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74942-47-5 |
CAS No: 74942-47-5 Catalog No: AG01FN6O MDL No:
Product Description
Catalog Number:
AG01FN6O
CAS Number:
74942-47-5
IUPAC Name:
5-benzylidene-1,3-thiazolidine-2,4-dione
InChI:
InChI=1S/C10H7NO2S/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
InChI Key:
SGIZECXZFLAGBW-UHFFFAOYSA-N
Properties
Complexity:
293
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
205.02g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
205.231g/mol
Monoisotopic Mass:
205.02g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
71.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1
XLogP3:
2.2
Literature
| Title | Journal |
|---|---|
| Synthesis and evaluation of 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of non-alcoholic fatty liver disease. | Archiv der Pharmazie 20120701 |
| 5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials. | Bioorganic & medicinal chemistry letters 20120415 |
| New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds. | Bioorganic & medicinal chemistry 20111215 |
| New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation. | European journal of medicinal chemistry 20111101 |
| Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases. | Journal of medicinal chemistry 20110414 |
| Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives. | European journal of medicinal chemistry 20101001 |
| Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase. | Journal of medicinal chemistry 20100923 |
| Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. | Journal of medicinal chemistry 20100325 |
| Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. | Bioorganic & medicinal chemistry 20100215 |
| A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. | Blood 20100128 |
| New benzylidenethiazolidinediones as antibacterial agents. | Bioorganic & medicinal chemistry letters 20031103 |
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