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77779-60-3 | 3H-Pyrazolo[4,3-c]quinolin-3-one,2,5-dihydro-2-phenyl-
CAS No: 77779-60-3 Catalog No: AG008OHC MDL No:
Product Description
Catalog Number:
AG008OHC
Chemical Name:
3H-Pyrazolo[4,3-c]quinolin-3-one,2,5-dihydro-2-phenyl-
CAS Number:
77779-60-3
Molecular Formula:
C16H11N3O
Molecular Weight:
261.2780
IUPAC Name:
2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one
InChI:
InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H
InChI Key:
XTYGFVVANLMBHE-UHFFFAOYSA-N
SMILES:
O=c1n(nc2c1c[nH]c1c2cccc1)c1ccccc1
Properties
Complexity:
380
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
261.09g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
261.284g/mol
Monoisotopic Mass:
261.09g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
45.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2
Literature
| Title | Journal |
|---|---|
| Antagonism by NOS inhibition of the behavioral effects of benzodiazepine and GABAA receptor agonists in the mouse elevated plus-maze. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801 |
| High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure-activity relationships and comparative molecular field analysis of pyrazolo[4,3-c]quinolin-3-ones. | Bioorganic & medicinal chemistry 20010201 |
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. | Journal of medicinal chemistry 20000113 |
| Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. | European journal of pharmacology 19951130 |
| Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. | Pharmacology, biochemistry, and behavior 19900801 |
| A benzodiazepine antagonist does not alter the course of hepatic encephalopathy or neural gamma-aminobutyric acid (GABA) binding. | Metabolic brain disease 19870901 |
| [Antiabstinent action of fenibut and baclofen on a model of abstinence induced by the benzodiazepine receptor antagonist CGS 8216 in rats receiving diazepam]. | Biulleten' eksperimental'noi biologii i meditsiny 19870601 |
| Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats. | Drug and alcohol dependence 19860701 |
| Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal? | Pharmacology, biochemistry, and behavior 19850701 |
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