200,000+ products from a single source!

sales@angenechem.com

Home > Other Building Blocks > 764-17-0

764-17-0

764-17-0 | Norleucine,6-diazo-5-oxo-

CAS No: 764-17-0 Catalog No: AG005CB6 MDL No:

Product Description

Catalog Number:
AG005CB6
Chemical Name:
Norleucine,6-diazo-5-oxo-
CAS Number:
764-17-0
Molecular Formula:
C6H9N3O3
Molecular Weight:
171.1540
IUPAC Name:
2-amino-6-diazo-5-oxohexanoic acid
InChI:
InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)
InChI Key:
YCWQAMGASJSUIP-UHFFFAOYSA-N
SMILES:
[O-]C(=C[N+]#N)CCC(C(=O)O)N
NSC Number:
7365

Properties

Complexity:
232  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
171.064g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
171.156g/mol
Monoisotopic Mass:
171.064g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
82.4A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
1  
XLogP3:
-3.5  

Literature

Title Journal
Preventing Allograft Rejection by Targeting Immune Metabolism. Cell reports 20151027
Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase. The Journal of biological chemistry 20121026
A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells. American journal of physiology. Cell physiology 20111001
Glutamine analogs promote cytoophidium assembly in human and Drosophila cells. Journal of genetics and genomics = Yi chuan xue bao 20110920
Evidence that chromium modulates cellular cholesterol homeostasis and ABCA1 functionality impaired by hyperinsulinemia--brief report. Arteriosclerosis, thrombosis, and vascular biology 20110501
Synergistic action of hypoosmolarity and glutamine in inducing acute swelling of retinal glial (Müller) cells. Glia 20110201
Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model. International journal of cancer 20101115
Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat. Neuroscience letters 20100326
Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins. Neoplasia (New York, N.Y.) 20100101
Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis. Neurobiology of disease 20090701
Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice. The Tohoku journal of experimental medicine 20090201
Blockade of microglial glutamate release protects against ischemic brain injury. Experimental neurology 20081101
Influence of hyaluronan accumulation during cumulus expansion on in vitro porcine oocyte maturation. Zygote (Cambridge, England) 20081101
Synthesis of potent water-soluble tissue transglutaminase inhibitors. Bioorganic & medicinal chemistry letters 20081015
Premature senescence of human endothelial cells induced by inhibition of glutaminase. Biogerontology 20080801
Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors. Life sciences 20080523
Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and alpha-keto acid homeostasis? Amino acids 20080201
[Isolation of Pseudomonas aurantiaca strains capable of overproduction of phenazine antibiotics]. Mikrobiologiia 20080101
Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus. Chemistry & biology 20071001
Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and alpha-keto acid homeostasis or immunocompetence. Amino acids 20070901
Influence of hyaluronic acid synthesis and cumulus mucification on bovine oocyte in vitro maturation, fertilisation and embryo development. Reproduction, fertility, and development 20070101
Glutamine in the mechanism of ammonia-induced astrocyte swelling. Neurochemistry international 20060101
Differential response of glutamine in cultured neurons and astrocytes. Journal of neuroscience research 20050101
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor. Journal of experimental & clinical cancer research : CR 20041201
Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. European journal of biochemistry 20040201
Glutamine stimulates argininosuccinate synthetase gene expression through cytosolic O-glycosylation of Sp1 in Caco-2 cells. The Journal of biological chemistry 20031226
High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. Endocrinology 20031001
Role of acetyl-L-carnitine in the brain: revealed by Bioradiography. Biochemical and biophysical research communications 20030711
The active conformation of glutamate synthase and its binding to ferredoxin. Journal of molecular biology 20030627
Glutamine delays spontaneous apoptosis in neutrophils. American journal of physiology. Cell physiology 20030601
A molecular warhead and its target: tissue transglutaminase and Celiac Sprue. Chemistry & biology 20030301
Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chemistry & biology 20030301
Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms. Endocrinology 20020101
gamma-Glutamyltranspeptidase and gamma-glutamyl peptide ligases: fluorophosphonate and phosphonodifluoromethyl ketone analogs as probes of tetrahedral transition state and gamma-glutamyl-phosphate intermediate. Methods in enzymology 20020101
Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu? Biochimica et biophysica acta 20011217
Mechanism for acivicin inactivation of triad glutamine amidotransferases. Biochemistry 20010130
Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro. Biochemical and biophysical research communications 20000413
Antiviral effects of 6-diazo-5-oxo-L-norleucin on replication of herpes simplex virus type 1. Antiviral research 19970201
Discriminative effect of gamma-glutamyl transpeptidase inhibitors on metabolism of leukotriene C4 in peritoneal cells. Life sciences 19841119

Related Products

© 2019 Angene International Limited. All rights Reserved.