effects of pravastatin and pioglitazone in renal tubular epithelial cells induced by transforming growth factor-beta1.

Cell biology international 20070501

The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

Drug metabolism and disposition: the biological fate of chemicals 20070501

Amiodarone interacts with simvastatin but not with pravastatin disposition kinetics.

Clinical pharmacology and therapeutics 20070501

Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage.

Stroke 20070501

Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line.

Journal of cardiovascular pharmacology 20070501

Gemfibrozil and its glucuronide inhibit the hepatic uptake of pravastatin mediated by OATP1B1.

Xenobiotica; the fate of foreign compounds in biological systems 20070501

Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study.

Blood 20070401

Amelioration of steroids and cyclosporine-resistant nephrotic syndrome by pravastatin.

Pediatric nephrology (Berlin, Germany) 20070401

Comparison of the antiatherosclerotic effects of dihydropyridine calcium channel blocker and HMG-CoA reductase inhibitor on hypercholesterolemic rabbits.

Vascular pharmacology 20070401

Tissue factor and nitric oxide: a controversial relationship!

Journal of thrombosis and thrombolysis 20070401

Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: results from the PROSPER MRI study.

Stroke 20070401

Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb Ischaemia in type-1 diabetic mice.

British journal of pharmacology 20070401

Acquired ichthyosis with pravastatin.

Journal of the European Academy of Dermatology and Venereology : JEADV 20070401

Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans.

Xenobiotica; the fate of foreign compounds in biological systems 20070401

Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study.

Annals of the New York Academy of Sciences 20070401

Effects of pravastatin on ventricular remodeling by activation of myocardial KATP channels in infarcted rats: role of 70-kDa S6 kinase.

Basic research in cardiology 20070301

Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.

Arteriosclerosis, thrombosis, and vascular biology 20070301

Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat.

Journal of molecular and cellular cardiology 20070301

Statins and renal function. Is the compound and dose making a difference?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070301

Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.

Journal of pharmacological sciences 20070301

Impact of gender on statin efficacy.

Current medical research and opinion 20070301

Two-week treatment with pravastatin improves ventriculo-vascular haemodynamic interactions in young men with type 1 diabetes.

Diabetes & vascular disease research 20070301

C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

Circulation 20070227

Pravastatin and cancer: an unproven association.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070227

Does pravastatin promote cancer in elderly patients? A meta-analysis.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070227

Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE).

Circulation 20070213

Statin therapy and the elderly: SAGE advice?

Circulation 20070213

Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells.

European journal of pharmacology 20070205

Development and validation of a preclinical food effect model.

Journal of pharmaceutical sciences 20070201

Effect of colestimide therapy for glycemic control in type 2 diabetes mellitus with hypercholesterolemia.

Endocrine journal 20070201

[Medical treatment in peripheral arterial disease: a professional practice study in 262 patients].

La Revue de medecine interne 20070201

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans.

Pharmaceutical research 20070201

Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis.

International immunology 20070201

Effect of atorvastatin and pravastatin on platelet inhibition by aspirin and clopidogrel treatment in patients with coronary stent thrombosis.

The American journal of cardiology 20070201

Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system).

The American journal of cardiology 20070201

[The comparison in vitro the effects of pravastatin and quercetin on the selected structural parameters of membrane erythrocytes from patients with hypercholesterolemia].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070201

Can telomere length predict cardiovascular risk?

Lancet (London, England) 20070113

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study.

Lancet (London, England) 20070113

Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity.

Journal of hepatology 20070101

Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction.

Clinical science (London, England : 1979) 20070101

Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol.

Vascular pharmacology 20070101

The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1alpha(betaS*, deltaS*), 2alpha, 6alpha, 8beta-(R*), 8a alpha]]-1,2,6,7,8,8a-Hexahydro-beta, delta, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester)], reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice.

The Journal of pharmacology and experimental therapeutics 20070101

Vasoactive drugs enhance pancreatic islet blood flow, augment insulin secretion and improve glucose tolerance in female rats.

Clinical science (London, England : 1979) 20070101

The value of the electrocardiogram in risk assessment in primary prevention: experience from the West of Scotland Coronary Prevention Study.

Journal of electrocardiology 20070101

A rapid and specific approach for direct measurement of pravastatin concentration in plasma by LC-MS/MS employing solid-phase extraction.

Biomedical chromatography : BMC 20070101

Impact of high dose statin trials on hospital prescribers.

European journal of clinical pharmacology 20070101

Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study.

American heart journal 20070101

Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes.

Circulation journal : official journal of the Japanese Circulation Society 20070101

Update on heart disease. Evidence mounts for even lower LDL.

Diabetes self-management 20070101

Pravastatin inhibits carboxymethyllysine-induced monocyte chemoattractant protein 1 expression in podocytes via prevention of signalling events.

Nephron. Experimental nephrology 20070101

Effects of statins on restenosis after coronary stent implantation.

Angiology 20070101

Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin.

Clinical therapeutics 20070101

Pravastatin in HIV-infected patients treated with protease inhibitors: a placebo-controlled randomized study.

HIV clinical trials 20070101

Can clopidogrel monotherapy influence vascular remodeling?

Vascular and endovascular surgery 20070101

Statin's cost-effectiveness: a Canadian analysis of commonly prescribed generic and brand name statins.

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20070101

Ezetimibe is effective when added to maximally tolerated lipid lowering therapy in patients with HIV.

Lipids in health and disease 20070101

Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy.

Vascular pharmacology 20070101

[Rhabdomyolysis probably caused by interaction between efalizumab and pravastatin].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.

Journal of vascular research 20070101

Does pravastatin therapy affect cardiac enzyme levels after percutaneous coronary intervention?

Advances in therapy 20070101

Effect of medium pH on the cytotoxicity of hydrophilic statins.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

Estimation of treatment effect adjusting for dependent censoring using the IPCW method: an application to a large primary prevention study for coronary events (MEGA study).

Clinical trials (London, England) 20070101

Improvement of myocardial blood flow by lipid-lowering therapy with pravastatin is modulated by apolipoprotein E genotype.

Scandinavian journal of clinical and laboratory investigation 20070101

Effects of long-term pravastatin treatment on serum and urinary monocyte chemoattractant protein-1 levels and renal function in type 2 diabetic patients with normoalbuminuria.

Renal failure 20070101

Effect of pravastatin on phenotypical transformation of fibroblasts and hypertrophy of cardiomyocytes in culture.

Bulletin of experimental biology and medicine 20070101

Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption - an individual-level prescription database study.

BMC clinical pharmacology 20070101

[Long-term follow-up of the West of Scotland Coronary Prevention Study].

Kardiologiia 20070101

[Pravastatin and acetylsalycilic acid fixed-combination: a strategy to improve cardiovascular outcomes].

American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

Crystalline polymorphism and molecular structure of sodium pravastatin.

The journal of physical chemistry. B 20061228

The MEGA study.

Lancet (London, England) 20061209

The MEGA study.

Lancet (London, England) 20061209

Beyond lipid lowering: What have we learned about the benefits of statins from the acute coronary syndromes trials?

The American journal of cardiology 20061204

Molecular basis of differences among statins and a comparison with antioxidant vitamins.

The American journal of cardiology 20061204

Effect of pravastatin on left ventricular mass in the two-kidney, one-clip hypertensive rats.

American journal of physiology. Heart and circulatory physiology 20061201

Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.

Arteriosclerosis, thrombosis, and vascular biology 20061201

The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin.

Naunyn-Schmiedeberg's archives of pharmacology 20061201

[Multiple mononeuropathy associated to treatment with pravastatin].

Revista de neurologia 20061201

Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.

Journal of Alzheimer's disease : JAD 20061201

Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease.

Journal of Alzheimer's disease : JAD 20061201

Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.

Journal of atherosclerosis and thrombosis 20061201

Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy.

AIDS (London, England) 20061128

Pravastatin: a potential cause for acute pancreatitis.

World journal of gastroenterology 20061121

Multitherapy for diabetes.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20061107

Paradoxical increase in lumen size during progression of coronary atherosclerosis: observations from the REVERSAL trial.

Atherosclerosis 20061101

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.

Pharmacogenetics and genomics 20061101

Statins, fibrates, and melanoma risk: a systematic review and meta-analysis.

Journal of the National Cancer Institute 20061101

Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs.

Molecular cancer therapeutics 20061101

[J-STARS (Japan statin treatment against recurrent stroke)].

Nihon rinsho. Japanese journal of clinical medicine 20061028

Are statins analogues of vitamin D?

Lancet (London, England) 20061007

Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone.

American journal of physiology. Heart and circulatory physiology 20061001

Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity.

Cardiovascular research 20061001

Statins and cerebral vasomotor reactivity: implications for a new therapy?

Stroke 20061001

Toxicity of statins on rat skeletal muscle mitochondria.

Cellular and molecular life sciences : CMLS 20061001

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin.

Clinical pharmacology and therapeutics 20061001

Not all age-related white matter hyperintensities are the same: a magnetization transfer imaging study.

AJNR. American journal of neuroradiology 20061001

Japan: are statins still good for everybody?

Lancet (London, England) 20060930

Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial.

Lancet (London, England) 20060930

Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage.

Neurosurgical focus 20060915

Additive effects of combined blockade of AT1 receptor and HMG-CoA reductase on left ventricular remodeling in infarcted rats.

American journal of physiology. Heart and circulatory physiology 20060901

Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia.

The Journal of pathology 20060901

Pravastatin prolongs graft survival in an allogeneic rat model of orthotopic single lung transplantation.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS.

Naunyn-Schmiedeberg's archives of pharmacology 20060901

Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury.

Clinical and experimental pharmacology & physiology 20060901

Pravastatin prevents ischemia-reperfusion injury in rat sciatic nerve.

Surgical neurology 20060901

Pravastatin decreases blood pressure in hypertensive and hypercholesterolemic patients receiving antihypertensive treatment.

Circulation journal : official journal of the Japanese Circulation Society 20060901

Pravastatin use and the five-year incidence of cancer in coronary heart disease patients: from the prevention of coronary sclerosis study.

Journal of epidemiology 20060901

Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060901

Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.

Molecular cancer therapeutics 20060901

Pravastatin in vivo reduces mononuclear cell migration through endothelial monolayers.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060901

Pleiotropic effects of statins and early benefit in the PROVE IT-TIMI-22 study.

Journal of the American College of Cardiology 20060815

Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase.

Atherosclerosis 20060801

Effect of pravastatin on blood pressure in people with cardiovascular disease.

Journal of human hypertension 20060801

Cholesterol, C-reactive protein, and cerebrovascular events following intensive and moderate statin therapy.

Journal of thrombosis and thrombolysis 20060801

Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome.

Intensive care medicine 20060801

Screening of compactin-resistant microorganisms capable of converting compactin to pravastatin.

Current microbiology 20060801

Statin treatment is not associated with consistent alterations in inflammatory status of carotid atherosclerotic plaques: a retrospective study in 378 patients undergoing carotid endarterectomy.

Stroke 20060801

Protective effect of pravastatin on vascular endothelium in patients with systemic sclerosis: a pilot study.

Annals of the rheumatic diseases 20060801

Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin.

Free radical biology & medicine 20060801

Clopidogrel-statin interaction: a mountain or a mole hill?

American heart journal 20060801

The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin.

Journal of thrombosis and haemostasis : JTH 20060801

Plasma cholesteryl ester transfer protein concentrations predict cardiovascular events in patients with coronary artery disease treated with pravastatin.

Journal of internal medicine 20060801

The effects of HMG-CoA reductase inhibitor on vascular progenitor cells.

Journal of pharmacological sciences 20060801

Statins, fracture risk, and bone remodeling: What is true?

The American journal of the medical sciences 20060801

Pravastatin prevents myocardium from ischemia-induced fibrosis by protecting vascular endothelial cells exposed to oxidative stress.

Cardiovascular drugs and therapy 20060801

Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.

Urologic nursing 20060801

Both hepatitis C virus and Chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy.

Fukuoka igaku zasshi = Hukuoka acta medica 20060801

Pancreatic islet blood flow is selectively enhanced by captopril, irbesartan and pravastatin, and suppressed by palmitate.

Biochemical and biophysical research communications 20060721

The year in non-ST-segment elevation acute coronary syndromes.

Journal of the American College of Cardiology 20060718

Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites.

The EMBO journal 20060712

Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.

Circulation 20060704

Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study.

Atherosclerosis 20060701

Management of cardiovascular risk in patients receiving calcineurin inhibitors--a case report.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701

Persistence and adherence to cholesterol lowering agents: evidence from Régie de l'Assurance Maladie du Québec data.

American heart journal 20060701

Pravastatin reduces microvascular basal lamina damage following focal cerebral ischemia and reperfusion.

The European journal of neuroscience 20060701

Statin but not non-statin lipid-lowering drugs decrease fracture risk: a nation-wide case-control study.

Calcified tissue international 20060701

Combination therapy with ezetimibe and simvastatin to achieve aggressive LDL reduction.

Expert review of cardiovascular therapy 20060701

The effect of 6 months of treatment with pravastatin on serum adiponection concentrations in Japanese patients with coronary artery disease and hypercholesterolemia: a pilot study.

Clinical therapeutics 20060701

Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial.

Circulation 20060620

[High lowering of lipids can melt coronary plaques -- is coronary disease reversible?].

MMW Fortschritte der Medizin 20060615

[For coronary disease patients is certain: the lower the LDL the better].

MMW Fortschritte der Medizin 20060615

Intensive statin therapy and the risk of hospitalization for heart failure after an acute coronary syndrome in the PROVE IT-TIMI 22 study.

Journal of the American College of Cardiology 20060606

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.

British journal of clinical pharmacology 20060601

Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study).

The American journal of cardiology 20060601

Pravastatin improves remodeling and cardiac function after myocardial infarction by an antiinflammatory mechanism rather than by the induction of angiogenesis.

The Annals of thoracic surgery 20060601

Invited commentary.

The Annals of thoracic surgery 20060601

Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells.

Experimental biology and medicine (Maywood, N.J.) 20060601

Effects of preoperative statin therapy on cytokines after cardiac surgery.

The Thoracic and cardiovascular surgeon 20060601

Cost-effectiveness of cholesterol-lowering therapy with pravastatin in patients with previous acute coronary syndromes aged 65 to 74 years compared with younger patients: results from the LIPID study.

American heart journal 20060601

Statins: beneficial or adverse for glucose metabolism.

Journal of atherosclerosis and thrombosis 20060601

Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS).

Acta cardiologica 20060601

[Myocardial dysfunction].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601

Does pravastatin safely and effectively improve lipid profiles in children who have received a kidney transplant?

Nature clinical practice. Nephrology 20060601

[Therapeutic effects of pravastatin on colitis induced by acetic acid and relevant mechanism: experiment with rats].

Zhonghua yi xue za zhi 20060516

Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects.

Life sciences 20060508

Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin.

Journal of the American College of Cardiology 20060502

Statins and stroke: current clinical practice.

Stroke 20060501

The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.

Journal of neurochemistry 20060501

Involvement of 2-C-methyl-D-erythritol-4-phosphate pathway in biosynthesis of aphidicolin-like tetracyclic diterpene of Scoparia dulcis.

Chemical & pharmaceutical bulletin 20060501

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin.

Clinical pharmacology and therapeutics 20060501

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

Clinical pharmacology and therapeutics 20060501

A switch in time saves more than nine. Two popular statins, Pravachol and Zocor, go generic this summer, paving the way for significant savings.

Harvard heart letter : from Harvard Medical School 20060501

[Statin therapy: cost-effectiveness and evaluation of evidence as criterium for improving expenditure within the National Health Program].

Recenti progressi in medicina 20060501

Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.

Reviews on recent clinical trials 20060501

Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.

Biochemical pharmacology 20060428

Effect of pravastatin on body composition and markers of cardiovascular disease in HIV-infected men--a randomized, placebo-controlled study.

AIDS (London, England) 20060424

Statins in HIV-associated lipodystrophy and metabolic syndrome: is there a missing link?

AIDS (London, England) 20060424

Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) trial.

Circulation 20060411

Effect of pravastatin, simvastatin and atorvastatin on the phagocytic activity of mouse peritoneal macrophages.

Experimental and molecular pathology 20060401

Changes of plasma inflammatory markers after withdrawal of statin therapy in patients with hyperlipidemia.

Clinica chimica acta; international journal of clinical chemistry 20060401

Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels.

Naunyn-Schmiedeberg's archives of pharmacology 20060401

Influences of statins on glucose tolerance in patients with type 2 diabetes mellitus.

Journal of atherosclerosis and thrombosis 20060401

[Infiltrative lung disease with alveolar density on x-ray: observation].

Revue des maladies respiratoires 20060401

Pharmacokinetic interaction between nelfinavir and pravastatin in HIV-seronegative volunteers: ACTG Study A5108.

AIDS (London, England) 20060321

A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22.

Circulation 20060321

Direct comparison of the A to Z and PROVE IT trials: a second chance to gain a first impression.

Circulation 20060321

Effect of statin treatment on coronary collateral development in patients with diabetes mellitus.

The American journal of cardiology 20060315

Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist.

Molecular immunology 20060301

Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.

Biomedical chromatography : BMC 20060301

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.

The Journal of pharmacology and experimental therapeutics 20060301

Pravastatin inhibits expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in Watanabe heritable hyperlipidemic rabbits: a new pleiotropic effect of statins.

Arteriosclerosis, thrombosis, and vascular biology 20060301

Low high-density lipoprotein cholesterol and cardiovascular disease: risk reduction with statin therapy.

American heart journal 20060301

Increased inflammatory markers in children with familial hypercholesterolaemia.

European journal of clinical investigation 20060301

Localized rhabdomyolysis after exertion in a cardiac transplant recipient on statin therapy.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060301

Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.

Journal of the American Geriatrics Society 20060301

Statin-associated myasthenia gravis: report of 4 cases and review of the literature.

Medicine 20060301

Cost-effectiveness of screening for albuminuria with subsequent fosinopril treatment to prevent cardiovascular events: A pharmacoeconomic analysis linked to the prevention of renal and vascular endstage disease (PREVEND) study and the prevention of renal and vascular endstage disease intervention trial (PREVEND IT).

Clinical therapeutics 20060301

Treatment of hypercholesterolemia in patients with metabolic syndrome: how do different statins compare?

Nature clinical practice. Endocrinology & metabolism 20060301

[Effect of pravastatin on cholesteryl esters in foam cells and the relation with caveolin-1].

Sheng li xue bao : [Acta physiologica Sinica] 20060225

Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.

Cardiovascular research 20060215

Improving effect of ethyl eicosapentanoate on statin-induced rhabdomyolysis in Eisai hyperbilirubinemic rats.

Biochemical and biophysical research communications 20060203

Pharmacogenetics: progress, pitfalls and clinical potential for coronary heart disease.

Vascular pharmacology 20060201

Is there an interaction between pravastatin and clinical events other than vasospasm in patients with aneurysmal subarachnoid hemorrhage?

Stroke 20060201

Pravastatin-induced lichenoid drug eruption.

The Australasian journal of dermatology 20060201

Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population.

Journal of neurology, neurosurgery, and psychiatry 20060201

Use of hydroxy-methyl-glutaryl coenzyme A reductase inhibitors is associated with risk of lymphoid malignancies.

Cancer science 20060201

Are statins created equal? Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention.

American heart journal 20060201

'Anti-inflammatory' drugs and their effects on type 2 diabetes.

Diabetes technology & therapeutics 20060201

Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy.

The Journal of pediatrics 20060201

[Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant].

Presse medicale (Paris, France : 1983) 20060201

Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury.

Acta orthopaedica 20060201

Letter regarding article by Tonelli et al, 'effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease'.

Circulation 20060131

[Recurrent acute pancreatitis during pravastatin-therapy].

Praxis 20060125

Comparison of effects of pravastatin and hormone therapy on soluble P-selectin and platelet P-selectin expression in postmenopausal hypercholesterolemic women.

Maturitas 20060120

Cholecystokinin stimulates the recruitment of the Src-RhoA-phosphoinositide 3-kinase pathway by Vav-2 downstream of G(alpha13) in pancreatic acini.

Biochemical and biophysical research communications 20060106

Statins for high-risk patients without heart disease or high cholesterol.

The Medical letter on drugs and therapeutics 20060102

Effects of statins on endothelial function and lipid profile in HIV infected persons receiving protease inhibitor-containing anti-retroviral combination therapy: a randomised double blind crossover trial.

Heart (British Cardiac Society) 20060101

Protective role of pravastatin in the pathogenesis of the metabolic syndrome.

Medical hypotheses 20060101

Determinants of the differences in LDL-cholesterol after initiation of statin treatment.

The Annals of pharmacotherapy 20060101

Effects of pravastatin on the in vitro phagocytic function and hydrogen peroxide production by monocytes of healthy individuals.

International immunopharmacology 20060101

Electrochemical properties and square-wave voltammetric determination of pravastatin.

Analytical and bioanalytical chemistry 20060101

Preoperative statin therapy and troponin T predict early complications of coronary artery surgery.

The Annals of thoracic surgery 20060101

Effect of pravastatin on plasma sterols and oxysterols in men.

European journal of clinical pharmacology 20060101

Statins and osteoporosis: new role for old drugs.

The Journal of pharmacy and pharmacology 20060101

Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro.

Pharmacology 20060101

Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101

Muscle symptoms associated with statins: a series of twenty patients.

Basic & clinical pharmacology & toxicology 20060101

Time course of rapid C-reactive protein reduction by pravastatin in patients with stable angina.

Angiology 20060101

Statin wars following coronary revascularization--evidence-based clinical practice?

The Canadian journal of cardiology 20060101

C-reactive protein levels and outcomes after statin therapy.

Current atherosclerosis reports 20060101

Pravastatin and clopidogrel combined inhibit intimal hyperplasia in a rat carotid endarterectomy model.

Vascular and endovascular surgery 20060101

Effect of pravastatin and atorvastatin on glucose metabolism in nondiabetic patients with hypercholesterolemia.

Internal medicine (Tokyo, Japan) 20060101

The statins: drug interactions of significance to the dental practitioner.

Dental update 20060101

Who should receive statin therapy among the elderly?

The American journal of geriatric cardiology 20060101

Comparative study on the bioequivalence of two formulations of pravastatin. Data from a crossover, randomised, open-label bioequivalence study in healthy volunteers.

Arzneimittel-Forschung 20060101

Basilar artery dolichoectasia with partial thrombosis.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20060101

Effect of probucol on elderly hypercholesterolemic patients in the FAST study.

Fukuoka igaku zasshi = Hukuoka acta medica 20060101

The fading of reported effectiveness. A meta-analysis of randomised controlled trials.

BMC medical research methodology 20060101

Prevention of positive coronary artery remodeling with statin therapy in patients with coronary artery diseases.

Angiology 20060101

Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats.

Journal of gastroenterology and hepatology 20060101

Vascular endothelial growth factor serum concentrations in hypercholesterolemic patients.

Scandinavian journal of clinical and laboratory investigation 20060101

Assessing health state utilities in elderly patients at cardiovascular risk.

Medical decision making : an international journal of the Society for Medical Decision Making 20060101

Cost-effectiveness analysis of cholesterol-lowering therapies in Spain.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

Pharmacogenetic determinants of variability in lipid-lowering response to pravastatin therapy.

Journal of human genetics 20060101

Effects of pravastatin treatment on blood pressure regulation after renal transplantation.

Kidney & blood pressure research 20060101

[C-reactive protein in cardiovascular diseases].

Przeglad lekarski 20060101

Generic pravastatin approved.

FDA consumer 20060101

[The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia].

Przeglad lekarski 20060101

Lipid-modifying and pleiotropic effects of gemfibrozil, simvastatin and pravastatin in patients with dyslipidemia.

Folia medica 20060101

Effect of atorvastatin (80 mg/day) versus pravastatin (40 mg/day) on arterial remodeling at coronary branch points (from the REVERSAL study).

The American journal of cardiology 20051215

Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease.

Journal of the American College of Cardiology 20051206

Effect of pravastatin in people with diabetes and chronic kidney disease.

Journal of the American Society of Nephrology : JASN 20051201

Prospective monitoring of lipid profiles in children receiving pravastatin preemptively after renal transplantation.

Pediatric transplantation 20051201

Effect of statin use in patients with acute coronary syndromes and a serum low-density lipoprotein<or=80 mg/dl.

The American journal of cardiology 20051201

Does pravastatin increase chylomicron remnant catabolism in postmenopausal women with type 2 diabetes mellitus?

Clinical endocrinology 20051201

Achieving lipid goals in real life: the Dutch DISCOVERY study.

International journal of clinical practice 20051201

Improved outcome after acute coronary syndromes with an intensive versus standard lipid-lowering regimen: results from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) trial.

The American journal of medicine 20051201

The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients.

International journal of clinical pharmacology and therapeutics 20051201

Renoprotective effect of pravastatin in salt-loaded Dahl salt-sensitive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20051201

Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

Circulation 20051115

Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial.

Circulation 20051115

[How can lipid therapy be improved? Cardiologists insist on dual cholesterol inhibition].

MMW Fortschritte der Medizin 20051110

The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.

The Journal of surgical research 20051101

The effect of pravastatin on intima media thickness of the carotid artery in patients with normal cholesterol.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20051101

Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats.

Drug metabolism and disposition: the biological fate of chemicals 20051101

[Pravastatin-induced dermatomyositis].

La Revue de medecine interne 20051101

Systemic inflammatory markers in acute coronary syndrome: association with cardiovascular risk factors and effect of early lipid lowering.

Coronary artery disease 20051101

Optimal goals for statin use in patients with coronary artery disease.

Current opinion in cardiology 20051101

Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.

Stroke 20051101

A novel nitric oxide-releasing statin derivative exerts an antiplatelet/antithrombotic activity and inhibits tissue factor expression.

Journal of thrombosis and haemostasis : JTH 20051101

Intensity of lipid lowering with statins and brachial artery vascular endothelium reactivity after acute coronary syndromes (from the BRAVER trial).

The American journal of cardiology 20051101

HMG-CoA reductase inhibitors do not improve glucose intolerance in spontaneously diabetic Goto-Kakizaki rats.

Biological & pharmaceutical bulletin 20051101

Differential associations of statin and fibrate treatment with carotid arterial remodeling.

American journal of hypertension 20051101

Ten-year follow-up of a randomized trial of pravastatin in heart transplant patients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051101

In-hospital initiation of statin therapy in acute coronary syndromes: maximizing the early and long-term benefits.

Chest 20051101

Pravastatin reduces thrombogenicity by mechanisms beyond plasma cholesterol lowering.

Thrombosis and haemostasis 20051101

Safety of statins when response is carefully monitored: a study of 336 heart recipients.

Transplantation proceedings 20051101

Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction.

International journal of cardiology 20051020

Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes: results from the PROVE IT-TIMI 22 trial.

Journal of the American College of Cardiology 20051018

Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy.

Journal of the American College of Cardiology 20051018

Relationship between uncontrolled risk factors and C-reactive protein levels in patients receiving standard or intensive statin therapy for acute coronary syndromes in the PROVE IT-TIMI 22 trial.

Journal of the American College of Cardiology 20051018

Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus.

Arthritis and rheumatism 20051015

Effect of pravastatin on malondialdehyde-modified low-density lipoprotein levels and coronary plaque regression as determined by three-dimensional intravascular ultrasound.

The American journal of cardiology 20051015

Beneficial effects of atorvastatin on sd LDL and LDL phenotype B in statin-naive patients and patients previously treated with simvastatin or pravastatin.

International journal of cardiology 20051010

Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation.

Chinese medical journal 20051005

In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells.

Clinical immunology (Orlando, Fla.) 20051001

Short-term reduction in bone markers with high-dose simvastatin.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20051001

Effect of combined treatment with an angiotensin II receptor antagonist and an HMG-CoA reductase inhibitor on atherosclerosis in genetically hyperlipidemic rabbits.

Journal of cardiovascular pharmacology 20051001

Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels.

Pharmacotherapy 20051001

Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition.

Journal of vascular surgery 20051001

The long-term course of low-density lipoprotein cholesterol after initiation of statin treatment: retrospective database analysis over 3 years in health maintenance organization enrollees.

Clinical therapeutics 20051001

[Hypolipidemic treatment under special conditions: posttransplant and/or immunosuppressive therapy].

Arquivos brasileiros de cardiologia 20051001

Cost-effectiveness of pravastatin for primary prevention of coronary artery disease in Japan.

International journal of cardiology 20050930

Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.

Journal of pharmaceutical and biomedical analysis 20050915

Binding thermodynamics of statins to HMG-CoA reductase.

Biochemistry 20050906

Review of primary and secondary prevention trials with lovastatin, pravastatin, and simvastatin.

The American journal of cardiology 20050905

Early time to benefit with intensive statin treatment: could it be the pleiotropic effects?

The American journal of cardiology 20050905

Effect of intensive lipid lowering on progression of coronary atherosclerosis: evidence for an early benefit from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial.

The American journal of cardiology 20050905

Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein.

The Journal of pharmacology and experimental therapeutics 20050901

Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin.

Molecular pharmacology 20050901

The effect of statin therapy on lipoprotein associated phospholipase A2 levels.

Atherosclerosis 20050901

Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050901

REVERSAL and PROVE-IT: are clinically oriented trials really better than 'pure' scientific studies?

International journal of cardiology 20050901

The -514C/T polymorphism of the hepatic lipase gene significantly modulates the HDL-cholesterol response to statin treatment.

Atherosclerosis 20050901

Survival, graft atherosclerosis, and rejection incidence in heart transplant recipients treated with statins: 5-year follow-up.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901

Differences between statins on clinical endpoints: a population-based cohort study.

Current medical research and opinion 20050901

A randomized trial of the efficacy and safety of fenofibrate versus pravastatin in HIV-infected subjects with lipid abnormalities: AIDS Clinical Trials Group Study 5087.

AIDS research and human retroviruses 20050901

Statin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian family.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050901

Stroke prevention, blood cholesterol and statins.

Acta neurologica Taiwanica 20050901

Increase in plasma malondialdehyde-modified low-density lipoprotein in patients with atherothrombotic cerebral infarction.

The Tokai journal of experimental and clinical medicine 20050901

[The effects of pravastatin on platelet-derived nitric oxide system in rabbits].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050901

Impact of the pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22/Reversal of Atherosclerosis with Aggressive Lipid Lowering trials on trends in intensive versus moderate statin therapy in Ontario, Canada.

Circulation 20050830

[Intensive LDL lowering to under 80 mg/dl: hypercholesteremia patients with stable coronary disease and diabetes profit especially significantly].

MMW Fortschritte der Medizin 20050818

Fast analysis of pravastatin in production media.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.

The Journal of pharmacology and experimental therapeutics 20050801

Hydroxymethylglutaryl co-enzyme A reductase inhibition attenuates endotoxin-mediated inflammatory responses.

The British journal of surgery 20050801

Comparison of the effects of pravastatin and atorvastatin on fracture incidence in the PROVE IT-TIMI 22 trial--secondary analysis of a randomized controlled trial.

Bone 20050801

Add-on and withdrawal effect of pravastatin on proteinuria in hypertensive patients treated with AT receptor blockers.

Kidney international 20050801

The effects of multiple doses of fenofibrate on the pharmacokinetics of pravastatin and its 3alpha-hydroxy isomeric metabolite.

Journal of clinical pharmacology 20050801

Three-year follow-up results of angiographic intervention trial using an HMG-CoA reductase inhibitor to evaluate retardation of obstructive multiple atheroma (ATHEROMA) study.

Circulation journal : official journal of the Japanese Circulation Society 20050801

Statin use after acute myocardial infarction: a nationwide study in Denmark.

British journal of clinical pharmacology 20050801

Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial.

Stroke 20050801

Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease.

Stroke 20050801

Treatment strategies in endothelial dysfunction: physical exercise versus pharmacological therapy.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20050801

Effect of mild endurance exercise training and pravastatin on peripheral vasodilatation of forearm resistance vessels in patients with coronary artery disease.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20050801

Not all statins interfere with clopidogrel during antiplatelet therapy.

European journal of clinical investigation 20050801

Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050801

Statins and cancer development.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050801

The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease.

Thrombosis and haemostasis 20050801

New light on statin side effects. What recent research on the cholesterol drugs means to you.

Heart advisor 20050801

Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease.

Circulation 20050712

Intensive lipid lowering with atorvastatin in coronary disease.

The New England journal of medicine 20050707

Effect of pravastatin on development of left ventricular hypertrophy in spontaneously hypertensive rats.

American journal of physiology. Heart and circulatory physiology 20050701

Impact of statins in microalbuminuric subjects with the metabolic syndrome: a substudy of the PREVEND Intervention Trial.

European heart journal 20050701

Metabolic syndrome criteria: ready for clinical prime time or work in progress?

European heart journal 20050701

D-4F and statins synergize to render HDL antiinflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice.

Arteriosclerosis, thrombosis, and vascular biology 20050701

Improved cerebral vasoreactivity after statin administration in healthy adults.

Journal of neuroimaging : official journal of the American Society of Neuroimaging 20050701

Biomarkers of inflammation and progression of chronic kidney disease.

Kidney international 20050701

Comparison of rosuvastatin with atorvastatin, simvastatin and pravastatin in achieving cholesterol goals and improving plasma lipids in hypercholesterolaemic patients with or without the metabolic syndrome in the MERCURY I trial.

Diabetes, obesity & metabolism 20050701

Substitution of nevirapine or efavirenz for protease inhibitor versus lipid-lowering therapy for the management of dyslipidaemia.

AIDS (London, England) 20050701

Pravastatin does not have a consistent antiviral effect in chronically HIV-infected individuals on antiretroviral therapy.

AIDS (London, England) 20050701

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.

Pharmacogenetics and genomics 20050701

Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study.

Journal of acquired immune deficiency syndromes (1999) 20050701

Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients.

Metabolism: clinical and experimental 20050701

In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis.

European journal of endocrinology 20050701

Methysergide-induced scleroderma-like changes of the legs.

The British journal of dermatology 20050701

Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular ultrasound.

Journal of the American College of Cardiology 20050621

Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy.

Transplantation 20050615

Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events.

Clinical science (London, England : 1979) 20050601

Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins.

Arteriosclerosis, thrombosis, and vascular biology 20050601

Pravastatin restores DDAH activity and endothelium-dependent relaxation of rat aorta after exposure to glycated protein.

Journal of cardiovascular pharmacology 20050601

Cost effectiveness of rosuvastatin in treating patients to low-density lipoprotein cholesterol goals compared with atorvastatin, pravastatin, and simvastatin (a US Analysis of the STELLAR Trial).

The American journal of cardiology 20050601

Plasma lipoprotein(a) [Lp(a)] concentrations and cardiovascular events in the elderly: evidence from the prospective study of pravastatin in the elderly at risk (PROSPER).

Atherosclerosis 20050601

Effect of pravastatin on progression of coronary atherosclerosis in patients after coronary artery bypass surgery.

Circulation journal : official journal of the Japanese Circulation Society 20050601

Baseline levels of low-density lipoprotein cholesterol and lipoprotein (a) and the AvaII polymorphism of the low-density lipoprotein receptor gene influence the response of low-density lipoprotein cholesterol to pravastatin treatment.

Metabolism: clinical and experimental 20050601

Pravastatin reduces fibrinogen receptor gpIIIa on platelet-derived microparticles in patients with type 2 diabetes.

Journal of thrombosis and haemostasis : JTH 20050601

Atorvastatin.

Expert opinion on pharmacotherapy 20050601

Early effects of statin therapy on endothelial function and microvascular reactivity in patients with coronary artery disease.

American heart journal 20050601

Induction of micronuclei in CHO cells by bleomycin but not by X-irradiation is decreased by treatment with HMG-CoA reductase inhibitors.

Journal of radiation research 20050601

Acute onset and worsening of diabetes concurrent with administration of statins.

Endocrine journal 20050601

[Erythrocyte fluidity in patients with hyperlipidemia during statins therapy].

Polskie Archiwum Medycyny Wewnetrznej 20050601

Effect of pravastatin on cerebral infarcts and white matter lesions.

Neurology 20050524

Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: an analysis of the PROVE-IT TIMI-22 trial.

Journal of the American College of Cardiology 20050517

Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens.

Biochimica et biophysica acta 20050515

Rapid effect of pravastatin on endothelial function and lipid peroxidation in unstable angina.

International journal of cardiology 20050511

Pharmacogenetic study of statin therapy and cholesterol reduction.

Current atherosclerosis reports 20050501

Cholesteryl ester transfer protein TaqIB polymorphism in the cholesterol and recurrent events study.

Current atherosclerosis reports 20050501

Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia.

The American journal of cardiology 20050501

Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses.

Radiation research 20050501

Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat.

Journal of gastroenterology and hepatology 20050501

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

Pharmacogenetics and genomics 20050501

Value for money in disease management of acute coronary syndrome--the price of aspirin to reduce the costs of ACS.

Journal of managed care pharmacy : JMCP 20050501

The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: a comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia.

Metabolism: clinical and experimental 20050501

A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial.

Mayo Clinic proceedings 20050501

[Effects of pravastatin, fosinopril and their combination on myocardium TNF-alpha expression and ventricular remodeling after myocardial infarction in rats].

Zhonghua xin xue guan bing za zhi 20050501

Gitelman's syndrome presenting as intolerance to statin therapy.

Annals of clinical biochemistry 20050501

Pravastatin attenuates ceramide-induced cytotoxicity in mouse cerebral endothelial cells with HIF-1 activation and VEGF upregulation.

Annals of the New York Academy of Sciences 20050501

Cardiac preconditioning during percutaneous coronary interventions.

Cardiovascular drugs and therapy 20050501

Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050426

Quantification of pravastatin in human plasma and urine after solid phase extraction using high performance liquid chromatography with ultraviolet detection.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study.

International journal of cardiology 20050420

White blood cell count predicts reduction in coronary heart disease mortality with pravastatin.

Circulation 20050412

[The PROVE IT-TIMI-22 study or the biter being bit].

Revue medicale suisse 20050406

Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats.

Clinical science (London, England : 1979) 20050401

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

Drug metabolism and disposition: the biological fate of chemicals 20050401

Efficacy and safety of pravastatin in children and adolescents with heterozygous familial hypercholesterolemia: a prospective clinical follow-up study.

The Journal of clinical endocrinology and metabolism 20050401

Lovastatin-induced apoptosis in human melanoma cell lines.

Melanoma research 20050401

Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients.

Endocrine journal 20050401

[Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits].

Arquivos brasileiros de cardiologia 20050401

Effect of anticholesterol therapy on soluble ICAM-1 in chronic stroke patients with hyperlipidemia.

The Tokai journal of experimental and clinical medicine 20050401

Electrocardiographic events and cholesterol reduction with pravastatin in patients with hypercholesterolemia: the Hokuriku Lipid Coronary Heart Disease Study-Pravastatin Atherosclerosis Trial.

International journal of cardiology 20050330

Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment.

Circulation 20050322

[Protective effects of pravastatin against atherosclerosis in children with familial hypercholesterolemia].

Revue medicale suisse 20050302

Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

Journal of leukocyte biology 20050301

Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease.

Arteriosclerosis, thrombosis, and vascular biology 20050301

HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301

Effects of statins on vascular function of endothelin-1.

British journal of pharmacology 20050301

Effects of fosinopril and pravastatin on carotid intima-media thickness in subjects with increased albuminuria.

Stroke 20050301

Intensive versus moderate lipid lowering with statins in acute coronary syndromes.

Current atherosclerosis reports 20050301

Reversal of atherosclerosis with aggressive lipid lowering.

Current atherosclerosis reports 20050301

Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis.

Metabolism: clinical and experimental 20050301

Modulation of the inflammatory process by statins.

Timely topics in medicine. Cardiovascular diseases 20050301

How common is rhabdomyolysis in patients receiving lipid-lowering therapy?

Nature clinical practice. Cardiovascular medicine 20050301

By the way, doctor. I take Pravachol to control my cholesterol, and because of high triglycerides, my doctor wants to add TriCor. But my pharmacist warns against taking both medications. If I don't take TriCor, are there alternatives?

Harvard health letter 20050301

[Clinical protocol. Pravastatin for the prevention of the destruction of the nutritional status of hemodialysis patients exhibiting chronic inflammation].

Nephrologie & therapeutique 20050301

Quantitative determination of pravastatin and R-416, its main metabolite in human plasma, by liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings.

Life sciences 20050225

Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.

World journal of gastroenterology 20050221

A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease.

Transplantation 20050215

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex.

The Journal of pharmacology and experimental therapeutics 20050201

Long-term effects of statins on arterial pressure and stiffness of hypertensives.

Journal of human hypertension 20050201

A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.

Journal of clinical pharmacy and therapeutics 20050201

Effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on atherogenic dyslipidemia in patients with characteristics of the metabolic syndrome.

The American journal of cardiology 20050201

Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level.

Acta physiologica Scandinavica 20050201

Pravastatin modulates early diabetic nephropathy in an experimental model of diabetic renal disease.

The Journal of surgical research 20050201

Rosuvastatin is cost-effective in treating patients to low-density lipoprotein-cholesterol goals compared with atorvastatin, pravastatin and simvastatin: analysis of the STELLAR trial.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20050201

Effects of switching pravastatin to cerivastatin on C-reactive protein, butyrylcholinesterase, and lipids.

Current medical research and opinion 20050201

[Effects of interaction between vascular endothelial cells and monocytes on expression of matrix metalloproteinase-2 and of tissue inhibitor of metalloproteinases 2 and regulation of pravastatin].

Zhonghua bing li xue za zhi = Chinese journal of pathology 20050201

Effect of statins on LDL particle size in patients with familial combined hyperlipidemia: a comparison between atorvastatin and pravastatin.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20050201

Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects.

Circulation 20050125

C-reactive protein levels and outcomes after statin therapy.

The New England journal of medicine 20050106

Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.

The New England journal of medicine 20050106

Effects of combined estriol/pravastatin therapy on intima-media thickness of common carotid artery in hyperlipidemic postmenopausal women.

Gynecologic and obstetric investigation 20050101

Pravastatin therapy is associated with reduction in coronary allograft vasculopathy in pediatric heart transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050101

Effect of pravastatin on impaired endothelium-dependent relaxation induced by lysophosphatidylcholine in rat aorta.

Acta pharmacologica Sinica 20050101

Are Canadian guidelines for cholesterol lowering in high-risk patients optimal?

The Canadian journal of cardiology 20050101

PROVE IT then believe it.

International journal of clinical practice 20050101

A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia.

Journal of atherosclerosis and thrombosis 20050101

Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy.

Drug safety 20050101

Adverse events with concomitant amiodarone and statin therapy.

Preventive cardiology 20050101

Acute myopathy in a patient with concomitant use of pravastatin and colchicine.

The Annals of pharmacotherapy 20050101

[Clinical study of pravastatin with different dosage in early admission period in patients with unstable angina].

Zhonghua xin xue guan bing za zhi 20050101

HMG-CoA reductase inhibitors suppress the development and progression of carotid artery intimal-medial thickening in hypercholesterolemic type 2 diabetic patients.

Journal of atherosclerosis and thrombosis 20050101

Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes.

Journal of atherosclerosis and thrombosis 20050101

Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.

Preventive cardiology 20050101

Unblinding of trial participants to their treatment allocation: lessons from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

Clinical trials (London, England) 20050101

Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy.

American journal of nephrology 20050101

[Effect of n-3 polyunsaturated fatty acids on plasma lipid, LDL lipoperoxidation, homocysteine and inflammation indicators in diabetic dyslipidemia treated with statin + fibrate combination].

Casopis lekaru ceskych 20050101

Isolation of a cDNA encoding the alpha-subunit of CAAX-prenyltransferases from Catharanthus roseus and the expression of the active recombinant protein farnesyltransferase.

Cellular & molecular biology letters 20050101

[Hypertension combined with atherosclerotic lesions in carotid arteries: should angiotensin converting enzyme inhibitors be prescribed?].

Kardiologiia 20050101

Pravastatin improves insulin resistance in dyslipidemic patients.

Journal of atherosclerosis and thrombosis 20050101

Comparison of the effects of D-003, a mixture of high-molecular-weight aliphatic acids from sugarcane wax, and pravastatin on bones and osteoclast apoptosis of ovariectomized rats.

Drugs under experimental and clinical research 20050101

Statin-associated exacerbation of myasthenia gravis.

Neurology 20041214

Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.

The Journal of pharmacology and experimental therapeutics 20041201

[Statin therapy in patients with acute coronary syndrome. 'Prove-it' study].

Der Internist 20041201

Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind trial.

Stroke 20041201

Pharmacogenetic study of statin therapy in cholesterol reduction.

Current hypertension reports 20041201

Intensive statin therapy in acute coronary syndromes: clinical benefits and vascular biology.

Current opinion in lipidology 20041201

Therapy and clinical trials: clinical therapy and trials.

Current opinion in lipidology 20041201

Effects of a statin group drug, pravastatin, on the insulin resistance in patients with metabolic syndrome.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20041201

Effect of aggressive versus moderate lipid-lowering therapy on myocardial ischemia: the rationale, design, and baseline characteristics of the Study Assessing Goals in the Elderly (SAGE).

American heart journal 20041201

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy.

Drug metabolism and pharmacokinetics 20041201

What did PROVE-IT prove?

Diabetes technology & therapeutics 20041201

Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention.

Platelets 20041201

Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.

Journal of cellular biochemistry 20041115

Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria.

Circulation 20041102

Disorder resembling Guillain-Barré syndrome on initiation of statin therapy.

Muscle & nerve 20041101

Elevated soluble tumor necrosis factor receptor levels in non-obese adults with the atherogenic dyslipoproteinemia.

Atherosclerosis 20041101

Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.

The American journal of cardiology 20041101

Statins: can the new generation make an impression?

Expert opinion on emerging drugs 20041101

Tracking regression and progression of atherosclerosis in human carotid arteries using high-resolution magnetic resonance imaging.

Magnetic resonance imaging 20041101

Effects of statins on circulating oxidized low-density lipoprotein in patients with hypercholesterolemia.

Japanese heart journal 20041101

Can pravastatin lower coronary event rate if HDL and LDL cholesterol are at low levels?

Nature clinical practice. Cardiovascular medicine 20041101

Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase.

Circulation 20041012

Effects of pravastatin on the expression of ATP-binding cassette transporter A1.

The Journal of pharmacology and experimental therapeutics 20041001

Randomized, controlled trial of secondary prevention of coronary sclerosis in normocholesterolemic patients using pravastatin: final 5-year angiographic follow-up of the Prevention of Coronary Sclerosis (PCS) study.

International journal of cardiology 20041001

An approach to the residence time distribution for stochastic multi-compartment models.

Mathematical biosciences 20041001

Effect of pravastatin on left ventricular mass by activation of myocardial K ATP channels in hypercholesterolemic rabbits.

Atherosclerosis 20041001

[Endothelial dysfunction, inflammation and statins: new evidences].

Revista espanola de cardiologia 20041001

[Effect of the early administration of pravastatin on C-reactive protein and interleukin-6 levels in the acute phase of myocardial infarction with ST segment elevation].

Revista espanola de cardiologia 20041001

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. 1995.

Atherosclerosis. Supplements 20041001

Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals. 2003.

Atherosclerosis. Supplements 20041001

Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain.

Neurochemical research 20041001

Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions.

Drug metabolism and pharmacokinetics 20041001

How low should your cholesterol go? Even lower may be better. For those at highest risk, very low cholesterol levels may help prevent a second heart attack or stroke.

Health news (Waltham, Mass.) 20041001

Effect of pravastatin on cardiovascular events in people with chronic kidney disease.

Circulation 20040921

[Lowering of cholesterol. What role is played by the choice of statins?].

MMW Fortschritte der Medizin 20040902

An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.

Clinical science (London, England : 1979) 20040901

Early effect of pravastatin on serum soluble CD40L, matrix metalloproteinase-9, and C-reactive protein in patients with acute myocardial infarction.

Clinical chemistry 20040901

Lessons learned from the prospective pravastatin pooling project.

Current atherosclerosis reports 20040901

ALLHAT-LLT: questions, questions, and more questions (and some answers).

Current atherosclerosis reports 20040901

HMG-CoA reductase inhibitors and the risk of vertebral fracture.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040901

Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?

British journal of clinical pharmacology 20040901

Design and baseline characteristics of a study of primary prevention of coronary events with pravastatin among Japanese with mildly elevated cholesterol levels.

Circulation journal : official journal of the Japanese Circulation Society 20040901

Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells.

Journal of the American Society of Nephrology : JASN 20040901

Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin.

Journal of molecular and cellular cardiology 20040901

Oral administration of pravastatin reduces egg cholesterol but not plasma cholesterol in laying hens.

Poultry science 20040901

Effects of rosuvastatin versus atorvastatin, simvastatin, and pravastatin on non-high-density lipoprotein cholesterol, apolipoproteins, and lipid ratios in patients with hypercholesterolemia: additional results from the STELLAR trial.

Clinical therapeutics 20040901

Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation.

Circulation 20040831

Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model.

Journal of the American College of Cardiology 20040818

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040812

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040812

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040812

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040812

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040812

Updated guidelines support even lower cholesterol levels for at-risk patients.

Report on medical guidelines & outcomes research 20040806

[Patient feels completely well. The PROCAM Score first reveals the high infarct risk].

MMW Fortschritte der Medizin 20040805

Treatment of type IIb familial combined hyperlipidemia with the combination pravastatin-piperazine sultosilate.

European journal of pharmacology 20040802

Cholesterol-lowering independent regression and stabilization of atherosclerotic lesions by pravastatin and by antimonocyte chemoattractant protein-1 therapy in nonhuman primates.

Arteriosclerosis, thrombosis, and vascular biology 20040801

Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease.

Arteriosclerosis, thrombosis, and vascular biology 20040801

Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat.

Journal of gastroenterology and hepatology 20040801

CETP gene variation: relation to lipid parameters and cardiovascular risk.

Current opinion in lipidology 20040801

AT-1 receptor blockade prevents proteinuria, renal failure, hyperlipidemia, and glomerulosclerosis in the Imai rat.

Kidney international 20040801

Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound.

Circulation journal : official journal of the Japanese Circulation Society 20040801

Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir.

Infection 20040801

Treatment of hyperlipidemia in cardiac transplant recipients.

American heart journal 20040801

Lessons from the PROVE-IT trial. Higher dose of potent statin better for high-risk patients.

Cleveland Clinic journal of medicine 20040801

Rosuvastatin: new preparation. Opt for statins with evidence of efficacy on clinical outcome.

Prescrire international 20040801

Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial.

JAMA 20040721

[Decreasing LDL level moderately or drastically. Is differential therapy with statins available? (interview by Dirk Einecke)].

MMW Fortschritte der Medizin 20040708

Effect of pravastatin on low-density lipoprotein oxidation and myocardial perfusion in young adults with type 1 diabetes.

Arteriosclerosis, thrombosis, and vascular biology 20040701

Understanding why older people participate in clinical trials: the experience of the Scottish PROSPER participants.

Age and ageing 20040701

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest.

Anti-cancer drugs 20040701

Effect of pravastatin compared with placebo initiated within 24 hours of onset of acute myocardial infarction or unstable angina: the Pravastatin in Acute Coronary Treatment (PACT) trial.

American heart journal 20040701

Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively.

The American journal of cardiology 20040701

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

Pharmacogenetics 20040701

New LDL goals: even lower?

The Johns Hopkins medical letter health after 50 20040701

[Pharmacoeconomic analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor therapy for the secondary prevention of coronary heart disease].

Nihon eiseigaku zasshi. Japanese journal of hygiene 20040701

Pharmacogenetic study of statin therapy and cholesterol reduction.

JAMA 20040616

Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.

Biochemical pharmacology 20040615

Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells.

The Journal of surgical research 20040601

Effect of pravastatin on myocardial perfusion after percutaneous transluminal coronary angioplasty.

The American journal of cardiology 20040601

Intensive lipid-lowering therapy in coronary artery disease: implications of the REVERSAL and PROVE-IT trials.

Expert opinion on investigational drugs 20040601

Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.

American journal of hypertension 20040601

High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.

Steroids 20040601

Clopidogrel-atorvastatin interaction.

Circulation 20040525

Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces delayed neuronal death following transient forebrain ischemia in the adult rat hippocampus.

Neuroscience letters 20040520

The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.

Circulation 20040518

Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes.

British journal of clinical pharmacology 20040501

HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women.

Journal of thrombosis and haemostasis : JTH 20040501

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.

Clinical pharmacology and therapeutics 20040501

Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis.

Thrombosis and haemostasis 20040501

Treating low HDL-cholesterol in normocholesterolaemic patients with coronary disease: statins, fibrates or horses for courses?

European heart journal 20040501

Effects of pravastatin on coronary events in 2073 patients with low levels of both low-density lipoprotein cholesterol and high-density lipoprotein cholesterol: results from the LIPID study.

European heart journal 20040501

Effects of a novel antihyperlipidemic agent, S-2E, on the blood lipid abnormalities in homozygous WHHL rabbits.

Metabolism: clinical and experimental 20040501

Lipitor bests Pravachol at certain doses.

Health news (Waltham, Mass.) 20040501

Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study.

Atherosclerosis 20040501

Cholesterol: low is good. Lower is better. PROVE IT has doctors rethinking how to treat high cholesterol and what's a good target.

Harvard heart letter : from Harvard Medical School 20040501

Cholesterol limbo: How low should the bar go. Ratcheting down LDL to extra-low levels with high-dose statins seems to work wonders.

Harvard health letter 20040501

Bioequivalence of pravastatin tablet formulations assessed in Korean males.

International journal of clinical pharmacology and therapeutics 20040501

[The Prosper-Study: practical consequences?].

Der Internist 20040501

'Major surprise' in a new study means likely changes in treatment.

Heart advisor 20040501

[Comparison of effects of taizhi' an capsule and pravastatin on vascular endothelial function in senile patients with coronary heart disease].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501

Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

The New England journal of medicine 20040408

Intensive statin therapy--a sea change in cardiovascular prevention.

The New England journal of medicine 20040408

HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice.

American journal of physiology. Heart and circulatory physiology 20040401

Hydroxy-methylglutaryl-coenzyme A reductase inhibition improves endothelial dysfunction in type-1 diabetes.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20040401

Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese.

British journal of clinical pharmacology 20040401

Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter.

Metabolism: clinical and experimental 20040401

Effects of pravastatin on lipoproteins and endothelial function in patients receiving human immunodeficiency virus protease inhibitors.

American heart journal 20040401

Effects of switching statins on achievement of lipid goals: Measuring Effective Reductions in Cholesterol Using Rosuvastatin Therapy (MERCURY I) study.

American heart journal 20040401

Impaired myocardial vasodilatation during hyperaemic stress is improved by simvastatin but not by pravastatin in patients with hypercholesterolaemia.

European heart journal 20040401

Statins and secondary prevention of coronary heart disease.

British journal of community nursing 20040401

Believe-it then PROVE-IT.

International journal of clinical practice 20040401

[Lower, lower, lower. The LDL goal value of 200 mg/dl is still much too high].

MMW Fortschritte der Medizin 20040325

[Results of randomized study: intensive lipid lowering treatment stops coronary atherosclerosis].

MMW Fortschritte der Medizin 20040325

[Regarding LDL cholesterol: the lower, the better (interview by Dr. Dirk Einecke)].

MMW Fortschritte der Medizin 20040325

Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.

Circulation 20040323

Analysis of pravastatin to prevent recurrence of atrial fibrillation after electrical cardioversion.

The American journal of cardiology 20040315

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons.

Biochemical and biophysical research communications 20040305

Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.

JAMA 20040303

High-intensity statin treatment for coronary heart disease.

JAMA 20040303

The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy.

Journal of the American College of Cardiology 20040303

Determination of pravastatin in tablets by capillary electrophoresis.

Farmaco (Societa chimica italiana : 1989) 20040301

Hypercholesterolemia is common after pediatric heart transplantation: initial experience with pravastatin.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040301

[Clinical study of the month. REVERAL and PROVE-IT: confirmation of the concept ' the lower, the better' for cholesterol therapy in patients with coronary heart disease].

Revue medicale de Liege 20040301

A boy with autosomal recessive hypercholesterolaemia.

The Netherlands journal of medicine 20040301

[Interactions of statins with antithrombotic drugs].

Medizinische Klinik (Munich, Germany : 1983) 20040215

Pravastatin up-regulates transforming growth factor-beta1 in THP-1 human macrophages: effect on scavenger receptor class A expression.

Biochemical and biophysical research communications 20040213

Statins reduce oxidized low-density lipoprotein levels, but do not alter soluble intercellular cell-adhesion molecule-1 and vascular cell-adhesion molecule-1 levels in subjects with hypercholesterolaemia.

Clinical science (London, England : 1979) 20040201

More Western hypercholesterolemic patients achieve Japan Atherosclerosis Society LDL-C goals with rosuvastatin therapy than with atorvastatin, pravastatin, or simvastatin therapy.

Circulation journal : official journal of the Japanese Circulation Society 20040201

Statins induce the regression of left ventricular mass in patients with angina.

Circulation journal : official journal of the Japanese Circulation Society 20040201

Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes.

Diabetes care 20040201

Acute and chronic regulation of thick ascending limb endothelial nitric oxide synthase by statins.

Journal of the American Society of Nephrology : JASN 20040201

Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects.

British journal of clinical pharmacology 20040201

[Role of lipid lowering therapy in patients with peripheral arterial occlusive disease].

Herz 20040201

Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.

Journal of pharmacological sciences 20040201

Clash of the statins? A trial pitting two popular statins against each other helps answer a far more important question: how low should cholesterol go?

Harvard heart letter : from Harvard Medical School 20040201

Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry.

Archives of internal medicine 20040126

[Treatment with statins of the elderly].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20040122

Effect of physical activity on serum C-reactive protein.

The American journal of cardiology 20040115

Additive benefits of pravastatin and aspirin to decrease risks of cardiovascular disease: randomized and observational comparisons of secondary prevention trials and their meta-analyses.

Archives of internal medicine 20040112

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy.

American journal of physiology. Renal physiology 20040101

Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities.

Journal of cardiovascular pharmacology 20040101

Characterization of uremic toxin transport by organic anion transporters in the kidney.

Kidney international 20040101

Differential effects of lipid-lowering agents on human cholinesterases.

Clinical biochemistry 20040101

Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events.

American heart journal 20040101

Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects.

The American journal of cardiology 20040101

Does statin therapy influence steroid hormone synthesis?

Zeitschrift fur Kardiologie 20040101

Marked low-density lipoprotein cholesterol reduction below current national cholesterol education program targets provides the greatest reduction in carotid atherosclerosis.

Clinical cardiology 20040101

Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression.

Clinical pharmacology and therapeutics 20040101

Aggressive lipid-lowering regimen halts CHD progression.

Geriatrics 20040101

Is there a 'best' statin drug?

The Johns Hopkins medical letter health after 50 20040101

Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS).

European journal of clinical investigation 20040101

Is Lipitor better than Pravachol?

Health news (Waltham, Mass.) 20040101

Prolonged inadvertent pravastatin use in pregnancy.

Reproductive toxicology (Elmsford, N.Y.) 20040101

C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.

Medical hypotheses 20040101

Pravastatin sodium, an inhibitor of HMG-CoA reductase, decreases HDL cholesterol by transfer of cholesteryl ester from HDL to VLDL in Japanese white rabbits.

Journal of atherosclerosis and thrombosis 20040101

Rosuvastatin-induced arrest in progression of renal disease.

Cardiology 20040101

What to do about cholesterol now. Here's the take-home message from startling new research findings.

Heart advisor 20040101

Comparison of urinary excretion of pravastatin and temocapril in bile duct-ligated rats and Eisai hyperbilirubinemic rats (EHBR).

Journal of hepato-biliary-pancreatic surgery 20040101

A prospective study of pravastatin in the elderly at risk: new hope for older persons.

The American journal of geriatric cardiology 20040101

[Pravastatin-associated polymyositis, a case report].

Rinsho shinkeigaku = Clinical neurology 20040101

Pravastatin potentiates the anticoagulant effects of low molecular weight heparin.

Thrombosis research 20040101

Statin drugs do not affect serum complement activation in vitro.

Scandinavian journal of immunology 20040101

Treatment of HCC with pravastatin, octreotide, or gemcitabine--a critical evaluation.

Hepato-gastroenterology 20040101

Aggressive lowering of low-density lipoprotein cholesterol: do the studies apply to the elderly?

The American journal of geriatric cardiology 20040101

Battle of the statins, or how the news media can change patient care.

JAAPA : official journal of the American Academy of Physician Assistants 20040101

Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation.

Journal of biomedical science 20040101

Looking for prognostic information in the ST-T segment--is it really worth it?

Journal of electrocardiology 20040101

Statins: much more than just a lipid-lowering therapy.

Indian heart journal 20040101

Atorvastatin and pravastatin elevated pre-heparin lipoprotein lipase mass of type 2 diabetes with hypercholesterolemia.

Journal of atherosclerosis and thrombosis 20040101

[Effect of eprosartan in combination with pravastatin on some parameters of endothelial function in patients with metabolic syndrome.].

Kardiologiia 20040101

Closing out a large clinical trial: lessons from the prospective study of pravastatin in the elderly at risk (PROSPER).

Clinical trials (London, England) 20040101

[First comparison of 2 statins shows: only radical LDL lowering stops coronary atherosclerosis].

MMW Fortschritte der Medizin 20031218

Effect of statins on the progression of bioprosthetic aortic valve degeneration.

The American journal of cardiology 20031215

[LDL cholesterol in normal range. The lower the better? Implications of the GREACE study].

MMW Fortschritte der Medizin 20031211

Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness.

Circulation 20031202

Different effects of simvastatin and pravastatin on adrenal sensitivity to angiotensin II.

British journal of clinical pharmacology 20031201

Perspectives from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial--Lipid Lowering Trial and the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm.

Current opinion in lipidology 20031201

Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins.

Atherosclerosis 20031201

Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin.

Biological & pharmaceutical bulletin 20031201

Effects of pravastatin on cardiomyocyte hypertrophy and ventricular vulnerability in normolipidemic rats after myocardial infarction.

Journal of molecular and cellular cardiology 20031201

Direct vascular effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.

Clinical and experimental pharmacology & physiology 20031201

Pravastatin decreases cold ischemia--but not alloantigen-dependent transplant arteriosclerosis.

Transplantation proceedings 20031201

Accuracy of the Australian National Death Index: comparison with adjudicated fatal outcomes among Australian participants in the Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) study.

Australian and New Zealand journal of public health 20031201

The next step in cardiovascular protection.

Atherosclerosis. Supplements 20031201

Preventing the next event in the elderly: the PROSPER perspective.

Atherosclerosis. Supplements 20031201

[Ezetimibe: from pharmacology to clinical trials].

Annales d'endocrinologie 20031201

Statin face-off. Surprises from the first head-to-head comparison.

Time 20031124

Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection.

The American journal of cardiology 20031115

Individual difference in the pharmacokinetics of a drug, pravastatin, in healthy subjects.

Journal of clinical pharmacology 20031101

Statin therapy: new therapy for cardiac microvascular dysfunction.

European heart journal 20031101

Benefits of statin treatment in cardiac syndrome-X1.

European heart journal 20031101

Long-term administration of pravastatin reduces serum lipoprotein(a) levels.

International journal of clinical pharmacology and therapeutics 20031101

Effects of statins on adhesion molecule expression in endothelial cells.

Journal of thrombosis and haemostasis : JTH 20031101

[Systemic treatment for hepatocellular carcinoma].

Zentralblatt fur Chirurgie 20031101

Bioconversion of compactin into pravastatin by Streptomyces sp.

Biotechnology letters 20031101

Rhabdomyolysis caused by distigmine bromide.

Internal medicine (Tokyo, Japan) 20031101

Pravastatin reduces the incidence of cardiac events among patients with myocardial infarction.

Japanese heart journal 20031101

Rapid effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition on coronary endothelial function.

Circulation research 20031031

Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-beta (Abeta) 40 or Abeta 42 in humans.

Neuroscience letters 20031030

Effect of pravastatin on coronary plaque volume.

The American journal of cardiology 20031015

Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose: results from the LIPID trial.

Diabetes care 20031001

Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men.

Pharmacogenetics 20031001

Pravastatin in hyperlipidemia secondary to HIV protease inhibitors without response to fenofibrate: a brief preliminary report.

Nutrition (Burbank, Los Angeles County, Calif.) 20031001

A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study.

European heart journal 20031001

Effect of pravastatin on LDL particle concentration as determined by NMR spectroscopy: a substudy of a randomized placebo controlled trial.

European heart journal 20031001

Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS).

American heart journal 20031001

Effects of atorvastatin and pravastatin on malondialdehyde-modified LDL in hypercholesterolemic patients.

Circulation journal : official journal of the Japanese Circulation Society 20031001

IL-6 is a key factor in growth inhibition of human myeloma cells induced by pravastatin, an HMG-CoA reductase inhibitor.

International journal of oncology 20030901

Lovastatin induces relaxation and inhibits L-type Ca(2+) current in the rat basilar artery.

Pharmacology & toxicology 20030901

Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells.

Cardiovascular research 20030901

Pravastatin prevents arrhythmias induced by coronary artery ischemia/reperfusion in anesthetized normocholesterolemic rats.

Journal of pharmacological sciences 20030901

Role of the pharmacist in establishing lipid intervention programs.

Pharmacotherapy 20030901

Prospective serial evaluation of myocardial perfusion and lipids during the first six months of pravastatin therapy: coronary artery disease regression single photon emission computed tomography monitoring trial.

Journal of the American College of Cardiology 20030820

Syntheses of 3-ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels.

Bioorganic & medicinal chemistry 20030815

Plasma C-reactive protein as a marker of cardiac allograft vasculopathy in heart transplant recipients.

Journal of the American College of Cardiology 20030806

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

The Journal of pharmacology and experimental therapeutics 20030801

Pharmacokinetics and pharmacodynamics of pravastatin in children with familial hypercholesterolemia.

Clinical pharmacology and therapeutics 20030801

Statins: new data in secondary prevention and diabetes. Pravastatin and simvastatin are the best-assessed statins.

Prescrire international 20030801

Change in the protein level of mevalonate pyrophosphate decarboxylase in tissues of mouse by pravastatin.

Biological & pharmaceutical bulletin 20030801

Improvement of serum oxidation by pravastatin might be one of the mechanisms by which endothelial function in dilated coronary artery segments is ameliorated.

Atherosclerosis 20030801

Hypercholesterolemia. The evidence supports use of statins.

Geriatrics 20030801

Combination of statins and hormone replacement therapy in postmenopausal women is associated with increased bone mineral density.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20030801

[Long-term hypolipidemic treatment of mixed hyperlipidemia with a combination of statins and fibrates].

Casopis lekaru ceskych 20030801

Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study.

Circulation 20030729

Effect of pravastatin on intermediate-density and low-density lipoproteins containing apolipoprotein CIII in patients with diabetes mellitus.

The American journal of cardiology 20030715

Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial).

The American journal of cardiology 20030715

Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier.

The Journal of pharmacology and experimental therapeutics 20030701

Obesity and hyperhomocysteinaemia after kidney transplantation.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030701

The effect of statin therapy on ventricular late potentials in acute myocardial infarction.

International journal of cardiology 20030701

Pilot study examining the effect of cholesterol lowering on platelet nitric oxide responsiveness and arterial stiffness in subjects with isolated mild hypercholesterolaemia.

Clinical and experimental pharmacology & physiology 20030701

Allocating funds for cardiovascular disease prevention in light of the NCEP ATP III guidelines.

The American journal of managed care 20030701

Statin-associated memory loss: analysis of 60 case reports and review of the literature.

Pharmacotherapy 20030701

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.

Molecular and cellular biochemistry 20030701

Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.

Neurology 20030624

Beneficial effects of simvastatin and pravastatin on cardiac allograft rejection and survival.

Journal of the American College of Cardiology 20030604

Pilot study describing the use of pravastatin in pediatric renal transplant recipients.

Pediatric transplantation 20030601

Effect of pravastatin on loss of renal function in people with moderate chronic renal insufficiency and cardiovascular disease.

Journal of the American Society of Nephrology : JASN 20030601

Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes.

Diabetes care 20030601

Apo A-I promoter polymorphism influences basal HDL-cholesterol and its response to pravastatin therapy.

Atherosclerosis 20030601

Reduction in serum total cholesterol and risks of coronary events and cerebral infarction in Japanese men: the Kyushu Lipid Intervention Study.

Circulation journal : official journal of the Japanese Circulation Society 20030601

Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.

Biological & pharmaceutical bulletin 20030601

The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study.

Journal of cardiovascular pharmacology and therapeutics 20030601

Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance.

Clinical pharmacology and therapeutics 20030601

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Clinical pharmacology and therapeutics 20030601

Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.

Acta cardiologica 20030601

Current perspectives on statins.

Journal of the Indian Medical Association 20030601

[Coronary disease prevention: only the inhibition of inflammation is important. Why lower lipids, too?].

MMW Fortschritte der Medizin 20030522

Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events.

Circulation 20030520

LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients.

Arteriosclerosis, thrombosis, and vascular biology 20030501

DD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial.

Heart (British Cardiac Society) 20030501

Acute pancreatitis due to pravastatin therapy.

JOP : Journal of the pancreas 20030501

Effects of simvastatin and pravastatin on peroxidation of erythrocyte plasma membrane lipids in patients with type 2 hypercholesterolemia.

Canadian journal of physiology and pharmacology 20030501

[Caution about the use of statins in elderly individuals].

Revista medica de Chile 20030501

Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.

Cellular immunology 20030501

Statin therapy and small fibre neuropathy: a serial electrophysiological study.

Journal of the neurological sciences 20030415

Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.

Molecular pharmacology 20030401

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor pravastatin reduces disease activity and inflammation in dextran-sulfate induced colitis.

The Journal of pharmacology and experimental therapeutics 20030401

Results of two clinical trials on the safety and efficacy of pravastatin 80 and 160 mg per day.

The American journal of cardiology 20030401

Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: results from the Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) study.

American heart journal 20030401

Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease.

Archives of neurology 20030401

Lipid-lowering therapy and risk of coronary events.

JAMA 20030401

Lipid-lowering therapy and risk of coronary events.

JAMA 20030401

Lipid-lowering therapy and risk of coronary events.

JAMA 20030401

Efficacy and safety of ezetimibe coadministered with pravastatin in patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial.

European heart journal 20030401

Effects of cholesterol-lowering therapy on pressor hyperreactivity to stress in hypercholesterolemic patients.

Hypertension research : official journal of the Japanese Society of Hypertension 20030401

Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin.

Xenobiotica; the fate of foreign compounds in biological systems 20030401

81131-70-6 | 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)-

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