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Home > Other Heterocycles > 77-37-2

77-37-2

77-37-2 | carbamic acid, bicyclo[2.2.1]hept-2-yl-, ethyl ester

CAS No: 77-37-2 Catalog No: AG005BU2 MDL No:

Product Description

Catalog Number:
AG005BU2
Chemical Name:
carbamic acid, bicyclo[2.2.1]hept-2-yl-, ethyl ester
CAS Number:
77-37-2
Molecular Formula:
C10H17NO2
Molecular Weight:
183.2475
IUPAC Name:
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
InChI:
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
InChI Key:
WYDUSKDSKCASEF-UHFFFAOYSA-N
SMILES:
CCOC(=O)NC1CC2CC1CC2
EC Number:
201-023-0
NSC Number:
169103

Properties

Complexity:
301  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
287.225g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
287.447g/mol
Monoisotopic Mass:
287.225g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
23.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1  

Literature

Title Journal
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chemical research in toxicology 20170515
Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. Toxicology 20131215
Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor. Journal of medicinal chemistry 20120823
Adjunctive memantine therapy for cognitive impairment in chronic schizophrenia: a placebo-controlled pilot study. Psychiatry investigation 20120601
Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys. Environmental toxicology and pharmacology 20120101
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats. Neurotoxicology 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Non-enzymatic pretreatment of nerve agent (soman) poisoning: a brief state-of-the-art review. Toxicology letters 20110925
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry 20110714
Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110701
Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases. Journal of analytical toxicology 20110301
Risperidone associated tardive dyskinesia--a less common phenomenon. BMJ case reports 20110101
Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment. Neurotoxicology 20101201
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. Healthcare informatics research 20101201
Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. Pharmacology, biochemistry, and behavior 20100501
Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway. Journal of veterinary science 20100301
The use of organotypic hippocampal slice cultures to evaluate protection by non-competitive NMDA receptor antagonists against excitotoxicity. Alternatives to laboratory animals : ATLA 20100301
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. Neurotoxicology 20100101
Structured relaxation in the treatment of akathisia: case series. Neuropsychiatric disease and treatment 20100101
Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II. Current neuropharmacology 20091201
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes 20091101
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. International journal of molecular sciences 20090601
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. International journal of molecular sciences 20090301
Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. Psychosomatics 20090101
Acute dystonic reactions in a lady presenting with repetitive involuntary muscle twitching: a case report. Cases journal 20090101
Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors. The American journal of gastroenterology 20081001
Role of the central cholinergic system in the therapeutics of schizophrenia. Current neuropharmacology 20080901
Stuttering priapism--a review of the therapeutic options. International journal of clinical practice 20080801
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacology, biochemistry, and behavior 20080601
Amisulpride plus valproate vs haloperidol plus valproate in the treatment of acute mania of bipolar I patients: a multicenter, open-label, randomized, comparative trial. Neuropsychiatric disease and treatment 20080601
The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents. Interdisciplinary toxicology 20080601
Anticonvulsant efficacy of drugs with cholinergic and/or glutamatergic antagonism microinfused into area tempestas of rats exposed to soman. Neurochemical research 20080201
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry 20080124
Clozapine and co-prescribed psychotropics: a short report. Clinical practice and epidemiology in mental health : CP & EMH 20080101
Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study. Pharmacy world & science : PWS 20070601
An overview of the clinical use of ondansetron in preschool age children. Therapeutics and clinical risk management 20070601
The combination of donepezil and procyclidine protects against soman-induced seizures in rats. Toxicology and applied pharmacology 20070415
Newer antipsychotics and the rabbit syndrome. Clinical practice and epidemiology in mental health : CP & EMH 20070101
Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques. Journal of pharmacological and toxicological methods 20070101
Low dose quetiapine induced galactorrhoea: a case report. Clinical practice and epidemiology in mental health : CP & EMH 20070101
Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. European journal of pharmacology 20061024
Abdominal pain with rigidity secondary to the anti-emetic drug metoclopramide. The Journal of emergency medicine 20060501
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. Basic & clinical pharmacology & toxicology 20060201
Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. European journal of pharmacology 20051121
Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes. Journal of psychiatric research 20050501
Soman-induced convulsions in rats terminated with pharmacological agents after 45 min: neuropathology and cognitive performance. Neurotoxicology 20050101
Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort. BMC neurology 20050101
Primary care use of antipsychotic drugs: an audit and intervention study. Annals of general psychiatry 20050101
Screening and semi-quantitative analysis of post mortem blood for basic drugs using gas chromatography/ion trap mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats. European journal of pharmacology 20041128
Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Legal medicine (Tokyo, Japan) 20041001
Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis 20041001
Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. Toxicology and applied pharmacology 20040501
Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality. European journal of pharmacology 20040112
Effects of procyclidine on eye movements in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201
NMDA receptors might be involved in the impairing effects of procyclidine on cognition. Journal of clinical psychopharmacology 20031201
Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats. Neurotoxicology 20030601
Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology 20030501
Variable effects of previously untested muscarinic receptor antagonists on experimental myopia. Investigative ophthalmology & visual science 20030301
Probable dystonic reaction after a single dose of cyclizine in a patient with a history of encephalitis. Anaesthesia 20030301
Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study. Journal of psychopharmacology (Oxford, England) 20030301
Acute dystonic reaction in an elderly patient with mood disorder after titration of paroxetine: possible mechanisms and implications for clinical care. Journal of psychopharmacology (Oxford, England) 20021201
A possible association between high normal and high dose olanzapine and prolongation of the PR interval. Journal of psychopharmacology (Oxford, England) 20020601
Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects. Journal of psychopharmacology (Oxford, England) 20020601
Effects of oral procyclidine administration on cognitive functions in healthy subjects: implications for schizophrenia. Journal of clinical psychopharmacology 20020401
[Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs]. L'Encephale 20020101
Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environmental toxicology and pharmacology 20020101
Combination anticonvulsant treatment of soman-induced seizures. Journal of applied toxicology : JAT 20011201
Effects of advanced candidate anticonvulsants under two rodent models of 'counting'. Journal of applied toxicology : JAT 20011201
Simultaneous determination of enantiomers of structurally related anticholinergic analogs in human serum by liquid chromatography-electrospray ionization mass spectrometry with on-line sample cleanup. Journal of chromatography. B, Biomedical sciences and applications 20011025
Physostigmine as treatment for severe CNS anticholinergic toxicity. Emergency medicine journal : EMJ 20010901
Nasal absorption of procyclidine in rats and dogs. Archives of pharmacal research 20010601
Lessons to be learned: a case study approach. 'Spontaneous' intraperitoneal bladder rupture in a psychiatric patient--with diagnostic difficulties. The journal of the Royal Society for the Promotion of Health 20010601
Neuroleptics and family history of Parkinson diseases: case report. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20010501
Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers. Psychopharmacology 20010301
Anti-nicotinic properties of anticholinergic antiparkinson drugs. The Journal of pharmacy and pharmacology 19981101
An extrapyramidal reaction to ondansetron. British journal of anaesthesia 19981001
Bilateral ulnar nerve paralysis: an unreported complication of drug-induced extrapyramidal rigidity. The Australian and New Zealand journal of psychiatry 19970601
Antipsychotic drug-induced dysphoria. The British journal of psychiatry : the journal of mental science 19961001
Antipsychotic drug-induced dysphoria. The British journal of psychiatry : the journal of mental science 19951001
Acute dystonia due to amitriptyline. Journal of neurology, neurosurgery, and psychiatry 19920501
Pimozide-induced depression associated with polyuria and polydipsia. Journal of clinical psychopharmacology 19920401
Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion. DICP : the annals of pharmacotherapy 19910501
Rapid cycling following antidepressant in an adolescent. Biological psychiatry 19900515
Effects of mianserin in neuroleptic-induced parkinsonism. Psychopharmacology 19860101
Neuroleptic malignant syndrome. British medical journal (Clinical research ed.) 19830618
Toxic neurological reaction to lithium/thioridazine. Lancet (London, England) 19830402
Fluphenazine enanthate and fluphenazine decanoate in the treatment of schizophrenic outpatients: extrapyramidal symptoms and therapeutic effect. The American journal of psychiatry 19820301
[Experience with the use of new Bulgarian psychotropic drugs]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 19820101
Sleep disturbance associated with fluphenazine HCl: a case report. The American journal of psychiatry 19790701
Ethopropazine and benztropine in neuroleptic-induced parkinsonism. The Journal of clinical psychiatry 19790301
Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. Canadian Medical Association journal 19781007
A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism. The British journal of psychiatry : the journal of mental science 19770601
[The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis]. Der Nervenarzt 19760101
Abnormal involuntary movements induced by anticholinergic therapy. Acta neurologica Scandinavica 19740101
Letter: Delayed drug-induced dystonias. British medical journal 19731020
Development of extrapyramidal symptoms in hypertensive patients treated with diazoxide. British medical journal 19730901
Parenteral long-acting phenothiazines. British medical journal 19720325
Central role of solar information flow in pregenetic evolution. Journal of theoretical biology 19710601
Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. Neurology 19701201
Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. Neurology 19701201
Greater than recommended drug dosages--some effects. The American journal of psychiatry 19700601
Treatment of resistant schizophrenics with extreme high dosage fluphenazine hydrochloride. Psychosomatics 19700101
Drug-induced extrapyramidal symptoms: their incidence and treatment. The American journal of psychiatry 19670101
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism. The British journal of psychiatry : the journal of mental science 19660601

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