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79855-88-2 | 4H-Pyrimido[6,1-a]isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-
CAS No: 79855-88-2 Catalog No: AG005FWH MDL No:
Product Description
Catalog Number:
AG005FWH
Chemical Name:
4H-Pyrimido[6,1-a]isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-
CAS Number:
79855-88-2
Molecular Formula:
C24H27N3O3
Molecular Weight:
405.4895
IUPAC Name:
9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
InChI:
InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3
InChI Key:
MCMSJVMUSBZUCN-UHFFFAOYSA-N
SMILES:
COc1cc2c(cc1OC)CCn1c2c/c(=N\c2c(C)cc(cc2C)C)/n(c1=O)C
UNII:
739I2958C1
Properties
Complexity:
709
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
405.205g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
405.498g/mol
Monoisotopic Mass:
405.205g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
54.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
| Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. | Journal of medicinal chemistry 20111208 |
| The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one]. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception. | European journal of pharmacology 20050905 |
| Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. | The Journal of pharmacology and experimental therapeutics 20050801 |
| Effects of phosphodiesterase inhibitors on spontaneous nuclear maturation and cAMP concentrations in bovine oocytes. | Theriogenology 20031201 |
| Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. | Molecular pharmacology 20030501 |
| Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). | Molecular pharmacology 20030201 |
| Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. | Cancer research 20020601 |
| Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases. | Circulation research 20020517 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro. | Diseases of the colon and rectum 20020401 |
| Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. | Neuroscience letters 20020118 |
| Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme. | British journal of pharmacology 20010901 |
| The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. | The Journal of biological chemistry 20000929 |
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