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769-49-3 | 1-methyl-4-oxo-pyridine-3-carboxamide
CAS No: 769-49-3 Catalog No: AG00G4UB MDL No:MFCD16883574
Product Description
Catalog Number:
AG00G4UB
Chemical Name:
1-methyl-4-oxo-pyridine-3-carboxamide
CAS Number:
769-49-3
Molecular Formula:
C7H8N2O2
Molecular Weight:
152.1506
MDL Number:
MFCD16883574
IUPAC Name:
1-methyl-4-oxopyridine-3-carboxamide
InChI:
InChI=1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)
InChI Key:
KTLRWTOPTKGYQY-UHFFFAOYSA-N
SMILES:
Cn1ccc(=O)c(c1)C(=O)N
UNII:
VE4S15CI8D
Properties
Complexity:
266
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
152.059g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
152.153g/mol
Monoisotopic Mass:
152.059g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
63.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.1
Literature
| Title | Journal |
|---|---|
| Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100401 |
| Comparison of the nicotinamide catabolism among rat strains. | Bioscience, biotechnology, and biochemistry 20090201 |
| Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver. | Drug metabolism and disposition: the biological fate of chemicals 20080701 |
| 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. | Archivum immunologiae et therapiae experimentalis 20080401 |
| Nicotinamide metabolites accumulate in the tissues of uremic rats. | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101 |
| Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation. | International journal of clinical pharmacology and therapeutics 20070801 |
| Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. | Scandinavian journal of urology and nephrology 20070101 |
| Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. | Pediatric nephrology (Berlin, Germany) 20060601 |
| Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. | Journal of nutritional science and vitaminology 20060401 |
| Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. | Drug metabolism and disposition: the biological fate of chemicals 20060201 |
| Final report of the safety assessment of niacinamide and niacin. | International journal of toxicology 20050101 |
| Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes. | Journal of nutritional science and vitaminology 20041201 |
| Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20030101 |
| Increase in conversion of tryptophan to niacin in pregnant rats. | Advances in experimental medicine and biology 20030101 |
| Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. | Bioscience, biotechnology, and biochemistry 20020601 |
| Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats. | Bioscience, biotechnology, and biochemistry 20010601 |
| [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats]. | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20010601 |
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