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76894-77-4 | 1H-Indole-1-propanoicacid, 3-(1H-imidazol-1-ylmethyl)-2-methyl-
CAS No: 76894-77-4 Catalog No: AG005G4S MDL No:
Product Description
Catalog Number:
AG005G4S
Chemical Name:
1H-Indole-1-propanoicacid, 3-(1H-imidazol-1-ylmethyl)-2-methyl-
CAS Number:
76894-77-4
Molecular Formula:
C16H17N3O2
Molecular Weight:
283.3251
IUPAC Name:
3-[3-(imidazol-1-ylmethyl)-2-methylindol-1-yl]propanoic acid
InChI:
InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21)
InChI Key:
DEQLGSOHGTZKFB-UHFFFAOYSA-N
SMILES:
OC(=O)CCn1c2ccccc2c(c1C)Cn1cncc1
UNII:
31340R8PVU
Properties
Complexity:
377
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
283.132g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
283.331g/mol
Monoisotopic Mass:
283.132g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
60A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
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| Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. | Canadian journal of physiology and pharmacology 20060101 |
| Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis. | Acta neurochirurgica 20040501 |
| In vitro skin penetration of dazmegrel delivered with a bioelastic matrix. | International journal of pharmaceutics 20040301 |
| Skin concentrations of thromboxane synthetase inhibitor after topical application with bioelastic membrane. | Journal of veterinary pharmacology and therapeutics 20040201 |
| Endothelium-dependent noradrenergic hyperresponsiveness induced by thapsigargin in human saphenous veins: role of thromboxane and calcium. | European journal of pharmacology 20040126 |
| Bioelastic membranes for topical application of a thromboxane synthetase inhibitor for protection of skin from pressure injury: a preliminary study. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101 |
| Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. | Journal of cell science 20031101 |
| Chronic thromboxane synthase inhibition prevents fructose-induced hypertension. | Hypertension (Dallas, Tex. : 1979) 20011001 |
| The effects of thromboxane synthase inhibition on reperfusion injury and endothelin-1,2 levels in allograft kidney transplantation in rats. | Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 19990401 |
| 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. | Journal of medicinal chemistry 19920221 |
| Thromboxane A2 and development of genetic hypertension in the Lyon rat strain. | Hypertension (Dallas, Tex. : 1979) 19901201 |
| Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline. | British journal of pharmacology 19901001 |
| [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors. | Journal of medicinal chemistry 19890401 |
| Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | The Journal of clinical investigation 19850101 |
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