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7296-20-0 | Neocuproine Hydrochloride Monohydrate,
CAS No: 7296-20-0 Catalog No: AG003SYA MDL No:MFCD00012645
Product Description
Catalog Number:
AG003SYA
Chemical Name:
Neocuproine Hydrochloride Monohydrate,
CAS Number:
7296-20-0
MDL Number:
MFCD00012645
IUPAC Name:
2,9-dimethyl-1,10-phenanthroline;hydrochloride
InChI:
InChI=1S/C14H12N2.ClH/c1-9-3-5-11-7-8-12-6-4-10(2)16-14(12)13(11)15-9;/h3-8H,1-2H3;1H
InChI Key:
QUGBNSJLQDNNPK-UHFFFAOYSA-N
Properties
Complexity:
227
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
244.077g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
244.722g/mol
Monoisotopic Mass:
244.077g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
25.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Copper(I) (pseudo)halide complexes with neocuproine and aminomethylphosphines derived from morpholine and thiomorpholine - in vitro cytotoxic and antimicrobial activity and the interactions with DNA and serum albumins. | Chemical biology & drug design 20131101 |
| Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20130601 |
| Reactions of the cationic zinc thiolate model complex [Zn(Tab)4](PF6)2 with N-donor ligands and cobalt dichloride. | Inorganic chemistry 20121001 |
| Differences in responsivity of original cupric reducing antioxidant capacity and cupric-bathocuproine sulfonate assays to antioxidant compounds. | Analytical biochemistry 20120401 |
| Neocuproine-KOtBu promoted intramolecular cross coupling to approach fused rings. | Chemical communications (Cambridge, England) 20110921 |
| Carnosine and neocuproine as neutralizing agents for copper overload-induced damages in cultured human cells. | Chemico-biological interactions 20110715 |
| DNA binding and gel electrophoresis studies of a new silver(I) complex containing 2,9-dimethyl-1,10-phenanthroline ligands. | DNA and cell biology 20110301 |
| Highly diastereoselective C(sp3)-C(sp) cross-coupling reactions between 1,3- and 1,4-substituted cyclohexylzinc reagents and bromoalkynes through remote stereocontrol. | Angewandte Chemie (International ed. in English) 20110225 |
| Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles. | Angewandte Chemie (International ed. in English) 20101011 |
| Determination of peroxide-based explosives with copper(II)-neocuproine assay combined with a molecular spectroscopic sensor. | The Analyst 20100801 |
| Determination of antioxidants by a novel on-line HPLC-cupric reducing antioxidant capacity (CUPRAC) assay with post-column detection. | Analytica chimica acta 20100726 |
| Development of a low-cost optical sensor for cupric reducing antioxidant capacity measurement of food extracts. | Analytical chemistry 20100515 |
| Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells. | Mutagenesis 20090901 |
| Equilibrium and ab initio computational studies on the adduct formation of 1,3-diketonato-lithium(I), -sodium(I) and -potassium(I) with 1,10-phenanthroline and its 2,9-dimethyl derivatives. | Talanta 20090615 |
| Differential effect of neocuproine, a copper(I) chelator, on contractile activity in isolated ovariectomized non-pregnant rat, pregnant rat and pregnant human uterus. | European journal of pharmacology 20090301 |
| A selective resonance scattering assay for immunoglobulin G using Cu(II)-ascorbic acid-immunonanogold reaction. | Analytical biochemistry 20080915 |
| A strategy for direct identification of protein S-nitrosylation sites by quadrupole time-of-flight mass spectrometry. | Journal of the American Society for Mass Spectrometry 20080901 |
| Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism. | Free radical research 20080801 |
| The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA. | Toxicology 20080710 |
| Hydroxyl radical scavenging assay of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method using catalase for hydrogen peroxide degradation. | Analytica chimica acta 20080602 |
| Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation. | Toxicological sciences : an official journal of the Society of Toxicology 20080301 |
| DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants. | Phytochemistry 20080101 |
| Vitamin B12b increases the cytotoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage. | European journal of pharmacology 20070702 |
| Effect of copper on the cytotoxicity of phenanthrene and 9,10-phenanthrenequinone to the human placental cell line, JEG-3. | Reproductive toxicology (Elmsford, N.Y.) 20070601 |
| Simultaneous kinetic determination of levodopa and carbidopa by H-point standard addition method. | Journal of pharmaceutical and biomedical analysis 20070509 |
| Spectrophotometric determination of ascorbic acid by the modified CUPRAC method with extractive separation of flavonoids-La(III) complexes. | Analytica chimica acta 20070404 |
| Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. | Toxicology and applied pharmacology 20070201 |
| Nucleic acid biosensor for detection of hepatitis B virus using 2,9-dimethyl-1,10-phenanthroline copper complex as electrochemical indicator. | Analytica chimica acta 20070116 |
| Dithiocarbamates have a common toxic effect on zebrafish body axis formation. | Toxicology and applied pharmacology 20061001 |
| Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. | FEBS letters 20060123 |
| Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. | The international journal of biochemistry & cell biology 20060101 |
| The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. | International journal of food sciences and nutrition 20060101 |
| Neocuproine, a copper (I) chelator, potentiates purinergic component of vas deferens contractions elicited by electrical field stimulation. | Pharmacology 20051001 |
| Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: the CUPRAC method. | Free radical research 20050901 |
| Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition. | Journal of medicinal chemistry 20050505 |
| Effect of neocuproine, a copper(i) chelator, on rat bladder function. | The Journal of pharmacology and experimental therapeutics 20050301 |
| Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. | Journal of agricultural and food chemistry 20041229 |
| Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. | Carcinogenesis 20040901 |
| Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper. | Yeast (Chichester, England) 20040901 |
| Nitric oxide and BCNU chemoresistance in C6 glioma cells: role of S-nitrosoglutathione. | Free radical biology & medicine 20040515 |
| General method for the synthesis of 8-arylsulfanyl adenine derivatives. | The Journal of organic chemistry 20040430 |
| Evidence that NiNi acetyl-CoA synthase is active and that the CuNi enzyme is not. | Biochemistry 20040406 |
| Sensitive indirect spectrophotometric determination of isoniazid. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040301 |
| Neocuproine inhibits the decomposition of endogenous S-nitrosothiol by ultraviolet irradiation in the mouse gastric fundus. | European journal of pharmacology 20040206 |
| Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes. | Journal of neurochemistry 20031001 |
| Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells. | Free radical biology & medicine 20030315 |
| Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation. | European journal of biochemistry 20021101 |
| The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide. | European journal of biochemistry 20020901 |
| Low-density lipoprotein modification by normal, myeloperoxidase-deficient and NADPH oxidase-deficient granulocytes and the impact of redox active transition metal ions. | Redox report : communications in free radical research 20020101 |
| Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II). | Cancer letters 20010828 |
| Nitric oxide initiates iron binding to neocuproine. | Nitric oxide : biology and chemistry 20010401 |
| Role of copper ions and cytochrome P450 in the vasodilator actions of the nitroxyl anion generator, Angeli's salt, on rat aorta. | European journal of pharmacology 20010202 |
| Evaluation of antioxidant activity of epigallocatechin gallate in biphasic model systems in vitro. | Molecular and cellular biochemistry 20010201 |
| Pre- and postjunctional protective effect of neocuproine on the nitrergic neurotransmitter in the mouse gastric fundus. | British journal of pharmacology 20010101 |
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