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Home > Nitro Compounds > 77372-73-7
77372-73-7 | Quinoline,6-nitro-2-(1-piperazinyl)-
CAS No: 77372-73-7 Catalog No: AG005BU0 MDL No:MFCD04115271
Product Description
Catalog Number:
AG005BU0
Chemical Name:
Quinoline,6-nitro-2-(1-piperazinyl)-
CAS Number:
77372-73-7
Molecular Formula:
C13H14N4O2
Molecular Weight:
258.2759
MDL Number:
MFCD04115271
IUPAC Name:
6-nitro-2-piperazin-1-ylquinoline
InChI:
InChI=1S/C13H14N4O2/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16/h1-4,9,14H,5-8H2
InChI Key:
GGDBEAVVGFNWIA-UHFFFAOYSA-N
SMILES:
[O-][N+](=O)c1ccc2c(c1)ccc(n2)N1CCNCC1
UNII:
28M0X094BH
Properties
Complexity:
327
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
258.112g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
258.281g/mol
Monoisotopic Mass:
258.112g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
74A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8
Literature
| Title | Journal |
|---|---|
| Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. | European journal of medicinal chemistry 20120301 |
| Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors. | Analytical and bioanalytical chemistry 20120101 |
| Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? | The Journal of experimental biology 20091101 |
| Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. | The Biochemical journal 20091023 |
| Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20081201 |
| Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines. | Bioorganic & medicinal chemistry 20070515 |
| Presynaptic modulation of 5-HT release in the rat septal region. | Neuroscience 20070511 |
| Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. | Brain research bulletin 20060615 |
| Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor. | The Journal of pharmacy and pharmacology 20051001 |
| Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines. | Bioorganic & medicinal chemistry 20050815 |
| Zinc modulation of serotonin uptake in the adult rat corpus callosum. | Journal of neuroscience research 20050401 |
| Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release. | British journal of pharmacology 20050101 |
| Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine. | Bioorganic & medicinal chemistry 20031117 |
| Biochemical evidence for the presence of serotonin transporters in the rat cochlea. | Hearing research 20030801 |
| Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter. | Bioorganic & medicinal chemistry letters 20021216 |
| Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain. | Bioorganic & medicinal chemistry letters 20021007 |
| Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET. | Bioorganic & medicinal chemistry 20020801 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. | Bioorganic & medicinal chemistry letters 20020311 |
| Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. | Journal of medicinal chemistry 19980226 |
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