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7229-50-7 | 2-Pyrrolidineacetamide,4-[(2E,4E,6R)-6-[(1R,2'R,3R,4S,5R)-1,4-dimethylspiro[2,9-dioxabicyclo[3.3.1]non-6-ene-8,2'-oxiran]-3-yl]-1-hydroxy-4-methyl-2,4-heptadien-1-ylidene]-N,a-dimethyl-3,5-dioxo-1-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-,
CAS No: 7229-50-7 Catalog No: AG005UJX MDL No:
Product Description
Catalog Number:
AG005UJX
Chemical Name:
2-Pyrrolidineacetamide,4-[(2E,4E,6R)-6-[(1R,2'R,3R,4S,5R)-1,4-dimethylspiro[2,9-dioxabicyclo[3.3.1]non-6-ene-8,2'-oxiran]-3-yl]-1-hydroxy-4-methyl-2,4-heptadien-1-ylidene]-N,a-dimethyl-3,5-dioxo-1-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-,
CAS Number:
7229-50-7
Molecular Formula:
C32H44N2O9
Molecular Weight:
600.6998
IUPAC Name:
(2S)-2-[(2S,4E)-4-[(2E,4E,6R)-6-[(1R,3R,4S,5R,8R)-1,4-dimethylspiro[2,9-dioxabicyclo[3.3.1]non-6-ene-8,2'-oxirane]-3-yl]-1-hydroxy-4-methylhepta-2,4-dienylidene]-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3,5-dioxopyrrolidin-2-yl]-N-methylpropanamide
InChI:
InChI=1S/C32H44N2O9/c1-16(14-17(2)28-18(3)23-12-13-32(15-40-32)31(6,42-23)43-28)8-9-22(36)25-27(37)26(19(4)29(38)33-7)34(30(25)39)24-11-10-21(35)20(5)41-24/h8-9,12-14,17-21,23-24,26,28,35-36H,10-11,15H2,1-7H3,(H,33,38)/b9-8+,16-14+,25-22+/t17-,18+,19+,20+,21+,23-,24+,26+,28-,31-,32-/m1/s1
InChI Key:
KVTPRMVXYZKLIG-NCAOFHFGSA-N
SMILES:
CC(=CC(C1OC2(C)OC(C1C)C=CC12CO1)C)C=CC(=O)C1=C(O)N(C(C1=O)C(C(=O)N)(C)C)C1CCC(C(O1)C)O
UNII:
6MON4029Q8
Properties
Complexity:
1290
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
11
Defined Bond Stereocenter Count:
3
Exact Mass:
600.305g/mol
Formal Charge:
0
Heavy Atom Count:
43
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
600.709g/mol
Monoisotopic Mass:
600.305g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
147A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1
Literature
| Title | Journal |
|---|---|
| Mycobacterium tuberculosis is resistant to streptolydigin. | Tuberculosis (Edinburgh, Scotland) 20130701 |
| Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus. | Microbiology (Reading, England) 20121001 |
| Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus. | Microbial biotechnology 20120901 |
| Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin. | The Journal of antibiotics 20120701 |
| Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics. | Journal of the American Chemical Society 20110810 |
| Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. | Nature chemistry 20110801 |
| Hutchinson's legacy: keeping on polyketide biosynthesis. | The Journal of antibiotics 20110101 |
| Synthesis of streptolydigin, a potent bacterial RNA polymerase inhibitor. | Journal of the American Chemical Society 20101020 |
| Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. | Chemistry & biology 20091030 |
| fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin. | Applied microbiology and biotechnology 20090501 |
| Structural basis for substrate loading in bacterial RNA polymerase. | Nature 20070712 |
| Biosynthesis of streptolydigin: origin of the oxygen atoms. | Organic letters 20061109 |
| Differential analysis of secondary metabolites by LC-MS following strain improvement of Streptomyces lydicus AS 4.2501. | Biotechnology and applied biochemistry 20061101 |
| Functional analysis of type II thioesterase of Streptomyces lydicus AS 4.2501. | Applied biochemistry and biotechnology 20061101 |
| Structural basis of transcription inhibition by antibiotic streptolydigin. | Molecular cell 20050902 |
| Inhibition of RNA polymerase by streptolydigin: no cycling allowed. | Cell 20050826 |
| Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. | Cell 20050826 |
| Homogeneous fluorescent assay for RNA polymerase. | Analytical biochemistry 20050715 |
| Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase. | European journal of biochemistry 20040801 |
| New inhibitors targeting bacterial RNA polymerase. | Trends in biochemical sciences 20040401 |
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