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80809-81-0 | 2,5-Cyclohexadiene-1,4-dione,2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-
CAS No: 80809-81-0 Catalog No: AG005J0X MDL No:MFCD00210243
Product Description
Catalog Number:
AG005J0X
Chemical Name:
2,5-Cyclohexadiene-1,4-dione,2-(12-hydroxy-5,10-dodecadiyn-1-yl)-3,5,6-trimethyl-
CAS Number:
80809-81-0
Molecular Formula:
C21H26O3
Molecular Weight:
326.4293
MDL Number:
MFCD00210243
IUPAC Name:
2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
InChI:
InChI=1S/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3
InChI Key:
WDEABJKSGGRCQA-UHFFFAOYSA-N
SMILES:
OCC#CCCCC#CCCCCC1=C(C)C(=O)C(=C(C1=O)C)C
UNII:
2XRX3BD53M
Properties
Complexity:
692
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
326.188g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
326.436g/mol
Monoisotopic Mass:
326.188g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
54.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
| Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | Toxicological sciences : an official journal of the Society of Toxicology 20150201 |
| Pro-apoptotic effects of tepoxalin, a cyclooxygenase/lipoxygenase dual inhibitor, on canine synovial fibroblasts. | The Journal of veterinary medical science 20120601 |
| Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120201 |
| Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors. | European journal of medicinal chemistry 20120101 |
| Evaluation of the antioxidative properties of lipoxygenase inhibitors. | Pharmacological reports : PR 20120101 |
| Effects of transient receptor potential channel blockers on pacemaker activity in interstitial cells of Cajal from mouse small intestine. | Molecules and cells 20110831 |
| Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110201 |
| Identification of clinically used drugs that activate pregnane X receptors. | Drug metabolism and disposition: the biological fate of chemicals 20110101 |
| Platelet membranes induce airway smooth muscle cell proliferation. | Platelets 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Lipoxygenase and cyclooxygenase inhibitors reveal a complementary role of arachidonic acid derivatives in pregnant human myometrium. | American journal of obstetrics and gynecology 20100901 |
| Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. | Glia 20100401 |
| The direct effect of levobupivacaine in isolated rat aorta involves lipoxygenase pathway activation and endothelial nitric oxide release. | Anesthesia and analgesia 20100201 |
| Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators. | Arteriosclerosis, thrombosis, and vascular biology 20091101 |
| Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. | The Journal of bone and joint surgery. American volume 20091101 |
| 5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway. | Molecular and cellular biochemistry 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Neuroprotection by melatonin on astrocytoma cell death. | Annals of the New York Academy of Sciences 20090801 |
| Mechanisms involved in the rat peritoneal leukocyte migration induced by a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds. | Toxicon : official journal of the International Society on Toxinology 20090301 |
| Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. | Biology of reproduction 20080301 |
| Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. | Toxicological sciences : an official journal of the Society of Toxicology 20080101 |
| Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. | American journal of physiology. Gastrointestinal and liver physiology 20080101 |
| Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. | The Journal of pharmacology and experimental therapeutics 20071201 |
| Blockade of avidity and focal clustering of beta 2-integrin by cysteinyl leukotriene antagonism attenuates eosinophil adhesion. | The Journal of allergy and clinical immunology 20071201 |
| Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis. | Cancer science 20070901 |
| Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. | Oncology reports 20070101 |
| Acute pulmonary inflammation induced by exposure of the airways to staphylococcal enterotoxin type B in rats. | Toxicology and applied pharmacology 20061115 |
| Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices. | Chemico-biological interactions 20061107 |
| Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells. | International journal of urology : official journal of the Japanese Urological Association 20060801 |
| Ca2+ signal stimulates the expression of steroidogenic acute regulatory protein and steroidogenesis in bovine adrenal fasciculata-reticularis cells. | Life sciences 20060515 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | Journal of hypertension 20060101 |
| A mechanistic study of colon cancer growth promoted by cigarette smoke extract. | European journal of pharmacology 20050905 |
| Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention. | Carcinogenesis 20050401 |
| Multiple contributions from long-chain fatty acid metabolism in Y-1 and MA-10 cells. | Endocrine research 20041101 |
| Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities. | Bioorganic & medicinal chemistry letters 20040517 |
| Photodynamic therapy upregulates expression of Mac-1 and generation of leukotriene B(4) by human polymorphonuclear leukocytes. | Oral oncology 20040501 |
| Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells. | Acta pharmacologica Sinica 20040501 |
| Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. | European journal of pharmacology 20040426 |
| Pharmacological modulation of TNF production in macrophages. | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20040201 |
| [Apoptosis in P388 leukemia cells induced by specific inhibitors of 5- and 12-lipoxygenase and the product of cyclooxygenase, prostaglandin E2]. | Izvestiia Akademii nauk. Seriia biologicheskaia 20040101 |
| Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901 |
| Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal. | British journal of pharmacology 20030901 |
| Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20030401 |
| Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. | European journal of pharmacology 20030319 |
| Bothrops lanceolatus (Fer de lance) venom stimulates leukocyte migration into the peritoneal cavity of mice. | Toxicon : official journal of the International Society on Toxinology 20030101 |
| Role of downstream metabolic processing of proinflammatory fatty acids by 5-lipoxygenase in HL-60 cell apoptosis. | The Journal of trauma 20030101 |
| 5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism. | Cancer research 20021201 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation. | American journal of physiology. Heart and circulatory physiology 20020201 |
| Involvement of cysteinyl leukotrienes in angiotensin II-induced contraction in isolated aortas from transgenic (mRen-2)27 rats. | Journal of hypertension 20020201 |
| 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. | Gastroenterology 20020201 |
| 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101 |
| Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin-induced diabetic rats. | Arteriosclerosis, thrombosis, and vascular biology 20011101 |
| Histamine stimulates alveolar macrophages to release neutrophil and monocyte chemotactic activity. | The Journal of laboratory and clinical medicine 20011001 |
| Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR. | American journal of physiology. Heart and circulatory physiology 20010701 |
| Leukotriene metabolism by intrapulmonary vessels of newborn lambs: effect of platelet-activating factor. | Experimental lung research 20010601 |
| Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase? | Annals of the New York Academy of Sciences 20010601 |
| Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. | British journal of pharmacology 20010401 |
| Effect of 5-lipoxygenase inhibition on Kupffer cell clearance capacity in obstructive jaundiced rats. | The Journal of surgical research 20010401 |
| Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition. | Nature immunology 20010201 |
| Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection. | Folia morphologica 20010101 |
| Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor. | Journal of lipid mediators and cell signalling 19940901 |
| Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. | British journal of pharmacology 19931201 |
| Species difference of 5-lipoxygenase derived from polymorphonuclear leukocytes on sensitivity to drugs. | Japanese journal of pharmacology 19890501 |
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