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77671-31-9 | enoximone
CAS No: 77671-31-9 Catalog No: AG005GLA MDL No:MFCD00867130
Product Description
Catalog Number:
AG005GLA
Chemical Name:
enoximone
CAS Number:
77671-31-9
Molecular Formula:
C12H12N2O2S
Molecular Weight:
248.3009
MDL Number:
MFCD00867130
SMILES:
CSc1ccc(cc1)C(=O)c1[nH]c(=O)[nH]c1C
Literature
| Title | Journal |
|---|---|
| Vasopressors and inotropes in the treatment of human septic shock: effect on innate immunity? | Inflammation 20120201 |
| The impact of a pulmonary-artery-catheter-based protocol on fluid and catecholamine administration in early sepsis. | Critical care research and practice 20120101 |
| cGMP Signaling, Phosphodiesterases and Major Depressive Disorder. | Current neuropharmacology 20111201 |
| Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe. | Intensive care medicine 20110801 |
| Retraction Note: Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. | Intensive care medicine 20110701 |
| The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients: Retraction. | Anesthesia and analgesia 20110501 |
| Case report and mini literature review: anesthetic management for severe peripartum cardiomyopathy complicated with preeclampsia using sufetanil in combined spinal epidural anesthesia. | Yonsei medical journal 20110101 |
| Prolonged Refractory Hypotension following Combined Amlodipine and Losartan Ingestion Responsive to Metaraminol. | Case reports in medicine 20110101 |
| Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials. | Critical care (London, England) 20110101 |
| Patient characteristics in persistent pulmonary hypertension of the newborn. | Pulmonary medicine 20110101 |
| Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass. | Journal of cardiothoracic surgery 20110101 |
| Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema. | Intensive care medicine 20101101 |
| Blood transfusion in pediatric cardiac surgery. | Artificial organs 20101101 |
| Inotropic therapy for end-stage heart failure patients. | Current treatment options in cardiovascular medicine 20101001 |
| Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS. | Intensive care medicine 20100501 |
| Assessment of residual viability by enoximone echocardiography in patients with previous myocardial infarction correlation with positron emission tomographic studies and functional follow-up. | Echocardiography (Mount Kisco, N.Y.) 20100501 |
| Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition. | Basic research in cardiology 20100301 |
| Pulmonary hypertension in cardiac surgery. | Current cardiology reviews 20100201 |
| Weaning failure of cardiac origin: recent advances. | Critical care (London, England) 20100101 |
| Enoxaparin, effective dosage for intensive care patients: double-blinded, randomised clinical trial. | Critical care (London, England) 20100101 |
| Clinical review: practical recommendations on the management of perioperative heart failure in cardiac surgery. | Critical care (London, England) 20100101 |
| S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system. | German medical science : GMS e-journal 20100101 |
| Effects of phosphodiesterase (III/IV)-inhibitors and cytokines on mechanical properties of neutrophilic granulocytes in neonates and adults. | Clinical hemorheology and microcirculation 20100101 |
| Levosimendan as treatment option in severe verapamil intoxication: a case report and review of the literature. | Case reports in medicine 20100101 |
| Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review. | Critical care (London, England) 20100101 |
| Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial infarction. | Vascular health and risk management 20100101 |
| Double-blind placebo-controlled comparison of enoximone and dobutamine infusions in patients with moderate to severe chronic heart failure. | Congestive heart failure (Greenwich, Conn.) 20100101 |
| Vasodilators in the treatment of acute heart failure: what we know, what we don't. | Heart failure reviews 20091201 |
| Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials. | European heart journal 20091201 |
| Inotropic therapy for heart failure: paradise lost. | European heart journal 20091201 |
| Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. | Heart failure reviews 20091201 |
| Cardiorespiratory effects of enoximone in anaesthetised colic horses. | Equine veterinary journal 20091101 |
| The use of exercise echocardiography in the evaluation of mitral regurgitation. | Current cardiology reviews 20091101 |
| Investigational positive inotropic agents for acute heart failure. | Cardiovascular & hematological disorders drug targets 20090901 |
| Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction. | Critical care medicine 20090901 |
| Masquerade: fulminant viral myocarditis mimicking a Q-wave anterolateral myocardial infarction. | The American journal of medicine 20090601 |
| Influence of continuous perioperative beta-blockade in combination with phosphodiesterase inhibition on haemodynamics and myocardial ischaemia in high-risk vascular surgery patients. | British journal of anaesthesia 20090501 |
| Long-term outcome of coronary artery bypass grafting in patients with left ventricular dysfunction. | The Annals of thoracic surgery 20090501 |
| Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. | Veterinary anaesthesia and analgesia 20090501 |
| Evaluation of 30-day mortality of levosimendan versus enoximone. | Critical care medicine 20090301 |
| Levosimendan or enoximone in refractory cardiogenic shock? | Critical care medicine 20090301 |
| Influence of calcium chloride on the cardio-respiratory effects of a bolus of enoximone in isoflurane anaesthetized ponies. | Veterinary anaesthesia and analgesia 20090301 |
| Inflammatory response to cardiopulmonary bypass with enoximone or steroids in patients undergoing myocardial revascularization: a preliminary report study. | International journal of clinical pharmacology and therapeutics 20090201 |
| Newer treatments for decompensated heart failure: focus on levosimendan. | Drug design, development and therapy 20090101 |
| Left ventricular diastolic dysfunction of the cardiac surgery patient; a point of view for the cardiac surgeon and cardio-anesthesiologist. | Journal of cardiothoracic surgery 20090101 |
| Apart from the other members of PDE inhibitors' family, enoximone does not enhance renal ischemic reperfusion injury: the effects of enoximone on renal ischemia reperfusion. | Renal failure 20090101 |
| Is there a role for carvedilol in the management of pediatric heart failure? A meta analysis and e-mail survey of expert opinion. | Annals of pediatric cardiology 20090101 |
| ABCD of the phosphodiesterase family: interaction and differential activity in COPD. | International journal of chronic obstructive pulmonary disease 20081201 |
| Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction. | Critical care medicine 20080801 |
| Levosimendan in cardiogenic shock: better than enoximone! | Critical care medicine 20080801 |
| Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies. | Veterinary anaesthesia and analgesia 20080701 |
| Recovery of heart function in children with acute severe heart failure. | Transplantation 20080415 |
| [Continuous beta-block with esmolol in combination with enoximone: influence on cardiac function in high risk patients undergoing vascular surgery]. | Der Anaesthesist 20080301 |
| Effects of enoximone on peripheral and central chemoreflex responses in humans. | American journal of physiology. Heart and circulatory physiology 20080101 |
| Understanding cardiac output. | Critical care (London, England) 20080101 |
| Spontaneous perforation of the cystic duct in streptococcal toxic shock syndrome: a case report. | Journal of medical case reports 20080101 |
| [Potentialitis of phosphodiesterase inhibitors in management of patients with chronic heart failure complicating cardiac ischemia]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101 |
| Cardiovascular effects of enoximone in isoflurane anaesthetized ponies. | Veterinary anaesthesia and analgesia 20071101 |
| [Rational use of catecholamines and inotropes]. | Pneumologie (Stuttgart, Germany) 20071101 |
| Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: results of the oral enoximone in intravenous inotrope-dependent subjects trial. | American heart journal 20071101 |
| [Pleural effusion following coronary bypass surgery]. | Harefuah 20071101 |
| Peripartum cardiomyopathy: review of the literature. | Yonsei medical journal 20071031 |
| Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone. | Expert opinion on pharmacotherapy 20070901 |
| Effects of preemptive enoximone on left ventricular diastolic function after valve replacement for aortic stenosis. | Journal of cardiothoracic and vascular anesthesia 20070601 |
| Current practice of hemodynamic monitoring and vasopressor and inotropic therapy in post-operative cardiac surgery patients in Germany: results from a postal survey. | Acta anaesthesiologica Scandinavica 20070301 |
| Factors influencing the outcome of paediatric cardiac surgical patients during extracorporeal circulatory support. | Journal of cardiothoracic surgery 20070101 |
| The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting. | Critical care (London, England) 20070101 |
| Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use? | Critical care (London, England) 20070101 |
| Acute heart failure: inotropic agents and their clinical uses. | Expert opinion on pharmacotherapy 20061101 |
| Intraaortic balloon pumping during cardioplegic arrest preserves lung function in patients with chronic obstructive pulmonary disease. | The Annals of thoracic surgery 20060701 |
| Enoximone in cardiac arrest caused by propranolol: two case reports. | Acta anaesthesiologica Scandinavica 20060701 |
| A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. | Anesthesia and analgesia 20060601 |
| Effect of combining phosphodiesterase III inhibitors with St Thomas Hospital's solution used as transplantation preservative solution in isolated rat hearts. | Transplantation proceedings 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure. | Critical care (London, England) 20060101 |
| The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass graft surgery on oxygen delivery and clinical outcome--a randomized controlled study [ISRCTN35655335]. | Critical care (London, England) 20060101 |
| Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury. | Critical care (London, England) 20060101 |
| Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers. | Critical care (London, England) 20060101 |
| The year in heart failure. | Journal of the American College of Cardiology 20051206 |
| Rationale and design of the enoximone clinical trials program. | Journal of cardiac failure 20051201 |
| Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE. | European journal of heart failure 20051001 |
| Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone. | Journal of cardiovascular pharmacology 20050901 |
| Natriuretic peptides and E-selectin as predictors of acute deterioration in patients with inotrope-dependent heart failure. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050501 |
| Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine. | European journal of anaesthesiology 20050401 |
| Determinants and prognosis of myocardial damage after coronary artery bypass grafting. | The Annals of thoracic surgery 20050301 |
| Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, on myocyte calcium cycling and contractility. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review. | Critical care (London, England) 20050101 |
| Time course of endothelial damage in septic shock: prediction of outcome. | Critical care (London, England) 20050101 |
| [Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan]. | Medizinische Klinik (Munich, Germany : 1983) 20041215 |
| Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD. | European journal of heart failure 20041201 |
| The prophylactic use of the beta-blocker esmolol in combination with phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients. | Anesthesia and analgesia 20041001 |
| Effect of activators and the phosphodiesterase inhibitors pentoxifylline and enoximone on the deformability of neutrophils in neonates and adults. | Acta paediatrica (Oslo, Norway : 1992) 20041001 |
| Perioperative enoximone infusion improves cardiac enzyme release after CABG. | Journal of cardiothoracic and vascular anesthesia 20040801 |
| Successful treatment with enoximone for severe poisoning with atenolol and verapamil: a case report. | Acta anaesthesiologica Scandinavica 20040701 |
| New strategies to control the inflammatory response in cardiac surgery. | Current opinion in anaesthesiology 20040201 |
| Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. | Clinical pharmacokinetics 20040101 |
| Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. | Critical care (London, England) 20040101 |
| Stress echocardiography in heart failure. | Cardiovascular ultrasound 20040101 |
| Na(+)-channel modulation, a new principle of inotropic intervention: effects on hemodynamic and myocardial energetics in the immature rabbit heart. | Pediatric research 20031201 |
| Cardiac rescue with enoximone in volume and catecholamine refractory septic shock. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20031001 |
| Neonatal flecainide toxicity following supraventricular tachycardia treatment. | The Annals of pharmacotherapy 20030901 |
| Enoximone very low-dose dobutamine stress echocardiography: a new test for detecting viability in severe myocardial dysfunction after acute myocardial infarction. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20030901 |
| [Sex, erectile dysfunction, and the heart: a growing problem]. | Herz 20030601 |
| In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine. | Anesthesiology 20030401 |
| Role of nonglycosidic inotropic agents: indications, ethics, and limitations. | The Medical clinics of North America 20030301 |
| Enoximone echocardiography: a novel test to evaluate left ventricular contractile reserve in patients with heart failure on chronic beta-blocker therapy. | Cardiovascular ultrasound 20030101 |
| Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol. | Journal of the American College of Cardiology 20021002 |
| Prophylactic use of the phospodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. | Intensive care medicine 20021001 |
| [Therapy of verapamil poisoning with noradrenaline and the phosphodiesterase inhibitor enoximone]. | Deutsche medizinische Wochenschrift (1946) 20020927 |
| Incidence and risk calculation of inotropic support in patients undergoing cardiac surgery with cardiopulmonary bypass using an automated anaesthesia record-keeping system. | British journal of anaesthesia 20020901 |
| The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis. | European journal of heart failure 20020801 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| [Twin-twin transfusion syndrome: report of two cases with hemodynamic complications]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020401 |
| Coronary artery bypass grafting in patients with severe left ventricular dysfunction: a prospective randomized study on the timing of perioperative intraaortic balloon pump support. | The International journal of artificial organs 20020201 |
| Severe reperfusion lung injury after double lung transplantation. | Critical care (London, England) 20020101 |
| Clinical review: splanchnic ischaemia. | Critical care (London, England) 20020101 |
| Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts. | Acta medica (Hradec Kralove) 20020101 |
| Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients. | Critical care medicine 20010801 |
| Inotropes and beta-blockers: is there a need for new guidelines? | Journal of cardiac failure 20010601 |
| Rhabdomyolysis following cardiopulmonary bypass and treatment with enoximone in a patient susceptible to malignant hyperthermia. | Anesthesiology 20010201 |
| Enoximone maintains intestinal villus blood flow during endotoxemia. | International journal of surgical investigation 20010101 |
| [Use of enoximone in patients with acute and subacute heart failure in the intensive care unit]. | Zeitschrift fur Kardiologie 19940101 |
| [Neurohumoral and hemodynamic effects in combination therapy of enoximone and dopamine]. | Zeitschrift fur Kardiologie 19940101 |
| Low-dose enoximone therapy in pre-transplant patients: hemodynamic, echocardiographic, and neurohumoral findings. | Zeitschrift fur Kardiologie 19940101 |
| [Treatment of low cardiac output syndrome in newborn infants and children]. | Zeitschrift fur Kardiologie 19940101 |
| Effect of enoximone alone and in combination with metoprolol on myocardial function and energetics in severe congestive heart failure: improvement in hemodynamic and metabolic profile. | Cardiovascular drugs and therapy 19930601 |
| Intravenous enoximone or dobutamine for severe heart failure after acute myocardial infarction: a randomized double-blind trial. | European heart journal 19930501 |
| The influence of clinical intervention on pressure-volume relationships--the conductance (volume) technique. | European heart journal 19921101 |
| Improved heart failure protection by FK664, a novel positive inotropic agent, in dog heart-lung preparations. | Life sciences 19920101 |
| Clinical pharmacology of intravenous enoximone: pharmacodynamics and pharmacokinetics in patients with heart failure. | American heart journal 19910901 |
| [Use of a new inotropic agent, enoximone, in heart surgery]. | Revista espanola de anestesiologia y reanimacion 19910101 |
| [Vasodilatation and positive inotropic effect of the phosphodiesterase inhibitor enoximone]. | Zeitschrift fur Kardiologie 19910101 |
| Enoximone: true inotropic effects? Do they cause ischemia? Analysis of end-systolic pressure-volume relations using the conductance (volume) catheter technique. | Cardiovascular drugs and therapy 19901001 |
| Effects of enoximone in patients with heart failure uncontrolled by captopril and diuretics. | International journal of cardiology 19900701 |
| Convulsions induced by enoximone administered as a continuous intravenous infusion. | BMJ (Clinical research ed.) 19900303 |
| Augmentation of diastolic function with phosphodiesterase inhibition in congestive heart failure. | The Journal of laboratory and clinical medicine 19890901 |
| Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure. | Journal of medicinal chemistry 19890201 |
| A dose-response study of intravenous enoximone in congestive heart failure. | The American journal of cardiology 19870814 |
| Long-term oral enoximone therapy in chronic cardiac failure. | The American journal of cardiology 19870814 |
| Inotropic effect of enoximone in patients with severe heart failure: demonstration by left ventricular end-systolic pressure-volume analysis. | Journal of the American College of Cardiology 19870501 |
| Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856). | Journal of medicinal chemistry 19870201 |
| Comparison of acute hemodynamic response to dobutamine and intravenous MDL 17,043 (enoximone) in severe congestive heart failure secondary to ischemic cardiomyopathy or idiopathic dilated cardiomyopathy. | The American journal of cardiology 19860601 |
| Enoximone (MDL 17,043), a phosphodiesterase inhibitor, in the treatment of advanced, unstable chronic heart failure. | The Journal of heart transplantation 19860101 |
| Comparative hemodynamic effects of intravenous dobutamine and MDL-17,043, a new cardioactive drug, in severe congestive heart failure. | American heart journal 19850101 |
| The new inotropic phosphodiesterase inhibitors. | Archives internationales de physiologie et de biochimie 19841101 |
| Cardiovascular properties of a new cardiotonic agent: MDL 17,043 (1.3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one). | Journal of cardiovascular pharmacology 19820101 |
| Characterization of the cardiovascular activities of a new cardiotonic agent, MDL 17043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazole-2-one). | Journal of cardiovascular pharmacology 19820101 |
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