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77-67-8 | EthosuXimide
CAS No: 77-67-8 Catalog No: AG003PYU MDL No:MFCD00072123
Product Description
Catalog Number:
AG003PYU
Chemical Name:
EthosuXimide
CAS Number:
77-67-8
Molecular Formula:
C7H11NO2
Molecular Weight:
141.1677
MDL Number:
MFCD00072123
IUPAC Name:
3-ethyl-3-methylpyrrolidine-2,5-dione
InChI:
InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI Key:
HAPOVYFOVVWLRS-UHFFFAOYSA-N
SMILES:
CC1(CC)CC(=O)NC1=O
EC Number:
201-048-7
Properties
Complexity:
188
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
141.079g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
141.17g/mol
Monoisotopic Mass:
141.079g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
46.2A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
0.4
Literature
| Title | Journal |
|---|---|
| Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. | The Journal of biological chemistry 20151120 |
| Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | Chemical research in toxicology 20150518 |
| Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs. | Reproductive toxicology (Elmsford, N.Y.) 20141101 |
| Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. | Progress in neuro-psychopharmacology & biological psychiatry 20121203 |
| Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring. | Biomedical chromatography : BMC 20121201 |
| Non-convulsive status epilepticus of frontal origin in mucopolysaccharidosis type II successfully treated with ethosuximide. | Developmental medicine and child neurology 20121001 |
| Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans. | Environmental toxicology and chemistry 20121001 |
| Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. | Neuroscience 20120918 |
| Synthesis and anticonvulsant properties of new mannich bases derived from 3,3-disubstituted pyrrolidine-2,5-diones. Part IV. | Archiv der Pharmazie 20120901 |
| Randomised controlled monotherapy trials: which comparators to use? | Epileptic disorders : international epilepsy journal with videotape 20120901 |
| A rat model for LGI1-related epilepsies. | Human molecular genetics 20120815 |
| Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide. | Journal of controlled release : official journal of the Controlled Release Society 20120810 |
| Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice. | Journal of neural transmission (Vienna, Austria : 1996) 20120801 |
| Synthesis and anticonvulsant activity of new N-Mannich bases derived from 3-(2-fluorophenyl)- and 3-(2-bromophenyl)-pyrrolidine-2,5-diones. Part II. | Bioorganic & medicinal chemistry 20120801 |
| Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives. | European journal of medicinal chemistry 20120801 |
| Does antiepileptogenesis affect sleep in genetic epileptic rats? | International journal of psychophysiology : official journal of the International Organization of Psychophysiology 20120701 |
| Treatment of idiopathic generalized epilepsy - a review of the evidence. | Expert opinion on pharmacotherapy 20120601 |
| Long-term effectiveness of ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. | Brain & development 20120501 |
| 8p deletion and 9p duplication in two children with electrical status epilepticus in sleep syndrome. | Seizure 20120501 |
| Design, synthesis and anticonvulsant activities of novel 1-(substituted/unsubstituted benzylidene)-4-(4-(6,8-dibromo-2-(methyl/phenyl)-4-oxoquinazolin-3(4H)-yl)phenyl) semicarbazide derivatives. | Bioorganic & medicinal chemistry letters 20120501 |
| Cognitive function of idiopathic childhood epilepsy. | Korean journal of pediatrics 20120501 |
| Prevalence of treated epilepsy in Korea based on national health insurance data. | Journal of Korean medical science 20120301 |
| T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. | Science translational medicine 20120215 |
| Ethosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release. | Neuropharmacology 20120201 |
| Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones. | European journal of medicinal chemistry 20120201 |
| Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120201 |
| Ethosuximide reduces allodynia and hyperalgesia and potentiates morphine effects in the chronic constriction injury model of neuropathic pain. | European journal of pharmacology 20120115 |
| Ethosuximide and phenobarbital promote wound healing via enhancing collagenization. | Chemical biology & drug design 20120101 |
| From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid? | Pflugers Archiv : European journal of physiology 20120101 |
| Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders. | Expert opinion on drug metabolism & toxicology 20120101 |
| L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats. | Molecular pain 20120101 |
| Clinical utility of adjunctive retigabine in partial onset seizures in adults. | Therapeutics and clinical risk management 20120101 |
| Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders. | Current topics in medicinal chemistry 20120101 |
| Evaluation of lercanidipine in Paclitaxel-induced neuropathic pain model in rat: a preliminary study. | Pain research and treatment 20120101 |
| The adolescent or adult with generalized tonic-clonic seizures. | Annals of Indian Academy of Neurology 20120101 |
| Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder. | Journal of pharmacology & pharmacotherapeutics 20120101 |
| N- and L-type voltage-dependent Ca2+ channels contribute to the generation of after-discharges in the spinal ventral root after cessation of noxious mechanical stimulation. | Journal of pharmacological sciences 20120101 |
| Synthesis, anticonvulsant activity and 5-HT1A/5-HT7 receptors affinity of 1-[(4-arylpiperazin-1-yl)-propyl]-succinimides. | Pharmacological reports : PR 20120101 |
| The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. | International journal of hepatology 20120101 |
| Brain anticonvulsant protection of mice given chronic carbamazepine under various fatty acid and magnesium diet conditions. | Prostaglandins, leukotrienes, and essential fatty acids 20120101 |
| Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions. | Annals of agricultural and environmental medicine : AAEM 20120101 |
| [Therapeutic drug monitoring of ethosuximide]. | Therapie 20120101 |
| Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice. | Progress in neuro-psychopharmacology & biological psychiatry 20111201 |
| Transition to absence seizures and the role of GABA(A) receptors. | Epilepsy research 20111201 |
| Quantum mechanical and spectroscopic (FT-IR, FT-Raman, 13C, 1H and UV) investigations of antiepileptic drug Ethosuximide. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201 |
| Design, synthesis and antiepileptic properties of novel 1-(substituted benzylidene)-3-(1-(morpholino/piperidino methyl)-2,3-dioxoindolin-5-yl)urea derivatives. | European journal of medicinal chemistry 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Early-onset childhood absence epilepsy: is it a distinct entity? | Epileptic disorders : international epilepsy journal with videotape 20111201 |
| Nitric oxide, epileptic seizures, and action of antiepileptic drugs. | CNS & neurological disorders drug targets 20111101 |
| Generic substitution of antiepileptic drugs: a systematic review of prospective and retrospective studies. | The Annals of pharmacotherapy 20111101 |
| Synthesis and anticonvulsant activity of new N-Mannich bases derived from 5-cyclopropyl-5-phenyl- and 5-cyclopropyl-5-(4-chlorophenyl)-imidazolidine-2,4-diones. | Bioorganic & medicinal chemistry 20111015 |
| Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines. | European journal of medicinal chemistry 20111001 |
| Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones. | Bioorganic & medicinal chemistry letters 20111001 |
| Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism. | Journal of molecular medicine (Berlin, Germany) 20110901 |
| Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs. | European journal of medicinal chemistry 20110901 |
| The effects of ion channel blockers validate the conductance-based model of saccadic oscillations. | Annals of the New York Academy of Sciences 20110901 |
| Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats. | Neuroscience 20110811 |
| Ethosuximide-induced mania in a 10-year-old boy. | Epilepsy & behavior : E&B 20110801 |
| Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. | Epilepsia 20110701 |
| Effect of intracranial administration of ethosuximide in rats with spontaneous or pentylenetetrazol-induced spike-wave discharges. | Epilepsia 20110701 |
| Ethosuximide was superior to valproate and lamotrigine in controlling seizures and minimising side effects. | Archives of disease in childhood. Education and practice edition 20110601 |
| Interictal paroxysmal EEG abnormalities in childhood absence epilepsy. | Seizure 20110501 |
| Orphenadrine induces secondarily generalized convulsive status epilepticus in rats. | Brain research bulletin 20110405 |
| Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy. | International journal of neural systems 20110401 |
| Synthesis and anticonvulsant activity of new n-mannich bases derived from 5-cyclopropyl-5-phenyl-hydantoins. | Archiv der Pharmazie 20110401 |
| Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures. | Neurobiology of disease 20110201 |
| Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. | Pharmacology, biochemistry, and behavior 20110201 |
| Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency. | Journal of inherited metabolic disease 20110201 |
| Long term outcome in children affected by absence epilepsy with onset before the age of three years. | Epilepsy & behavior : E&B 20110201 |
| Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice. | Indian journal of pharmacology 20110201 |
| Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases. | Neuropediatrics 20110201 |
| An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. | Brain research 20110131 |
| Effects of L- and T-type Ca²(+) channel blockers on spermatogenesis and steroidogenesis in the prepubertal mouse testis. | Journal of assisted reproduction and genetics 20110101 |
| Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis. | Archives of neurology 20110101 |
| [Symptoms and clinical course of epilepsy with myoclonic absences]. | No to hattatsu = Brain and development 20110101 |
| Myoclonus. | Handbook of clinical neurology 20110101 |
| Transcriptomic analysis in a Drosophila model identifies previously implicated and novel pathways in the therapeutic mechanism in neuropsychiatric disorders. | Frontiers in neuroscience 20110101 |
| Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey. | BMC pediatrics 20110101 |
| [Does antiabsence drug ethosuximide exert antidepressant effect?]. | Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20110101 |
| Experimental re-evaluation of flunarizine as add-on antiepileptic therapy. | Journal of pharmacy & bioallied sciences 20110101 |
| Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis. | Reproductive biology and endocrinology : RB&E 20110101 |
| Update on rufinamide in childhood epilepsy. | Neuropsychiatric disease and treatment 20110101 |
| An integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments. | PloS one 20110101 |
| Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors. | Advances in pharmacological sciences 20110101 |
| Severe myoclonic epilepsy of infancy (Dravet syndrome): Clinical and genetic features of nine Turkish patients. | Annals of Indian Academy of Neurology 20110101 |
| Acute alterations of somatodendritic action potential dynamics in hippocampal CA1 pyramidal cells after kainate-induced status epilepticus in mice. | PloS one 20110101 |
| Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands. | Molecular pain 20110101 |
| Studies of properties of 'Pain Networks' as predictors of targets of stimulation for treatment of pain. | Frontiers in integrative neuroscience 20110101 |
| Effect of Gentiana olivieri on experimental epilepsy models. | Pharmacognosy magazine 20110101 |
| [Transitory cognitive dysfunction in rolandic epilepsy]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| [Idiopathic focal epilepsies of infancy and childhood]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| Screening of the anticonvulsant activity of some plants from Fabaceae family in experimental seizure models in mice. | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101 |
| [Epilepsies with electric status epilepticus in sleep: peculiarities of clinical course and rational approaches to treatment]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. | European journal of medicinal chemistry 20101201 |
| Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status. | Epileptic disorders : international epilepsy journal with videotape 20101201 |
| Atypical benign partial epilepsy: recognition can prevent pseudocatastrophe. | Pediatric neurology 20101201 |
| 1-Benzyl-2,5-dioxopyrrolidine-3,4-diyl diacetate. | Acta crystallographica. Section E, Structure reports online 20101201 |
| Use of antiepileptic drugs for hyperkinetic movement disorders. | Current neuropharmacology 20101201 |
| 'Epileptic encephalopathy' of infancy and childhood: electro-clinical pictures and recent understandings. | Current neuropharmacology 20101201 |
| T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. | Neuropharmacology 20101101 |
| Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress. | Developmental medicine and child neurology 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Treatment initiation in epilepsy: an expert consensus in Spain. | Epilepsy & behavior : E&B 20101101 |
| Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome. | Epilepsia 20101001 |
| Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones. | European journal of medicinal chemistry 20100901 |
| Antiepileptic drug interactions - principles and clinical implications. | Current neuropharmacology 20100901 |
| Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins. | Bioorganic & medicinal chemistry 20100815 |
| Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100804 |
| Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy. | Epilepsia 20100801 |
| Epilepsy: old drugs do the trick in childhood absence epilepsy. | Nature reviews. Neurology 20100801 |
| Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity. | Bioorganic & medicinal chemistry letters 20100715 |
| Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides. | European journal of medicinal chemistry 20100701 |
| Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association? | Seizure 20100701 |
| In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein. | Life sciences 20100605 |
| Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives. | European journal of medicinal chemistry 20100601 |
| Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601 |
| An older drug for childhood absence epilepsy. | The American journal of nursing 20100601 |
| When the past challenges the present: are older antiepileptic drugs still the best choice in childhood absence epilepsy? | The Lancet. Neurology 20100501 |
| Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening. | European journal of medicinal chemistry 20100401 |
| [Specific language impairment and electroencephalogram: which recommendations in clinical practice? A cohort of 24 children]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100401 |
| Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. | The New England journal of medicine 20100304 |
| Ethosuximide in childhood absence epilepsy--older and better. | The New England journal of medicine 20100304 |
| Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS). | Epilepsy research 20100301 |
| Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect. | Neuropharmacology 20100301 |
| Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. | Biogerontology 20100201 |
| Pharmacological neuroprotection: that long, long road from idea to practice. | Korean journal of anesthesiology 20100201 |
| The effects of gabapentin pretreatment on brain injury induced by focal cerebral ischemia/reperfusion in the rat. | Korean journal of anesthesiology 20100201 |
| Spike-wave discharges are necessary for the expression of behavioral depression-like symptoms. | Epilepsia 20100101 |
| Effects of antiepileptics on behavioral and electroencephalographic seizure induced by pentetrazol in mice. | Journal of pharmacological sciences 20100101 |
| Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. | PloS one 20100101 |
| Epilepsy in patients with Angelman syndrome. | Italian journal of pediatrics 20100101 |
| Management of refractory complex partial seizures: current state of the art. | Neuropsychiatric disease and treatment 20100101 |
| Quality of life in childhood epilepsy with lateralized epileptogenic foci. | BMC neurology 20100101 |
| BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. | Molecular neurodegeneration 20100101 |
| Molecular and therapeutic potential and toxicity of valproic acid. | Journal of biomedicine & biotechnology 20100101 |
| Oxcarbazepine-induced tardive dyskinesia: A rare adverse reaction. | Journal of pediatric neurosciences 20100101 |
| Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. | BMJ (Clinical research ed.) 20100101 |
| Advances in epilepsy: new perspectives on new-onset epilepsy, comorbidities, and pharmacotherapy. | F1000 medicine reports 20100101 |
| Design and Synthesis of Some Novel 4-(4-substituted aryl) Semicarbazones as Anticonvulsant Agents. | Indian journal of pharmaceutical sciences 20100101 |
| Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients. | Nutrition journal 20100101 |
| [Absence epilepsy models in rodents]. | Gaceta medica de Mexico 20100101 |
| Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. | Clinical pharmacology : advances and applications 20100101 |
| Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. | Journal of medicinal chemistry 20091210 |
| A flexible drug delivery chip for the magnetically-controlled release of anti-epileptic drugs. | Journal of controlled release : official journal of the Controlled Release Society 20091103 |
| Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. | Seizure 20091101 |
| Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. | Diabetes 20091101 |
| Acceleration of pentylenetetrazol seizure kindling associated with induction of sensitized visual responses evoked by strobe stimulation. | Neuroscience 20091006 |
| Impact of antiepileptic drugs on cognition, behavior, and motor skills in children with new-onset, idiopathic epilepsy. | Epilepsy & behavior : E&B 20091001 |
| Use of a new antiepileptic drug or an old one as first drug for treatment of absence epilepsy. | Epilepsia 20090901 |
| Absence seizures: a review of recent reports with new concepts. | Epilepsy & behavior : E&B 20090801 |
| Ethosuximide-induced de novo systemic lupus erythematosus with anti-double-strand DNA antibodies: a case report with definite evidence. | Epilepsia 20090801 |
| Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years. | Epilepsia 20090801 |
| Ethosuximide converts ictogenic neurons initiating absence seizures into normal neurons in a genetic model. | Epilepsia 20090701 |
| [Anti-aging drugs]. | Nihon rinsho. Japanese journal of clinical medicine 20090701 |
| Clinical spectrum and medical treatment of children with electrical status epilepticus in sleep (ESES). | Epilepsia 20090601 |
| [Case report of dentatorubral pallidoluysian atrophy in a patient on a ketogenic diet]. | Masui. The Japanese journal of anesthesiology 20090601 |
| Antiepileptic drug monotherapy: the initial approach in epilepsy management. | Current neuropharmacology 20090601 |
| Truly 'rational' polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. | Current neuropharmacology 20090601 |
| New antiepileptic drugs: molecular targets. | Central nervous system agents in medicinal chemistry 20090601 |
| Depression- and anxiety-like behaviors of a rat model with absence epileptic discharges. | Neuroscience 20090505 |
| Frontal-onset absences in children: associated with worse outcome? A replication study. | Seizure 20090501 |
| Infantile spasms and Down syndrome: a new animal model. | Pediatric research 20090501 |
| Effects of antiepileptics on lateral geniculate nucleus-kindled seizures in rats. | Journal of pharmacological sciences 20090401 |
| Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009. | Epilepsia 20090301 |
| The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice. | Circulation research 20090227 |
| Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. | Neuropharmacology 20090201 |
| Dose adjustment of phenytoin for comedication in Japanese patients with epilepsy. | Therapeutic drug monitoring 20090201 |
| Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography. | Expert opinion on drug metabolism & toxicology 20090201 |
| Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride. | Indian journal of pharmacology 20090201 |
| Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants. | European journal of medicinal chemistry 20090101 |
| Successful treatment of intractable post-ictal psychosis with adjunctive ethosuximide. | Seizure 20090101 |
| A Drosophila systems model of pentylenetetrazole induced locomotor plasticity responsive to antiepileptic drugs. | BMC systems biology 20090101 |
| Managing epilepsy in women of childbearing age. | Drug safety 20090101 |
| Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice. | Pharmacological reports : PR 20090101 |
| Psychopharmacology of ADHD in pediatrics: current advances and issues. | Neuropsychiatric disease and treatment 20090101 |
| Causal hierarchy within the thalamo-cortical network in spike and wave discharges. | PloS one 20090101 |
| In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence. | PloS one 20090101 |
| Drugs associated with more suicidal ideations are also associated with more suicide attempts. | PloS one 20090101 |
| Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come? | Frontiers in behavioral neuroscience 20090101 |
| Neuroprotective effects of blockers for T-type calcium channels. | Molecular neurodegeneration 20090101 |
| Drug-induced hematologic syndromes. | Advances in hematology 20090101 |
| [Anticonvulsants as bioantioxidants under stress conditions]. | Biomeditsinskaia khimiia 20090101 |
| Social phobia following maprotiline: the first case report. | Cases journal 20090101 |
| Anticonvulsant Activity of Argyreia speciosa in Mice. | Indian journal of pharmaceutical sciences 20090101 |
| Aqueous stem bark extract of Stereospermum kunthianum (Cham, Sandrine Petit) protects against generalized seizures in pentylenetetrazole and electro-convulsive models in rodents. | African journal of traditional, complementary, and alternative medicines : AJTCAM 20090101 |
| Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach. | European journal of medicinal chemistry 20081201 |
| Lamotrigine monotherapy for newly diagnosed typical absence seizures in children. | Epilepsy research 20081201 |
| Treatment of Lennox-Gastaut syndrome: overview and recent findings. | Neuropsychiatric disease and treatment 20081201 |
| Pregabalin for the management of partial epilepsy. | Neuropsychiatric disease and treatment 20081201 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20081112 |
| Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. | Naunyn-Schmiedeberg's archives of pharmacology 20081101 |
| Television-provoked epilepsy in children: a follow-up survey from Isfahan, Iran. | Archives of Iranian medicine 20081101 |
| Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. | Journal of medicinal chemistry 20081023 |
| The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. | PLoS genetics 20081001 |
| CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. | European journal of medicinal chemistry 20080901 |
| Cognitive effects of antiepileptic drugs. | Journal of clinical neurology (Seoul, Korea) 20080901 |
| Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy. | Epilepsy & behavior : E&B 20080801 |
| Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. | Journal of pharmacological sciences 20080801 |
| Drug interactions between chemotherapeutic regimens and antiepileptics. | Clinical therapeutics 20080801 |
| The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. | Epilepsia 20080701 |
| Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. | Human molecular genetics 20080615 |
| Valproic acid extends Caenorhabditis elegans lifespan. | Aging cell 20080601 |
| The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. | Epilepsy research 20080501 |
| Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones. | Bioorganic & medicinal chemistry 20080501 |
| Early treatment suppresses the development of spike-wave epilepsy in a rat model. | Epilepsia 20080301 |
| Varied effects of conventional antiepileptics on responding maintained by negative versus positive reinforcement. | Physiology & behavior 20080227 |
| Inhibition of human aromatase complex (CYP19) by antiepileptic drugs. | Toxicology in vitro : an international journal published in association with BIBRA 20080201 |
| Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children. | Journal of clinical pharmacy and therapeutics 20080201 |
| Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. | PLoS biology 20080201 |
| Monotherapy for partial epilepsy: focus on levetiracetam. | Neuropsychiatric disease and treatment 20080201 |
| Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. | European journal of medicinal chemistry 20080101 |
| Childhood absence epilepsy with clinically apparent genetic and acquired burdens: a diagnostic consideration. | Journal of child neurology 20080101 |
| Effects of various antiepileptics on behavioral and electroencephalographic seizures induced by maximal electroshock in mice. | Journal of pharmacological sciences 20080101 |
| Absence seizures in children. | BMJ clinical evidence 20080101 |
| Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas. | Seizure 20071201 |
| Treatment of pediatric epilepsy: European expert opinion, 2007. | Epileptic disorders : international epilepsy journal with videotape 20071201 |
| Cannabinoids in health and disease. | Dialogues in clinical neuroscience 20071201 |
| Hydrogen sulfide as a novel nociceptive messenger. | Pain 20071101 |
| Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice. | Seizure 20071001 |
| Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. | Neuropharmacology 20071001 |
| Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis. | Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie 20071001 |
| Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915 |
| Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia. | Epilepsia 20070901 |
| T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy. | Neuropharmacology 20070901 |
| Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. | The Journal of pharmacology and experimental therapeutics 20070801 |
| Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children. | Epilepsy & behavior : E&B 20070801 |
| Thalidomide inhibits pentylenetetrazole-induced seizures. | Journal of the neurological sciences 20070715 |
| Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach. | Bioorganic & medicinal chemistry letters 20070701 |
| Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice. | Epilepsy research 20070701 |
| Complex seizure disorder caused by Brunol4 deficiency in mice. | PLoS genetics 20070701 |
| Absence epilepsy in childhood: electroencephalography (EEG) does not predict outcome. | Journal of child neurology 20070701 |
| Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms. | Epilepsy & behavior : E&B 20070601 |
| Antiepileptic drugs and visual function. | Pediatric neurology 20070601 |
| Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach. | Journal of medicinal chemistry 20070517 |
| A novel high sensitivity HPLC assay for topiramate, using 4-chloro-7-nitrobenzofurazan as pre-column fluorescence derivatizing agent. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501 |
| Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype. | Neurobiology of disease 20070501 |
| Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice. | Journal of pharmacological sciences 20070501 |
| Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. | Hearing research 20070401 |
| Is ethosuximide a risk factor for generalised tonic-clonic seizures in absence epilepsy? | Neuropediatrics 20070401 |
| Evaluation of anticonvulsant and analgesic effects of benzyl- and benzhydryl ureides. | European journal of pharmacology 20070322 |
| Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration. | Experimental brain research 20070301 |
| Yale University School of Medicine: 2007 student thesis abstracts. | The Yale journal of biology and medicine 20070301 |
| The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. | Brain research 20070216 |
| Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore. | European journal of medicinal chemistry 20070201 |
| Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. | Epilepsy research 20070201 |
| Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test. | Behavioural pharmacology 20070201 |
| Genetic and pharmacological factors that influence reproductive aging in nematodes. | PLoS genetics 20070201 |
| Sleep-related epilepsy in the A/J mouse. | Sleep 20070201 |
| Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy). | Neuropsychiatric disease and treatment 20070201 |
| Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers. | The Journal of physiology 20070101 |
| 7-12 Hz high-voltage rhythmic spike discharges in rats evaluated by antiepileptic drugs and flicker stimulation. | Journal of neurophysiology 20070101 |
| Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain. | Bioorganic & medicinal chemistry letters 20070101 |
| Redrawing Papez' circuit: a theory about how acute stress becomes chronic and causes disease. | Medical hypotheses 20070101 |
| Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress. | Medical hypotheses 20070101 |
| Arthritis and pain. Future targets to control osteoarthritis pain. | Arthritis research & therapy 20070101 |
| Negative effects of antiepileptic drugs on mood in patients with epilepsy. | Drug safety 20070101 |
| Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat. | BMC neuroscience 20070101 |
| Ethosuximide: from bench to bedside. | CNS drug reviews 20070101 |
| Glutamatergic alterations in the cortex of genetic absence epilepsy rats. | BMC neuroscience 20070101 |
| Response of spinal myoclonus to a combination therapy of autogenic training and biofeedback. | BioPsychoSocial medicine 20070101 |
| The effects of chronic administration of ethosuximide on learning and memory: a behavioral and biochemical study on nonepileptic rats. | Behavioural pharmacology 20061101 |
| Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze. | Behavioural pharmacology 20061101 |
| Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. | Epilepsia 20061101 |
| Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. | Experimental gerontology 20061001 |
| Coexistence of idiopathic rolandic epilepsy and CSWS in two families. | Epilepsia 20061001 |
| Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. | The Journal of pharmacology and experimental therapeutics 20060901 |
| Levetiracetam-induced myoclonic status epilepticus in myoclonic-astatic epilepsy: a case report. | Epileptic disorders : international epilepsy journal with videotape 20060901 |
| Differences between prescribed daily doses and defined daily doses of antiepileptics--therapeutic drug monitoring as a marker of the quality of the treatment. | International journal of clinical pharmacology and therapeutics 20060901 |
| Zonisamide - a review of experience and use in partial seizures. | Neuropsychiatric disease and treatment 20060901 |
| Diagnostic issues and treatment of cryptogenic or symptomatic generalized epilepsies. | Epilepsy research 20060801 |
| GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures. | European journal of pharmacology 20060710 |
| Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. | Journal of ethnopharmacology 20060630 |
| Early-onset absence epilepsy: clinical and electroencephalographic features in three children. | Brain & development 20060601 |
| Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. | Brain & development 20060601 |
| Limited P-glycoprotein mediated efflux for anti-epileptic drugs. | Journal of drug targeting 20060601 |
| Yale University School of Medicine: 2006 student thesis abstracts. | The Yale journal of biology and medicine 20060601 |
| Effects of anticonvulsant drugs on life span. | Archives of neurology 20060401 |
| Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures. | Epilepsia 20060401 |
| Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. | Epilepsia 20060301 |
| The effects of ethosuximide on amino acids in genetic absence epilepsy rat model. | Journal of pharmacological sciences 20060301 |
| Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro. | Neuropharmacology 20060101 |
| Influence of cimetidine on the anticonvulsant activity of conventional antiepileptic drugs against pentetrazole-induced seizures in mice. | Pharmacological reports : PR 20060101 |
| Valproate as a mainstay of therapy for pediatric epilepsy. | Paediatric drugs 20060101 |
| [Carbamazepine-induced systemic lupus erythematosus--a case report]. | Neurologia i neurochirurgia polska 20060101 |
| Effects of calcium channel blockers on the spermatogenesis and gene expression in peripubertal mouse testis. | Archives of andrology 20060101 |
| Role of valproate across the ages. Treatment of epilepsy in children. | Acta neurologica Scandinavica. Supplementum 20060101 |
| Epilepsy with myoclonic absences. | CNS drugs 20060101 |
| Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice. | Pharmacological reports : PR 20060101 |
| Anticonvulsant and antidepressant activity of the selected terpene GABA derivatives in experimental tests in mice. | Pharmacological reports : PR 20060101 |
| Negative myoclonus. An overview of its clinical features, pathophysiological mechanisms, and management. | Neurophysiologie clinique = Clinical neurophysiology 20060101 |
| Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. | Epilepsy & behavior : E&B 20051201 |
| Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances. | Pharmacology 20051201 |
| Photic-induced sensitization: acquisition of an augmenting spike-wave response in the adult rat through repeated strobe exposure. | Journal of neurophysiology 20051201 |
| Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome. | Epilepsia 20051201 |
| Gender aspects of pharmacokinetics of new and old AEDs: pregnancy and breast-feeding. | Therapeutic drug monitoring 20051201 |
| Treatment of pediatric epilepsy: expert opinion, 2005. | Journal of child neurology 20051201 |
| Role of a novel maintained low-voltage-activated inward current permeable to sodium and calcium in pacemaking of insect neurosecretory neurons. | Invertebrate neuroscience : IN 20051101 |
| Drug induced pseudolymphoma secondary to ethosuximide. | Journal of neurology, neurosurgery, and psychiatry 20051101 |
| Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. | The Cochrane database of systematic reviews 20051019 |
| The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. | European journal of pharmacology 20051003 |
| Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. | Brain research 20050928 |
| Estimation of pK(a) values using microchip capillary electrophoresis and indirect fluorescence detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925 |
| Chiral aspects of the human metabolism of ethosuximide. | Biopharmaceutics & drug disposition 20050901 |
| Treatment of epilepsy in adults: expert opinion, 2005. | Epilepsy & behavior : E&B 20050901 |
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. | Journal of pharmaceutical sciences 20050701 |
| GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior. | Brain research. Developmental brain research 20050630 |
| Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats. | Neuropharmacology 20050601 |
| Motor impairment on awakening in a patient with an EEG pattern of 'unilateral, continuous spikes and waves during slow sleep'. | Epileptic disorders : international epilepsy journal with videotape 20050601 |
| Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats. | Epilepsia 20050601 |
| Voltage-dependent calcium channels. | General physiology and biophysics 20050601 |
| Antiepileptic drug monotherapy: pediatric concerns. | Seminars in pediatric neurology 20050601 |
| Absence seizures in children. | Clinical evidence 20050601 |
| Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050501 |
| Epilepsy with myoclonic absences. | Brain & development 20050401 |
| Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330 |
| A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine. | Seizure 20050301 |
| Effect of antiepileptic drug polytherapy on crystalluria. | Pediatric neurology 20050201 |
| Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography. | Electrophoresis 20050201 |
| [Antiepileptic drugs in the treatment of autistic regression syndromes]. | Revista de neurologia 20050115 |
| Anticonvulsant medications extend worm life-span. | Science (New York, N.Y.) 20050114 |
| Mechanisms of action of antiepileptic drugs. | Current topics in medicinal chemistry 20050101 |
| Voltage gated ion channels: targets for anticonvulsant drugs. | Current topics in medicinal chemistry 20050101 |
| A magnetoencephalographic study of negative myoclonus in a patient with atypical benign partial epilepsy. | Seizure 20050101 |
| [Electroencephalography in status epilepticus in sleep (ESES) in various clinical pictures]. | Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20050101 |
| Bupropion-induced convulsions: preclinical evaluation of antiepileptic drugs. | Epilepsy research 20050101 |
| A chronic dysfunctional stress response can cause stroke by stimulating platelet activation, migraine, and hypertension. | Medical hypotheses 20050101 |
| Ion channels and epilepsy. | Current pharmaceutical design 20050101 |
| Influence of the antagonist of the glycine site of NMDA receptors, MRZ 2/576, on the anticonvulsant activity of conventional antiepileptic drugs in mice. | Pharmacological reports : PR 20050101 |
| Photosensitivity in idiopathic generalized epilepsies. | Epilepsia 20050101 |
| Best practice guidelines for the management of women with epilepsy. | Epilepsia 20050101 |
| Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies. | Epilepsia 20050101 |
| Evidence-based treatment of idiopathic generalized epilepsies with older antiepileptic drugs. | Epilepsia 20050101 |
| Management of Landau-Kleffner syndrome. | Paediatric drugs 20050101 |
| Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice. | Toxicology letters 20041201 |
| Learning and memory impairment in rats with chronic atypical absence seizures. | Experimental neurology 20041201 |
| Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor. | Biological & pharmaceutical bulletin 20041201 |
| Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats. | Epilepsy & behavior : E&B 20041201 |
| Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels. | Epilepsy & behavior : E&B 20041201 |
| [Childhood and juvenile absence epilepsy. Treatment and prognosis]. | Ugeskrift for laeger 20041108 |
| Fracture risk associated with use of antiepileptic drugs. | Epilepsia 20041101 |
| Refractory atypical absence seizures in rat: a two hit model. | Epilepsy research 20041101 |
| Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy. | Pharmacology, biochemistry, and behavior 20041101 |
| Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. | The Journal of pharmacology and experimental therapeutics 20041001 |
| Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. | The Lancet. Neurology 20041001 |
| Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum. | Biomedical chromatography : BMC 20041001 |
| Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. | Epilepsia 20041001 |
| fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation. | Epilepsia 20041001 |
| Uptake of GABA and activity of GABA transaminase in blood platelets from children with absence epilepsy. | Neurochemical research 20041001 |
| PXR and the regulation of apoA1 and HDL-cholesterol in rodents. | Pharmacological research 20040901 |
| [Long-term follow-up of a case of eyelid myoclonia with absences]. | No to hattatsu = Brain and development 20040901 |
| [Anticonvulsant hypersensitivity syndrome]. | Orvosi hetilap 20040808 |
| Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats. | Naunyn-Schmiedeberg's archives of pharmacology 20040801 |
| Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. | Seizure 20040701 |
| The activity of antiepileptic drugs as histone deacetylase inhibitors. | Epilepsia 20040701 |
| Absence seizures in children. | Clinical evidence 20040601 |
| Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. | Pain 20040501 |
| Is the persistent sodium current a specific target of anti-absence drugs? | Neuroreport 20040429 |
| Pharmacology of recombinant low-voltage activated calcium channels. | Current drug targets. CNS and neurological disorders 20040401 |
| Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. | Journal of neurobiology 20040301 |
| Is spontaneous high-voltage rhythmic spike discharge in Long Evans rats an absence-like seizure activity? | Journal of neurophysiology 20040101 |
| Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats. | The Journal of pharmacology and experimental therapeutics 20040101 |
| Cortical-area specific block of genetically determined absence seizures by ethosuximide. | Neuroscience 20040101 |
| [Idiopathic epilepsies: some therapeutic aspects]. | Revista de neurologia 20040101 |
| Speech and language deterioration in benign rolandic epilepsy. | Journal of child neurology 20040101 |
| Riluzole enhances the anti-seizure action of conventional antiepileptic drugs against pentetrazole-induced convulsions in mice. | Polish journal of pharmacology 20040101 |
| Effects of the combination of valproate and ethosuximide on spike wave discharges in WAG/Rij rats. | Epilepsy research 20040101 |
| Hippocampal afterdischarges in rats. I. Effects of antiepileptics. | Physiological research 20040101 |
| Therapeutic drug monitoring of old and newer anti-epileptic drugs. | Clinical chemistry and laboratory medicine 20040101 |
| When breastfeeding mothers need CNS-acting drugs. | The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20040101 |
| Diagnosis and treatment of epilepsy. | Epilepsia 20040101 |
| Assessment of anticonvulsant effectiveness and safety in patients with Angelman's syndrome using an Internet questionnaire. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031215 |
| Absence seizures in children. | Clinical evidence 20031201 |
| Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. | British journal of cancer 20031117 |
| Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro. | Epilepsia 20031101 |
| Ethosuximide induced agranulocytosis. | Brain & development 20031001 |
| Absence seizures in patients with localization-related epilepsy. | Brain & development 20030901 |
| Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. | British journal of pharmacology 20030901 |
| Reversal of experimental neuropathic pain by T-type calcium channel blockers. | Pain 20030901 |
| Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge. | Journal of ethnopharmacology 20030701 |
| Epilepsy. | Disease-a-month : DM 20030701 |
| Thermal and rheological study of lipophilic ethosuximide suppositories. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030601 |
| Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. | Epilepsia 20030501 |
| Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy. | Epilepsy research 20030501 |
| Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. | Xenobiotica; the fate of foreign compounds in biological systems 20030301 |
| Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation. | Neuroscience letters 20030102 |
| Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030101 |
| Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. | The Cochrane database of systematic reviews 20030101 |
| Clinical trials for treatment of primary generalized epilepsies. | Epilepsia 20030101 |
| Influence of vigabatrin, a novel antiepileptic drug, on the anticonvulsant activity of conventional antiepileptics in pentetrazole-induced seizures in mice. | Polish journal of pharmacology 20030101 |
| Angelman syndrome: etiology, clinical features, diagnosis, and management of symptoms. | Paediatric drugs 20030101 |
| Some antiepileptic compounds impair learning by rats in a Morris water maze. | Integrative physiological and behavioral science : the official journal of the Pavlovian Society 20030101 |
| Influence of SIB 1893, a selective mGluR5 receptor antagonist, on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. | Polish journal of pharmacology 20030101 |
| [Modulating effect of anticonvulsive agents on Ca2+ dependent membrane fusion in cell-free model of neurosecretion]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101 |
| Characteristics of flurothyl-induced seizures and the effect of antiepileptic drugs on flurothyl-induced seizures in Mongolian gerbils. | Pharmacology, biochemistry, and behavior 20021201 |
| Absence seizures in children. | Clinical evidence 20021201 |
| Primary standardization of assays for anticonvulsant drugs: comparison of accuracy and precision. | Clinical chemistry 20021101 |
| Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide. | Experimental brain research 20021001 |
| Does lamotrigine influence valproate concentrations? | Therapeutic drug monitoring 20021001 |
| T-channel-like pharmacological properties of high voltage-activated, nifedipine-insensitive Ca2+ currents in the rat terminal mesenteric artery. | British journal of pharmacology 20021001 |
| Early-onset absence epilepsy and paroxysmal dyskinesia. | Epilepsia 20021001 |
| Idiopathic generalised epilepsies with 3 Hz and faster spike wave discharges: a population-based study with evaluation and long-term follow-up in 71 patients. | Epileptic disorders : international epilepsy journal with videotape 20020901 |
| Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. | European journal of pharmacology 20020802 |
| Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia. | Epilepsy research 20020801 |
| The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. | British journal of pharmacology 20020701 |
| Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats. | The Journal of pharmacy and pharmacology 20020701 |
| A sensitive gas chromatographic/mass spectrometric method for the resolution and quantification of ethosuximide enantiomers in biological fluids. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020605 |
| Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats. | Investigative ophthalmology & visual science 20020601 |
| Anti-epileptic drugs. | Journal of the Indian Medical Association 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. | Journal of neural transmission (Vienna, Austria : 1996) 20020401 |
| Effect of some antiepileptic drugs on brain histaminergic systems in the rat. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401 |
| Some common issues in the use of antiepileptic drugs. | Seminars in neurology 20020301 |
| Effects of antiepileptic drugs on afterdischarge generation in rat hippocampal slices. | Brain research 20020104 |
| Anticonvulsants: aspects of their mechanisms of action. | European journal of pain (London, England) 20020101 |
| Interactions between antiepileptic drugs and hormonal contraception. | CNS drugs 20020101 |
| Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations. | Clinical pharmacokinetics 20020101 |
| Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity. | Molecular psychiatry 20020101 |
| Suggestion for another anti-epileptic drug to use for migraine prophylaxis. | Headache 20020101 |
| [Childhood absence epilepsy(pyknolepsy)]. | Ryoikibetsu shokogun shirizu 20020101 |
| [Juvenile absence epilepsy(JAE)]. | Ryoikibetsu shokogun shirizu 20020101 |
| [Epilepsy with myoclonic absences]. | Ryoikibetsu shokogun shirizu 20020101 |
| [Epilepsy with continuous spikes and waves during slow sleep]. | Ryoikibetsu shokogun shirizu 20020101 |
| Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. | Epilepsy research 20011201 |
| Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. | Molecular pharmacology 20011101 |
| High-dose ethosuximide for epilepsy in Angelman syndrome: implication of GABA(A) receptor subunit. | Neurology 20011023 |
| Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced 'epilepsy'. | Stroke 20011001 |
| Possible induction of systemic lupus erythematosus by zonisamide. | Pediatric neurology 20011001 |
| Interaction of flunarizine with sodium valproate or ethosuximide in gamahydroxybutyrate induced absence seizures in rats. | Indian journal of experimental biology 20011001 |
| Lorazepam: an adjuvant therapy in patients with seizure and heliotaxis. | Neurology India 20010901 |
| Atypical evolution in childhood epilepsy with occipital paroxysms (Panayiotopoulos type). | Epileptic disorders : international epilepsy journal with videotape 20010901 |
| Therapeutic drug monitoring of antiepileptics by capillary electrophoresis. Characterization of assays via analysis of quality control sera containing 14 analytes. | Journal of chromatography. A 20010727 |
| Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. | European journal of pediatrics 20010501 |
| Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures. | Pharmacology, biochemistry, and behavior 20010401 |
| Quantification of urinary excretion of ethosuximide enantiomers and their major metabolites in the rat. | Biopharmaceutics & drug disposition 20010401 |
| Forced normalization induced by ethosuximide therapy in a patient with intractable myoclonic epilepsy. | Brain & development 20010301 |
| Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats. | European journal of pharmacology 20010301 |
| The pharmacokinetics of ethosuximide enantiomers in the rat. | Biopharmaceutics & drug disposition 20010301 |
| A model of atypical absence seizures: EEG, pharmacology, and developmental characterization. | Neurology 20010213 |
| [Use of lamotrigine in the treatment of absence epilepsy crises]. | Revista de neurologia 20010201 |
| Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice. | Neuroscience letters 20010119 |
| Time-related configuration change in benign focal epileptiform discharges of childhood: from a dipole to a negative monopole in a patient with generalized epilepsy. | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20010101 |
| Effect of positively and negatively charged liposomes on skin permeation of drugs. | Journal of drug targeting 20010101 |
| Treatment of typical absence seizures and related epileptic syndromes. | Paediatric drugs 20010101 |
| Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells. | Anticancer research 20010101 |
| The management of refractory idiopathic epilepsies. | Epilepsia 20010101 |
| [Hormonal contraception and epilepsy]. | Akusherstvo i ginekologiia 20010101 |
| Ethosuximide induced lymphadenopathy--a case report. | The Central African journal of medicine 20010101 |
| Ethosuximide-associated lupus with cerebral and renal manifestations. | European journal of pediatrics 19980901 |
| Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. | Developmental medicine and child neurology 19980801 |
| Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring. | Cancer causes & control : CCC 19970501 |
| Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. | The International journal of neuroscience 19961101 |
| Ethosuximide-induced lupus-like syndrome with renal involvement. | Internal medicine (Tokyo, Japan) 19960701 |
| Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice. | Journal of pharmacological and toxicological methods 19960201 |
| Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models. | The Journal of pharmacology and experimental therapeutics 19950901 |
| Aplastic anemia following therapy for absence seizures with ethosuximide. | Pediatric neurology 19940701 |
| Absence seizures and carbamazepine in adults. | Epilepsia 19940101 |
| Ethosuximide suppresses seizures and lethality induced by picrotoxin in developing rats. | Pharmacology, biochemistry, and behavior 19930401 |
| Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons. | Neuroscience 19921201 |
| Ethosuximide and tremor in Parkinson's disease: a pilot study. | Movement disorders : official journal of the Movement Disorder Society 19920101 |
| Effect of ethosuximide on rest tremor in the MPTP monkey model. | Movement disorders : official journal of the Movement Disorder Society 19920101 |
| In vivo evidence that ethosuximide is a substrate for cytochrome P450IIIA. | Pharmacology 19920101 |
| Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. | British journal of pharmacology 19900801 |
| Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio. | The Journal of pharmacology and experimental therapeutics 19900401 |
| Synthesis and anticonvulsant activity of 2-benzylglutarimides. | Journal of medicinal chemistry 19900301 |
| Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones. | Journal of medicinal chemistry 19900101 |
| Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. | Annals of neurology 19890601 |
| Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. | Neuroscience letters 19890313 |
| Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone. | Epilepsia 19890101 |
| Episodic barrel rotations induced by intrastriatal injection of quinolinic acid in rats. Inhibition by anticonvulsants. | Pharmacology, biochemistry, and behavior 19880901 |
| Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. | Epilepsia 19880101 |
| Only certain antiepileptic drugs prevent seizures induced by pilocarpine. | Brain research 19870701 |
| Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions. | Brain research 19870407 |
| Use of ethosuximide and valproate in the treatment of epilepsy. | Neurologic clinics 19860801 |
| Phenytoin-induced benign intracranial hypertension. | Neurology 19860301 |
| Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. | Epilepsia 19860101 |
| Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. | Arzneimittel-Forschung 19850101 |
| A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures. | Epilepsia 19840601 |
| Aplastic anemia during ethosuximide medication. Treatment with bolus-methylprednisolone. | Acta paediatrica Scandinavica 19831101 |
| Ethosuximide-induced liver dysfunction. | Archives of neurology 19830601 |
| Anticonvulsant sensitivity of absence seizures in the tottering mutant mouse. | Epilepsia 19830201 |
| Carbamazepine-induced choreoathetoid dyskinesias. | Journal of neurology, neurosurgery, and psychiatry 19820601 |
| A case of petit mal epilepsy aggravated by lithium. | The American journal of psychiatry 19810501 |
| Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. | Science (New York, N.Y.) 19801128 |
| Dyskinesia and akathisia induced by ethosuximide. | American journal of diseases of children (1960) 19780501 |
| Nephrotic syndrome associated with ethosuccimide. | American journal of diseases of children (1960) 19780101 |
| [Quantitative analysis of conditional-optimal doses of succilep and trimetin in the treatment of children and adolescents with minor forms of epilepsy]. | Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 19770101 |
| Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. | Research communications in chemical pathology and pharmacology 19770101 |
| Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy. | The Journal of pediatrics 19760801 |
| Di-n-propylacetic acid--profile of anticonvulsant activity in mice. | Arzneimittel-Forschung 19760201 |
| Lupus-scleroderma syndrome induced by ethosuximide. | Archives of disease in childhood 19750801 |
| Serum clonazepam concentrations in children with absence seizures. | Neurology 19750301 |
| Dyskinesia-an unusual reaction to ethosuximide. | Archives of neurology 19750201 |
| Movement disorder as a manifestation of diphenylhydantoin toxicity. | Pediatrics 19740901 |
| Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation. | Neurology 19740501 |
| Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins. | Lancet (London, England) 19731117 |
| Pseudodegenerative disease due to diphenylhydantoin intoxication. | Archives of neurology 19691201 |
| Treatment of generalized epilepsy with acrisuxine. | Confinia neurologica 19690101 |
| Phenytoin (Dilantin) intoxication. | Acta neurologica Scandinavica 19670101 |
| Anticonvulsant activity and toxicity of phensuximide, methsuximide and ethosuximide. | Epilepsia 19630301 |
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