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Home > Other Building Blocks > 75899-68-2
75899-68-2 | 2-Nonenal, 4-hydroxy-, (2E)-
CAS No: 75899-68-2 Catalog No: AG000YP4 MDL No:MFCD00211020
Product Description
Catalog Number:
AG000YP4
Chemical Name:
2-Nonenal, 4-hydroxy-, (2E)-
CAS Number:
75899-68-2
Molecular Formula:
C9H16O2
Molecular Weight:
156.2221
MDL Number:
MFCD00211020
IUPAC Name:
(E)-4-hydroxynon-2-enal
InChI:
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChI Key:
JVJFIQYAHPMBBX-FNORWQNLSA-N
SMILES:
CCCCCC(/C=C/C=O)O
Properties
Complexity:
119
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
156.115g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
156.225g/mol
Monoisotopic Mass:
156.115g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
37.3A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7
Literature
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|---|---|
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| Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. | European journal of pharmacology 20120305 |
| Effects of 4-hydroxy-2-nonenal on beef heart mitochondrial ultrastructure, oxygen consumption, and metmyoglobin reduction. | Meat science 20120301 |
| 4-hydroxy-2-nonenal mediates genotoxicity and bystander effects caused by Enterococcus faecalis-infected macrophages. | Gastroenterology 20120301 |
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| Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation. | Diabetes 20120301 |
| 4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin-proteasome degradation. | Molecular and cellular endocrinology 20120226 |
| Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: dose- and time-response studies in female MRL+/+ mice. | Toxicology 20120226 |
| Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. | Chemical research in toxicology 20120220 |
| Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. | The Biochemical journal 20120215 |
| Protective effect of indigo naturalis extract against oxidative stress in cultured human keratinocytes. | Journal of ethnopharmacology 20120215 |
| Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120201 |
| Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain. | American journal of physiology. Heart and circulatory physiology 20120201 |
| Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. | Free radical biology & medicine 20120201 |
| Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical. | Free radical biology & medicine 20120201 |
| Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin. | Free radical biology & medicine 20120201 |
| Interplay between plasma oxidative status, cortisol and coping styles in wild alpine marmots, Marmota marmota. | The Journal of experimental biology 20120115 |
| Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA: implication for breast carcinogenesis. | Cancer biology & therapy 20120115 |
| The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4. | Biochemical and biophysical research communications 20120106 |
| Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells. | Chemico-biological interactions 20120105 |
| Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. | Microvascular research 20120101 |
| Tert-Butylhydroquinone pretreatment protects kidney from ischemia-reperfusion injury. | Journal of nephrology 20120101 |
| Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. | American journal of physiology. Renal physiology 20120101 |
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| Biotinylated probes for the analysis of protein modification by electrophiles. | Methods in molecular biology (Clifton, N.J.) 20120101 |
| Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells. | Molecular vision 20120101 |
| Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. | PloS one 20120101 |
| Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. | Biological & pharmaceutical bulletin 20120101 |
| Amyloid-β metabolite sensing: biochemical linking of glycation modification and misfolding. | Journal of Alzheimer's disease : JAD 20120101 |
| Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. | PloS one 20120101 |
| Oxidative stress level in the testes of mice and rats during nickel intoxication. | TheScientificWorldJournal 20120101 |
| Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats. | Oxidative medicine and cellular longevity 20120101 |
| Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. | PloS one 20120101 |
| Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | PloS one 20120101 |
| Multidrug resistance associated protein 1 together with glutathione plays a protective role against 4-hydroxy-2-nonenal-induced oxidative stress in bovine aortic endothelial cells. | Biological & pharmaceutical bulletin 20120101 |
| Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes. | PloS one 20120101 |
| Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. | PloS one 20120101 |
| Gender disparity in susceptibility to oxidative stress and apoptosis induced by autoantibodies specific to RLIP76 in vascular cells. | Antioxidants & redox signaling 20111201 |
| TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. | Journal of the Association for Research in Otolaryngology : JARO 20111201 |
| PEP-1-frataxin significantly increases cell proliferation and neuroblast differentiation by reducing lipid peroxidation in the mouse dentate gyrus. | Neurochemical research 20111201 |
| Development of angiotensin II-induced abdominal aortic aneurysms is independent of catalase in mice. | Journal of cardiovascular pharmacology 20111201 |
| Asbestos surface provides a niche for oxidative modification. | Cancer science 20111201 |
| The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury. | Molecular nutrition & food research 20111201 |
| Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis. | Chemical research in toxicology 20111121 |
| 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. | Chemical research in toxicology 20111121 |
| Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). | Chemico-biological interactions 20111115 |
| Oxidative stress in keratoconus? | Investigative ophthalmology & visual science 20111104 |
| Protective effects of L-type fatty acid-binding protein (L-FABP) in proximal tubular cells against glomerular injury in anti-GBM antibody-mediated glomerulonephritis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101 |
| Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity. | Neurochemical research 20111101 |
| Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion. | Diabetes 20111101 |
| Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress. | Journal of medicinal food 20111101 |
| Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice. | Indian journal of experimental biology 20111101 |
| Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria. | Journal of proteomics 20111019 |
| To tag or not to tag: a comparative evaluation of immunoaffinity-labeling and tandem mass spectrometry for the identification and localization of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation. | Journal of proteomics 20111019 |
| Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells. | Free radical biology & medicine 20111015 |
| Catabolism of 4-hydroxy-2-trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile. | Chemico-biological interactions 20111015 |
| Liquid chromatography/electrospray ionisation mass spectrometric tracking of 4-hydroxy-2(E)-nonenal biotransformations by mouse colon epithelial cells using [1,2-13C2]-4-hydroxy-2(E)-nonenal as stable isotope tracer. | Rapid communications in mass spectrometry : RCM 20111015 |
| Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct. | Journal of the American Chemical Society 20111012 |
| Skeletal muscle effects of electrostimulation after COPD exacerbation: a pilot study. | The European respiratory journal 20111001 |
| Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | Progress in lipid research 20111001 |
| The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas. | Molecular carcinogenesis 20111001 |
| TRPA1 and substance P mediate colitis in mice. | Gastroenterology 20111001 |
| Lipid peroxidation and neurodegenerative disease. | Free radical biology & medicine 20111001 |
| Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin. | Journal of dermatological science 20111001 |
| Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111001 |
| Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. | Journal of receptor and signal transduction research 20111001 |
| Endogenous 4-hydroxy-2-nonenal in microalga Chlorella kessleri acts as a bioactive indicator of pollution with common herbicides and growth regulating factor of hormesis. | Aquatic toxicology (Amsterdam, Netherlands) 20111001 |
| FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia. | Neurological research 20111001 |
| Isotope-coded dimethyl tagging for differential quantification of posttranslational protein carbonylation by 4-hydroxy-2-nonenal, an end-product of lipid peroxidation. | Journal of mass spectrometry : JMS 20111001 |
| Exploring the biology of lipid peroxidation-derived protein carbonylation. | Chemical research in toxicology 20110919 |
| Relationship of electrophilic stress to aging. | Free radical biology & medicine 20110915 |
| Oxidative stress in spiral ganglion cells of pigmented and albino guinea pigs exposed to impulse noise. | Acta oto-laryngologica 20110901 |
| Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. | American journal of physiology. Heart and circulatory physiology 20110901 |
| Oxidative stress in schizophrenia - focusing on the main markers. | Psychiatria Danubina 20110901 |
| Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal. | Chemical research in toxicology 20110815 |
| Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. | Chemical research in toxicology 20110815 |
| Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
| Protective potential of 17β-estradiol against co-exposure of 4-hydroxynonenal and 6-hydroxydopamine in PC12 cells. | Human & experimental toxicology 20110801 |
| Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance. | Antioxidants & redox signaling 20110801 |
| Comparison of immunoreactivities in 4-HNE and superoxide dismutases in the cervical and the lumbar spinal cord between adult and aged dogs. | Experimental gerontology 20110801 |
| Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice. | Experimental dermatology 20110801 |
| Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20110801 |
| Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress. | Journal of neurochemistry 20110801 |
| Distribution and time-course of 4-hydroxynonenal, heat shock protein 110/105 family members and cyclooxygenase-2 expression in the hippocampus of rat during trimethyltin-induced neurodegeneration. | Neurochemical research 20110801 |
| Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. | Gastroenterology 20110801 |
| Brain biomolecules oxidation in portacaval-shunted rats. | Liver international : official journal of the International Association for the Study of the Liver 20110801 |
| Protective effects of tubular liver-type fatty acid-binding protein against glomerular damage in murine IgA nephropathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110701 |
| Lipid peroxidation of poly-unsaturated fatty acids in normal and obese adipose tissues. | Archives of physiology and biochemistry 20110701 |
| A method for detection of 4-hydroxy-2-nonenal adducts in proteins. | Free radical biology & medicine 20110701 |
| Exercise training improves basal blood glucose metabolism with no changes of cytosolic inhibitor B kinase or c-Jun N-terminal kinase activation in skeletal muscle of Otsuka Long-Evans Tokushima fatty rats. | Experimental physiology 20110701 |
| SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy. | American journal of obstetrics and gynecology 20110701 |
| Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice. | Naunyn-Schmiedeberg's archives of pharmacology 20110701 |
| Relating protein adduction to gene expression changes: a systems approach. | Molecular bioSystems 20110701 |
| Complementary antioxidant function of caffeine and green tea polyphenols in normal human skin fibroblasts. | Journal of drugs in dermatology : JDD 20110701 |
| Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615 |
| Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice. | Antioxidants & redox signaling 20110601 |
| Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms. | Anti-cancer drugs 20110601 |
| Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro. | Experimental and molecular pathology 20110601 |
| Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. | The Journal of pharmacology and experimental therapeutics 20110601 |
| Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. | Molecular pharmacology 20110601 |
| Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. | Chemico-biological interactions 20110530 |
| The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase. | Chemico-biological interactions 20110530 |
| Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal. | Chemico-biological interactions 20110530 |
| Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation. | Chemico-biological interactions 20110530 |
| Aldose reductase (AKR1B3) regulates the accumulation of advanced glycosylation end products (AGEs) and the expression of AGE receptor (RAGE). | Chemico-biological interactions 20110530 |
| Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans. | Chemico-biological interactions 20110530 |
| Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds. | Chemico-biological interactions 20110530 |
| Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity. | Chemico-biological interactions 20110530 |
| Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells. | Biochemistry 20110517 |
| 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. | Chemical research in toxicology 20110516 |
| Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal. | Chemical research in toxicology 20110516 |
| Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren syndrome or systemic lupus erythematosus in BALB/c mice. | Free radical biology & medicine 20110515 |
| PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function. | Free radical biology & medicine 20110515 |
| Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats. | Biochemical and biophysical research communications 20110513 |
| Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110501 |
| Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment. | Investigative ophthalmology & visual science 20110501 |
| Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks. | Neuromuscular disorders : NMD 20110501 |
| Interactions of glutathione transferases with 4-hydroxynonenal. | Drug metabolism reviews 20110501 |
| Localization of 4-hydroxy 2-nonenal immunoreactivity in aging human retinal Müller cells. | Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20110501 |
| Aldehyde reduction by cytochrome P450. | Current protocols in toxicology 20110501 |
| Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis. | Histopathology 20110501 |
| Overexpression of aldehyde dehydrogenase-2 attenuates neurotoxicity induced by 4-hydroxynonenal in cultured primary hippocampal neurons. | Neurotoxicity research 20110401 |
| 4-Hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A(2) in cultured Ra2 microglial cells via MAPK pathways. | Neuropathology : official journal of the Japanese Society of Neuropathology 20110401 |
| Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. | European heart journal 20110401 |
| Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice. | Acta neuropathologica 20110401 |
| Therapeutic window for ferulic acid protection against noise-induced hearing loss in the guinea pig. | Acta oto-laryngologica 20110401 |
| Increased levels of 4HNE-protein plasma adducts in Rett syndrome. | Clinical biochemistry 20110401 |
| Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues. | Chemical research in toxicology 20110321 |
| Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes. | Chemico-biological interactions 20110315 |
| Lipid peroxidation products as potential bioindicators of Lyme arthritis. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110301 |
| Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo. | Journal of neurochemistry 20110301 |
| Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. | Neurourology and urodynamics 20110301 |
| A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c. | Journal of mass spectrometry : JMS 20110301 |
| Growth modulation of human cells in vitro by mild oxidative stress and 1,4-dihydropyridine derivative antioxidants. | Collegium antropologicum 20110301 |
| The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. | Toxicology in vitro : an international journal published in association with BIBRA 20110201 |
| The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. | Diabetologia 20110201 |
| The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties. | Free radical biology & medicine 20110201 |
| Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells. | Experimental eye research 20110201 |
| Muscle oxidative capacity during IL-6-dependent cancer cachexia. | American journal of physiology. Regulatory, integrative and comparative physiology 20110201 |
| Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents. | Journal of medicinal chemistry 20110127 |
| Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells. | Free radical biology & medicine 20110115 |
| Trans-4-oxo-2-nonenal potently alters mitochondrial function. | Free radical biology & medicine 20110115 |
| Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: low concentrations of HNE open protein-mediated leaks in the membrane. | Free radical biology & medicine 20110115 |
| SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice. | Brain research 20110112 |
| Dose-dependent effect of nutritional sulfite intake on visual evoked potentials and lipid peroxidation. | Neurotoxicology and teratology 20110101 |
| The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats. | Neurochemical research 20110101 |
| Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease. | Free radical research 20110101 |
| Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal. | Free radical biology & medicine 20110101 |
| Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. | Free radical biology & medicine 20110101 |
| Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry. | Methods in molecular biology (Clifton, N.J.) 20110101 |
| Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart. | Physiological research 20110101 |
| Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis. | Mechanisms of ageing and development 20110101 |
| Effect of Waon therapy on oxidative stress in chronic heart failure. | Circulation journal : official journal of the Japanese Circulation Society 20110101 |
| Effects of 4-hydroxy-2-nonenal, a major lipid peroxidation-derived aldehyde, and N-acetylcysteine on the cyclooxygenase-2 expression in human uterine myometrium. | Gynecologic and obstetric investigation 20110101 |
| Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. | Journal of toxicology and environmental health. Part A 20110101 |
| Role of oxidative tissue injury in the pathophysiology of experimentally induced equine laminitis: a comparison of 2 models. | Journal of veterinary internal medicine 20110101 |
| p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury. | PloS one 20110101 |
| Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment. | Journal of Alzheimer's disease : JAD 20110101 |
| Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. | PloS one 20110101 |
| Hepatotoxicity and nephrotoxicity produced by 4-hydroxy-2-nonenal (4-HNE) following 4-week oral administration to Sprague-Dawley rats. | Journal of toxicology and environmental health. Part A 20110101 |
| Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress. | Medical science monitor : international medical journal of experimental and clinical research 20110101 |
| Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage. | PloS one 20110101 |
| 4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G in rat neutrophils. | Oxidative medicine and cellular longevity 20110101 |
| Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. | PloS one 20110101 |
| The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. | PloS one 20110101 |
| Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats. | The Journal of toxicological sciences 20110101 |
| Indomethacin ameliorates trimethyltin-induced neuronal damage in vivo by attenuating oxidative stress in the dentate gyrus of mice. | Biological & pharmaceutical bulletin 20110101 |
| Protein oxidative damage and heme oxygenase in sunlight-exposed human skin: roles of MAPK responses to oxidative stress. | The Tokai journal of experimental and clinical medicine 20101220 |
| Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal. | Archives of biochemistry and biophysics 20101215 |
| Adipokines, endothelial dysfunction and nutritional status in peritoneal dialysis patients. | Scandinavian journal of urology and nephrology 20101201 |
| Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study. | Free radical biology & medicine 20101201 |
| Xanthine oxidase-derived reactive oxygen species mediate 4-oxo-2-nonenal-induced hepatocyte cell death. | Toxicology and applied pharmacology 20101201 |
| Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. | Diabetes 20101201 |
| Teratogen-induced oxidative stress targets glyceraldehyde-3-phosphate dehydrogenase in the organogenesis stage mouse embryo. | Toxicological sciences : an official journal of the Society of Toxicology 20101201 |
| Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability. | Experimental eye research 20101201 |
| The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats. | Metabolic brain disease 20101201 |
| Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. | Free radical biology & medicine 20101130 |
| Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal. | Blood 20101118 |
| Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. | Free radical biology & medicine 20101115 |
| Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes. | Archives of biochemistry and biophysics 20101115 |
| Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal. | Chemical research in toxicology 20101115 |
| Mass spectrometric characterization of modifications to angiotensin II by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-hydroxy-2(E)-nonenal. | Chemical research in toxicology 20101115 |
| Combined proteomic approaches for the identification of specific amino acid residues modified by 4-hydroxy-2-nonenal under physiological conditions. | Journal of proteome research 20101105 |
| Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. | Journal of the National Cancer Institute 20101103 |
| HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages. | Cardiovascular research 20101101 |
| The physiological behaviour of IMR-32 neuroblastoma cells is affected by a 12-h hypoxia/24-h reoxygenation period. | Neurochemical research 20101101 |
| Qo site of mitochondrial complex III is the source of increased superoxide after transient exposure to hydrogen peroxide. | Journal of molecular and cellular cardiology 20101101 |
| A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. | Experimental neurology 20101101 |
| Suppression of choroidal neovascularization by N-acetyl-cysteine in mice. | Current eye research 20101101 |
| Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice. | Experimental biology and medicine (Maywood, N.J.) 20101101 |
| Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats. | European journal of pharmacology 20101025 |
| Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes. | Chemical research in toxicology 20101018 |
| Quantitative structure-activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells. | Chemico-biological interactions 20101006 |
| Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. | Investigational new drugs 20101001 |
| PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. | Antioxidants & redox signaling 20101001 |
| GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart. | Biochimica et biophysica acta 20101001 |
| Long-acting genipin derivative protects retinal ganglion cells from oxidative stress models in vitro and in vivo through the Nrf2/antioxidant response element signaling pathway. | Journal of neurochemistry 20101001 |
| 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway. | Journal of molecular and cellular cardiology 20101001 |
| Chemistry and biochemistry of lipid peroxidation products. | Free radical research 20101001 |
| Advances in methods for the determination of biologically relevant lipid peroxidation products. | Free radical research 20101001 |
| An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples. | Free radical research 20101001 |
| 4-hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity. | The Journal of nutritional biochemistry 20100901 |
| Dysfunction of glutathione S-transferase leads to excess 4-hydroxy-2-nonenal and H(2)O(2) and impaired cytokine pattern in cultured keratinocytes and blood of vitiligo patients. | Antioxidants & redox signaling 20100901 |
| Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. | American journal of physiology. Gastrointestinal and liver physiology 20100901 |
| NGF induced differentiated PC12 cells as in vitro tool to study 4-hydroxynonenal induced cellular damage. | Toxicology in vitro : an international journal published in association with BIBRA 20100901 |
| Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells. | American journal of physiology. Cell physiology 20100901 |
| Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20100901 |
| Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. | The journal of sexual medicine 20100901 |
| Oxidative stress induction by nanoparticles in THP-1 cells with 4-HNE production: stress biomarker or oxidative stress signalling molecule? | Toxicology in vitro : an international journal published in association with BIBRA 20100901 |
| Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo. | Heart and vessels 20100901 |
| 4-Hydroxynonenal and fat storage: A paradoxical pro-obesity mechanism? | Cell cycle (Georgetown, Tex.) 20100901 |
| Role of 4-hydroxy-trans-2-nonenal in cell functions. | Biochemistry. Biokhimiia 20100901 |
| Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction. | European journal of pharmacology 20100825 |
| Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. | Life sciences 20100814 |
| Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. | Neuroscience 20100811 |
| X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. | Protein science : a publication of the Protein Society 20100801 |
| Melatonin protects against taurolithocholic-induced oxidative stress in rat liver. | Journal of cellular biochemistry 20100801 |
| Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction. | Annals of the New York Academy of Sciences 20100801 |
| Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. | Biochemistry 20100727 |
| Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. | Journal of medicinal chemistry 20100722 |
| Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity. | Free radical biology & medicine 20100715 |
| Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats. | Shock (Augusta, Ga.) 20100701 |
| 5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase. | Free radical research 20100701 |
| Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry. | Journal of the American Society for Mass Spectrometry 20100701 |
| A fish-oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice. | Free radical research 20100701 |
| DNA cross-link induced by trans-4-hydroxynonenal. | Environmental and molecular mutagenesis 20100701 |
| Effect of the overexpression of mutant ubiquitin (K48R) on the cellular response induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation. | Neuroscience letters 20100625 |
| Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue. | Neuron 20100624 |
| Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease. | Free radical biology & medicine 20100615 |
| Levels of oxidative damage and lipid peroxidation in thyroid neoplasia. | Head & neck 20100601 |
| Investigation of the use of antioxidants to diminish the adverse effects of postnatal glucocorticoid treatment on mortality and cardiac development. | Neonatology 20100601 |
| Profiles of antioxidant gene expression and physiological changes by thermal and hypoosmotic stresses in black porgy (Acanthopagrus schlegeli). | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601 |
| Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. | Hypertension research : official journal of the Japanese Society of Hypertension 20100601 |
| The effects of the selective mineralocorticoid receptor antagonist eplerenone on hepatic fibrosis induced by bile duct ligation in rat. | International journal of molecular medicine 20100601 |
| Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal. | Environmental and molecular mutagenesis 20100601 |
| Exposure to chrysotile asbestos causes carbonylation of glucose 6-phosphate dehydrogenase through a reaction with lipid peroxidation products in human lung epithelial cells. | Toxicology letters 20100519 |
| Systems analysis of protein modification and cellular responses induced by electrophile stress. | Accounts of chemical research 20100518 |
| Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death. | Free radical biology & medicine 20100515 |
| Using isotopic tools to dissect and quantitate parallel metabolic pathways. | Journal of the American Chemical Society 20100512 |
| Reduced cellular redox status induces 4-hydroxynonenal-mediated caspase 3 activation leading to erythrocyte death during chronic arsenic exposure in rats. | Toxicology and applied pharmacology 20100501 |
| Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. | Journal of applied physiology (Bethesda, Md. : 1985) 20100501 |
| Natural IgM antibodies against oxidation-specific epitopes. | Journal of clinical immunology 20100501 |
| Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea. | Neuroscience letters 20100412 |
| Hydrogen sulfide scavenges the cytotoxic lipid oxidation product 4-HNE. | Neurotoxicity research 20100401 |
| Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. | Antioxidants & redox signaling 20100401 |
| Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease. | Journal of gastroenterology 20100401 |
| Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. | Radiology 20100401 |
| Identification of carbonylation sites in apomyoglobin after exposure to 4-hydroxy-2-nonenal by solid-phase enrichment and liquid chromatography-electrospray ionization tandem mass spectrometry. | Journal of mass spectrometry : JMS 20100401 |
| Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. | Bioorganic & medicinal chemistry 20100401 |
| Science to practice: will randomized prospective clinical trials be necessary for RF ablation of large liver tumors with liposomal doxorubicin? | Radiology 20100401 |
| Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20100401 |
| Lutein and docosahexaenoic acid prevent cortex lipid peroxidation in streptozotocin-induced diabetic rat cerebral cortex. | Neuroscience 20100310 |
| Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. | American journal of physiology. Gastrointestinal and liver physiology 20100301 |
| p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. | American journal of physiology. Cell physiology 20100301 |
| Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. | Neuropharmacology 20100301 |
| Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid beta formation in NT2N neurons. | Biochimie 20100301 |
| Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells. | Experimental eye research 20100301 |
| The antioxidant effect of green tea catechin ameliorates experimental liver injury. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20100301 |
| Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteins. | Shock (Augusta, Ga.) 20100301 |
| Oxidative stress, inflammation and nutritional status during darbepoetin alpha treatment in peritoneal dialysis patients. | Clinical nephrology 20100301 |
| Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress. | Metabolic brain disease 20100301 |
| C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. | IUBMB life 20100301 |
| Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. | Biochemistry 20100223 |
| Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells. | Journal of neuroscience research 20100215 |
| Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats. | Neurochemical research 20100201 |
| Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex. | Free radical biology & medicine 20100201 |
| HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats. | Free radical research 20100201 |
| Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action. | Experimental eye research 20100201 |
| Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid. | Neurochemistry international 20100201 |
| Oxidative stress in the progression of Alzheimer disease in the frontal cortex. | Journal of neuropathology and experimental neurology 20100201 |
| Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration. | Archives of ophthalmology (Chicago, Ill. : 1960) 20100201 |
| Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis. | The Journal of pharmacy and pharmacology 20100201 |
| Selenium attenuates A beta production and A beta-induced neuronal death. | Neuroscience letters 20100129 |
| Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway. | World journal of gastroenterology 20100121 |
| 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | Toxicology and applied pharmacology 20100115 |
| The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal. | Biochemical and biophysical research communications 20100115 |
| High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases. | Mutation research 20100105 |
| Melatonin and Trolox ameliorate duodenal LPS-induced disturbances and oxidative stress. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100101 |
| 4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy. | Neurotoxicity research 20100101 |
| Participation of 5-lipoxygenase-derived LTB(4) in 4-hydroxynonenal-enhanced MMP-2 production in vascular smooth muscle cells. | Atherosclerosis 20100101 |
| The human hGSTA5 gene encodes an enzymatically active protein. | Biochimica et biophysica acta 20100101 |
| Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. | Free radical biology & medicine 20100101 |
| Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells. | Investigative ophthalmology & visual science 20100101 |
| In utero exposure to benzene disrupts fetal hematopoietic progenitor cell growth via reactive oxygen species. | Toxicological sciences : an official journal of the Society of Toxicology 20100101 |
| Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study. | Free radical biology & medicine 20100101 |
| Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. | Investigative ophthalmology & visual science 20100101 |
| Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration. | Neurochemistry international 20100101 |
| Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. | American journal of physiology. Gastrointestinal and liver physiology 20100101 |
| Disruption of the mGsta4 gene increases life span of C57BL mice. | The journals of gerontology. Series A, Biological sciences and medical sciences 20100101 |
| Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101 |
| Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. | Circulation journal : official journal of the Japanese Circulation Society 20100101 |
| Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats. | Pathology 20100101 |
| Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid. | Chemical research in toxicology 20100101 |
| N-acetylcysteine prevents 4-hydroxynonenal- and amyloid-beta-induced modification and inactivation of neprilysin in SH-SY5Y cells. | Journal of Alzheimer's disease : JAD 20100101 |
| Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes. | Arthritis research & therapy 20100101 |
| Exploring the antiperoxidative potential of morin on cyclophosphamide and flutamide-induced lipid peroxidation and changes in cholesterol profile in rabbit model. | Acta poloniae pharmaceutica 20100101 |
| Influence of 4-hydroxynonenal and spleen cells on primary hepatocyte culture and a novel liver-derived cell line resembling hepatocyte stem cells. | Acta biochimica Polonica 20100101 |
| Induction of CMV-1 promoter by 4-hydroxy-2-nonenal in human embryonic kidney cells. | Acta biochimica Polonica 20100101 |
| Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses. | Acta biochimica Polonica 20100101 |
| Interval hypoxic training in complex treatment of Helicobacter pylori-associated peptic ulcer disease. | Acta biochimica Polonica 20100101 |
| Growth suppression of human breast carcinoma stem cells by lipid peroxidation product 4-hydroxy-2-nonenal and hydroxyl radical-modified collagen. | Acta biochimica Polonica 20100101 |
| Decreased carbohydrate metabolism enzyme activities in the glaucomatous trabecular meshwork. | Molecular vision 20100101 |
| A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice. | Biological & pharmaceutical bulletin 20100101 |
| Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence of hypertension. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101 |
| Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis. | Arthritis research & therapy 20100101 |
| Activation of metallothionein transcription by 4-hydroxynonenal. | Journal of biochemical and molecular toxicology 20100101 |
| Pinealectomy aggravates acute pancreatitis in the rat. | Pharmacological reports : PR 20100101 |
| Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease. | Molecular vision 20100101 |
| Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments. | Journal of lipid research 20091201 |
| Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature. | Investigative ophthalmology & visual science 20091201 |
| Antioxidative and antigenotoxic effects of garlic (Allium sativum L.) prepared by different processing methods. | Plant foods for human nutrition (Dordrecht, Netherlands) 20091201 |
| Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. | Free radical biology & medicine 20091201 |
| Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. | American journal of physiology. Endocrinology and metabolism 20091201 |
| Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear. | Acta oto-laryngologica 20091201 |
| A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats. | Nutritional neuroscience 20091201 |
| The effect of antioxidant on development of fibrosis by cisplatin in rats. | Journal of pharmacological sciences 20091201 |
| Influence of pyridoxylidene aminoguanidine on biomarkers of the oxidative stress and selected metabolic parameters of rats with diabetes mellitus. | General physiology and biophysics 20091201 |
| Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. | The Journal of biological chemistry 20091127 |
| Paving a catabolic highway: catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. | The Journal of biological chemistry 20091127 |
| Differential distribution of 4-hydroxynonenal adducts to sulfur and nitrogen residues in blood proteins as revealed using Raney nickel and gas chromatography-mass spectrometry. | Free radical biology & medicine 20091115 |
| Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization. | Chemico-biological interactions 20091110 |
| Cruciferous nutraceutical 3H-1,2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by MPTP, MPP(+), 6-OHDA, HNE and acrolein. | Neurochemical research 20091101 |
| The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury. | Neurotoxicity research 20091101 |
| Detection and identification of 4-hydroxy-2-nonenal Schiff-base adducts along with products of Michael addition using data-dependent neutral loss-driven MS3 acquisition: method evaluation through an in vitro study on cytochrome c oxidase modifications. | Proteomics 20091101 |
| Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. | American journal of physiology. Gastrointestinal and liver physiology 20091101 |
| Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. | The Biochemical journal 20091023 |
| Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. | The Journal of biological chemistry 20091016 |
| The role of c-Jun phosphorylation in EpRE activation of phase II genes. | Free radical biology & medicine 20091015 |
| Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. | The Journal of biological chemistry 20091002 |
| Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. | Experimental gerontology 20091001 |
| Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal. | Chemical research in toxicology 20091001 |
| 4-Hydroxy-2-nonenal induces calcium overload via the generation of reactive oxygen species in isolated rat cardiac myocytes. | Journal of cardiac failure 20091001 |
| Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. | Journal of medicinal food 20091001 |
| Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. | The Journal of biological chemistry 20090925 |
| Mass spectrometric characterization and redox instability of turkey and chicken myoglobins as induced by unsaturated aldehydes. | Journal of agricultural and food chemistry 20090923 |
| Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. | Free radical biology & medicine 20090901 |
| An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. | Molecular & cellular proteomics : MCP 20090901 |
| Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation. | Chemical research in toxicology 20090901 |
| Increased lipid peroxidation in Down's syndrome mouse models. | Journal of neurochemistry 20090901 |
| Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones. | Chemical research in toxicology 20090901 |
| Fluorescent detection of lipid peroxidation derived protein adducts upon in-vitro cigarette smoke exposure. | Toxicology mechanisms and methods 20090901 |
| Persistent accumulation of 4-hydroxynonenal-protein adducts in gastric mucosa after Helicobacter pylori eradication. | Collegium antropologicum 20090901 |
| Sulforaphane improves cognitive function administered following traumatic brain injury. | Neuroscience letters 20090828 |
| Rapid and easy method for monitoring oxidative stress markers in body fluids of patients with asbestos or silica-induced lung diseases. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815 |
| Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity. | The Biochemical journal 20090813 |
| Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: reduction of oxidative stress and maintenance of the glutathione redox state. | Brain research 20090804 |
| Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells. | Biochimica et biophysica acta 20090801 |
| Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury. | Journal of neurotrauma 20090801 |
| Adduct formation of 4-hydroxynonenal and malondialdehyde with elongation factor-2 in vitro and in vivo. | Free radical biology & medicine 20090801 |
| Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. | Hepatology (Baltimore, Md.) 20090801 |
| Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes. | European heart journal 20090801 |
| Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. | Bipolar disorders 20090801 |
| Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells. | Annals of the New York Academy of Sciences 20090801 |
| Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase. | Annals of the New York Academy of Sciences 20090801 |
| Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease. | Biomedical research (Tokyo, Japan) 20090801 |
| Ochratoxin A-mediated DNA and protein damage: roles of nitrosative and oxidative stresses. | Toxicological sciences : an official journal of the Society of Toxicology 20090701 |
| Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090701 |
| Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig. | Neurochemistry international 20090701 |
| Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice. | Hypertension (Dallas, Tex. : 1979) 20090701 |
| Soluble endoglin modulates aberrant cerebral vascular remodeling. | Annals of neurology 20090701 |
| Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung. | The Chinese journal of physiology 20090630 |
| Methylamine dichloramine may play a role in the process of colorectal disease through architectural and oxidative changes in crypts in mice. | Life sciences 20090619 |
| Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal. | Mutation research 20090618 |
| Tissue concentrations of 4-HNE in the black walnut extract model of laminitis: indication of oxidant stress in affected laminae. | Veterinary immunology and immunopathology 20090615 |
| Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma. | Free radical biology & medicine 20090615 |
| B vitamins alleviate indices of neuropathic pain in diabetic rats. | European journal of pharmacology 20090610 |
| Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. | Behavioural brain research 20090608 |
| Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. | Brain research 20090605 |
| Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury. | Neuroscience letters 20090522 |
| Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. | Chemical research in toxicology 20090518 |
| Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. | Free radical biology & medicine 20090515 |
| Comparative study on high fat diet-induced 4-hydroxy-2E-nonenal adducts in the hippocampal CA1 region of C57BL/6N and C3H/HeN mice. | Neurochemical research 20090501 |
| High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. | Journal of lipid research 20090501 |
| How much ozone bactericidal activity is compromised by plasma components? | Journal of applied microbiology 20090501 |
| Mrp1 localization and function in cardiac mitochondria after doxorubicin. | Molecular pharmacology 20090501 |
| L-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress. | Alcohol (Fayetteville, N.Y.) 20090501 |
| Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. | Chemical research in toxicology 20090501 |
| Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. | Journal of cardiovascular pharmacology 20090501 |
| Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice. | Neurobiology of disease 20090501 |
| Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. | Chemical research in toxicology 20090501 |
| Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex. | Journal of neurochemistry 20090501 |
| A rat model of human immunodeficiency virus 1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors. | Journal of neuropathology and experimental neurology 20090501 |
| HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins. | The Journal of biological chemistry 20090403 |
| Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal. | Molecular & cellular proteomics : MCP 20090401 |
| Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. | Molecular and cellular biochemistry 20090401 |
| Cruciferous dithiolethione-mediated coordinated induction of total cellular and mitochondrial antioxidants and phase 2 enzymes in human primary cardiomyocytes: cytoprotection against oxidative/electrophilic stress and doxorubicin toxicity. | Experimental biology and medicine (Maywood, N.J.) 20090401 |
| Western blot analysis for 4-hydroxy-2-nonenal (HNE)-modified proteins in paraquat-treated mice. | Legal medicine (Tokyo, Japan) 20090401 |
| Oxidative stress in small-for-gestational age (SGA) term newborns and their mothers. | Free radical research 20090401 |
| N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with Type 2 diabetes mellitus. | Journal of endocrinological investigation 20090401 |
| Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1. | Circulation 20090331 |
| Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. | Chemico-biological interactions 20090316 |
| Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes. | Chemico-biological interactions 20090316 |
| Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts. | Chemico-biological interactions 20090316 |
| Comparative analysis of gene expression changes mediated by individual constituents of hemozoin. | Chemical research in toxicology 20090316 |
| Neuroprotective effects of vitamin E on adult rat motor neurones following facial nerve avulsion. | Acta oto-laryngologica 20090301 |
| Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases. | Journal of neuroscience research 20090301 |
| RLIP76: A novel glutathione-conjugate and multi-drug transporter. | Biochemical pharmacology 20090301 |
| Multicenter study to assess potential hazards from exposure to lipid peroxidation products in soya bean oil from Trilucent breast implants. | Regulatory toxicology and pharmacology : RTP 20090301 |
| Ethambutol-induced toxicity is mediated by zinc and lysosomal membrane permeabilization in cultured retinal cells. | Toxicology and applied pharmacology 20090301 |
| 4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase. | Free radical biology & medicine 20090301 |
| Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. | American journal of physiology. Gastrointestinal and liver physiology 20090301 |
| Aging augments mitochondrial susceptibility to heat stress. | American journal of physiology. Regulatory, integrative and comparative physiology 20090301 |
| NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart. | American journal of physiology. Heart and circulatory physiology 20090301 |
| Elevated oxidative stress, iron accumulation around microvessels and increased 4-hydroxynonenal immunostaining in zone 1 of the liver acinus in hypercholesterolemic rabbits. | Free radical research 20090301 |
| Activated intrarenal reactive oxygen species and renin angiotensin system in IgA nephropathy. | Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20090301 |
| [Metabolism and detoxification of the lipid derived aldehyde, 4-Hydroxynonenal in diabetic cataractogenesis in rat]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20090301 |
| Electrochemical determination of thioredoxin redox states. | Analytical chemistry 20090215 |
| 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells. | Biochemical and biophysical research communications 20090213 |
| Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. | Circulation research 20090213 |
| Development of a derivatisation method for the analysis of aldehyde modified amino acid residues in proteins by Fourier transform mass spectrometry. | Analytica chimica acta 20090209 |
| Changes in transient receptor potential vanilloid (TRPV) 1, 2, 3 and 4 expression in mouse inner ear following gentamicin challenge. | Acta oto-laryngologica 20090201 |
| Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE. | Investigative ophthalmology & visual science 20090201 |
| Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs. | Carcinogenesis 20090201 |
| Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells. | Journal of neurochemistry 20090201 |
| Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification. | Molecular nutrition & food research 20090201 |
| [Inflammation-related oxidized lipid mediators]. | Seikagaku. The Journal of Japanese Biochemical Society 20090201 |
| [Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20090201 |
| Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. | The Biochemical journal 20090115 |
| MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. | Free radical biology & medicine 20090115 |
| Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. | Analytical chemistry 20090115 |
| Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090115 |
| Relationship between protein and mitochondrial DNA oxidative injury and telomere length and muscle loss in healthy elderly subjects. | Archives of gerontology and geriatrics 20090101 |
| Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101 |
| Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury. | Journal of neuroscience research 20090101 |
| Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats. | Psychopharmacology 20090101 |
| Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. | Journal of pineal research 20090101 |
| Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells. | Archives of biochemistry and biophysics 20090101 |
| Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal. | Toxicological sciences : an official journal of the Society of Toxicology 20090101 |
| Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction. | Free radical research 20090101 |
| Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA. | Chemical research in toxicology 20090101 |
| Effect of zinc exposure on HNE and GLT-1 in spinal cord culture. | Neurotoxicology 20090101 |
| Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates. | International journal of oncology 20090101 |
| Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse. | Neurochemistry international 20090101 |
| Pore dilation occurs in TRPA1 but not in TRPM8 channels. | Molecular pain 20090101 |
| Practical highly enantioselective synthesis of (R)- and (S)-(E)-4-hydroxynon-2-enal. | Acta biochimica Polonica 20090101 |
| Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters. | Journal of biomedical science 20090101 |
| Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat. | Journal of biomedical science 20090101 |
| Detection of 4-hydroxy-2-nonenal- and 3-nitrotyrosine-modified proteins using a proteomics approach. | Methods in molecular biology (Clifton, N.J.) 20090101 |
| Oxidative changes in the rat brain by intraperitoneal injection of ferric nitrilotriacetate. | Redox report : communications in free radical research 20090101 |
| Mechanisms of nitrosamine-mediated neurodegeneration: potential relevance to sporadic Alzheimer's disease. | Journal of Alzheimer's disease : JAD 20090101 |
| Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive nonshivering thermogenesis but displays increased sensitivity toward carbon-centered radicals. | Physiological and biochemical zoology : PBZ 20090101 |
| Frailty syndrome is associated with altered circulating redox balance and increased markers of oxidative stress. | International journal of immunopathology and pharmacology 20090101 |
| Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli. | International journal of biological sciences 20090101 |
| Increased markers of oxidative stress in plasma of patients with chronic pancreatitis. | Neuro endocrinology letters 20090101 |
| Proteomics identification of carbonylated and HNE-bound brain proteins in Alzheimer's disease. | Methods in molecular biology (Clifton, N.J.) 20090101 |
| Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). | Aging 20090101 |
| Distribution of 4-hydroxynonenal-protein conjugates as a marker of lipid peroxidation and parameter of malignancy in astrocytic and ependymal tumors of the brain. | Tumori 20090101 |
| The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. | FEBS letters 20081224 |
| NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity. | Free radical biology & medicine 20081215 |
| 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. | Archives of biochemistry and biophysics 20081215 |
| Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain. | Cellular and molecular neurobiology 20081201 |
| Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk--a preliminary study. | Molecular nutrition & food research 20081201 |
| The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS. | Analytical and bioanalytical chemistry 20081201 |
| Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. | Free radical biology & medicine 20081201 |
| Mechanism of alcohol-induced oxidative stress and neuronal injury. | Free radical biology & medicine 20081201 |
| Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption. | Free radical biology & medicine 20081201 |
| Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage. | Journal of neuropathology and experimental neurology 20081201 |
| Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury. | Rejuvenation research 20081201 |
| Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke. | Polskie Archiwum Medycyny Wewnetrznej 20081201 |
| Melatonin decreases homocysteine level in blood of rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201 |
| In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal. | Chemical research in toxicology 20081201 |
| Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. | Journal of molecular biology 20081128 |
| Observation of heavy atom effects in the development of water soluble caged 4-hydroxy-trans-2-nonenal. | Organic & biomolecular chemistry 20081121 |
| Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. | Free radical biology & medicine 20081115 |
| 4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways. | Free radical biology & medicine 20081115 |
| Proteomic analysis of brain protein expression levels in NF-kappabeta p50 -/- homozygous knockout mice. | Brain research 20081113 |
| The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence. | Biochemistry 20081104 |
| Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria. | American journal of physiology. Renal physiology 20081101 |
| Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading. | Journal of applied physiology (Bethesda, Md. : 1985) 20081101 |
| Low glutathione level favors formation of DNA adducts to 4-hydroxy-2(E)-nonenal, a major lipid peroxidation product. | Chemical research in toxicology 20081101 |
| The effect of green tea on oxidative damage and tumour formation in Lobund-Wistar rats. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20081101 |
| Down-regulation of Notch1 expression is involved in HL-60 cell growth inhibition induced by 4-hydroxynonenal, a product of lipid peroxidation. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101 |
| Comparative effects of N-acetyl-L-cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats. | Canadian journal of physiology and pharmacology 20081101 |
| Identification of proteins adducted by lipid peroxidation products in plasma and modifications of apolipoprotein A1 with a novel biotinylated phospholipid probe. | Journal of proteome research 20081003 |
| Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver. | Cell biology and toxicology 20081001 |
| Immunohistochemical localization of alpha-tocopherol transfer protein and lipoperoxidation products in human first-trimester and term placenta. | European journal of obstetrics, gynecology, and reproductive biology 20081001 |
| Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. | Thorax 20081001 |
| Age-related alterations of oxidative stress markers in the mouse hippocampal CA1 sector. | Experimental and molecular pathology 20081001 |
| Effect of water-soluble coenzyme Q10 on noise-induced hearing loss in guinea pigs. | Acta oto-laryngologica 20081001 |
| Influence of cytotoxic doses of 4-hydroxynonenal on selected neurotransmitter receptors in PC-12 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20081001 |
| 4-Hydroxynonenal-modified Ro 60 autoantigen accelerates autoimmunity in experimental animals. | Rheumatology (Oxford, England) 20081001 |
| Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. | American journal of physiology. Renal physiology 20081001 |
| Inhibition of the lipopolysaccharide-induced stimulation of the members of the MAPK family in human monocytes/macrophages by 4-hydroxynonenal, a product of oxidized omega-6 fatty acids. | The American journal of pathology 20081001 |
| High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function. | Biochemical Society transactions 20081001 |
| RLIP76 in defense of radiation poisoning. | International journal of radiation oncology, biology, physics 20081001 |
| Use of an in vitro digestion model to study the bioaccessibility of 4-hydroxy-2-nonenal and related aldehydes present in oxidized oils rich in omega-6 acyl groups. | Journal of agricultural and food chemistry 20080924 |
| The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. | Archives of biochemistry and biophysics 20080915 |
| Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. | Science (New York, N.Y.) 20080912 |
| Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. | Experimental neurology 20080901 |
| Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions. | American journal of physiology. Gastrointestinal and liver physiology 20080901 |
| C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080901 |
| The effects of NaCl on lipid peroxidation-derived aldehyde, 4-hydroxy-2-hexenal formation in boiled yellowtail meat. | Bioscience, biotechnology, and biochemistry 20080901 |
| Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus. | Journal of Alzheimer's disease : JAD 20080901 |
| Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. | Brain research 20080821 |
| Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA. | Journal of the American Chemical Society 20080820 |
| Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases. | Toxicological sciences : an official journal of the Society of Toxicology 20080801 |
| Peroxide-induced cell death and lipid peroxidation in C6 glioma cells. | Toxicology in vitro : an international journal published in association with BIBRA 20080801 |
| Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells. | American journal of physiology. Cell physiology 20080801 |
| Mammalian cytosolic glutathione transferases. | Current protein & peptide science 20080801 |
| Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | Mutation research 20080731 |
| alpha-Tocopherol, MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-free beer. | Toxicology 20080730 |
| Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation. | Biochemistry 20080722 |
| Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE. | Chemical research in toxicology 20080721 |
| High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation. | The Biochemical journal 20080715 |
| Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. | Free radical biology & medicine 20080715 |
| 4-hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation. | Free radical biology & medicine 20080715 |
| TRPA1: irritant detector of the airways. | The Journal of physiology 20080715 |
| 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest. | Medicinal research reviews 20080701 |
| SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase. | American journal of respiratory cell and molecular biology 20080701 |
| Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. | Gut 20080701 |
| Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage. | American journal of physiology. Regulatory, integrative and comparative physiology 20080701 |
| Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia. | Journal of neuropathology and experimental neurology 20080701 |
| An integrated approach for the analysis of biological pathways using mixed models. | PLoS genetics 20080701 |
| Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | The Journal of biological chemistry 20080620 |
| Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. | Blood 20080615 |
| The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases. | The Journal of biological chemistry 20080613 |
| Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611 |
| Dibromoacetonitrile-induced protein oxidation and inhibition of proteasomal activity in rat glioma cells. | Toxicology letters 20080610 |
| Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. | The Journal of biological chemistry 20080606 |
| Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080601 |
| S-allylcysteine ameliorates ischemia and reperfusion induced renal damage. | Phytotherapy research : PTR 20080601 |
| Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart. | American journal of physiology. Heart and circulatory physiology 20080601 |
| Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. | Arteriosclerosis, thrombosis, and vascular biology 20080601 |
| Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. | Apoptosis : an international journal on programmed cell death 20080601 |
| Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease. | Journal of cellular and molecular medicine 20080601 |
| A lipid-derived endogenous inducer of COX-2: a bridge between inflammation and oxidative stress. | Molecules and cells 20080531 |
| Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. | Human molecular genetics 20080515 |
| Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. | Transplantation 20080515 |
| Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. | Brain research 20080513 |
| Edaravone prevents kainic acid-induced neuronal death. | Brain research 20080513 |
| FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes. | Diabetes 20080501 |
| Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation. | Journal of neurochemistry 20080501 |
| Lipid peroxidation product 4-hydroxynonenal contributes to bladder smooth muscle damage. | Urology 20080501 |
| Redox regulation of diaphragm proteolysis during mechanical ventilation. | American journal of physiology. Regulatory, integrative and comparative physiology 20080501 |
| Role of gp91phox-containing NADPH oxidase in left ventricular remodeling induced by intermittent hypoxic stress. | American journal of physiology. Heart and circulatory physiology 20080501 |
| Immunohistochemical analysis of aldehyde-modified proteins in drusen in cynomolgus monkeys (Macaca fascicularis). | Experimental eye research 20080501 |
| [The mechanism of inhibition by ginkgolide B on interleukin-8 production induced by 4-hydroxynonenal in bronchial epithelial cells]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20080501 |
| Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential. | Bioscience reports 20080429 |
| A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. | Neuroscience 20080422 |
| Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. | Journal of molecular biology 20080404 |
| Glutathione content as a potential mediator of the vulnerability of cultured fetal cortical neurons to ethanol-induced apoptosis. | Journal of neuroscience research 20080401 |
| Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells. | Free radical biology & medicine 20080401 |
| Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species? | Chemical research in toxicology 20080401 |
| Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease. | Neurobiology of disease 20080401 |
| Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice. | Biochemistry 20080325 |
| Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080319 |
| Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. | The Biochemical journal 20080315 |
| Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide. | Brain research 20080304 |
| Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on 4-hydroxy-2-nonenal-induced apoptotic T cell death. | The Journal of nutritional biochemistry 20080301 |
| Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat. | Journal of applied physiology (Bethesda, Md. : 1985) 20080301 |
| Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells. | Toxicology and applied pharmacology 20080301 |
| Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid. | Neurotoxicology 20080301 |
| Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer. | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080301 |
| Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation. | Biochemistry 20080212 |
| Aberrant expression of selenoproteins in the progression of colorectal cancer. | Cancer letters 20080208 |
| Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose. | Toxicology 20080203 |
| Oxidative damage in gill of Mytilus edulis from Merseyside, UK, and reversibility after depuration. | Environmental pollution (Barking, Essex : 1987) 20080201 |
| Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal. | Journal of lipid research 20080201 |
| Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase. | American journal of physiology. Endocrinology and metabolism 20080201 |
| S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory. | Hepatology (Baltimore, Md.) 20080201 |
| A Phytochemically characterized extract of Cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils. | Planta medica 20080201 |
| Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. | Chemical research in toxicology 20080201 |
| Toxic oxygenated alpha,beta-unsaturated aldehydes and their study in foods: a review. | Critical reviews in food science and nutrition 20080201 |
| Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. | Toxicology and applied pharmacology 20080115 |
| Oxidative stress in neurodegeneration in dentatorubral-pallidoluysian atrophy. | Journal of the neurological sciences 20080115 |
| Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress. | Brain research 20080110 |
| 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. | Biochemistry 20080108 |
| Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. | Biochemistry 20080108 |
| Selective iNOS inhibition reduces renal damage induced by cisplatin. | Toxicology letters 20080104 |
| Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women. | Life sciences 20080102 |
| Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. | Neurobiology of aging 20080101 |
| Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. | British journal of pharmacology 20080101 |
| The role of amino phospholipids in the removal of the cito- and geno-toxic aldehydes produced during lipid oxidation. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101 |
| Comparative study of hydrogen peroxide- and 4-hydroxy-2-nonenal-induced cell death in HT22 cells. | Neurochemistry international 20080101 |
| Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog. | Experimental neurology 20080101 |
| 4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases. | Molecular aspects of medicine 20080101 |
| Mitochondrial dysfunction in aging rat brain following transient global ischemia. | Advances in experimental medicine and biology 20080101 |
| Mechanism of destruction of microtubule structures by 4-hydroxy-2-nonenal. | Cell structure and function 20080101 |
| Alcohol-induced oxidative stress in the liver: in vivo measurements. | Methods in molecular biology (Clifton, N.J.) 20080101 |
| Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption. | Methods in molecular biology (Clifton, N.J.) 20080101 |
| Changes in IL-8 release and intracellular content in DMSO-differentiated HL-60 cells after treatment with 4-hydroxynonenal. | Cell biochemistry and function 20080101 |
| Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. | Acute cardiac care 20080101 |
| Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. | BMC medical genetics 20080101 |
| The various impacts of the hepatitis C virus core protein upon hepatic oxidative stress after common bile duct ligation and partial hepatectomy. | Redox report : communications in free radical research 20080101 |
| 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase. | Arthritis research & therapy 20080101 |
| Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. | Scandinavian journal of gastroenterology 20080101 |
| The Cytotoxic lipid peroxidation product 4-hydroxy-2-nonenal covalently modifies a selective range of proteins linked to respiratory function in plant mitochondria. | The Journal of biological chemistry 20071228 |
| Site-specific effects of peptide lipidation on beta-amyloid aggregation and cytotoxicity. | The Journal of biological chemistry 20071221 |
| 4-Hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G. | Free radical biology & medicine 20071215 |
| Lipid peroxidation scavengers prevent the carbonylation of cytoskeletal brain proteins induced by glutathione depletion. | Neurochemical research 20071201 |
| Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury. | Toxicology in vitro : an international journal published in association with BIBRA 20071201 |
| An expeditious synthesis of 4-hydroxy-2E-nonenal (4-HNE), its dimethyl acetal and of related compounds. | Chemistry and physics of lipids 20071201 |
| Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. | Free radical biology & medicine 20071201 |
| Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide. | Free radical biology & medicine 20071201 |
| X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants. | The European journal of neuroscience 20071201 |
| Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4-hydroxy-2-nonenal by liquid chromatography-tandem mass spectrometry using data-dependent and neutral loss-driven MS3 acquisition. | Journal of mass spectrometry : JMS 20071201 |
| Oxidative stress and cellular stress response in diabetic nephropathy. | Cell stress & chaperones 20071201 |
| Angiotensin II receptor blocker reduces oxidative stress and attenuates hypoxia-induced left ventricular remodeling in apolipoprotein E-knockout mice. | Hypertension research : official journal of the Japanese Society of Hypertension 20071201 |
| Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties. | Neuroscience 20071123 |
| Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL. | The Journal of biological chemistry 20071116 |
| Fourier transform ion cyclotron resonance mass spectrometry of covalent adducts of proteins and 4-hydroxy-2-nonenal, a reactive end-product of lipid peroxidation. | Analytical and bioanalytical chemistry 20071101 |
| 4-hydroxy-2-alkenals in polyunsaturated fatty acids-fortified infant formulas and other commercial food products. | Food additives and contaminants 20071101 |
| 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. | Arteriosclerosis, thrombosis, and vascular biology 20071101 |
| Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation. | American journal of physiology. Cell physiology 20071101 |
| The effects of the wood preservative copper dimethyldithiocarbamate in the hippocampus of maternal and newborn Long-Evans rats. | Toxicology letters 20071101 |
| Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion. | The American journal of pathology 20071101 |
| Protein oxidative modifications and replicative senescence of WI-38 human embryonic fibroblasts. | Annals of the New York Academy of Sciences 20071101 |
| Effect of fetuin, a TGFbeta antagonist and pentoxifylline, a cytokine antagonist on hepatic stellate cell function and fibrotic parameters in fibrosis. | European journal of pharmacology 20071031 |
| An ion channel essential for sensing chemical damage. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071017 |
| Increased lipid peroxidation and neuron specific enolase in treatment refractory schizophrenics. | Journal of psychiatric research 20071001 |
| Oxidative imbalance in the aging inner ear. | Neurobiology of aging 20071001 |
| Characterization of Taenia solium cysticerci microsomal glutathione S-transferase activity. | Parasitology research 20071001 |
| Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate. | Chemical research in toxicology 20071001 |
| Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: transcriptional responses and cellular pathways. | Neuropharmacology 20071001 |
| Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjögren's syndrome. | The Journal of rheumatology 20071001 |
| Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. | Investigative ophthalmology & visual science 20071001 |
| Olmesartan ameliorates renovascular injury and oxidative stress in Zucker obese rats enhanced by dietary protein. | American journal of hypertension 20071001 |
| Suppression of oxidized LDL-induced PDGF receptor beta activation by ginkgo biloba extract reduces MMP-1 production in coronary smooth muscle cells. | Journal of atherosclerosis and thrombosis 20071001 |
| Quantification of trans-4-hydroxy-2-nonenal enantiomers and metabolites by LC-ESI-MS/MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070915 |
| Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertility. | The Journal of urology 20070901 |
| active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: mapping of modified sites by Fourier transform-ion cyclotron resonance mass spectrometry. | Chemical research in toxicology 20070901 |
| Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. | Journal of neurochemistry 20070901 |
| An angiotensin II type-I receptor blocker, olmesartan medoxomil, attenuates lipid peroxidation in renal injury induced by subtotal nephrectomy. | Clinical and experimental nephrology 20070901 |
| Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response. | The Journal of biological chemistry 20070831 |
| Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal. | The Journal of biological chemistry 20070817 |
| 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. | Proceedings of the National Academy of Sciences of the United States of America 20070814 |
| Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases. | The Journal of biological chemistry 20070810 |
| Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers. | Journal of neuroscience research 20070801 |
| Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization. | Chemical research in toxicology 20070801 |
| Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal. | Investigative ophthalmology & visual science 20070801 |
| Improving the solubility and pharmacological efficacy of curcumin by heat treatment. | Assay and drug development technologies 20070801 |
| Involvement of sensory afferent fibers and lipid peroxidation in the pathogenesis of stress-induced gastric mucosa damage. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070801 |
| Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: in vivo and in vitro studies. | World journal of gastroenterology 20070721 |
| Oxidative stress in a rat model of chronic gliosis. | Neurobiology of aging 20070701 |
| Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta. | Placenta 20070701 |
| Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. | Journal of neurotrauma 20070701 |
| Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. | Free radical biology & medicine 20070615 |
| 4-Hydroxynonenal and PPARgamma ligands affect proliferation, differentiation, and apoptosis in colon cancer cells. | Free radical biology & medicine 20070601 |
| Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent. | Chemical research in toxicology 20070601 |
| Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. | The American journal of pathology 20070601 |
| Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS. | Proteomics 20070601 |
| Temporal characterization of mitochondrial bioenergetics after spinal cord injury. | Journal of neurotrauma 20070601 |
| Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas. | Neuropathology : official journal of the Japanese Society of Neuropathology 20070601 |
| The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell. | FEBS letters 20070529 |
| Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis. | Toxicology 20070520 |
| Theoretical prediction of the p53 gene mutagenic mechanism induced by trans-4-hydroxy-2-nonenal. | The journal of physical chemistry. B 20070517 |
| Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry. | Analytical chemistry 20070515 |
| Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070501 |
| Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury. | Experimental neurology 20070501 |
| Design, synthesis, and application of a hydrazide-functionalized isotope-coded affinity tag for the quantification of oxylipid-protein conjugates. | Analytical chemistry 20070501 |
| Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats. | Alcoholism, clinical and experimental research 20070501 |
| Antioxidant therapy in idiopathic tinnitus: preliminary outcomes. | Archives of medical research 20070501 |
| Antioxidant capacity and protein oxidation in cerebrospinal fluid of amyotrophic lateral sclerosis. | Journal of neurology 20070501 |
| Associative and predictive biomarkers of dementia in HIV-1-infected patients. | Neurology 20070501 |
| Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. | Journal of gastroenterology 20070501 |
| Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid. | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20070501 |
| Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain. | Journal of ethnopharmacology 20070420 |
| Macromolecule oxidation and DNA repair in mussel (Mytilus edulis L.) gill following exposure to Cd and Cr(VI). | Aquatic toxicology (Amsterdam, Netherlands) 20070420 |
| The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). | Free radical biology & medicine 20070415 |
| Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells. | Free radical biology & medicine 20070415 |
| Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. | Atherosclerosis 20070401 |
| The potentiating and protective effects of ascorbate on oxidative stress depend upon the concentration of dietary iron fed C3H mice. | The Journal of nutritional biochemistry 20070401 |
| Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade. | Journal of cellular biochemistry 20070401 |
| Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure. | American journal of respiratory cell and molecular biology 20070401 |
| Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes. | Toxicological sciences : an official journal of the Society of Toxicology 20070401 |
| Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. | Molecular & cellular proteomics : MCP 20070401 |
| Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina. | Experimental eye research 20070401 |
| Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. | Experimental and molecular pathology 20070401 |
| Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica. | The FEBS journal 20070401 |
| Vinylogous Amadori rearrangement: implications in food and biological systems. | Molecular nutrition & food research 20070401 |
| Involvement of oxidative stress on corneal epithelial alterations in a blink-suppressed dry eye. | Investigative ophthalmology & visual science 20070401 |
| Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats. | Investigative ophthalmology & visual science 20070401 |
| Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. | Investigative ophthalmology & visual science 20070401 |
| A nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat. | Neuroscience letters 20070326 |
| Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification--an in vitro study. | Journal of ethnopharmacology 20070321 |
| Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system. | Carcinogenesis 20070301 |
| 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. | Molecular pharmacology 20070301 |
| 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. | Experimental eye research 20070301 |
| Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. | Annals of surgical oncology 20070301 |
| Actin Cys374 as a nucleophilic target of alpha,beta-unsaturated aldehydes. | Free radical biology & medicine 20070301 |
| Role of oxidative stress on pathogenesis of hypertensive cerebrovascular lesions. | Pathology international 20070301 |
| 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approach. | Journal of gastroenterology and hepatology 20070301 |
| Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytes. | Chemical research in toxicology 20070301 |
| Glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia. | The American journal of pathology 20070301 |
| Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis. | Investigative ophthalmology & visual science 20070301 |
| Endotoxemia in newborn rats attenuates acute pancreatitis at adult age. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301 |
| Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation. | The Journal of biological chemistry 20070223 |
| Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. | The Journal of biological chemistry 20070216 |
| The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. | Biochemistry 20070213 |
| Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson's disease. | Neuroscience 20070209 |
| N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death. | Neuroscience research 20070201 |
| Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice. | Journal of hepatology 20070201 |
| Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. | Mechanisms of ageing and development 20070201 |
| Role of peroxynitrite in secondary oxidative damage after spinal cord injury. | Journal of neurochemistry 20070201 |
| Expression and characterization of a sigma-class glutathione S-transferase of the fall webworm, Hyphantria cunea. | Bioscience, biotechnology, and biochemistry 20070201 |
| Proteomics of lipid oxidation-induced oxidation of porcine and bovine oxymyoglobins. | Proteomics 20070201 |
| Evaluation of the 1-methyl-2-phenylindole colorimetric assay for aldehydic lipid peroxidation products in plants: malondialdehyde and 4-hydroxynonenal. | Plant physiology and biochemistry : PPB 20070201 |
| Ethanol-induced modulation of hepatocellular extracellular signal-regulated kinase-1/2 activity via 4-hydroxynonenal. | The Journal of biological chemistry 20070119 |
| Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. | Toxicology 20070118 |
| Edaravone protects the vestibular periphery from free radical-induced toxicity in response to perilymphatic application of (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid. | European journal of pharmacology 20070112 |
| Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. | Neurotoxicology 20070101 |
| Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. | Neurotoxicology 20070101 |
| Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. | Neurotoxicology 20070101 |
| Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity. | The Journal of pharmacology and experimental therapeutics 20070101 |
| Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation. | Chemical research in toxicology 20070101 |
| Role of 4-hydroxynonenal and its metabolites in signaling. | Redox report : communications in free radical research 20070101 |
| Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway. | Redox report : communications in free radical research 20070101 |
| Analysis of HNE metabolism in CNS models. | Redox report : communications in free radical research 20070101 |
| Alpha,beta-unsaturated aldehydes adducts to actin and albumin as potential biomarkers of carbonylation damage. | Redox report : communications in free radical research 20070101 |
| 4-hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production. | Redox report : communications in free radical research 20070101 |
| Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway. | Redox report : communications in free radical research 20070101 |
| The LEC rat: a useful model for studying liver carcinogenesis related to oxidative stress and inflammation. | Redox report : communications in free radical research 20070101 |
| 4-hydroxynonenal in foodstuffs: heme concentration, fatty acid composition and freeze-drying are determining factors. | Redox report : communications in free radical research 20070101 |
| Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. | Redox report : communications in free radical research 20070101 |
| Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells. | Redox report : communications in free radical research 20070101 |
| Synthesis and characterization of 4-hydroxy-2-nonenal derivatives for gas chromatographic analysis with electron capture detection (GC-ECD). | Redox report : communications in free radical research 20070101 |
| Degradation of HNE-modified proteins--possible role of ubiquitin. | Redox report : communications in free radical research 20070101 |
| Higher circulating 4-hydroxynonenal-protein thioether adducts correlate with more severe diastolic dysfunction in spontaneously hypertensive rats. | Redox report : communications in free radical research 20070101 |
| HNE produced by the malaria parasite Plasmodium falciparum generates HNE-protein adducts and decreases erythrocyte deformability. | Redox report : communications in free radical research 20070101 |
| Lipid peroxidation and inflammatory molecules as markers of coronary artery disease. | Redox report : communications in free radical research 20070101 |
| Lipid oxidation products and oxidized low-density lipoproteins impair platelet-derived growth factor receptor activity in smooth muscle cells: implication in atherosclerosis. | Redox report : communications in free radical research 20070101 |
| Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells. | Redox report : communications in free radical research 20070101 |
| Effect of aldehydes derived from oxidative deamination and oxidative stress on beta-amyloid aggregation; pathological implications to Alzheimer's disease. | Journal of neural transmission (Vienna, Austria : 1996) 20070101 |
| Inhibition of lipid peroxidation induced by hydroxyprogesterone caproate by some conventional antioxidants in goat liver homogenates. | Acta poloniae pharmaceutica 20070101 |
| Exploring effects of different nonsteroidal antiinflammatory drugs on lipid peroxidation. Part II. 4-HNE profile. | Acta poloniae pharmaceutica 20070101 |
| Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat. | Redox report : communications in free radical research 20070101 |
| Increased sensitivity to transient global ischemia in aging rat brain. | Advances in experimental medicine and biology 20070101 |
| Uteroplacental inflammation results in blood brain barrier breakdown, increased activated caspase 3 and lipid peroxidation in the late gestation ovine fetal cerebellum. | Developmental neuroscience 20070101 |
| N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology. | Cerebellum (London, England) 20070101 |
| Oxidative modifications of cardiac mitochondria and inhibition of cytochrome c oxidase activity by 4-hydroxynonenal. | Redox report : communications in free radical research 20070101 |
| Effects of ebselen on glutathione level in neurons exposed to arachidonic acid and 4-hydroxynonenal during simulated ischemia in vitro. | Pharmacological reports : PR 20070101 |
| Local and systemic impacts of pleural oxygen exposure in thoracotomy. | BioFactors (Oxford, England) 20070101 |
| In vitro evaluation of protective effects of ascorbic acid and water extract of Spirulina plantesis (blue green algae) on 5-fluorouracil-induced lipid peroxidation. | Acta poloniae pharmaceutica 20070101 |
| Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation. | American journal of respiratory and critical care medicine 20061215 |
| Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. | Free radical biology & medicine 20061215 |
| Weight increase and overweight are associated with DNA oxidative damage in skeletal muscle. | Clinical nutrition (Edinburgh, Scotland) 20061201 |
| In vitro protective effect of a Jacquez grapes wine extract on UVB-induced skin damage. | Toxicology in vitro : an international journal published in association with BIBRA 20061201 |
| CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. | Experimental and molecular pathology 20061201 |
| Clinical oxidation parameters of aging. | Free radical research 20061201 |
| Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone. | Journal of neurotrauma 20061201 |
| Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins. | The Journal of biological chemistry 20061117 |
| Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy. | Biochemical and biophysical research communications 20061110 |
| Levels of 4-hydroxynonenal and malondialdehyde are increased in brain of human chronic users of methamphetamine. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Combining lung-protective strategies in experimental acute lung injury: The impact of high-frequency partial liquid ventilation. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20061101 |
| Depletion of glutathione induces 4-hydroxynonenal protein adducts and hydroxyurea teratogenicity in the organogenesis stage mouse embryo. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts. | Free radical biology & medicine 20061101 |
| Odorant binding protein has the biochemical properties of a scavenger for 4-hydroxy-2-nonenal in mammalian nasal mucosa. | The FEBS journal 20061101 |
| Glutathione ester protects against hydroxynonenal-induced loss of auditory hair cells. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20061101 |
| Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice. | Molecular cancer therapeutics 20061101 |
| Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols. | The Journal of pharmacy and pharmacology 20061101 |
| 4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen species. | Toxicology letters 20061025 |
| 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. | Toxicology and applied pharmacology 20061015 |
| Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. | Biochemistry 20061010 |
| UCP3 in muscle wasting, a role in modulating lipotoxicity? | FEBS letters 20061002 |
| The basis of the immunomodulatory activity of malaria pigment (hemozoin). | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20061001 |
| Increased expression of stress proteins in the surf clam Donax variabilis following hydrogen sulfide exposure. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061001 |
| Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease. | Journal of neurochemistry 20061001 |
| Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis. | European journal of cancer (Oxford, England : 1990) 20061001 |
| Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis. | Toxicology 20060921 |
| 4-Hydroxynonenal modifies IgA in rat intestine after lipopolysaccharide injection. | Free radical biology & medicine 20060915 |
| The neuroprotective effect of heme oxygenase (HO) on oxidative stress in HO-1 siRNA-transfected HT22 cells. | Brain research 20060907 |
| Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions. | Biochemistry 20060905 |
| Ferric iron increases ROS formation, modulates cell growth and enhances genotoxic damage by 4-hydroxynonenal in human colon tumor cells. | Toxicology in vitro : an international journal published in association with BIBRA 20060901 |
| Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes. | Archives of biochemistry and biophysics 20060901 |
| Enhanced lipid peroxidation in tourniquet-release mice. | Clinica chimica acta; international journal of clinical chemistry 20060901 |
| Oxidative stress in the brain at early preclinical stages of mouse scrapie. | Experimental neurology 20060901 |
| Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites. | Prostaglandins, leukotrienes, and essential fatty acids 20060901 |
| Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal. | Journal of mass spectrometry : JMS 20060901 |
| Lipid peroxidation during human cerebral myelination. | Journal of neuropathology and experimental neurology 20060901 |
| Amyloid beta peptide, 4-hydroxynonenal and apoptosis. | Current Alzheimer research 20060901 |
| Convenient and efficient syntheses of 4-hydroxy-2(E)-nonenal and 4-oxo-2(E)-nonenal. | Lipids 20060901 |
| Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration. | Neuroscience 20060825 |
| PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments. | Journal of neuroscience research 20060815 |
| Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. | Neurobiology of aging 20060801 |
| Protracted juvenile neuronal ceroid lipofuscinosis--an autopsy report and immunohistochemical analysis. | Brain & development 20060801 |
| c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. | Free radical biology & medicine 20060801 |
| Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal. | Biochimica et biophysica acta 20060801 |
| Involvement of Raf-1/MEK/ERK1/2 signaling pathway in zinc-induced injury in rat renal cortical slices. | The Journal of toxicological sciences 20060801 |
| Enzyme-linked immunosorbent assay for 4-hydroxynonenal-histidine conjugates. | Free radical research 20060801 |
| 4-Hydroxy-2-nonenal upregulates endogenous antioxidants and phase 2 enzymes in rat H9c2 myocardiac cells: protection against overt oxidative and electrophilic injury. | Free radical research 20060801 |
| Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. | American journal of physiology. Lung cellular and molecular physiology 20060701 |
| Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets. | Experimental eye research 20060701 |
| Free radical oxidation of 15-(S)-hydroxyeicosatetraenoic acid with the Fenton reagent: characterization of an epoxy-alcohol and cytotoxic 4-hydroxy-2E-nonenal from the heptatrienyl radical pathway. | Chemistry and physics of lipids 20060701 |
| N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death. | Neuroscience research 20060701 |
| Generation of 4-hydroxy-2-nonenal modified proteins in testes predicts improvement in spermatogenesis after varicocelectomy. | Fertility and sterility 20060701 |
| Oxidative stress in head trauma in aging. | Free radical biology & medicine 20060701 |
| Circulating 4-hydroxynonenal-protein thioether adducts assessed by gas chromatography-mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats. | Free radical biology & medicine 20060701 |
| Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) ototoxicity in vitro. | Acta oto-laryngologica 20060701 |
| Interrelationship between uremic toxicity and oxidative stress. | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20060701 |
| Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. | The Journal of biological chemistry 20060630 |
| Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. | Diabetes research and clinical practice 20060601 |
| Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. | American journal of physiology. Heart and circulatory physiology 20060601 |
| Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease. | Neurochemistry international 20060601 |
| Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly. | The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 20060601 |
| Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. | Arthritis and rheumatism 20060601 |
| Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. | Cell metabolism 20060601 |
| Astrocytic biotransformation of trans-4-hydroxy-2-nonenal is dose-dependent. | Chemical research in toxicology 20060601 |
| Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria. | Biochemical pharmacology 20060528 |
| Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. | Brain research 20060523 |
| UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent. | The Journal of biological chemistry 20060519 |
| Redox instability induced by 4-hydroxy-2-nonenal in porcine and bovine myoglobins at pH 5.6 and 4 degrees C. | Journal of agricultural and food chemistry 20060503 |
| Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease. | American journal of physiology. Endocrinology and metabolism 20060501 |
| Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. | American journal of physiology. Heart and circulatory physiology 20060501 |
| Fasciola hepatica: effects on the antioxidative properties and lipid peroxidation of rat serum. | Experimental parasitology 20060501 |
| Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. | The Biochemical journal 20060501 |
| Crotonaldehyde accumulates in glial cells of Alzheimer's disease brain. | Acta neuropathologica 20060501 |
| Modifications of proteins by 4-hydroxy-2-nonenal in the ventilatory muscles of rats. | American journal of physiology. Lung cellular and molecular physiology 20060501 |
| 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines. | Free radical biology & medicine 20060501 |
| Detection and quantification of endogenous cyclic DNA adducts derived from trans-4-hydroxy-2-nonenal in human brain tissue by isotope dilution capillary liquid chromatography nanoelectrospray tandem mass spectrometry. | Chemical research in toxicology 20060501 |
| Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. | Neuroscience letters 20060424 |
| Bispecific abs against modified protein and DNA with oxidized lipids. | Proceedings of the National Academy of Sciences of the United States of America 20060418 |
| gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells. | Free radical biology & medicine 20060415 |
| Urinalysis of 4-hydroxynonenal, a marker of oxidative stress, using stir bar sorptive extraction-thermal desorption-gas chromatography/mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060413 |
| A novel role of phospholipase A2 in mediating spinal cord secondary injury. | Annals of neurology 20060401 |
| Therapeutic value of melatonin in an experimental model of liver injury and regeneration. | Journal of pineal research 20060401 |
| Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal. | Journal of neurochemistry 20060401 |
| Proteomic analysis of nitrated and 4-hydroxy-2-nonenal-modified serum proteins during aging. | The journals of gerontology. Series A, Biological sciences and medical sciences 20060401 |
| Effect of NaCl on the lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal, formation in boiled pork. | Bioscience, biotechnology, and biochemistry 20060401 |
| Neurofibrillary tangles and deposition of oxidative products in the brain in cases of myotonic dystrophy. | Neuropathology : official journal of the Japanese Society of Neuropathology 20060401 |
| [The expression of 4-hydroxy-2-nonenal caused by cigarette smoke condensate exposure in human bronchial epithelial cells and the interventional effects of ginkgolide B]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20060401 |
| Desensitization of platelet-derived growth factor receptor-beta by oxidized lipids in vascular cells and atherosclerotic lesions: prevention by aldehyde scavengers. | Circulation research 20060331 |
| Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. | Journal of agricultural and food chemistry 20060322 |
| Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. | Toxicological sciences : an official journal of the Society of Toxicology 20060301 |
| In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. | Neurochemistry international 20060301 |
| Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis. | Liver international : official journal of the International Association for the Study of the Liver 20060301 |
| 'In vitro' effect of lipid peroxidation metabolites on elongation factor-2. | Biochimica et biophysica acta 20060301 |
| Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. | Free radical biology & medicine 20060301 |
| Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. | Free radical biology & medicine 20060301 |
| Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. | Free radical biology & medicine 20060301 |
| Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. | The Journal of biological chemistry 20060224 |
| Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo. | Journal of the American Chemical Society 20060215 |
| Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation. | The Journal of biological chemistry 20060203 |
| 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. | American journal of respiratory cell and molecular biology 20060201 |
| Oxidative DNA damage and antioxidant defenses in the European common lizard (Lacerta vivipara) in supercooled and frozen states. | Cryobiology 20060201 |
| Vitamin E-coated filter decreases levels of free 4-hydroxyl-2-nonenal during haemodialysis sessions. | Free radical research 20060201 |
| Markers of oxidative stress in placental villi exposed to ethanol. | Journal of the Society for Gynecologic Investigation 20060201 |
| Alcohol and oxidative liver injury. | Hepatology (Baltimore, Md.) 20060201 |
| Adaptive response induced by lipid peroxidation products in cell cultures. | FEBS letters 20060123 |
| The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice. | Toxicology 20060120 |
| Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. | Brain research 20060119 |
| Behaviour of some indicators of oxidative stress in postmenopausal and fertile women. | Maturitas 20060110 |
| Mitochondrial damage induced by fetal hyperphenylalaninemia in the rat brain and liver: its prevention by melatonin, Vitamin E, and Vitamin C. | Neuroscience letters 20060109 |
| Stimulation of Epstein-Barr virus-infected human B cell growth by physiological concentrations of 4-hydroxynonenal. | Cell biochemistry and function 20060101 |
| 4-Hydroxynonenal disrupts zinc export in primary rat cortical cells. | Neurotoxicology 20060101 |
| Interaction with phospholipids modulates alpha-synuclein nitration and lipid-protein adduct formation. | The Biochemical journal 20060101 |
| Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. | Pharmacological research 20060101 |
| The exocytosis induced in HL-60 cells by 4-hydroxynonenal, a lipid peroxidation product, is not prevented by reduced glutathione. | Cell biochemistry and function 20060101 |
| Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells. | International journal of molecular medicine 20060101 |
| Activation of nuclear factor-kappaB in airway epithelial cells in patients with chronic obstructive pulmonary disease. | Respiration; international review of thoracic diseases 20060101 |
| Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. | Free radical biology & medicine 20060101 |
| Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos. | Free radical biology & medicine 20060101 |
| Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation. | Free radical biology & medicine 20060101 |
| Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? | Free radical biology & medicine 20060101 |
| Accumulation of advanced glycation end products in women with preeclampsia: possible involvement of placental oxidative and nitrative stress. | Placenta 20060101 |
| Production of lipid peroxidation products in osteoarthritic tissues: new evidence linking 4-hydroxynonenal to cartilage degradation. | Arthritis and rheumatism 20060101 |
| Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. | Chemical research in toxicology 20060101 |
| Aging and oxidative stress in progressive supranuclear palsy. | European journal of neurology 20060101 |
| In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress. | Neuroscience 20060101 |
| Markers of oxidative stress in children with Down syndrome. | Clinical chemistry and laboratory medicine 20060101 |
| Novel electrochemical approach to enhanced toxicity of 4-oxo-2-nonenal vs. 4-hydroxy-2-nonenal (role of imine): oxidative stress and therapeutic modalities. | Medical hypotheses 20060101 |
| A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. | Drugs & aging 20060101 |
| Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. | Respiratory research 20060101 |
| 4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects? | IUBMB life 20060101 |
| Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation. | Journal of diabetes and its complications 20060101 |
| Uncoupling proteins: a role in protection against reactive oxygen species--or not? | Biochimica et biophysica acta 20060101 |
| Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal. | Arthritis research & therapy 20060101 |
| Protein adducts generated from products of lipid oxidation: focus on HNE and one. | Drug metabolism reviews 20060101 |
| Strecker type degradation of phenylalanine by 4-hydroxy-2-nonenal in model systems. | Journal of agricultural and food chemistry 20051228 |
| 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. | The Journal of biological chemistry 20051223 |
| 4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: the role of PKC-delta. | Biochimica et biophysica acta 20051215 |
| Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-driven malignancies. | Mutation research 20051211 |
| Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal. | American journal of physiology. Lung cellular and molecular physiology 20051201 |
| Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension. | Hypertension (Dallas, Tex. : 1979) 20051201 |
| Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. | Aging cell 20051201 |
| Adreno-leukodystrophy: oxidative stress of mice and men. | Journal of neuropathology and experimental neurology 20051201 |
| AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. | Alcoholism, clinical and experimental research 20051201 |
| High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase. | Journal of molecular biology 20051125 |
| Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. | Biochemistry 20051122 |
| Susceptibility of actin to modification by 4-hydroxy-2-nonenal. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051115 |
| LC-ESI-MS/MS determination of 4-hydroxy-trans-2-nonenal Michael adducts with cysteine and histidine-containing peptides as early markers of oxidative stress in excitable tissues. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051115 |
| Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051115 |
| Time-dependent effect of p-aminophenol (PAP) toxicity in renal slices and development of oxidative stress. | Toxicology and applied pharmacology 20051115 |
| Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. | Neurobiology of disease 20051101 |
| Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats. | Arteriosclerosis, thrombosis, and vascular biology 20051101 |
| Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats. | Journal of neurochemistry 20051101 |
| Paraquat neurotoxicity is distinct from that of MPTP and rotenone. | Toxicological sciences : an official journal of the Society of Toxicology 20051101 |
| Flow cytometry as a method for studying effects of stressors on primary rat neurons. | Journal of neuroscience research 20051101 |
| Decreased antioxidant enzyme expression and increased oxidative damage in erosive lichen planus of the vulva. | BJOG : an international journal of obstetrics and gynaecology 20051101 |
| Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. | Circulation 20051101 |
| 4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis. | Molecular nutrition & food research 20051101 |
| Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain. | Free radical research 20051101 |
| Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. | Chemical research in toxicology 20051101 |
| Iron accumulation in alcoholic liver diseases. | Alcoholism, clinical and experimental research 20051101 |
| Post-exposure administration of edaravone attenuates noise-induced hearing loss. | European journal of pharmacology 20051017 |
| Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults. | Journal of neuroscience research 20051015 |
| Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. | The Journal of pharmacology and experimental therapeutics 20051001 |
| Potential markers of oxidative stress in stroke. | Free radical biology & medicine 20051001 |
| Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses. | Free radical biology & medicine 20051001 |
| Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria. | Free radical biology & medicine 20051001 |
| Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. | Aging cell 20051001 |
| Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. | Stroke 20051001 |
| Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. | Investigative ophthalmology & visual science 20051001 |
| Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin. | Journal of neurotrauma 20051001 |
| Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine. | Journal of medicinal chemistry 20050922 |
| Effect of 4-hydroxynonenal on phosphatidylethanolamine containing condensed monolayer and on its interaction with apolipoprotein A-I. | FEBS letters 20050912 |
| Protective effect of green tea on erythrocyte membrane of different age rats intoxicated with ethanol. | Chemico-biological interactions 20050910 |
| Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection. | Brain research 20050907 |
| Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice. | American journal of physiology. Renal physiology 20050901 |
| Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele. | Human reproduction (Oxford, England) 20050901 |
| Anti-CD11d antibody treatment reduces free radical formation and cell death in the injured spinal cord of rats. | Journal of neurochemistry 20050901 |
| Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. | Free radical biology & medicine 20050901 |
| Evidence of oxidative stress in the neocortex in incidental Lewy body disease. | Journal of neuropathology and experimental neurology 20050901 |
| The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: a pathogenic role in osteoarthritis. | Arthritis and rheumatism 20050901 |
| Heat shock protein-70 and 4-hydroxy-2-nonenal adducts in human placental villous tissue of normotensive, preeclamptic and intrauterine growth restricted pregnancies. | American journal of obstetrics and gynecology 20050901 |
| Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia. | Life sciences 20050826 |
| Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. | Biochemical and biophysical research communications 20050826 |
| L-carnitine inhibits hypoglycemia-induced brain damage in the rat. | Brain research 20050816 |
| Antioxidant potential of rat liver in experimental infection with Fasciola hepatica. | Parasitology research 20050801 |
| Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin. | Biochemical pharmacology 20050801 |
| HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. | Free radical biology & medicine 20050801 |
| Rapid increase in serum lipid peroxide 4-hydroxynonenal (HNE) through monocyte NADPH oxidase in early endo-toxemia. | Free radical research 20050801 |
| Carbonylation of milk powder proteins as a consequence of processing conditions. | Proteomics 20050801 |
| In vitro modification of solid phase multiple antigenic peptides/autoantigens with 4-hydroxy-2-nonenal (HNE) provide ideal substrates for detection of anti-HNE antibodies and peptide antioxidants. | Journal of immunological methods 20050801 |
| ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. | The Journal of clinical investigation 20050801 |
| Beneficial effect of candesartan on rat diastolic heart failure. | Journal of pharmacological sciences 20050801 |
| 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. | Chemical research in toxicology 20050801 |
| Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. | Chemical research in toxicology 20050801 |
| Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. | Neurotoxicology 20050801 |
| Estimation of daily exposure to 4-hydroxy-2-alkenals in Korean foods containing n-3 and n-6 polyunsaturated fatty acids. | Food additives and contaminants 20050801 |
| Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. | The Journal of biological chemistry 20050729 |
| Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. | Biochemical and biophysical research communications 20050715 |
| Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate. | Toxicological sciences : an official journal of the Society of Toxicology 20050701 |
| Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells. | Neuroscience letters 20050701 |
| Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adduction. | Journal of mass spectrometry : JMS 20050701 |
| Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. | Journal of clinical gastroenterology 20050701 |
| MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats. | Transplant international : official journal of the European Society for Organ Transplantation 20050701 |
| Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. | The American journal of pathology 20050701 |
| Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress. | Cellular and molecular life sciences : CMLS 20050701 |
| Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. | Molecular cancer therapeutics 20050701 |
| Degradation of glyceraldehyde-3-phosphate dehydrogenase triggered by 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal. | Archives of biochemistry and biophysics 20050615 |
| Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. | Journal of cellular physiology 20050601 |
| High-density lipoproteins prevent the oxidized low-density lipoprotein-induced epidermal [corrected] growth factor receptor activation and subsequent matrix metalloproteinase-2 upregulation. | Arteriosclerosis, thrombosis, and vascular biology 20050601 |
| Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury. | Gut 20050601 |
| Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats. | Free radical biology & medicine 20050601 |
| Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo. | Acta neuropathologica 20050601 |
| Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050601 |
| In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis. | Journal of gastroenterology 20050601 |
| Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver. | Free radical biology & medicine 20050515 |
| Analysis of derivatized biogenic aldehydes by LC tandem mass spectrometry. | Analytical chemistry 20050515 |
| Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat liver. | American journal of physiology. Renal physiology 20050501 |
| Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. | The Journal of pharmacology and experimental therapeutics 20050501 |
| Tryptophan metabolism and oxidative stress in patients with Huntington's disease. | Journal of neurochemistry 20050501 |
| Role of oxidative stress in paraquat-induced dopaminergic cell degeneration. | Journal of neurochemistry 20050501 |
| Moderation of morphogenetic and oxidative stress responses in flax in vitro cultures by hydroxynonenal and desferrioxamine. | Journal of plant physiology 20050501 |
| Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells. | Toxicology and applied pharmacology 20050415 |
| beta-Hematin (hemozoin) mediated decompostion of polyunsaturated fatty acids to 4-hydroxy-2-nonenal. | Inorganic chemistry 20050404 |
| The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. | Experimental and molecular pathology 20050401 |
| Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes. | Free radical biology & medicine 20050401 |
| Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis. | Free radical biology & medicine 20050401 |
| Liquid chromatography-multistage tandem mass spectrometry for the quantification of dihydroxynonene mercapturic acid (DHN-MA), a urinary end-metabolite of 4-hydroxynonenal. | Analytical and bioanalytical chemistry 20050401 |
| Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. | Experimental eye research 20050401 |
| Role of oxidative stress in the pathogenesis of septic ileus in mice. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401 |
| 4-Hydroperoxy-2-nonenal-induced formation of 1,N2-etheno-2'-deoxyguanosine adducts. | Chemical research in toxicology 20050401 |
| Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model. | European journal of pharmacology 20050328 |
| Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. | Free radical biology & medicine 20050315 |
| Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. | Free radical biology & medicine 20050315 |
| HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons. | Brain research 20050310 |
| Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction. | Brain research 20050310 |
| Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. | Brain research 20050302 |
| Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302 |
| Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301 |
| NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. | Journal of neuroscience research 20050301 |
| Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal. | Free radical biology & medicine 20050301 |
| Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress. | Stroke 20050301 |
| Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. | Journal of neurochemistry 20050301 |
| Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy. | Journal of cardiac failure 20050301 |
| Accumulation of acrolein-protein adducts after traumatic spinal cord injury. | Neurochemical research 20050301 |
| 4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways. | Free radical biology & medicine 20050215 |
| Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. | Neurobiology of disease 20050201 |
| Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. | Journal of neurochemistry 20050201 |
| Exposure to ethanol induces oxidative damage in the pituitary gland. | Alcohol (Fayetteville, N.Y.) 20050201 |
| 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line. | Free radical biology & medicine 20050115 |
| Tau modifiers as therapeutic targets for Alzheimer's disease. | Biochimica et biophysica acta 20050103 |
| Impact of marathon running on cardiac structure and function in recreational runners. | Clinical science (London, England : 1979) 20050101 |
| 4-Hydroxynonenal inhibits cell proliferation and alters differentiation pathways in human fetal liver hematopoietic stem cells. | Biochemical pharmacology 20050101 |
| Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. | Investigative ophthalmology & visual science 20050101 |
| Post-exposure treatment attenuates noise-induced hearing loss. | Neuroscience 20050101 |
| Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain. | Neuroscience 20050101 |
| A study on ceftriaxone-induced lipid peroxidation using 4-hydroxy-2-nonenal as model marker. | Acta poloniae pharmaceutica 20050101 |
| Evaluation of ascorbic acid as suppressor of cyclophosphamide induced lipid peroxidation using common laboratory markers. | Acta poloniae pharmaceutica 20050101 |
| Injury and recovery of pyramidal neurons in the rat hippocampus after a single episode of oxidative stress induced by intracerebroventricular injection of ferrous ammonium citrate. | Reproduction, nutrition, development 20050101 |
| Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases. | Cardiovascular toxicology 20050101 |
| Metal ions and oxidative protein modification in neurological disease. | Annali dell'Istituto superiore di sanita 20050101 |
| Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. | Methods in enzymology 20050101 |
| Possible involvement of 4-hydroxynonenal in splenocyte regulated liver regeneration. | BioFactors (Oxford, England) 20050101 |
| Immunohistochemical appearance of HNE-protein conjugates in human astrocytomas. | BioFactors (Oxford, England) 20050101 |
| Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectives. | BioFactors (Oxford, England) 20050101 |
| Dihydroxynonene mercapturic acid, a urinary metabolite of 4-hydroxynonenal, as a biomarker of lipid peroxidation. | BioFactors (Oxford, England) 20050101 |
| Enantioselective metabolism of (R)- and (S)-4-hydroxy-2-nonenal in rat. | BioFactors (Oxford, England) 20050101 |
| Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage. | BioFactors (Oxford, England) 20050101 |
| Inhibition of defective adenylosuccinate lyase by HNE: a neurological disease that may be affected by oxidative stress. | BioFactors (Oxford, England) 20050101 |
| Inhibition of ion transport ATPases by HNE. | BioFactors (Oxford, England) 20050101 |
| The influence of 4-hydroxy-2-nonenal on proliferation, differentiation and apoptosis of human osteosarcoma cells. | BioFactors (Oxford, England) 20050101 |
| 4-hydroxynonenal and cell cycle. | BioFactors (Oxford, England) 20050101 |
| Distribution of oxidized and HNE-modified proteins in U87 cells. | BioFactors (Oxford, England) 20050101 |
| Role of 4-hydroxy-2,3-nonenal in the pathogenesis of fibrosis. | BioFactors (Oxford, England) 20050101 |
| 4-hydroxynonenal and TGF-beta1 concur in inducing antiproliferative effects on the CaCo-2 human colon adenocarcinoma cell line. | BioFactors (Oxford, England) 20050101 |
| Role of 4-hydroxynonenal in the hemozoin-mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM-CSF/IL-4. | BioFactors (Oxford, England) 20050101 |
| HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin. | BioFactors (Oxford, England) 20050101 |
| Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal. | FEBS letters 20041217 |
| Activation and function of mitochondrial uncoupling protein in plants. | The Journal of biological chemistry 20041210 |
| Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. | Journal of lipid research 20041201 |
| Signaling kinases modulated by 4-hydroxynonenal. | Free radical biology & medicine 20041201 |
| Global shifts in protein sumoylation in response to electrophile and oxidative stress. | Chemical research in toxicology 20041201 |
| Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products. | Neurochemical research 20041201 |
| Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment. | Acta oto-laryngologica 20041201 |
| Lipid peroxidation and protein oxidation in patients affected by Hodgkin's lymphoma. | Mediators of inflammation 20041201 |
| Covalent binding of isoketals to ethanolamine phospholipids. | Free radical biology & medicine 20041115 |
| A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. | The Journal of biological chemistry 20041112 |
| 4-Hydroxynonenal modulates the long-term potentiation induced by L-type Ca2+ channel activation in the rat dentate gyrus in vitro. | Neuroscience letters 20041111 |
| Decreased cardiac mitochondrial NADP+-isocitrate dehydrogenase activity and expression: a marker of oxidative stress in hypertrophy development. | American journal of physiology. Heart and circulatory physiology 20041101 |
| Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041101 |
| 4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase. | Free radical biology & medicine 20041101 |
| Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal. | Chemical research in toxicology 20041101 |
| Serum levels of malondialdehyde and 4-hydroxy-2,3-nonenal in patients affected by familial chronic nail candidiasis. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20041101 |
| Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal. | Biochemistry 20041019 |
| Caged trans-4-hydroxy-2-nonenal. | Organic letters 20041014 |
| The effects of long-term vitamin E treatment on gene expression and oxidative stress damage in the aging Brown Norway rat epididymis. | Biology of reproduction 20041001 |
| Reactions of 4-hydroxynonenal with proteins and cellular targets. | Free radical biology & medicine 20041001 |
| Biochemical and molecular genetic correlation in adenylosuccinate lyase deficiency. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress. | Human gene therapy 20041001 |
| APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease. | Neuroscience letters 20040923 |
| Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy. | Circulation research 20040917 |
| Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. | Free radical biology & medicine 20040915 |
| Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease. | Free radical biology & medicine 20040915 |
| Hemozoin (malarial pigment) inhibits differentiation and maturation of human monocyte-derived dendritic cells: a peroxisome proliferator-activated receptor-gamma-mediated effect. | Journal of immunology (Baltimore, Md. : 1950) 20040915 |
| Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis. | Der Urologe. Ausg. A 20040901 |
| Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein. | Neurobiology of aging 20040901 |
| Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901 |
| Introduction to serial reviews on 4-hydroxy-2-nonenal as a signaling molecule. | Free radical biology & medicine 20040901 |
| 4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway. | Free radical biology & medicine 20040901 |
| Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. | Free radical biology & medicine 20040901 |
| Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain. | Journal of neural transmission (Vienna, Austria : 1996) 20040901 |
| Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats. | Hepatology (Baltimore, Md.) 20040901 |
| Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. | Frontiers in bioscience : a journal and virtual library 20040901 |
| Metabolism of 4-hydroxy-trans-2-nonenal by central nervous system mitochondria is dependent on age and NAD+ availability. | Chemical research in toxicology 20040901 |
| Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice. | Brain research 20040820 |
| Melatonin does not prevent the protection of ischemic preconditioning in vivo despite its antioxidant effect against oxidative stress. | Free radical biology & medicine 20040815 |
| 4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. | World journal of gastroenterology 20040815 |
| Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts. | Journal of the American Society for Mass Spectrometry 20040801 |
| Hyperoxia causes oxygen free radical-mediated membrane injury and alters myocardial function and hemodynamics in the newborn. | American journal of physiology. Heart and circulatory physiology 20040801 |
| Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats. | Life sciences 20040730 |
| Retinal oxidation, apoptosis and age- and sex-differences in the mnd mutant mouse, a model of neuronal ceroid lipofuscinosis. | Brain research 20040716 |
| Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions. | The Journal of comparative neurology 20040705 |
| Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. | The Journal of biological chemistry 20040702 |
| Interference with ubiquitination causes oxidative damage and increased protein nitration: implications for neurodegenerative diseases. | Journal of neurochemistry 20040701 |
| Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. | Chemical research in toxicology 20040701 |
| Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts. | Biochemistry 20040615 |
| Long-chain adducts of trans-4-hydroxy-2-nonenal to DNA bases cause recombination, base substitutions and frameshift mutations in M13 phage. | Mutation research 20040604 |
| Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4. | Antioxidants & redox signaling 20040601 |
| Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells. | Journal of neurochemistry 20040601 |
| Wine polyphenols induce hypotension, and decrease cardiac reactivity and infarct size in rats: involvement of nitric oxide. | British journal of pharmacology 20040601 |
| [Parameters of lipid peroxidation and low density lipoprotein (LDL) oxidation in the course of hyperthyroidism]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20040601 |
| Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. | Neurology 20040525 |
| Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. | Biochemical and biophysical research communications 20040521 |
| Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. | Free radical biology & medicine 20040515 |
| alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain. | Brain research 20040508 |
| Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusion. | Pediatric research 20040501 |
| Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. | Journal of hepatology 20040501 |
| Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. | European journal of biochemistry 20040501 |
| Oxidative stress and cell signalling. | Current medicinal chemistry 20040501 |
| Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells. | Free radical research 20040501 |
| Rapid formation of 4-hydroxy-2-nonenal, malondialdehyde, and phosphatidylcholine aldehyde from phospholipid hydroperoxide by hemoproteins. | Free radical biology & medicine 20040415 |
| Modulation of phospholipid asymmetry in synaptosomal membranes by the lipid peroxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's disease. | Brain research 20040409 |
| Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. | European journal of pharmacology 20040405 |
| Characterization of a class alpha glutathione-S-transferase with glutathione peroxidase activity in human liver microsomes. | Archives of biochemistry and biophysics 20040401 |
| Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. | Antioxidants & redox signaling 20040401 |
| Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress. | Metabolism: clinical and experimental 20040401 |
| Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. | Mechanisms of ageing and development 20040401 |
| Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. | Atherosclerosis 20040401 |
| Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia. | Haematologica 20040401 |
| Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. | Chemical research in toxicology 20040401 |
| Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. | Neurological research 20040401 |
| Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells. | The Journal of biological chemistry 20040319 |
| Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. | Circulation research 20040319 |
| Oxidatively damaged proteins of heart mitochondrial electron transport complexes. | Biochimica et biophysica acta 20040302 |
| Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. | American journal of physiology. Gastrointestinal and liver physiology 20040301 |
| Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. | The Biochemical journal 20040301 |
| New aspects of altitude adaptation in Tibetans: a proteomic approach. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301 |
| Immunolocalization of lipid peroxidation/advanced glycation end products in amyloid A amyloidosis. | Free radical biology & medicine 20040301 |
| Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on the cyclooxygenase-2 of human placenta in chorioamnionitis. | Molecular human reproduction 20040301 |
| TNF alpha-induced Ras activation due to ethanol promotes hepatocyte proliferation independently of liver injury in the mouse. | Hepatology (Baltimore, Md.) 20040301 |
| Melatonin precursor; L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301 |
| Inactivation of NADP+-dependent isocitrate dehydrogenase by lipid peroxidation products. | Free radical research 20040301 |
| 4-hydroxy-2,3 trans-nonenal nuclear concentration inversely correlates with the growth rate of T leukemia cells. | The Italian journal of biochemistry 20040301 |
| Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin. | The Journal of biological chemistry 20040220 |
| 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease. | Neuroscience letters 20040219 |
| Identification of 4-hydroxy-2-nonenal-modified peptides within unfractionated digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | Analytical chemistry 20040215 |
| Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway. | The Journal of biological chemistry 20040206 |
| Immunohistochemical evaluation of oxidative stress markers in chronic hepatitis C. | Antioxidants & redox signaling 20040201 |
| Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia. | Annals of neurology 20040201 |
| Modulation of voltage-gated Ca2+ current by 4-hydroxynonenal in dentate granule cells. | Biological & pharmaceutical bulletin 20040201 |
| Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. | Toxicology and applied pharmacology 20040201 |
| Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. | Aging cell 20040201 |
| Multidrug resistance-associated protein 2 (MRP2) enhances 4-hydroxynonenal-induced toxicity in Madin-Darby canine kidney II cells. | Chemical research in toxicology 20040201 |
| Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. | Virchows Archiv : an international journal of pathology 20040101 |
| 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells. | Journal of hepatology 20040101 |
| Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. | Journal of neurotrauma 20040101 |
| 4-Hydroxynonenal is markedly higher in patients on a standard long-term home parenteral nutrition. | Free radical research 20040101 |
| Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts. | BioFactors (Oxford, England) 20040101 |
| S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. | BMC clinical pharmacology 20040101 |
| Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteins. | Mass spectrometry reviews 20040101 |
| GSTA is a major glutathione S-transferase gene responsible for 4-hydroxynonenal conjugation in largemouth bass liver. | Marine environmental research 20040101 |
| Acute effects of nonlethal in utero hypoxia on fetal guinea pig heart and lack of persistent cardiac or cerebral effects in the neonate. | Biology of the neonate 20040101 |
| Mechanisms of apoptosis induced by cisplatin in marginal cells in mouse stria vascularis. | ORL; journal for oto-rhino-laryngology and its related specialties 20040101 |
| Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients. | International urology and nephrology 20040101 |
| Lipid peroxidation in diabetic retinopathy. | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101 |
| Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. | The American journal of pathology 20031201 |
| Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources. | The British journal of nutrition 20031201 |
| Increase in molecular rigidity of the protein conformation of brain Na+-K+-ATPase by modification with 4-hydroxy-2-nonenal. | Biological & pharmaceutical bulletin 20031201 |
| Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts. | Chemical research in toxicology 20031201 |
| Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. | Gastroenterology 20031201 |
| Hypothermia attenuates delayed cortical cell death and ROS generation following CO inhalation. | Toxicology letters 20031130 |
| Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons. | Journal of neuroscience research 20031115 |
| Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development. | The Journal of biological chemistry 20031114 |
| Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20031101 |
| Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress. | Free radical biology & medicine 20031101 |
| Detoxification of 4-hydroxynonenal (HNE) in keratinocytes: characterization of conjugated metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry. | Journal of mass spectrometry : JMS 20031101 |
| Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. | Mutation research 20031029 |
| Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. | The Journal of biological chemistry 20031017 |
| Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling. | Free radical biology & medicine 20031015 |
| High sensitivity of plasma membrane ion transport ATPases from human neutrophils towards 4-hydroxy-2,3-trans-nonenal. | Life sciences 20031003 |
| Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity. | Antioxidants & redox signaling 20031001 |
| Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? | FEBS letters 20030911 |
| Chronic intragastric alcohol exposure causes hypoxia and oxidative stress in the rat pancreas. | Archives of biochemistry and biophysics 20030901 |
| Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure. | Inhalation toxicology 20030901 |
| Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells. | Toxicology and applied pharmacology 20030901 |
| Influence of predialysis oxidative stress on peroxidation processes after renal transplantation. | Transplantation proceedings 20030901 |
| The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901 |
| Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. | American journal of physiology. Cell physiology 20030801 |
| Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells. | Investigative ophthalmology & visual science 20030801 |
| Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium. | Investigative ophthalmology & visual science 20030801 |
| Protein oxidative damage in the stratum corneum: Evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan. | The British journal of dermatology 20030801 |
| A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. | Free radical research 20030801 |
| 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. | Progress in lipid research 20030701 |
| The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats. | International journal of molecular medicine 20030701 |
| The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats. | International journal of molecular medicine 20030701 |
| Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. | Cell death and differentiation 20030701 |
| Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. | Biochemistry 20030701 |
| Enhancement of mitochondrial oxidative stress and up-regulation of antioxidant protein peroxiredoxin III/SP-22 in the mitochondria of human pre-eclamptic placentae. | Placenta 20030701 |
| Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C. | Hepatology (Baltimore, Md.) 20030701 |
| Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. | Chemical research in toxicology 20030701 |
| Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). | Journal of neurochemistry 20030701 |
| Protective effects of probucol treatment on pancreatic beta-cell function of SZ-induced diabetic APA hamsters. | Experimental animals 20030701 |
| Experimental researches on the role of phosphoinositide-specific phospholipase C in 4-hydroxynonenal induced exocytosis. | Cell biochemistry and function 20030601 |
| Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens. | Investigative ophthalmology & visual science 20030601 |
| Activation of a caspase-dependent oxidative damage response mediates TGFbeta1 apoptosis in rat hepatocytes. | Experimental and molecular pathology 20030601 |
| Contribution of lipid dynamics on the inhibition of bovine brain synaptosomal Na+-K+-ATPase activity induced by 4-hydroxy-2-nonenal. | Biological & pharmaceutical bulletin 20030601 |
| Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. | Alcoholism, clinical and experimental research 20030601 |
| Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal. | Mutation research 20030515 |
| Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal. | Journal of the American Chemical Society 20030514 |
| Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses. | Journal of lipid research 20030501 |
| NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy. | Arteriosclerosis, thrombosis, and vascular biology 20030501 |
| 4-hydroxynonenal contributes to NGF withdrawal-induced neuronal apoptosis. | Journal of neurochemistry 20030501 |
| Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid beta-protein-induced cell death in nerve growth factor-differentiated PC12 cells. | Neuroscience research 20030501 |
| Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA. | DNA and cell biology 20030501 |
| Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants. | Biochemical and biophysical research communications 20030425 |
| Induction of redox instability of bovine myoglobin by adduction with 4-hydroxy-2-nonenal. | Biochemistry 20030422 |
| Ni2+ enhances Fe2+/peroxide-induced oxidation of arachidonic acid and formation of geno/cytotoxic 4-hydroxynonenal: a possible contributory mechanism in nickel toxicity and allergenicity. | Biochimica et biophysica acta 20030407 |
| Modulation of D1-like dopamine receptor function by aldehydic products of lipid peroxidation. | Brain research 20030404 |
| Molecular basis of enzyme inactivation by an endogenous electrophile 4-hydroxy-2-nonenal: identification of modification sites in glyceraldehyde-3-phosphate dehydrogenase. | Biochemistry 20030401 |
| Pathological significance of oxidative cellular damage in human alcoholic liver disease. | Histopathology 20030401 |
| H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK. | Experimental neurology 20030401 |
| Simultaneous determination of 4-hydroxy-2-alkenals, lipid peroxidation toxic products. | Food additives and contaminants 20030401 |
| Modulation of 4HNE-mediated signaling by proline-rich peptides from ovine colostrum. | Journal of molecular neuroscience : MN 20030401 |
| Activated PMNs lead to oxidative stress on chondrocytes: a study of swine knees. | Acta orthopaedica Scandinavica 20030401 |
| Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. | Archives of biochemistry and biophysics 20030315 |
| Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class. | The Biochemical journal 20030301 |
| Aceruloplasminemia, an inherited disorder of iron metabolism. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20030301 |
| Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells. | Journal of cellular biochemistry 20030301 |
| Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. | Journal of neurochemistry 20030301 |
| Serum profiles of E-selectin, interleukin-10, and interleukin-6 and oxidative stress parameters in patients with acute pancreatitis and nonpancreatic acute abdominal pain. | Pancreas 20030301 |
| Mitochondrial oxidation of 4-hydroxy-2-nonenal in rat cerebral cortex. | Journal of neurochemistry 20030301 |
| Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat. | Chemical research in toxicology 20030301 |
| Study of protein modification by 4-hydroxy-2-nonenal and other short chain aldehydes analyzed by electrospray ionization tandem mass spectrometry. | Journal of the American Society for Mass Spectrometry 20030301 |
| Oxidant-stimulated chloride secretion in rat jejunum in vitro is mediated by eicosanoids. | Digestive diseases and sciences 20030301 |
| Immunohistochemical study of myoglobin and oxidative injury-related markers in the kidney of methamphetamine abusers. | Legal medicine (Tokyo, Japan) 20030301 |
| 1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage. | The Journal of biological chemistry 20030221 |
| Structure of a Drosophila sigma class glutathione S-transferase reveals a novel active site topography suited for lipid peroxidation products. | Journal of molecular biology 20030207 |
| Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. | International journal of oncology 20030201 |
| Enhanced lipid peroxidation in synoviocytes from patients with osteoarthritis. | The Journal of rheumatology 20030201 |
| Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum. | Journal of neuropathology and experimental neurology 20030201 |
| Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions. | Arteriosclerosis, thrombosis, and vascular biology 20030201 |
| Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal. | Chemico-biological interactions 20030201 |
| Oxidation of 4-hydroxynonenal in rat brain slices. | Chemico-biological interactions 20030201 |
| S100B protein and 4-hydroxynonenal in the spinal cord of wobbler mice. | Neurochemical research 20030201 |
| Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. | Neurology 20030128 |
| Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. | Biochimica et biophysica acta 20030120 |
| Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase. | The Journal of biological chemistry 20030110 |
| The effect of high-density lipoproteins on the formation of lipid/protein conjugates during in vitro oxidation of low-density lipoprotein. | Biochemical and biophysical research communications 20030110 |
| Patterns of oxidized epitopes, but not NF-kappa B expression, change during atherogenesis in WHHL rabbits. | Atherosclerosis 20030101 |
| Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum. | Neurobiology of aging 20030101 |
| Increase of lipid peroxidation by cisplatin in WI38 cells but not in SV40-transformed WI38 cells. | Journal of biochemical and molecular toxicology 20030101 |
| Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | BMC ophthalmology 20030101 |
| Oxidative stress in Parkinson's disease. | Annals of neurology 20030101 |
| Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha. | Oncology reports 20030101 |
| Anticancer and antioxidative effects of micronized zeolite clinoptilolite. | Anticancer research 20030101 |
| Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. | Acta biochimica Polonica 20030101 |
| Basic aspects of the biochemical reactivity of 4-hydroxynonenal. | Molecular aspects of medicine 20030101 |
| Genotoxicity of HNE. | Molecular aspects of medicine 20030101 |
| Intracellular metabolism of 4-hydroxynonenal. | Molecular aspects of medicine 20030101 |
| Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways. | Molecular aspects of medicine 20030101 |
| HNE--signaling pathways leading to its elimination. | Molecular aspects of medicine 20030101 |
| The proteasomal system and HNE-modified proteins. | Molecular aspects of medicine 20030101 |
| Role of PKC-dependent pathways in HNE-induced cell protein transport and secretion. | Molecular aspects of medicine 20030101 |
| 4-hydroxy-2-nonenal as a COX-2 inducer. | Molecular aspects of medicine 20030101 |
| Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. | Molecular aspects of medicine 20030101 |
| 4-hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. | Molecular aspects of medicine 20030101 |
| Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. | Molecular aspects of medicine 20030101 |
| 4-hydroxynonenal from pathology to physiology. | Molecular aspects of medicine 20030101 |
| 4-hydroxynonenal and transforming growth factor-beta1 expression in colon cancer. | Molecular aspects of medicine 20030101 |
| 4-hydroxynonenal as a bioactive marker of pathophysiological processes. | Molecular aspects of medicine 20030101 |
| 4-hydroxynonenal and neurodegenerative diseases. | Molecular aspects of medicine 20030101 |
| Hydroxynonenal, toxic carbonyls, and Alzheimer disease. | Molecular aspects of medicine 20030101 |
| Oxidative signaling and glutathione synthesis. | BioFactors (Oxford, England) 20030101 |
| The role of gamma-glutamyltranspeptidase in the metabolism and cytotoxicity of 4-hydroxynonenal-glutathione conjugate: evidence and hypothesis. | BioFactors (Oxford, England) 20030101 |
| Site-specific mutagenicity of stereochemically defined 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells. | Environmental and molecular mutagenesis 20030101 |
| The role of chemically induced glutathione and glutathione S-transferase in protecting against 4-hydroxy-2-nonenal-mediated cytotoxicity in vascular smooth muscle cells. | Cardiovascular toxicology 20030101 |
| Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. | The Journal of biological chemistry 20021227 |
| Immunoaffinity purification and characterization of 4-hydroxy-2-nonenal- and malondialdehyde-modified peptides by electrospray ionization tandem mass spectrometry. | Analytical chemistry 20021215 |
| Effect of 4-hydroxynonenal, a lipid peroxidation product, on exocytosis in HL-60 cells. | Cell biochemistry and function 20021201 |
| JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons. | Journal of neuroscience research 20021201 |
| Oxidative stress in chronic lymphoedema. | QJM : monthly journal of the Association of Physicians 20021201 |
| Astrocytic deformity and globular structures are characteristic of the brains of patients with aceruloplasminemia. | Journal of neuropathology and experimental neurology 20021201 |
| The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201 |
| The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes. | Plant & cell physiology 20021201 |
| Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt-Jakob disease. | Neurobiology of disease 20021201 |
| Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction? | Biochemical and biophysical research communications 20021115 |
| Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. | Free radical biology & medicine 20021115 |
| Quantitative gas chromatographic-mass spectrometric assay of 4-hydroxynonenal bound to thiol proteins in ischemic/reperfused rat hearts. | Free radical biology & medicine 20021115 |
| Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. | Free radical biology & medicine 20021115 |
| Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse. | Cancer letters 20021108 |
| Environmental stress causes oxidative damage to plant mitochondria leading to inhibition of glycine decarboxylase. | The Journal of biological chemistry 20021108 |
| Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure. | Atherosclerosis 20021101 |
| The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. | Carcinogenesis 20021101 |
| Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal. | Chemical research in toxicology 20021101 |
| 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway. | Toxicology and applied pharmacology 20021101 |
| Carbonyl toxicology and Alzheimer's disease. | Toxicology and applied pharmacology 20021101 |
| Glutathione in defense and signaling: lessons from a small thiol. | Annals of the New York Academy of Sciences 20021101 |
| A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. | American journal of physiology. Lung cellular and molecular physiology 20021001 |
| Cocoa extract protects against early alcohol-induced liver injury in the rat. | Archives of biochemistry and biophysics 20021001 |
| 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. | Free radical biology & medicine 20021001 |
| Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: a mechanism contributing to neurodegeneration? | Journal of neurochemistry 20021001 |
| Neurodegenerative mechanisms in subacute sclerosing panencephalitis. | Journal of child neurology 20021001 |
| Ozone exposure activates oxidative stress responses in murine skin. | Toxicology 20020930 |
| Solid phase extraction and liquid chromatography-tandem mass spectrometry for the evaluation of 4-hydroxy-2-nonenal in pork products. | Journal of agricultural and food chemistry 20020911 |
| Down-modulation of nuclear localisation and pro-fibrogenic effect of 4-hydroxy-2,3-nonenal by thiol- and carbonyl-reagents. | Biochimica et biophysica acta 20020905 |
| Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease. | Acta neuropathologica 20020901 |
| Cellular glutathione and thiols metabolism. | Biochemical pharmacology 20020901 |
| Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020901 |
| Effect of enzyme-resistant starch on formation of 1,N(2)-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal and cell proliferation in the colonic mucosa of healthy volunteers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20020901 |
| Proteasome function and protein oxidation in the aged retina. | Experimental eye research 20020901 |
| Differential modulation of growth and glutathione metabolism in cultured rat astrocytes by 4-hydroxynonenal and green tea polyphenol, epigallocatechin-3-gallate. | Neurotoxicology 20020901 |
| Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis. | Neurotoxicology 20020901 |
| Arachidonic acid-derived oxidation products initiate apoptosis in vascular smooth muscle cells. | Prostaglandins & other lipid mediators 20020901 |
| Mechanisms of iron-induced oxidative modifications of creatine kinase in rat brain in vitro. possible involvement of HNE. | General physiology and biophysics 20020901 |
| Effects of aminoguanidine Schiff's base on biomarkers of the oxidative stress, 4-hydroxy-2-nonenal and conjugated dienes, in the model diabetes mellitus. | General physiology and biophysics 20020901 |
| Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. | The Biochemical journal 20020815 |
| 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. | American journal of respiratory and critical care medicine 20020815 |
| Induction of vascular endothelial growth factor by 4-hydroxynonenal and its prevention by glutathione precursors in retinal pigment epithelial cells. | European journal of pharmacology 20020809 |
| Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. | Circulation research 20020809 |
| Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal. | Free radical biology & medicine 20020801 |
| Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal. | Journal of hepatology 20020801 |
| 4-hydroxynonenal detoxification by mitochondrial glutathione S-transferase is compromised by short-term ethanol consumption in rats. | Alcoholism, clinical and experimental research 20020801 |
| Free-radical damage: a possible mechanism of laryngeal aging. | Ear, nose, & throat journal 20020801 |
| Oxidative stress increases expression and activity of BACE in NT2 neurons. | Neurobiology of disease 20020801 |
| Measurement of 4-hydroxynonenal in small volume blood plasma samples: modification of a gas chromatographic-mass spectrometric method for clinical settings. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020715 |
| 4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells. | Biochemical and biophysical research communications 20020712 |
| The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. | The Journal of biological chemistry 20020705 |
| 4-hydroxynonenal decreases interleukin-6 expression and protein production in primary rat Kupffer cells by inhibiting nuclear factor-kappaB activation. | The Journal of pharmacology and experimental therapeutics 20020701 |
| In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. | Journal of hepatology 20020701 |
| Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. | Journal of neuropathology and experimental neurology 20020701 |
| Elevated serum concentration of cardiotoxic lipid peroxidation products in chronic renal failure in relation to severity of renal anemia. | Clinical nephrology 20020701 |
| Homocysteine in chronic renal failure in relation to renal anemia and to oxidative stress parameters 4-hydroxynonenal and malondialdehyde. | Clinical nephrology 20020701 |
| Adaptation of glutathion-peroxidase activity to oxidative stress occurs in children but not in adult patients with end-stage renal failure undergoing hemodialysis. | Clinical nephrology 20020701 |
| Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal. | Biochemistry 20020625 |
| Carvedilol decreases elevated oxidative stress in human failing myocardium. | Circulation 20020618 |
| Interleukin-6 protects PC12 cells from 4-hydroxynonenal-induced cytotoxicity by increasing intracellular glutathione levels. | Free radical biology & medicine 20020615 |
| Activation of PKC-beta isoforms mediates HNE-induced MCP-1 release by macrophages. | Biochemical and biophysical research communications 20020614 |
| Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes. | Free radical biology & medicine 20020601 |
| In vivo assessment of lipid peroxidation products associated with age-related neurodegenerative diseases. | Experimental neurology 20020601 |
| Method for analysis of 4-hydroxy-2-(E)-nonenal with solid-phase microextraction. | Lipids 20020601 |
| Effect of glutathione augmentation on lipid peroxidation after spinal cord injury. | Journal of neurotrauma 20020601 |
| Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. | Biochemical and biophysical research communications 20020524 |
| Unaltered brain levels of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in Alzheimer's disease. | Neuroscience letters 20020510 |
| An investigation into the mechanisms mediating plasma lipoprotein-potentiated beta-amyloid fibrillogenesis. | FEBS letters 20020508 |
| Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: quantitation and localization. | Toxicology 20020501 |
| Oxidative stress and cardiovascular disease in dialyzed patients. | Nephron 20020501 |
| Localization of indoleamine 2,3-dioxygenase and 4-hydroxynonenal in normal and pre-eclamptic placentae. | Placenta 20020501 |
| Immunological detection of 4-hydroxynonenal protein adducts in developing pontine and Purkinje neurons and in karyorrhexis in pontosubicular neuronal necrosis. | Early human development 20020401 |
| Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues. | Protein science : a publication of the Protein Society 20020401 |
| Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. | Journal of the American Society of Nephrology : JASN 20020401 |
| Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells. | Biochemical and biophysical research communications 20020322 |
| Lysophosphatidylcholine is a major contributor to the synergistic effect of mildly oxidized low-density lipoprotein with endothelin-1 on vascular smooth muscle cell proliferation. | Journal of cardiovascular pharmacology 20020301 |
| Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. | European journal of biochemistry 20020301 |
| Red blood cell antioxidant and iron status in alcoholic and nonalcoholic cirrhosis. | European journal of clinical investigation 20020301 |
| Inhibition of the mitochondrial permeability transition by aldehydes. | Biochemical and biophysical research communications 20020222 |
| High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. | The Journal of biological chemistry 20020215 |
| Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver. | Free radical biology & medicine 20020215 |
| Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells. | Free radical biology & medicine 20020215 |
| High-oleic peanuts are not different from normal peanuts in allergenic properties. | Journal of agricultural and food chemistry 20020213 |
| Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. | Neuroscience letters 20020208 |
| Infection of leaves of Arabidopsis thaliana by Botrytis cinerea: changes in ascorbic acid, free radicals and lipid peroxidation products. | Journal of experimental botany 20020201 |
| Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. | Free radical biology & medicine 20020201 |
| Reduction of free radical activity in amyloid deposits following liver transplantation for familial amyloidotic polyneuropathy. | Journal of internal medicine 20020201 |
| Heat shock preconditioning reduces the formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal modified proteins in ischemia-reperfused liver of rats. | Free radical research 20020201 |
| Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. | Journal of nutritional science and vitaminology 20020201 |
| Oxidative stress in bacterial meningitis in humans. | Neurology 20020122 |
| Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020115 |
| Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression. | Archives of biochemistry and biophysics 20020115 |
| Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner. | Brain research 20020104 |
| gamma-Glutamyltranspeptidase-dependent metabolism of 4-hydroxynonenal-glutathione conjugate. | Archives of biochemistry and biophysics 20020101 |
| Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. | Free radical biology & medicine 20020101 |
| Differential effects of iron overload on GST isoform expression in mouse liver and kidney and correlation between GSTA4 induction and overproduction of free radicles. | Free radical biology & medicine 20020101 |
| Synthesis and cellular effects of an intracellularly activated analogue of 4-hydroxynonenal. | Chemical research in toxicology 20020101 |
| The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease. | Neurobiology of aging 20020101 |
| Modified lipoproteins accumulate in human coronary atheroma. | Journal of cellular and molecular medicine 20020101 |
| Pyruvate dehydrogenase complex as a marker of mitochondrial metabolism. Inhibition by 4-hydroxy-2-nonenal. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Lipid peroxidation in rat brain is increased by simulated weightlessness and decreased by a soy-protein diet. | Annals of clinical and laboratory science 20020101 |
| [The level of 8-iso-prostaglandin F2 alpha, 4-hydroxynonenal and malondialdehyde in alcohol dependent men during combined therapy]. | Psychiatria polska 20020101 |
| Determination of 4-hydroxynonenal in rat plasma by gas chromatography/mass spectrometry. | Rapid communications in mass spectrometry : RCM 20020101 |
| Characterisation of adducts of the lipid peroxidation product 4-hydroxy-2-nonenal and amyloid beta-peptides by liquid chromatography/electrospray ionisation mass spectrometry. | Rapid communications in mass spectrometry : RCM 20020101 |
| Localization of oxidation-specific epitopes in tissue. | Methods in enzymology 20020101 |
| Ultrastructural localization and relative quantification of 4-hydroxynonenal-modified proteins in tissues and cell compartments. | Methods in enzymology 20020101 |
| Hemangioma model for in vivo angiogenesis: inducible oxidative stress and MCP-1 expression in EOMA cells. | Methods in enzymology 20020101 |
| Immunochemical detection of a fluorophore derived from the lipid peroxidation product 4-hydroxy-2-nonenal and lysine. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Cytofluorescence techniques for the visualization of distinct pools of protein thiols at the single cell level. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| 4-hydroxy-2-nonenal (4-HNE) staining by anti-HNE antibody. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Indirect immunofluorescence detection of protein-bound 4-hydroxynonenal in tissue sections and isolated cells. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Differential influence of the lipid peroxidation product 4-hydroxynonenal on the growth of human lymphatic leukaemia cells and human periopherial blood lymphocytes. | Anticancer research 20020101 |
| Aldehydes from n-6 fatty acid peroxidation. Effects on aminophospholipids. | Prostaglandins, leukotrienes, and essential fatty acids 20020101 |
| Conjugation of 4-hydroxynonenal by largemouth bass (Micropterus salmoides) glutathione S-transferases. | Marine environmental research 20020101 |
| Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal. | Acta biochimica Polonica 20020101 |
| Intracellular Ca2+ homeostatic regulation and 4-hydroxynonenal-induced aortic endothelial dysfunction. | Endothelium : journal of endothelial cell research 20020101 |
| Amelioration of cisplatin toxicity by a fermented grain food product. | BioFactors (Oxford, England) 20020101 |
| Rabbit brain glucose-6-phosphate dehydrogenase: biochemical properties and inactivation by free radicals and 4-hydroxy-2-nonenal. | Neuroreport 20011221 |
| Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization. | The Biochemical journal 20011201 |
| Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. | Hepatology (Baltimore, Md.) 20011201 |
| Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress. | Free radical research 20011201 |
| [Peritoneal fluid and plasma 4-hydroxynonenal and malonyldialdehyde concentrations in infertile women]. | Ginekologia polska 20011201 |
| 4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier. | Neuroscience letters 20011116 |
| Micellar electrokinetic chromatography separation and laser-induced fluorescence detection of the lipid peroxidation product 4-hydroxynonenal. | Journal of chromatography. B, Biomedical sciences and applications 20011105 |
| Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. | The Journal of biological chemistry 20011102 |
| Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. | The Journal of biological chemistry 20011102 |
| Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. | Mutation research 20011101 |
| Different onsets of oxidative damage to DNA and lipids in bone marrow and liver in rats given total body irradiation. | Free radical biology & medicine 20011101 |
| Stereocontrolled syntheses of all four stereoisomeric 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal. | Organic letters 20011101 |
| Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. | Experimental neurology 20011101 |
| Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20011101 |
| Role of 4-hydroxynonenal in modification of cytochrome c oxidase in ischemia/reperfused rat heart. | Journal of molecular and cellular cardiology 20011101 |
| Mildly oxidized LDL induces activation of platelet-derived growth factor beta-receptor pathway. | Circulation 20011009 |
| 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia. | Brain pathology (Zurich, Switzerland) 20011001 |
| Identification of biochemical pathways for the metabolism of oxidized low-density lipoprotein derived aldehyde-4-hydroxy trans-2-nonenal in vascular smooth muscle cells. | Atherosclerosis 20011001 |
| Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1,2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation. | Bioscience, biotechnology, and biochemistry 20011001 |
| Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats. | Chemico-biological interactions 20010928 |
| 2,4-Decadienal downregulates TNF-alpha gene expression in THP-1 human macrophages. | Atherosclerosis 20010901 |
| Oxidative stress and reactive nitrogen species generation during renal ischemia. | Toxicological sciences : an official journal of the Society of Toxicology 20010901 |
| Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells(1). | Free radical biology & medicine 20010901 |
| Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde. | QJM : monthly journal of the Association of Physicians 20010901 |
| In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. | The American journal of pathology 20010901 |
| Dietary antioxidants and dementia. | International psychogeriatrics 20010901 |
| Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling. | Archives of biochemistry and biophysics 20010815 |
| Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. | Cancer research 20010815 |
| Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. | The Journal of biological chemistry 20010810 |
| Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway. | The Journal of biological chemistry 20010810 |
| Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells. | Free radical biology & medicine 20010801 |
| Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-D-aspartate channels. | Journal of neurochemistry 20010801 |
| 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. | Chemical research in toxicology 20010801 |
| Distinct involvement of NF-kappaB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal. | Journal of cellular biochemistry 20010801 |
| Enrichment of eggs with n-3 polyunsaturated fatty acids: effects of vitamin E supplementation. | Lipids 20010801 |
| The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. | Oncogene 20010719 |
| Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. | Circulation 20010703 |
| Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress. | Free radical biology & medicine 20010701 |
| Enhanced protein levels of protein thiol/disulphide oxidoreductases in placentae from pre-eclamptic subjects. | Placenta 20010701 |
| Expression and activities of aldo-keto oxidoreductases in Alzheimer disease. | Journal of neuropathology and experimental neurology 20010701 |
| 4-hydroxynonenal prevents NO production in vascular smooth muscle cells by inhibiting nuclear factor-kappaB-dependent transcriptional activation of inducible NO synthase. | Arteriosclerosis, thrombosis, and vascular biology 20010701 |
| Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases and protection by Bcl-2. | Journal of neurochemistry 20010701 |
| The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42. | Journal of neurochemistry 20010701 |
| Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin. | Archives of dermatological research 20010701 |
| Vascular smooth muscle cell activation and growth by 4-hydroxynonenal. | Life sciences 20010629 |
| Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. | The Journal of biological chemistry 20010615 |
| Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. | Science (New York, N.Y.) 20010615 |
| Development of an animal model of chronic alcohol-induced pancreatitis in the rat. | American journal of physiology. Gastrointestinal and liver physiology 20010601 |
| Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria. | Archives of biochemistry and biophysics 20010601 |
| Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slices. | Free radical biology & medicine 20010601 |
| Characterization of cytosolic glutathione S-transferase in cultured astrocytes. | Brain research 20010601 |
| Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation. | Journal of hypertension 20010601 |
| In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal. | Alcoholism, clinical and experimental research 20010601 |
| Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. | Annals of the New York Academy of Sciences 20010601 |
| The phospholipase A2 inhibitor quinacrine prevents increased immunoreactivity to cytoplasmic phospholipase A2 (cPLA2) and hydroxynonenal (HNE) in neurons of the lateral septum following fimbria-fornix transection. | Experimental brain research 20010601 |
| Effect of 4-hydroxy-2(E)-nonenal on soybean lipoxygenase-1. | Lipids 20010601 |
| Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal. | Free radical research 20010601 |
| IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. | The Journal of biological chemistry 20010525 |
| Mechanisms of action of malondialdehyde and 4-hydroxynonenal on xanthine oxidoreductase. | Archives of biochemistry and biophysics 20010515 |
| Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. | Free radical biology & medicine 20010501 |
| Involvement of lipid peroxidation in spontaneous pancreatitis in WBN/Kob rats. | Pancreas 20010501 |
| Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products. | European journal of biochemistry 20010501 |
| Metabolism of 4-hydroxynonenal by rat Kupffer cells. | Archives of biochemistry and biophysics 20010501 |
| Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues. | Biochemical and biophysical research communications 20010420 |
| Apoptosis in RAW 264.7 cells exposed to 4-hydroxy-2-nonenal: dependence on cytochrome C release but not p53 accumulation. | Free radical biology & medicine 20010415 |
| (S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats. | The Biochemical journal 20010401 |
| Oxidative stress and disturbed glutamate transport in hereditary nucleotide repair disorders. | Journal of neuropathology and experimental neurology 20010401 |
| 4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial cells. | American journal of respiratory cell and molecular biology 20010401 |
| Phenolic antioxidants trolox and caffeic acid modulate the oxidized LDL-induced EGF-receptor activation. | British journal of pharmacology 20010401 |
| 4-hydroxynonenal induces apoptosis, NF-kappaB-activation and formation of 8-isoprostane in vascular smooth muscle cells. | Basic research in cardiology 20010401 |
| Differential oxidative injury in extrapancreatic tissues during experimental pancreatitis: modification of lung proteins by 4-hydroxynonenal. | Digestive diseases and sciences 20010401 |
| 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response. | Biochemical and biophysical research communications 20010330 |
| 4-Hydroxynonenal, a lipid peroxidation byproduct of spinal cord injury, is cytotoxic for oligodendrocyte progenitors and inhibits their responsiveness to PDGF. | Microscopy research and technique 20010315 |
| Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. | Free radical biology & medicine 20010315 |
| Effects of vitamin E on lipid peroxidation in healthy persons. | JAMA 20010307 |
| Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation. | Atherosclerosis 20010301 |
| Relative sensitivities of plasma lecithin:cholesterol acyltransferase, platelet-activating factor acetylhydrolase, and paraoxonase to in vitro gas-phase cigarette smoke exposure. | Atherosclerosis 20010301 |
| Ultrastructural analysis of HNE-treated Saccharomyces cerevisiae cells reveals fragmentation of the vacuole and an accumulation of lipids in the cytosol. | Cell biochemistry and function 20010301 |
| Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress. | Hepatology (Baltimore, Md.) 20010301 |
| Evidence for non-oxidative dopamine cytotoxicity: potent activation of NF-kappa B and lack of protection by anti-oxidants. | Journal of neurochemistry 20010301 |
| Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20010301 |
| Brain vessels normally undergo cyclic activation and inactivation: evidence from tumor necrosis factor-alpha, heme oxygenase-1, and manganese superoxide dismutase immunostaining of vessels and perivascular brain cells. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010301 |
| Lipid peroxidation in the postnatal rat brain. Formation of 4-hydroxynonenal in the supraventricular corpus callosum of postnatal rats. | Experimental brain research 20010301 |
| Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C. | Virchows Archiv : an international journal of pathology 20010301 |
| Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation. | Molecular and cellular biochemistry 20010301 |
| Redox-dependent modulation of lipid synthesis induced by oleic acid in the human intestinal epithelial cell line Caco-2. | Experimental biology and medicine (Maywood, N.J.) 20010301 |
| Ebselen prevents early alcohol-induced liver injury in rats. | Free radical biology & medicine 20010215 |
| Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat. | European journal of pharmacology 20010209 |
| The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis. | Biochemical and biophysical research communications 20010202 |
| Minor role of oxidative stress during intermediate phase of acute pancreatitis in rats. | Free radical biology & medicine 20010201 |
| Lipid peroxidation in human proteinuric disease. | Kidney international 20010201 |
| Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult. | Journal of neurochemistry 20010201 |
| Markers for oxidative stress associated with soft rots in French beans (Phaseolus vulgaris) infected by Botrytis cinerea. | Planta 20010201 |
| Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients. | Scandinavian journal of clinical and laboratory investigation 20010201 |
| Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells. | Chemico-biological interactions 20010130 |
| Characterization of the glutathione binding site of aldose reductase. | Chemico-biological interactions 20010130 |
| Involvement of aldose reductase in the metabolism of atherogenic aldehydes. | Chemico-biological interactions 20010130 |
| Physiological functions and hormonal regulation of mouse vas deferens protein (AKR1B7) in steroidogenic tissues. | Chemico-biological interactions 20010130 |
| Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway. | Chemico-biological interactions 20010130 |
| The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. | The Journal of biological chemistry 20010126 |
| A highly acidic tyrosine 9 and a normally titrating tyrosine 212 contribute to the catalytic mechanism of human glutathione transferase A4-4. | Biochemical and biophysical research communications 20010126 |
| Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils. | Brain research 20010105 |
| Interactions between mitochondrial proteins and lipid peroxidation products in the maintenance of the glomerular filtration barrier in the in vitro perfused kidney. | Experimental nephrology 20010101 |
| Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease. | Neuroscience 20010101 |
| Experimental studies on the mechanism of phospholipase C activation by the lipid peroxidation products 4-hydroxynonenal and 2-nonenal. | International journal of tissue reactions 20010101 |
| The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins. | Anticancer research 20010101 |
| Consequences of haemolysis without haptoglobin. | Redox report : communications in free radical research 20010101 |
| 4-Hydroxy-2,3-alkenals as signal molecules modulating proliferative and adaptative cell responses. | BioFactors (Oxford, England) 20010101 |
| Levels of lipid peroxidation products in a chronic inflammatory disorder. | Research communications in molecular pathology and pharmacology 20010101 |
| Butyrate induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal. | Nutrition and cancer 20010101 |
| The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. | Brain research. Molecular brain research 20001228 |
| Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. | Proceedings of the National Academy of Sciences of the United States of America 20001107 |
| Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. | Biochimica et biophysica acta 20000927 |
| Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. | Acta neuropathologica 20000901 |
| The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons. | Journal of neurochemistry 20000101 |
| Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. | The Biochemical journal 19991015 |
| The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells. | Toxicology letters 19990920 |
| Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. | The Journal of biological chemistry 19990122 |
| Structural and kinetic determinants of aldehyde reduction by aldose reductase. | Biochemistry 19990105 |
| Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. | Archives of biochemistry and biophysics 19981101 |
| Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. | The Biochemical journal 19980215 |
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| Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes. | Biochemical pharmacology 19970425 |
| Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells. | Archives of biochemistry and biophysics 19960901 |
| Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene. | Free radical biology & medicine 19960101 |
| Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme. | Toxicology and applied pharmacology 19950301 |
| Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues. | Archives of biochemistry and biophysics 19940601 |
| Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? | Hepatology (Baltimore, Md.) 19940501 |
| A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues. | Biochimica et biophysica acta 19940216 |
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