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78934-83-5 | Sandoz 58-035
CAS No: 78934-83-5 Catalog No: AG005D5R MDL No:
Product Description
Catalog Number:
AG005D5R
Chemical Name:
Sandoz 58-035
CAS Number:
78934-83-5
Molecular Formula:
C30H47NOSi
Molecular Weight:
465.7858
IUPAC Name:
3-[decyl(dimethyl)silyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide
InChI:
InChI=1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)
InChI Key:
NBYATBIMYLFITE-UHFFFAOYSA-N
SMILES:
CCCCCCCCCC[Si](CCC(=O)NC(c1ccccc1)Cc1ccc(cc1)C)(C)C
Properties
Complexity:
505
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
465.343g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
465.797g/mol
Monoisotopic Mass:
465.343g/mol
Rotatable Bond Count:
16
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice. | Cellular and molecular gastroenterology and hepatology 20170301 |
| Cholesterol esters as growth regulators of lymphocytic leukaemia cells. | Cell proliferation 20110801 |
| Mast cell death induced by 24(S),25-epoxycholesterol. | Experimental cell research 20101115 |
| First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors. | Bioorganic & medicinal chemistry letters 20100515 |
| Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway. | Atherosclerosis 20091101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts. | Histochemistry and cell biology 20080501 |
| Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts. | Investigative ophthalmology & visual science 20070801 |
| The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors. | The Journal of pharmacology and experimental therapeutics 20061001 |
| Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes. | Eukaryotic cell 20031001 |
| Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401 |
| Role of cholesterol ester pathway in the control of cell cycle in human aortic smooth muscle cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
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