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74536-44-0 | L-Proline, 5-oxo-, compd. with5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)OTHER CA INDEX NAMES:3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, compd. with5-oxo-L-proline (1:1)
CAS No: 74536-44-0 Catalog No: AG00ICJ7 MDL No:MFCD08704232
Product Description
Catalog Number:
AG00ICJ7
Chemical Name:
L-Proline, 5-oxo-, compd. with5-hydroxy-6-methyl-3,4-pyridinedimethanol (1:1)OTHER CA INDEX NAMES:3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, compd. with5-oxo-L-proline (1:1)
CAS Number:
74536-44-0
Molecular Formula:
C13H18N2O6
Molecular Weight:
298.2918
MDL Number:
MFCD08704232
IUPAC Name:
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;(2S)-5-oxopyrrolidine-2-carboxylic acid
InChI:
InChI=1S/C8H11NO3.C5H7NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5;7-4-2-1-3(6-4)5(8)9/h2,10-12H,3-4H2,1H3;3H,1-2H2,(H,6,7)(H,8,9)/t;3-/m.0/s1
InChI Key:
RYKKQQUKJJGFMN-HVDRVSQOSA-N
SMILES:
O=C1CC[C@H](N1)C(=O)O.OCc1c(CO)cnc(c1O)C
EC Number:
277-913-8
UNII:
EJQ7M98H5J
Properties
Complexity:
297
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
298.116g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
5
Isotope Atom Count:
0
Molecular Weight:
298.295g/mol
Monoisotopic Mass:
298.116g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
140A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease. | Human psychopharmacology 20111201 |
| [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101 |
| Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats. | Archives of pharmacal research 20100701 |
| Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. | Archives of biochemistry and biophysics 20090815 |
| [Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301 |
| [Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101 |
| Acute alcohol intoxication. | European journal of internal medicine 20081201 |
| Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. | Chemico-biological interactions 20070830 |
| Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers. | Chinese medical journal 20070120 |
| A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence. | Substance abuse treatment, prevention, and policy 20060101 |
| [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]. | Orvosi hetilap 20051120 |
| Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form. | Farmaco (Societa chimica italiana : 1989) 20050401 |
| [Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics]. | Voprosy onkologii 20050101 |
| [Antioxidants in liver protection]. | Orvosi hetilap 20040704 |
| [Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701 |
| Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine. | Liver international : official journal of the International Association for the Study of the Liver 20030801 |
| [Reproductive toxicity of metadoxine in rats]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20030501 |
| Metadoxine in the treatment of acute and chronic alcoholism: a review. | International journal of immunopathology and pharmacology 20030101 |
| A new approach to drug therapy in non-alcoholic steatohepatitis (NASH). | The Journal of international medical research 20030101 |
| Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. | Alcoholism, clinical and experimental research 20020301 |
| Efficacy of metadoxine in the management of acute alcohol intoxication. | The Journal of international medical research 20020101 |
| Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture. | Pharmacological research 20011101 |
| [Metadoxyl in combined treatment of alcohol damage to the liver]. | Klinicheskaia meditsina 20010101 |
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