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75693-75-3 | 4-Imidazolidineheptanoicacid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-
CAS No: 75693-75-3 Catalog No: AG005AI0 MDL No:
Product Description
Catalog Number:
AG005AI0
Chemical Name:
4-Imidazolidineheptanoicacid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-
CAS Number:
75693-75-3
Molecular Formula:
C19H32N2O5
Molecular Weight:
368.4678
IUPAC Name:
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid
InChI:
InChI=1S/C19H32N2O5/c22-16(14-8-4-3-5-9-14)12-13-21-15(18(25)20-19(21)26)10-6-1-2-7-11-17(23)24/h14-16,22H,1-13H2,(H,23,24)(H,20,25,26)
InChI Key:
ZIDQIOZJEJFMOH-UHFFFAOYSA-N
SMILES:
OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O
EC Number:
278-291-0
Properties
Complexity:
490
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
368.231g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
368.474g/mol
Monoisotopic Mass:
368.231g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
2
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9
Literature
| Title | Journal |
|---|---|
| PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. | The Journal of allergy and clinical immunology 20120201 |
| Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. | PloS one 20120101 |
| The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice. | The Journal of pharmacology and experimental therapeutics 20101101 |
| Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. | The Journal of biological chemistry 20100521 |
| GIF-0173 protects against cerebral infarction through DP1 receptor activation. | Experimental neurology 20091001 |
| Functional antagonism of IL-1alpha induced gene expression profiles define the cAMP/PKA pathway as a unique regulator of IL-1alpha signaling networks. | Journal of receptor and signal transduction research 20090101 |
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| Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species. | The journal of sexual medicine 20080201 |
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| Implication of prostaglandin receptors in the accumulation of osteoprotegerin in human osteoblast cultures. | The Journal of rheumatology 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. | Journal of immunology (Baltimore, Md. : 1950) 20051115 |
| Effects of BW245C, a prostaglandin dp receptor agonist, on systemic and regional haemodynamics in the anaesthetized rat. | Clinical and experimental pharmacology & physiology 20051101 |
| Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. | The Journal of pharmacology and experimental therapeutics 20050301 |
| Prostaglandin D2 mediates neuronal protection via the DP1 receptor. | Journal of neurochemistry 20050201 |
| Effect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo. | British journal of pharmacology 20040901 |
| Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801 |
| Excitatory action of prostanoids on the ferret isolated vagus nerve preparation. | European journal of pharmacology 20040426 |
| Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1. | Journal of pharmacological sciences 20040301 |
| Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates. | The Journal of pharmacy and pharmacology 20040201 |
| Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew). | European journal of pharmacology 20030923 |
| Modulation of guinea pig intrinsic cardiac neurons by prostaglandins. | American journal of physiology. Regulatory, integrative and comparative physiology 20030901 |
| Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. | British journal of pharmacology 20021201 |
| Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle. | International journal of impotence research 20021201 |
| Vascular activities of prostaglandins and selective prostanoid receptor agonists in human retinal microvessels. | Experimental eye research 20020801 |
| In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. | European journal of pharmacology 20020503 |
| Prostaglandin D(2) receptor-mediated desensitization of the alpha isoform of the human thromboxane A(2) receptor. | Biochemical pharmacology 20010715 |
| A functional study on prostanoid receptors involved in cultured human iridal melanocyte stimulation. | Experimental eye research 20010701 |
| A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. | European journal of pharmacology 19990714 |
| Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. | British journal of pharmacology 19980401 |
| Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | British journal of pharmacology 19970901 |
| Molecular cloning and characterization of the human prostanoid DP receptor. | The Journal of biological chemistry 19950811 |
| The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. | British journal of pharmacology 19900801 |
| The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | British journal of pharmacology 19890201 |
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