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CAS No: 73573-88-3 Catalog No: AG0038GT MDL No:MFCD05662341
Title | Journal |
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Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. | Reproductive sciences (Thousand Oaks, Calif.) 20120601 |
The differential effects of statins on the metastatic behaviour of prostate cancer. | British journal of cancer 20120508 |
Bisphosphonates as antimyeloma drugs. | Leukemia 20120401 |
Complete mitochondrial genome of compactin-producing fungus Penicillium solitum and comparative analysis of Trichocomaceae mitochondrial genomes. | FEMS microbiology letters 20120401 |
Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity. | Acta biomaterialia 20120301 |
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. | Diabetes 20120301 |
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. | Nature cell biology 20120212 |
Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production. | Current genetics 20120201 |
A unique regulator contributes to quorum sensing and virulence in Burkholderia cenocepacia. | PloS one 20120101 |
Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. | Journal of experimental botany 20111101 |
Efficient bioconversion of compactin to pravastatin by the quinoline-degrading microorganism Pseudonocardia carboxydivorans isolated from petroleum-contaminated soil. | Bioresource technology 20111101 |
Neurotoxic effect of statins on mouse neuroblastoma NB2a cell line. | European review for medical and pharmacological sciences 20110901 |
A plastidial sodium-dependent pyruvate transporter. | Nature 20110824 |
Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease. | Aging cell 20110801 |
Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression. | Neurochemistry international 20110801 |
The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane. | The Journal of physiology 20110701 |
Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages. | The Journal of veterinary medical science 20110501 |
Development of natural anti-tumor drugs by microorganisms. | Journal of bioscience and bioengineering 20110501 |
Statins downregulate K6a promoter activity: a possible therapeutic avenue for pachyonychia congenita. | The Journal of investigative dermatology 20110501 |
N-acetylcysteine and N-nitroarginine methyl ester attenuate Carboplatin-induced ototoxicity in dissociated spiral ganglion neuron cultures. | Clinical and experimental otorhinolaryngology 20110301 |
Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells. | The Prostate 20110215 |
Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor. | Biochemical and biophysical research communications 20110107 |
Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. | Journal of Alzheimer's disease : JAD 20110101 |
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. | Alzheimer's research & therapy 20110101 |
Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen. | Breast cancer research : BCR 20110101 |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage. | Malaria journal 20110101 |
Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus. | Drug design, development and therapy 20110101 |
Fluorescent analysis of the cell-selective Alzheimer's disease aβ Peptide surface membrane binding: influence of membrane components. | International journal of Alzheimer's disease 20110101 |
Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. | Journal of experimental & clinical cancer research : CR 20110101 |
Conversion of commensal Escherichia coli K-12 to an invasive form via expression of a mutant histone-like protein. | mBio 20110101 |
Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. | Respiratory research 20110101 |
Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. | PloS one 20110101 |
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation. | Annals of the rheumatic diseases 20101201 |
Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. | The Journal of clinical endocrinology and metabolism 20101201 |
IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells. | Cancer research 20101201 |
Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA). | Aging 20101201 |
Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum. | Biotechnology letters 20101101 |
Cancer and schizophrenia: is there a paradox? | Journal of psychopharmacology (Oxford, England) 20101101 |
Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner. | Neurobiology of aging 20100901 |
Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. | Biopolymers 20100901 |
Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer. | European urology 20100901 |
Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. | Anti-cancer drugs 20100801 |
Chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin(1A) receptors. | Biochemistry 20100706 |
A novel statin-mediated 'prenylation block-and-release' assay provides insight into the membrane targeting mechanisms of small GTPases. | Biochemical and biophysical research communications 20100618 |
Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616 |
Severe hypocholesterolaemia is often neglected in haematological malignancies. | European journal of cancer (Oxford, England : 1990) 20100601 |
A historical perspective on the discovery of statins. | Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511 |
[Mevastatin inhibits the differentiation of thyroid-associated ophthalmopathy derived orbital preadipocytes]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100501 |
Lipid metabolism and HCV infection. | Viruses 20100501 |
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry. | Chembiochem : a European journal of chemical biology 20100412 |
Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction. | Diabetes care 20100401 |
Effects of mevastatin on grafted bone in MRL/MpJ mice. | Connective tissue research 20100401 |
Antiviral therapy for hepatitis C virus: beyond the standard of care. | Viruses 20100401 |
Effect of simvastatin on culturing of kidney cells from pigs in vitro. | Molecular biology reports 20100301 |
Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults. | The Journal of pharmacology and experimental therapeutics 20100301 |
BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1. | Arteriosclerosis, thrombosis, and vascular biology 20100301 |
Cholesterol reduction impairs exocytosis of synaptic vesicles. | Journal of cell science 20100215 |
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. | The Journal of biological chemistry 20100115 |
Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target. | International journal of cancer 20100101 |
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. | The international journal of biochemistry & cell biology 20100101 |
Biotechnological production and applications of statins. | Applied microbiology and biotechnology 20100101 |
A role of nitric oxide in neurite outgrowth of neuroblastoma cells triggered by mevastatin or serum reduction. | Neuroscience letters 20100101 |
Chlamydia trachomatis growth inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin. | Comparative hepatology 20100101 |
Endothelial progenitor cells: what use for the cardiologist? | Journal of angiogenesis research 20100101 |
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer. | BMC cancer 20100101 |
A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. | Cellular immunology 20100101 |
Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis. | Respiratory research 20100101 |
Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum. | Malaria journal 20100101 |
Simvastatin impairs murine melanoma growth. | Lipids in health and disease 20100101 |
Controversial data on simvastatin in asthma: What about the rat model? | Journal of asthma and allergy 20100101 |
Pitavastatin: evidence for its place in treatment of hypercholesterolemia. | Core evidence 20100101 |
Screening of nutrient parameters for mevastatin production by Penicillium citrinum MTCC 1256 under submerged fermentation using the Plackett-Burman design. | Journal of pharmacy & bioallied sciences 20100101 |
Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201 |
Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. | British journal of pharmacology 20091201 |
Statins: in the beginning. | The journal of the Royal College of Physicians of Edinburgh 20091201 |
Compactin production studies using Penicillium brevicompactum under solid-state fermentation conditions. | Applied biochemistry and biotechnology 20091101 |
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. | International journal of molecular medicine 20091101 |
Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. | Lipids 20091001 |
Ezetimibe inhibits expression of acid sphingomyelinase in liver and intestine. | Lipids 20091001 |
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors. | Bioorganic & medicinal chemistry letters 20090801 |
Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. | Journal of neuroscience research 20090701 |
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development. | Hepatology (Baltimore, Md.) 20090701 |
Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells. | British journal of pharmacology 20090701 |
Effect of precultural and nutritional parameters on compactin production by solid-state fermentation. | Journal of microbiology and biotechnology 20090701 |
Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells. | Journal of immunology (Baltimore, Md. : 1950) 20090615 |
Heterologous expression, purification, and characterization of cytochrome P450sca-2 and mutants with improved solubility in Escherichia coli. | Protein expression and purification 20090601 |
MlcR, a zinc cluster activator protein, is able to bind to a single (A/T)CGG site of cognate asymmetric motifs in the ML-236B (compactin) biosynthetic gene cluster. | Molecular genetics and genomics : MGG 20090601 |
Improvement of compactin (ML-236B) production by genetic engineering in compactin high-producing Penicillium citrinum. | Applied microbiology and biotechnology 20090601 |
Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1. | Experimental biology and medicine (Maywood, N.J.) 20090601 |
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats. | Experimental lung research 20090601 |
Digoxin and ouabain increase the synthesis of cholesterol in human liver cells. | Cellular and molecular life sciences : CMLS 20090501 |
Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes. | Bioscience, biotechnology, and biochemistry 20090423 |
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. | Nature chemical biology 20090401 |
Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA. | American journal of physiology. Cell physiology 20090301 |
Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation. | Osteoarthritis and cartilage 20090201 |
Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. | British journal of haematology 20090101 |
Chapter 2. From microbial products to novel drugs that target a multitude of disease indications. | Methods in enzymology 20090101 |
Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. | PloS one 20090101 |
Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. | PloS one 20090101 |
Pleiotropic vasoprotective effects of statins: the chicken or the egg? | Drug design, development and therapy 20090101 |
Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3. | PloS one 20090101 |
Berberine decreases PCSK9 expression in HepG2 cells. | Atherosclerosis 20081201 |
Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081101 |
Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins. | Diabetes 20081001 |
Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). | Biochemical pharmacology 20081001 |
A gift from nature: the birth of the statins. | Nature medicine 20081001 |
Identification of the specific sequence recognized by Penicillium citrinum MlcR, a GAL4-type transcriptional activator of ML-236B (compactin) biosynthetic genes. | Fungal genetics and biology : FG & B 20080901 |
Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. | Journal of molecular and cellular cardiology 20080801 |
Roles of IL-6-gp130 Signaling in Vascular Inflammation. | Current cardiology reviews 20080801 |
Magnesium cation effect on passive diffusion of statin molecules: molecular chromatography approach. | Journal of pharmaceutical and biomedical analysis 20080715 |
Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. | Experimental cell research 20080610 |
Statins (HMG-coenzyme A reductase inhibitors)-biomimetic membrane binding mechanism investigated by molecular chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601 |
Pheromone biosynthetic pathways: PBAN-regulated rate-limiting steps and differential expression of desaturase genes in moth species. | Insect biochemistry and molecular biology 20080501 |
The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells. | Atherosclerosis 20080401 |
Intracellular cholesterol modifies the ERAD of glucocerebrosidase in Gaucher disease patients. | Molecular genetics and metabolism 20080401 |
Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival. | Journal of pharmacological sciences 20080401 |
Clinical efficacy and safety of statins in managing cardiovascular risk. | Vascular health and risk management 20080401 |
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. | PLoS medicine 20080301 |
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. | Biochemical pharmacology 20080215 |
Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis. | Journal of neuro-oncology 20080201 |
The real code of leonardo da vinci. | Current cardiology reviews 20080201 |
Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. | Biochemical and biophysical research communications 20080111 |
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. | BMC cancer 20080101 |
Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor. | BMC evolutionary biology 20080101 |
The prince and the pauper. A tale of anticancer targeted agents. | Molecular cancer 20080101 |
Microbial production and biomedical applications of lovastatin. | Indian journal of pharmaceutical sciences 20080101 |
Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. | Lipids 20071201 |
Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma. | Molecular cancer therapeutics 20071201 |
A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo. | Calcified tissue international 20071101 |
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro. | Molecular cancer therapeutics 20071101 |
Comparative evaluation of the effects of statins on human stem and cancer cells in vitro. | Reproductive biomedicine online 20071101 |
Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. | Cell biology international 20071001 |
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. | European journal of pharmacology 20070910 |
Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons. | American journal of physiology. Heart and circulatory physiology 20070901 |
Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells. | American journal of physiology. Renal physiology 20070901 |
Chemotherapy and zoledronate sensitize solid tumour cells to Vgamma9Vdelta2 T cell cytotoxicity. | Cancer immunology, immunotherapy : CII 20070801 |
Simvastatin inhibits IFN-gamma-induced CD40 gene expression by suppressing STAT-1alpha. | Journal of leukocyte biology 20070801 |
Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. | The Journal of biological chemistry 20070720 |
Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. | Stem cells (Dayton, Ohio) 20070701 |
Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus. | FEMS microbiology letters 20070701 |
Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070613 |
Modulation of COX-2 expression by statins in human monocytic cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070601 |
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition. | American journal of respiratory cell and molecular biology 20070601 |
Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. | Veterinary microbiology 20070310 |
Gamma delta T cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface. | Biochemical and biophysical research communications 20070309 |
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling. | The Journal of physiology 20070301 |
Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. | Analytical and bioanalytical chemistry 20070201 |
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. | The Journal of pharmacology and experimental therapeutics 20070101 |
The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | Immunity & ageing : I & A 20070101 |
Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. | Lipids in health and disease 20070101 |
Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1. | PloS one 20070101 |
Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells. | Clinical hemorheology and microcirculation 20070101 |
Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | European journal of pharmacology 20061215 |
Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity. | Biochemistry 20061205 |
Cholinesterase inhibitor blockade and its prevention by statins of sympathetic alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20061201 |
Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. | Talanta 20061115 |
Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity. | Cardiovascular research 20061001 |
Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. | Fertility and sterility 20061001 |
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901 |
Screening of compactin-resistant microorganisms capable of converting compactin to pravastatin. | Current microbiology 20060801 |
Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. | International journal of cancer 20060701 |
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. | Biology of reproduction 20060701 |
Regulation of de novo phosphatidylinositol synthesis. | Journal of lipid research 20060701 |
Cyclodextrins but not compactin inhibit the lateral diffusion of membrane proteins independent of cholesterol. | Traffic (Copenhagen, Denmark) 20060701 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060501 |
Involvement of Rho signaling in PAR2-mediated regulation of neutrophil adhesion to lung epithelial cells. | European journal of pharmacology 20060424 |
Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP. | The Journal of pharmacology and experimental therapeutics 20060401 |
HMG-CoA reductase inhibitors induce apoptosis in pericytes. | Microvascular research 20060301 |
Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. | Journal of agricultural and food chemistry 20060222 |
Formal enantioselective synthesis of (+)-compactin. | Organic letters 20060216 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | Immunology and cell biology 20060201 |
Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | Blood 20060115 |
HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. | Cellular signalling 20060101 |
Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. | Pharmacology 20060101 |
Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors. | Plant physiology and biochemistry : PPB 20060101 |
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. | Arthritis research & therapy 20060101 |
Statins prevent beta-amyloid inhibition of sympathetic alpha7-nAChR-mediated nitrergic neurogenic dilation in porcine basilar arteries. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20051201 |
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. | Cell metabolism 20051201 |
X-Hitting: an algorithm for novelty detection and dereplication by UV spectra of complex mixtures of natural products. | Analytical chemistry 20051101 |
Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells. | Brain research. Molecular brain research 20051003 |
Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001 |
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. | Journal of molecular biology 20050909 |
Fast analysis of pravastatin in production media. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805 |
Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. | Circulation 20050802 |
Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process. | European journal of clinical nutrition 20050801 |
Induction of macrophage elastase (MMP-12) gene expression by statins. | Journal of cellular physiology 20050701 |
Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. | Journal of the American Society of Nephrology : JASN 20050701 |
In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis. | European journal of endocrinology 20050701 |
JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998). | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050701 |
Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells. | The Chinese journal of physiology 20050630 |
Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. | Cancer letters 20050628 |
FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050601 |
4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway. | Journal of chemical ecology 20050601 |
Novel and simple high-performance liquid chromatographic method for determination of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525 |
HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma. | British journal of cancer 20050509 |
Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. | Arteriosclerosis, thrombosis, and vascular biology 20050501 |
Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells. | Biochimica et biophysica acta 20050415 |
Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. | Journal of agricultural and food chemistry 20050406 |
Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma. | Leukemia 20050401 |
Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes. | Experimental dermatology 20050401 |
Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro. | Biology of reproduction 20050301 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. | The AAPS journal 20050301 |
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA). | Bioorganic & medicinal chemistry letters 20050215 |
High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. | Drug metabolism and disposition: the biological fate of chemicals 20050101 |
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). | Biochemical pharmacology 20050101 |
Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK. | Molecular and cellular biochemistry 20050101 |
Chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes. | Respiratory research 20050101 |
Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux. | Arteriosclerosis, thrombosis, and vascular biology 20041201 |
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. | The Journal of biological chemistry 20041112 |
Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. | Circulation 20041109 |
Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. | Fertility and sterility 20041001 |
Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. 1976. | Atherosclerosis. Supplements 20041001 |
Therapeutic effects of ml-236B in primary hypercholesterolemia. 1980. | Atherosclerosis. Supplements 20041001 |
Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981. | Atherosclerosis. Supplements 20041001 |
Lowering plasma cholesterol by raising ldl receptors. 1981. | Atherosclerosis. Supplements 20041001 |
Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. | Blood 20040915 |
Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin. | Journal of molecular and cellular cardiology 20040901 |
New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum. | Journal of natural products 20040901 |
Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins. | Circulation 20040817 |
Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice. | American journal of physiology. Regulatory, integrative and comparative physiology 20040801 |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | Arteriosclerosis, thrombosis, and vascular biology 20040801 |
Lipid rafts mediate the synaptic localization of alpha-synuclein. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040728 |
Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis. | Biochemical and biophysical research communications 20040716 |
Compactin-a review. | Applied microbiology and biotechnology 20040601 |
[In vitro effects of mevastatin on the proliferation and apoptosis in human multiple myeloma cell line U266]. | Zhongguo shi yan xue ye xue za zhi 20040601 |
Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum. | The Journal of general and applied microbiology 20040601 |
Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. | The Journal of biological chemistry 20040409 |
Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling. | Biochemical and biophysical research communications 20040312 |
Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. | Arteriosclerosis, thrombosis, and vascular biology 20040301 |
De novo biosynthesis and radiolabeling of mammalian digitalis-like factors. | Clinical chemistry 20040301 |
Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040201 |
Statins potentiate caspase-3 activity in immortalized murine neurons. | Neuroscience letters 20040123 |
Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase. | Neuroscience letters 20040109 |
Differential effects of lipid-lowering agents on human cholinesterases. | Clinical biochemistry 20040101 |
Mevastatin-induced apoptosis and growth suppression in U266 myeloma cells. | Anticancer research 20040101 |
[Mevastatin induced apoptosis in U266 human myeloma cell line]. | Magyar onkologia 20040101 |
KGF-induced motility of breast cancer cells is dependent on Grb2 and Erk1,2. | Clinical & experimental metastasis 20040101 |
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031203 |
Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20031201 |
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. | American journal of physiology. Renal physiology 20031201 |
Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum. | Insect biochemistry and molecular biology 20031201 |
Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. | Hepatology (Baltimore, Md.) 20031101 |
Bioconversion of compactin into pravastatin by Streptomyces sp. | Biotechnology letters 20031101 |
p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. | The Journal of biological chemistry 20031031 |
The bisphosphonate pamidronate is a potent inhibitor of Ewing's sarcoma cell growth in vitro. | Anti-cancer drugs 20031001 |
Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase lower fecundity in the German cockroach: correlation between the effects on fecundity in vivo with the inhibition of enzymatic activity in embryo cells. | Pest management science 20031001 |
The mevalonate synthesis pathway as a therapeutic target in cancer. | Clinical orthopaedics and related research 20031001 |
Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. | Hypertension research : official journal of the Japanese Society of Hypertension 20030901 |
Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1. | Surgery 20030801 |
Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). | The Journal of biological chemistry 20030516 |
HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. | Circulation research 20030516 |
Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. | Blood 20030501 |
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415 |
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. | American journal of physiology. Heart and circulatory physiology 20030401 |
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. | Nature genetics 20030401 |
Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway. | Circulation research 20030321 |
Inhibition of cdk2 activating phosphorylation by mevastatin. | The Journal of biological chemistry 20030214 |
Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression. | Leukemia research 20030201 |
Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei. | Biotechnology and applied biochemistry 20030201 |
Ubiquinone does not rescue acute myeloid leukemia cells from growth inhibition by statins. | Leukemia 20030101 |
Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells. | Lipids in health and disease 20030101 |
HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. | BMC cardiovascular disorders 20030101 |
Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes. | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 20030101 |
Hypergravity-induced changes in gene expression in Arabidopsis hypocotyls. | Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20030101 |
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. | Brain research 20021220 |
Chelation-controlled reduction: stereoselective formation of syn-1,3-diols and synthesis of compactin and mevinolin lactone. | The Journal of organic chemistry 20021213 |
Enzyme inhibitors to increase poly-3-hydroxybutyrate production by transgenic tobacco. | Bioscience, biotechnology, and biochemistry 20021201 |
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. | The Journal of biological chemistry 20021122 |
Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101 |
Functional analysis of mlcR, a regulatory gene for ML-236B (compactin) biosynthesis in Penicillium citrinum. | Molecular genetics and genomics : MGG 20021101 |
Statins as immunomodulators: comparison with interferon-beta 1b in MS. | Neurology 20021008 |
A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. | The Journal of pharmacology and experimental therapeutics 20021001 |
Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001 |
Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20020901 |
Effect of increased dosage of the ML-236B (compactin) biosynthetic gene cluster on ML-236B production in Penicillium citrinum. | Molecular genetics and genomics : MGG 20020901 |
Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. | Biochemical pharmacology 20020801 |
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells. | Clinical science (London, England : 1979) 20020801 |
Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. | Molecular genetics and genomics : MGG 20020701 |
Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. | Journal of neuroscience research 20020601 |
Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | Cancer research 20020501 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Double-edged role of statins in angiogenesis signaling. | Circulation research 20020405 |
Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. | Atherosclerosis 20020401 |
CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. | Blood 20020401 |
Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach. | Archives of insect biochemistry and physiology 20020401 |
Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. | Applied microbiology and biotechnology 20020401 |
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. | Breast cancer research and treatment 20020201 |
Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. | Cellular microbiology 20020101 |
The role of statins as potential targets for bone formation. | Arthritis research 20020101 |
Mevastatin, an inhibitor of HMG-CoA reductase, induces apoptosis, differentiation and Rap1 expression in HL-60 cells. | Physiological chemistry and physics and medical NMR 20020101 |
The discovery and development of atorvastatin, a potent novel hypolipidemic agent. | Progress in medicinal chemistry 20020101 |
Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. | The Journal of biological chemistry 20011214 |
Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells. | The Biochemical journal 20011201 |
Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture. | Journal of the American College of Nutrition 20011201 |
CNS synaptogenesis promoted by glia-derived cholesterol. | Science (New York, N.Y.) 20011109 |
Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner. | Methods and findings in experimental and clinical pharmacology 20010901 |
HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. | Carcinogenesis 20010701 |
Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus. | Bioorganic & medicinal chemistry letters 20010618 |
Compactin enhances osteogenesis in murine embryonic stem cells. | Biochemical and biophysical research communications 20010608 |
Inhibition of growth of methane-producing bacteria of the ruminant forestomach by hydroxymethylglutaryl-SCoA reductase inhibitors. | Journal of dairy science 20010601 |
Plasmodium falciparum: the lethal effects of tunicamycin and mevastatin on the parasite are not mediated by the inhibition of N-linked oligosaccharide biosynthesis. | Experimental parasitology 20010601 |
Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. | Journal of chromatography. A 20010525 |
Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. | The Journal of biological chemistry 20010518 |
Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury. | Kidney international 20010501 |
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010425 |
Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts. | Journal of cellular physiology 20010401 |
Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. | Stroke 20010401 |
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene. | Insect biochemistry and molecular biology 20010315 |
Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228. | International journal of cancer 20010301 |
Butyrate-induced differentiation of Caco-2 cells occurs independently from p27. | Biochemical and biophysical research communications 20010223 |
Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. | Journal of neurochemistry 20010101 |
Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. | Journal of immunology (Baltimore, Md. : 1950) 20000901 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. | Biochemical and biophysical research communications 20000519 |
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. | Cancer research 19981201 |
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs. | Journal of medicinal chemistry 19921016 |
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. | Journal of medicinal chemistry 19910101 |
Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors. | Journal of medicinal chemistry 19910101 |
Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. | Journal of medicinal chemistry 19900101 |
Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin. | Journal of medicinal chemistry 19871001 |
Sources of extramitochondrial corticoidogenic cholesterol in the adrenal cortex. | Japanese journal of pharmacology 19850601 |
3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1. | Journal of medicinal chemistry 19850501 |
Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase. | Journal of medicinal chemistry 19850401 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives. | Journal of medicinal chemistry 19850301 |
Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. | FEBS letters 19761231 |
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. | The Journal of antibiotics 19761201 |
Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum. | Journal of the Chemical Society. Perkin transactions 1 19760101 |
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