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7327-87-9 | 1,4-Dihydrazinophthalazine hydrogen sulfate
CAS No: 7327-87-9 Catalog No: AG0039LT MDL No:MFCD00035271
Product Description
Catalog Number:
AG0039LT
Chemical Name:
1,4-Dihydrazinophthalazine hydrogen sulfate
CAS Number:
7327-87-9
Molecular Formula:
C8H12N6O4S
Molecular Weight:
288.2837
MDL Number:
MFCD00035271
IUPAC Name:
(4-hydrazinylphthalazin-1-yl)hydrazine;sulfuric acid
InChI:
InChI=1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)
InChI Key:
BWHAMWGGORIDBK-UHFFFAOYSA-N
SMILES:
OS(=O)(=O)O.NNc1nnc(c2c1cccc2)NN
EC Number:
230-808-0
UNII:
1C2B1W91NK
Properties
Complexity:
248
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
288.064g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
10
Hydrogen Bond Donor Count:
6
Isotope Atom Count:
0
Molecular Weight:
288.282g/mol
Monoisotopic Mass:
288.064g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
185A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs. | Anaesthesia 20120501 |
| Long-term efficacy and tolerability of a fixed-dose combination of antihypertensive agents: an open-label surveillance study in China. | Clinical drug investigation 20111101 |
| Flow-injection chemiluminescence determination of dihydralazine sulfate in serum using luminol and diperiodatocuprate (III) system. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100101 |
| Effects of dihydralazine on renal water and aquaporin-2 excretion in humans. | Scandinavian journal of clinical and laboratory investigation 20090101 |
| Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination. | American journal of physiology. Renal physiology 20080701 |
| Chemiluminescence investigation of carbon dioxide-enhanced oxidation of dihydralazine sulfate by peroxynitrite and its application to pharmaceutical analysis. | Analytica chimica acta 20080602 |
| Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery. | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20080101 |
| Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation? | Drug metabolism and disposition: the biological fate of chemicals 20071201 |
| Method development for dihydralazine with HPLC-MS/MS--an old but tricky substance in human plasma. | Journal of pharmaceutical and biomedical analysis 20070117 |
| Antihypertensive therapy in patients with pre-eclampsia: A prospective randomised multicentre study comparing dihydralazine with urapidil. | European journal of obstetrics, gynecology, and reproductive biology 20060801 |
| Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. | Critical care medicine 20060301 |
| Changes in metabolism and blood flow following catecholamine stimulation in the synovial membrane measured with microdialysis. | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20060201 |
| Morbidity and development in childhood of infants born after temporising treatment of early onset pre-eclampsia. | BJOG : an international journal of obstetrics and gynaecology 20050701 |
| Hypertension in children with chronic renal failure. | The Turkish journal of pediatrics 20050101 |
| Site-specific 99mTc-labeling of antibody using dihydrazinophthalazine (DHZ) conjugation to Fc region of heavy chain. | Archives of pharmacal research 20040901 |
| [Determination of five components in compound hypotensive tablet by HPLC]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040801 |
| The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study. | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20040401 |
| Flow injection chemiluminescence determination of dihydralazine sulphate based on permanganate oxidation sensitized by rhodamine B. | Luminescence : the journal of biological and chemical luminescence 20040101 |
| [When hypertension becomes an emergency case: lower the blood pressure, but slowly!]. | MMW Fortschritte der Medizin 20030529 |
| Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension. | Virchows Archiv : an international journal of pathology 20030401 |
| [Reversible loss of vision in severe preeclampsia: case report and review of the literature]. | Zeitschrift fur Geburtshilfe und Neonatologie 20030101 |
| Drug-induced lupus as a cause of relapsing inflammatory disease after renal transplantation. | Pediatric transplantation 20020801 |
| Immune-mediated drug-induced liver disease. | Clinics in liver disease 20020801 |
| [Effect of Urapidil in antihypertensive therapy of preeclampsia on newborns]. | Zentralblatt fur Gynakologie 20010901 |
| Influence of metabolic activation on the induction of micronuclei by antihypertensive drugs in L929 cells. | Archives of toxicology 20010201 |
| Ketanserin for the treatment of preeclampsia. | Journal of perinatal medicine 20010101 |
| Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 19880501 |
| Comparative study on the short-term effects of angiotensin converting enzyme inhibitors (Lopirin, SQUIBB and Tensiomin), and dihydralazine in chronic cardiac failure. | Acta physiologica Hungarica 19880101 |
| [Liver lesions induced by dihydralazine and propranolol]. | Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie 19850101 |
| Vagally mediated bradycardiac effect of prazosin in anaesthetized rats. | European journal of pharmacology 19841015 |
| Mode of antihypertensive action of nitrendipine. | Journal of cardiovascular pharmacology 19840101 |
| Action of vasodilating drugs on small and large arteries of hypertensive patients. | Journal of cardiovascular pharmacology 19830101 |
| [Hypotensive anaesthesia in the oto-rhino-laryngological surgery using nitroglycerine (author's transl)]. | Der Anaesthesist 19800501 |
| [Rare liver damage caused by an antihypertensive and anti-arrhythmic agents]. | Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete 19800401 |
| Effects of acute hypotension and hypertension on serum TSH concentrations in male rats. | Acta physiologica Scandinavica 19791001 |
| [Treatment of essential hypertension with a combination of propranolol, spironolactone-thiabutazide and dihydralazine (author's transl)]. | Deutsche medizinische Wochenschrift (1946) 19781020 |
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