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79350-37-1 | Cefixime
CAS No: 79350-37-1 Catalog No: AG003AX7 MDL No:MFCD03788802
Product Description
Catalog Number:
AG003AX7
Chemical Name:
Cefixime
CAS Number:
79350-37-1
Molecular Formula:
C16H15N5O7S2
Molecular Weight:
453.4496
MDL Number:
MFCD03788802
IUPAC Name:
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChI:
InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
InChI Key:
OKBVVJOGVLARMR-QSWIMTSFSA-N
SMILES:
Nc1nc(cs1)/C(=N/OCC(=O)O)/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C=C
UNII:
XZ7BG04GJX
Properties
Complexity:
861
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
1
Exact Mass:
453.041g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
453.444g/mol
Monoisotopic Mass:
453.041g/mol
Rotatable Bond Count:
8
Topological Polar Surface Area:
238A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.7
Literature
| Title | Journal |
|---|---|
| VITEK 2 may deduce false susceptibility to cefixime in Staphylococcus. | Journal of medical microbiology 20120901 |
| Update to CDC's Sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections. | MMWR. Morbidity and mortality weekly report 20120810 |
| Cefixime and ceftriaxone susceptibility of Neisseria gonorrhoeae in Italy from 2006 to 2010. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120601 |
| Recovery of E. coli O157 strains after exposure to acidification at pH 2. | Letters in applied microbiology 20120601 |
| Appropriate time for test-of-cure when diagnosing gonorrhoea with a nucleic acid amplification test. | Acta dermato-venereologica 20120501 |
| Cefixime-induced nonconvulsive status epilepticus. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120401 |
| Emergence and characterization of Neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001-2010. | Sexually transmitted diseases 20120401 |
| Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. | Pediatrics 20120201 |
| Efficacy and safety of ceftriaxone for uncomplicated gonorrhoea: a meta-analysis of randomized controlled trials. | International journal of STD & AIDS 20120201 |
| Electrochemical and spectroscopic investigations of isoniazide and its analogs with ds.DNA at physiological pH: evaluation of biological activities. | European journal of medicinal chemistry 20120101 |
| Cefixime-induced oculogyric crisis. | Pediatric emergency care 20120101 |
| A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. | PloS one 20120101 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Emergence of a Neisseria gonorrhoeae clone showing decreased susceptibility to cefixime in England and Wales. | The Journal of antimicrobial chemotherapy 20111101 |
| Characterization of profile of multidrug-resistant Neisseria gonorrhoeae using old and new definitions in India over a decade: 2000-2009. | Sexually transmitted diseases 20111101 |
| First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20111027 |
| Antimicrobial resistance in Neisseria gonorrhoeae in the UK: surveillance and management. | Expert review of anti-infective therapy 20111001 |
| Technical report—Diagnosis and management of an initial UTI in febrile infants and young children. | Pediatrics 20110901 |
| Simultaneous determination of cefdinir and cefixime in human plasma by RP-HPLC/UV detection method: Method development, optimization, validation, and its application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815 |
| Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. | Bioorganic & medicinal chemistry 20110801 |
| Cefixime-induced hepatotoxicity. | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20110801 |
| Cephalosporin susceptibility among Neisseria gonorrhoeae isolates--United States, 2000-2010. | MMWR. Morbidity and mortality weekly report 20110708 |
| Cefpodoxime 10 μg disc screening test for detection of Neisseria gonorrhoeae with mosaic PBP2 and decreased susceptibility to extended-spectrum cephalosporins for public health purposes. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110601 |
| Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs. | European journal of medicinal chemistry 20110501 |
| Cefixime-resistant Neisseria gonorrhoeae in the UK: a time to reflect on practice and recommendations. | International journal of STD & AIDS 20110501 |
| [Gonorrhea--time for new guidelines]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110408 |
| Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20110407 |
| An open study of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis: efficacy, complications and outcome. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20110401 |
| Spectrofluorimetric method for determination and validation of cefixime in pharmaceutical preparations through derivatization with 2-cyanoacetamide. | Journal of fluorescence 20110301 |
| [Efficacy and safety of cefixim and ciprofloxacin in acute cystitis (a multicenter randomized trial)]. | Urologiia (Moscow, Russia : 1999) 20110101 |
| [Cefixim: clinical pharmacology and role in therapy of urogenital infections]. | Urologiia (Moscow, Russia : 1999) 20110101 |
| Clinical role of Cefixime in community-acquired infections. | Prilozi 20110101 |
| Voltammetric determination of cefixime in pharmaceuticals and biological fluids. | Analytical biochemistry 20101201 |
| Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents. | European journal of medicinal chemistry 20101201 |
| Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains. | The Journal of antimicrobial chemotherapy 20101201 |
| Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20101125 |
| Emergence, spread and characteristics of Neisseria gonorrhoeae isolates with in vitro decreased susceptibility and resistance to extended-spectrum cephalosporins in Sweden. | Sexually transmitted infections 20101101 |
| Quick recertification series. Gonorrhea. | JAAPA : official journal of the American Academy of Physician Assistants 20101101 |
| Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations. | Biochemistry 20100921 |
| Emergence and spread of drug resistant Neisseria gonorrhoeae. | The Journal of urology 20100901 |
| Acute pyelonephritis in children: antibiotic therapy depending on the clinical context. | Prescrire international 20100801 |
| A novel sensor for cephalosporins based on electrocatalytic oxidation by poly(o-anisidine)/SDS/Ni modified carbon paste electrode. | Talanta 20100615 |
| Synthesis and antimicrobial activity of cholic acid hydrazone analogues. | European journal of medicinal chemistry 20100601 |
| Maternal blood and amniotic fluid levels of moxifloxacin, levofloxacin and cefixime. | The journal of obstetrics and gynaecology research 20100601 |
| Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone. | The Journal of antimicrobial chemotherapy 20100401 |
| Diagnosis and treatment of urethritis in men. | American family physician 20100401 |
| Simultaneous determination of cefixime trihydrate and dicloxacillin sodium in pharmaceutical dosage form by reversed-phase high-performance liquid chromatography. | Journal of AOAC International 20100101 |
| [Assessment of Cefixime stability, raw material used for pharmaceutical forms]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101 |
| [Clinical pattern of pediatric acute gastroenteritis in the community]. | La Pediatria medica e chirurgica : Medical and surgical pediatrics 20100101 |
| Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone. | Talanta 20091115 |
| Antimicrobial resistance in gonorrhea: the influence of epidemiologic and laboratory surveillance data on treatment guidelines: Alberta, Canada 2001-2007. | Sexually transmitted diseases 20091001 |
| Implications of current recommendations for third-generation cephalosporin use in the WHO Western Pacific Region following the emergence of multiresistant gonococci. | Sexually transmitted infections 20090801 |
| Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis. | Antimicrobial agents and chemotherapy 20090701 |
| Mechanism and implication of cephalosporin penetration into oropharyngeal mucosa. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090401 |
| [Whipple's disease]. | La Revue de medecine interne 20090301 |
| Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice. | Drug metabolism and disposition: the biological fate of chemicals 20090301 |
| Pancreatitis in typhoid fever relapse. | The Pediatric infectious disease journal 20090101 |
| Cephalosporins with clavulinic acid. | Indian pediatrics 20090101 |
| In vitro evaluation of a new cefixime-clavulanic acid combination for gram-negative bacteria. | The Southeast Asian journal of tropical medicine and public health 20090101 |
| [Determination of cefixime blood plasma levels by HPLC]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101 |
| Resistance pattern of breakthrough urinary tract infections in children on antibiotic prophylaxis. | Journal of infection and public health 20090101 |
| Simultaneous estimation of Cefixime and Erdosteine in capsule dosage form by spectrophotometric method. | Hindustan antibiotics bulletin 20090101 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Acute septic arthritis: remember gonorrhea. | Rheumatology international 20081101 |
| Growth of pure cultures of Verocytotoxin-producing Escherichia coli in a range of enrichment media. | Journal of applied microbiology 20081101 |
| Short- versus long-duration antimicrobial treatment for exacerbations of chronic bronchitis: a meta-analysis. | The Journal of antimicrobial chemotherapy 20080901 |
| Cefixime-tellurite rhamnose MacConkey agar for isolation of Vero cytotoxin-producing Escherichia coli serogroup O26 from Scottish cattle and sheep faeces. | Letters in applied microbiology 20080901 |
| Kinetic measurements of the hydrolytic degradation of cefixime: effect of Captisol complexation and water-soluble polymers. | The Journal of pharmacy and pharmacology 20080701 |
| Analysis of amino acid sequences of penicillin-binding protein 2 in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime and ceftriaxone. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080601 |
| Availability of cefixime 400 mg tablets--United States, April 2008. | MMWR. Morbidity and mortality weekly report 20080425 |
| Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells. | International journal of pharmaceutics 20080416 |
| Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A. | Pediatric nephrology (Berlin, Germany) 20080401 |
| Comparative bioavailability study of two cefixime formulations administered orally in healthy male volunteers. | Arzneimittel-Forschung 20080101 |
| Simultaneous determination of potassium clavulanate and cefixime in synthetic mixtures by high-performance liquid chromatography. | Journal of AOAC International 20080101 |
| [Antibiotic treatment of pyelonephritis in children. Recent advances]. | Recenti progressi in medicina 20080101 |
| [Study of the efficacy of cefixime (suprax) in patients with acute and recurrent chronic purulent sinusitis]. | Vestnik otorinolaringologii 20080101 |
| Cefpodoxime proxetil compared with cefixime for treatment of typhoid fever in children. | Indian pediatrics 20071101 |
| Antimicrobial resistance in clinical isolates of Neisseria subflava from the oral cavities of a Japanese population. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20071001 |
| Pharyngeal gonorrhoea - is dual therapy the way forward? | International journal of STD & AIDS 20070901 |
| [Variability in antibiotic prescription in the pediatric population of Castile and Leon (Spain) from 2001 to 2005 in relation to urban or rural setting]. | Anales de pediatria (Barcelona, Spain : 2003) 20070801 |
| Threat to cefixime treatment for gonorrhea. | Emerging infectious diseases 20070801 |
| Aminopenicillin-induced exanthema allows treatment with certain cephalosporins or phenoxymethyl penicillin. | The Journal of antimicrobial chemotherapy 20070701 |
| Early hospital discharge with oral antimicrobial therapy in patients with hematologic malignancies and low-risk febrile neutropenia. | Annals of hematology 20070401 |
| The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime. | International journal of STD & AIDS 20070401 |
| Variability in tellurite resistance and the ter gene cluster among Shiga toxin-producing Escherichia coli isolated from humans, animals and food. | Research in microbiology 20070301 |
| [Whipple's disease]. | Praxis 20070110 |
| Meropenem -valproic acid interaction in patients with cefepime-associated status epilepticus. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070101 |
| An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever. | PloS one 20070101 |
| Morbidity and mortality of mucocutaneous diseases in the pediatric population at a tertiary care center. | Journal of burn care & research : official publication of the American Burn Association 20070101 |
| [Co-sensitization to drugs belonging to different chemical classes during the same episode of cutaneous adverse drug reaction: two cases]. | Annales de dermatologie et de venereologie 20070101 |
| [Antimicrobial resistance in Neisseria gonorrheae in North-East Romania]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101 |
| [Efficacy of cefixime and cefepime vs. other cephalosporins in experimental plague of albino mice due to variants FI+ and FI- of the plague microbe]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101 |
| [Gonorrhea]. | Der Urologe. Ausg. A 20061201 |
| School-based screening for Chlamydia trachomatis and Neisseria gonorrhoeae among Philadelphia public high school students. | Sexually transmitted diseases 20061001 |
| In vitro synergistic effects of double combinations of beta-lactams and azithromycin against clinical isolates of Neisseria gonorrhoeae. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060801 |
| Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060801 |
| In vitro induction of resistance by tissue concentrations of azithromycin, clarithromycin, cefixime and amoxicillin/clavulanate in clinical isolates of Streptococcus pyogenes. | Journal of chemotherapy (Florence, Italy) 20060801 |
| Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. | Neurology 20060725 |
| [Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2004). I. Susceptibility distribution]. | The Japanese journal of antibiotics 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| [Management of acute pyelonephritis in patients older than 3 months: survey conducted in 39 paediatric emergency departments of the Ile de France Region in 2004]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060301 |
| Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060201 |
| Gonorrhea: update. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20060201 |
| [Antimicrobial resistance of Neisseria gonorrhoeae strains isolated from sex workers in Ankara]. | Mikrobiyoloji bulteni 20060101 |
| Spectrophotometric, difference spectroscopic, and high-performance liquid chromatographic methods for the determination of cefixime in pharmaceutical formulations. | Journal of AOAC International 20060101 |
| Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. | Neurology 20051213 |
| Comparative bioavailability study of cefixime (equivalent to 100 mg/5 ml) suspension (Winex vs Suprax) in healthy male volunteers. | International journal of clinical pharmacology and therapeutics 20051001 |
| Plasmid and drug resistance profile of sorbitol nonfermenting cefixime-tellurite resistant Escherichia coli isolates from the Gomti River. | Bulletin of environmental contamination and toxicology 20051001 |
| Susceptibility of European beta-lactamase-positive and -negative Haemophilus influenzae isolates from the periods 1997/1998 and 2002/2003. | The Journal of antimicrobial chemotherapy 20050701 |
| Pelvic inflammatory disease in adolescents: care delivery in pediatric ambulatory settings. | Pediatric emergency care 20050701 |
| Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. | Journal of medicinal chemistry 20050630 |
| Sensitive liquid chromatography-tandem mass spectrometry method for the determination of cefixime in human plasma: application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525 |
| Tissue penetration of cefpodoxime and cefixime in healthy subjects. | Journal of clinical pharmacology 20050501 |
| Expedited treatment for partners of patients with gonorrhea and/or chlamydial infection: impact on rates of persistence or recurrence. | Postgraduate medicine 20050501 |
| Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection. | The New England journal of medicine 20050217 |
| Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models. | International journal of antimicrobial agents 20050201 |
| Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050101 |
| Clinical outcomes in typhoid fever: adverse impact of infection with nalidixic acid-resistant Salmonella typhi. | BMC infectious diseases 20050101 |
| Salmonella typhi in a child with urinary tract infection and urolithiasis. | Le Journal medical libanais. The Lebanese medical journal 20050101 |
| Comparison of intravenous aminoglycoside therapy with switch therapy to cefixime in urinary tract infections. | Saudi medical journal 20041001 |
| Comparative evaluation of cefpodoxime versus cefixime in children with lower respiratory tract infections. | Indian journal of pediatrics 20040601 |
| Increasing cases of drug-resistant gonorrhea prompt new CDC treatment recommendations for gay and bisexual men. | Report on medical guidelines & outcomes research 20040514 |
| Effect of cefixime and cefdinir, oral cephalosporins, on cytochrome P450 activities in human hepatic microsomes. | Biological & pharmaceutical bulletin 20040101 |
| The acceptability and behavioral effects of antibiotic prophylaxis for syphilis prevention. | Sexually transmitted diseases 20031101 |
| Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer. | Journal of pharmaceutical sciences 20031101 |
| Evaluation of increased incubation temperature and cefixime-tellurite treatment for the isolation of Escherichia coli O157:H7 from minced beef. | International journal of food microbiology 20031015 |
| Multidrug-resistant Neisseria gonorrhoeae with decreased susceptibility to cefixime-Hawaii, 2001. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030915 |
| Bisacodyl rectal preparation can decrease infectious complications of transrectal ultrasound-guided prostate biopsy. | Urology 20030901 |
| Resistant Haemophilus influenzae in community-acquired respiratory tract infections: a role for cefixime. | International journal of antimicrobial agents 20030601 |
| The effect of amoxicillin-clavulanate, cefixime and azithromycin on normal throat flora in children with group A streptococcal pharyngitis. | Clinical pediatrics 20030601 |
| Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children. | The Pediatric infectious disease journal 20030401 |
| Voltammetric behavior of cefixime and cefpodoxime proxetil and determination in pharmaceutical formulations and urine. | Journal of pharmaceutical and biomedical analysis 20030326 |
| Treatment of uncomplicated gonococcal urethritis by double-dosing of 200 mg cefixime at a 6-h interval. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20030301 |
| A comparison of two pre-enrichment media prior to immunomagnetic separation for the isolation of E. coli O157 from bovine faeces. | Journal of applied microbiology 20030101 |
| Cefixime for the prophylaxis of urinary tract infections in children with malformative uropathies: an open study. | European review for medical and pharmacological sciences 20030101 |
| Discontinuation of cefixime tablets--United States. | MMWR. Morbidity and mortality weekly report 20021122 |
| Frequency of Escherichia coli O157:H7 in Turkish cattle. | Journal of food protection 20021001 |
| Sexually transmitted disease guidelines focus on prevention. | Report on medical guidelines & outcomes research 20020614 |
| Resistance of Helicobacter pylori isolated in Israel to metronidazole, clarithromycin, tetracycline, amoxicillin and cefixime. | The Journal of antimicrobial chemotherapy 20020601 |
| Evaluation of sorbitol-salicin MacConkey medium containing cefixime and tellurite (CT-SSMAC medium) for isolation of Escherichia coli O157:H7 from raw vegetables. | International journal of food microbiology 20020325 |
| Clinical practice. Antibiotic-associated diarrhea. | The New England journal of medicine 20020131 |
| Salmonella typhiin the past decade: learning to live with resistance. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020101 |
| Short-term effectiveness of ceftriaxone single dose in the initial treatment of acute uncomplicated pyelonephritis in women. A randomised controlled trial. | Emergency medicine journal : EMJ 20020101 |
| Longterm decrease in the CD57 lymphocyte subset in a patient with chronic Lyme disease. | Annals of agricultural and environmental medicine : AAEM 20020101 |
| [Prophylaxis of recurrent urinary tract infections in children. Results of an open, controlled and randomized study about the efficacy and tolerance of cefixime compared to nitrofurantoin]. | Klinische Padiatrie 20020101 |
| Transporter-mediated Drug Interactions. | Drug metabolism and pharmacokinetics 20020101 |
| Evaluation of techniques for enrichment and isolation of Escherichia coli O157:H7 from artificially contaminated sprouts. | International journal of food microbiology 20011204 |
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| Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. | American journal of obstetrics and gynecology 20011101 |
| Short term oral cefixime therapy for treatment of bacterial conjunctivitis. | The Pediatric infectious disease journal 20011101 |
| Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. | The Journal of pharmacology and experimental therapeutics 20011001 |
| A randomized trial that compared oral cefixime and intramuscular ceftriaxone for the treatment of gonorrhea in pregnancy. | American journal of obstetrics and gynecology 20010901 |
| Comparative study of ceftibuten and cefixime in the treatment of complicated urinary tract infections. | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20010901 |
| Pharmacodynamics of ceftriaxone and cefixime against community-acquired respiratory tract pathogens. | International journal of antimicrobial agents 20010601 |
| Comparative study of cefixime alone versus intramuscular ceftizoxime followed by cefixime in the treatment of urinary tract infections in children. | Journal of chemotherapy (Florence, Italy) 20010601 |
| A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010501 |
| The detection of Shiga toxin-producing Escherichia coli in diagnostic bovine faecal samples using vancomycin-cefixime-cefsulodin blood agar and PCR. | FEMS microbiology letters 20010420 |
| Oral ciprofloxacin in the management of children with cancer with lower risk febrile neutropenia. | Cancer 20010415 |
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| [Infectious complications of mandibular osteotomy]. | Revue de stomatologie et de chirurgie maxillo-faciale 20010201 |
| Oral cefixime is similar to continued intravenous antibiotics in the empirical treatment of febrile neutropenic children with cancer. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010101 |
| [Assessing the chemical cross-reaction from cefixime and some nonsteroidal anti-inflammatory agents in a soluble formulation]. | Bollettino chimico farmaceutico 20010101 |
| beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. | The Journal of biological chemistry 20000121 |
| Nephrotic syndrome following cefixime therapy in a 10-month-old girl: spontaneous resolution without corticosteroid treatment. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19991001 |
| Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. | The American journal of physiology 19971101 |
| The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. | The Journal of pharmacy and pharmacology 19970801 |
| Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. | Biochimica et biophysica acta 19970313 |
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| Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells. | Biochimica et biophysica acta 19940420 |
| Cefixime compared with amoxicillin for treatment of acute otitis media. | The Journal of pediatrics 19910701 |
| Double-blind comparison of cefixime and cefaclor in the treatment of acute otitis media in children. | Scandinavian journal of infectious diseases 19910101 |
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