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71145-03-4

71145-03-4 | Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

CAS No: 71145-03-4 Catalog No: AG005KPD MDL No:MFCD00036697

Product Description

Catalog Number:
AG005KPD
Chemical Name:
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
CAS Number:
71145-03-4
Molecular Formula:
C16H15F3N2O4
Molecular Weight:
356.2965
MDL Number:
MFCD00036697
IUPAC Name:
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
InChI:
InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChI Key:
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
SMILES:
COC(=O)C1=C(C)NC(=C(C1c1ccccc1C(F)(F)F)[N+](=O)[O-])C

Properties

Complexity:
634  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
356.098g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
356.301g/mol
Monoisotopic Mass:
356.098g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
84.2A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4  

Literature

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Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells. Endocrinology 20070201
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L, P-/Q- and T-type Ca2+ channels in smooth muscle cells from human umbilical artery. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Blocking L-type calcium channels enhances long-term depression induced by low-frequency stimulation at hippocampal CA1 synapses. Brain research 20061208
The actions of azelnidipine, a dihydropyridine-derivative Ca antagonist, on voltage-dependent Ba2+ currents in guinea-pig vascular smooth muscle. British journal of pharmacology 20061101
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Muscarinic regulation of neonatal rat bladder spontaneous contractions. American journal of physiology. Regulatory, integrative and comparative physiology 20061001
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Characterizing the efficacy of calcium channel agonist-release strategies for bone tissue engineering applications. Journal of controlled release : official journal of the Controlled Release Society 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Vasomotor action of insulin on the rabbit normal cavernous smooth muscle. European journal of pharmacology 20060424
Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway. Molecular and cellular neurosciences 20060401
Cross-bridge-dependent change in Ca2+ sensitivity is involved in the negative inotropic effect of nifedipine in aequorin-injected ferret ventricular muscles. Circulation journal : official journal of the Japanese Circulation Society 20060401
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Effects of congenital stationary night blindness type 2 mutations R508Q and L1364H on Cav1.4 L-type Ca2+ channel function and expression. Journal of neurochemistry 20060301
Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats. Acta pharmacologica Sinica 20060301
Functional inhibition of intestinal and uterine muscles by non-permeant triphenylethylene derivatives. European journal of pharmacology 20060217
Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. AIDS (London, England) 20060102
Arecoline inhibits catecholamine release from perfused rat adrenal gland. Acta pharmacologica Sinica 20060101
Effects of L-type Ca2+ channel modulation on direct myocardial effects of diazepam and midazolam in adult rat ventricular myocytes. Journal of anesthesia 20060101
Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval. Journal of pharmacological and toxicological methods 20060101
Brain activation pattern induced by stimulation of L-type Ca2+-channels: contribution of Ca(V)1.3 and Ca(V)1.2 isoforms. Neuroscience 20060101
Urocortin II inhibits the apoptosis of mesenteric arterial smooth muscle cells via L-type calcium channels in spontaneously hypertensive rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101
The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents. Developmental neuroscience 20060101
Slow Ca2+ channels neither contribute to upstroke of action potential nor to pacemaker potential in spontaneously active freshly isolated three day embryonic chick ventricle. Indian journal of physiology and pharmacology 20060101
Enhancement of methoxamine-induced contractile responses of rat ventricular muscle in streptozotocin-induced diabetes is associated with alpha1A adrenoceptor upregulation. Acta physiologica (Oxford, England) 20060101
[The effect of the time of death on the reactivity of rat caudal artery regulated by Bay-K 8644 (an agonist directly affecting the Ca channel)]. Archiwum medycyny sadowej i kryminologii 20060101
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) enhances triggered afterdepolarizations in rat ventricular myocytes. Cardiovascular toxicology 20060101
Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochemical and biophysical research communications 20051216
Overexpression of regucalcin suppresses apoptotic cell death in cloned normal rat kidney proximal tubular epithelial NRK52E cells: change in apoptosis-related gene expression. Journal of cellular biochemistry 20051215
Functional and molecular analysis of L-type calcium channels in human esophagus and lower esophageal sphincter smooth muscle. American journal of physiology. Gastrointestinal and liver physiology 20051201
Controlling cell biomechanics in orthopaedic tissue engineering and repair. Pathologie-biologie 20051201
Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder. The Journal of biological chemistry 20051118
The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. Biochemical and biophysical research communications 20051111
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A transitional period of Ca2+-dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells. The Journal of physiology 20050815
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Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology 20050501
Characterization of single L-type Ca2+ channels in myocytes isolated from the cricket lateral oviduct. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20050501
Role of l-Ca(2+) channels in intestinal pacing in wild-type and W/W(V) mice. American journal of physiology. Gastrointestinal and liver physiology 20050301
Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit. Nature neuroscience 20050301
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The responses to manipulation of extracellular and intracellular calcium are altered in the streptozotocin-diabetic rat colon and ileum. European journal of pharmacology 20050210
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Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas. European journal of endocrinology 20041201
Optimising the EVA descriptor for prediction of biological activity. Organic & biomolecular chemistry 20041121
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644. Journal of cellular biochemistry 20041015
Regional differences in L-type Ca2+ channel expression in feline lower esophageal sphincter. American journal of physiology. Gastrointestinal and liver physiology 20041001
Comparative effects of bupivacaine and ropivacaine on intracellular calcium transients and tension in ferret ventricular muscle. Anesthesiology 20041001
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Altered inotropic reactivity in diabetic rabbit right ventricular myocardium. Canadian journal of physiology and pharmacology 20041001
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A role for chromogranin A (4-16), a vasostatin-derived peptide, on human colonic motility. An in vitro study. Regulatory peptides 20040915
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Modulation of single channels underlying hippocampal L-type current enhancement by agonists depends on the permeant ion. Journal of neurophysiology 20040801
Adriamycin impairs the contraction of mesangial cells through the inhibition of protein kinase C and intracellular calcium. American journal of physiology. Renal physiology 20040801
A model of the rat phrenic motor neuron. IEEE transactions on bio-medical engineering 20040701
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Protease-activated receptor-2-mediated inhibition for Ca2+ response to lipopolysaccharide in Guinea pig tracheal epithelial cells. American journal of respiratory cell and molecular biology 20040601
Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells. The Journal of physiology 20040601
L-type Ca(2+) channel expression along feline smooth muscle oesophagus. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040601
MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20040601
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. The Journal of clinical investigation 20040515
New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties. Journal of medicinal chemistry 20040506
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. Behavioural brain research 20040505
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Slow calcium signals after tetanic electrical stimulation in skeletal myotubes. Biophysical journal 20040501
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Ceramide inhibits L-type calcium channel currents in GH3 cells. Molecular and cellular endocrinology 20040415
Cortisol rapidly suppresses intracellular calcium and voltage-gated calcium channel activity in prolactin cells of the tilapia (Oreochromis mossambicus). American journal of physiology. Endocrinology and metabolism 20040401
Effects of angiotensin II on sustained outward currents in rat ventricular myocytes. Pflugers Archiv : European journal of physiology 20040401
Heat-shock response is associated with enhanced contractility of vascular smooth muscle in isolated rat aorta. Naunyn-Schmiedeberg's archives of pharmacology 20040401
Single-channel activity of L-type Ca2+ channels reconstituted with the beta2c subunit cloned from the rat heart. European journal of pharmacology 20040308
Cholecystokinin octapeptide inhibits carotid sinus baroreflex in anesthetized rats. Sheng li xue bao : [Acta physiologica Sinica] 20040225
The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218
Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes. American journal of physiology. Heart and circulatory physiology 20040201
Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Investigative ophthalmology & visual science 20040201
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Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland. Autonomic neuroscience : basic & clinical 20040130
Roles of ryanodine and inositol triphosphate receptors in regulation of plateau potentials in turtle spinal motoneurons. Neuroscience 20040101
Role of Ca2+ in vascular smooth muscle contractions induced by Phoneutria nigriventer spider venom. Toxicon : official journal of the International Society on Toxinology 20040101
Pharmacological dissection of calcium channel subtype-related components of strontium inflow in large mossy fiber boutons of mouse hippocampus. Hippocampus 20040101
Modulation of tracheal smooth muscle responses in inducible T-cell kinase knockout mice. Pulmonary pharmacology & therapeutics 20040101
[Effects of agmatine on neuronal discharges in rat hippocampal CA1 area]. Sheng li xue bao : [Acta physiologica Sinica] 20031225
A role for Ca(v)1.3 in rat intestinal calcium absorption. Biochemical and biophysical research communications 20031212
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn-Schmiedeberg's archives of pharmacology 20031201
The effects of metabolic inhibition on intracellular calcium and contractility of human myometrium. BJOG : an international journal of obstetrics and gynaecology 20031201
Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L. Circulation research 20031114
Electrophysiological effects of capsaicin on guinea pig papillary muscles. Sheng li xue bao : [Acta physiologica Sinica] 20031025
The effects of paroxetine on rat isolated vas deferens. Pharmacological research 20031001
Direct, rapid effects of 25-hydroxyvitamin D3 on isolated intestinal cells. Journal of cellular biochemistry 20031001
Increased cAMP as a positive inotropic factor for mammalian skeletal muscle in vitro. Canadian journal of physiology and pharmacology 20031001
Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library. Molecular and cellular endocrinology 20030930
Relative and combined effects of estradiol and prolactin on corticosterone secretion in ovariectomized rats. The Chinese journal of physiology 20030930
Modulation of manganese currents by 1, 4-dihydropyridines, isoproterenol and forskolin in rabbit ventricular cells. Pflugers Archiv : European journal of physiology 20030901
Cotinine inhibits catecholamine release evoked by cholinergic stimulation from the rat adrenal medulla. Archives of pharmacal research 20030901
L-type calcium channel activation up-regulates the mRNAs for two different sodium channel alpha subunits (Nav1.2 and Nav1.3) in rat pituitary GH3 cells. Brain research. Molecular brain research 20030819
Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels. Neuroscience research 20030801
Electrophysiologic effects of capsaicin on pacemaker cells in sinoatrial nodes of rabbits. Acta pharmacologica Sinica 20030801
Calcium channel agonist, (+/-)-Bay K8644, causes an immediate increase in the striatal 1-methyl-4-phenylpyridinium level following systemic administration of the dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in Balb/c mice. Neuroscience letters 20030731
AII amacrine cells express L-type calcium channels at their output synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030709
Ligand-activated signal transduction in the 2-cell embryo. Biology of reproduction 20030701
Governance of arteriolar oscillation by ryanodine receptors. American journal of physiology. Regulatory, integrative and comparative physiology 20030701
Biophysical and pharmacological characterization of voltage-gated calcium currents in turtle auditory hair cells. The Journal of physiology 20030615
The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II. Endocrinology 20030601
Insulin secretagogues, but not glucose, stimulate an increase in [Ca2+]i in the fetal human and porcine beta-cell. The Journal of clinical endocrinology and metabolism 20030601
Fetal and postnatal development of Ca2+ transients and Ca2+ sparks in rat cardiomyocytes. Cardiovascular research 20030601
Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. The Journal of membrane biology 20030601
Calcium channel agonist, (+/-)-Bay K8644, causes a transient increase in striatal monoamine oxidase activity in Balb/c mice. Neuroscience letters 20030515
Calcium channels involved in noradrenaline release from sympathetic neurones in rabbit carotid artery. Pharmacology & toxicology 20030501
Catecholamine release from cultured bovine adrenal medullary chromaffin cells in the presence of 60-Hz magnetic fields. Bioelectrochemistry (Amsterdam, Netherlands) 20030401
Inhibition of cAMP signalling cascade-mediated Ca2+ influx by a prothoracicostatic peptide (Mas-MIP I) via dihydropyridine-sensitive Ca2+ channels in the prothoracic glands of the silkworm, Bombyx mori. Insect biochemistry and molecular biology 20030201
Postsynaptic firing produces long-term depression at inhibitory synapses of rat visual cortex. Neuroscience letters 20030130
Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. American journal of physiology. Heart and circulatory physiology 20030101
Slow deactivation and U-shaped inactivation properties in cloned Cav1.2b channels in Chinese hamster ovary cells. Biophysical journal 20030101
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. European journal of nutrition 20030101
Inhibitory effects of D2 agonists by striatal injection on excessive release of dopamine and hyperactivity induced by Bay K 8644 in rats. Neuroscience 20030101
Stretch-modulation of second messengers: effects on cardiomyocyte ion transport. Progress in biophysics and molecular biology 20030101
Self-biting induced by activation of L-type calcium channels in mice: dopaminergic influences. Developmental neuroscience 20030101
The role of Ca2+ in the generation of spontaneous astrocytic Ca2+ oscillations. Neuroscience 20030101
New treatment methods in verapamil poisoning: experimental studies. Polish journal of pharmacology 20030101
Ruthenium red-induced transition from ventricular fibrillation to tachycardia in isolated rat hearts: possible involvement of changes in mitochondrial calcium uptake. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20030101
Effect of some convulsants on the protective activity of loreclezole and its combinations with valproate or clonazepam in amygdala-kindled rats. Polish journal of pharmacology 20030101
The vasodepressor effect of androgens in pithed rats: potential role of calcium channels. Steroids 20021201
Different effects of mibefradil and amlodipine on coronary vessels and during beta-adrenergic stimulation in conscious dogs. Journal of cardiovascular pharmacology 20021201
Effects of tetrandrine on smooth muscle contraction induced by mediators in pulmonary hypertension. Acta pharmacologica Sinica 20021201
Pharmacologic thresholds for self-injurious behavior in a genetic mouse model of Lesch-Nyhan disease. Pharmacology, biochemistry, and behavior 20021001
Ramipril treatment alters Ca(2+) and K(+) channels in small mesenteric arteries from Wistar-Kyoto and spontaneously hypertensive rats. American journal of hypertension 20021001
Spinal cord regeneration induced by a voltage-gated calcium channel agonist. Neurological research 20021001
Pharmacological regulation of the late steps of exocytosis. Annals of the New York Academy of Sciences 20021001
L-type Ca2+ channels gaining respect in heart failure. Circulation research 20020920
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circulation research 20020920
Modulation of the negative inotropic effect of haloperidol by drugs with positive inotropic effects in isolated rabbit heart. Pharmacology 20020901
Functional properties of ryanodine receptors in hippocampal neurons change during early differentiation in culture. Journal of neurophysiology 20020901
Gender differences in vascular expression of endothelin and ET(A)/ET(B) receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020901
Biphasic effects of oxethazaine, a topical anesthetic, on the intracellular Ca(2+) concentration of PC12 cells. Biochemical pharmacology 20020815
Effects of methylmercury on human neuronal L-type calcium channels transiently expressed in human embryonic kidney cells (HEK-293). The Journal of pharmacology and experimental therapeutics 20020801
G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells. Molecular endocrinology (Baltimore, Md.) 20020801
Upregulation of L-type Ca2+ channels in mesenteric and skeletal arteries of SHR. Hypertension (Dallas, Tex. : 1979) 20020801
Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. American journal of obstetrics and gynecology 20020801
Inhibitory mechanism of bromocriptine on catecholamine release evoked by cholinergic stimulation and membrane depolarization from the rat adrenal medulla. Archives of pharmacal research 20020801
Inhibitory effects of 1,4-DHP antagonists on synaptic GABA release modulated by BAY-K 8644 in mechanically dissociated rat substantia innominata. Life sciences 20020726
Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. Molecular and cellular endocrinology 20020628
Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine. The Journal of physiology 20020615
Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin. American journal of physiology. Cell physiology 20020601
Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020601
Role of L-type Ca2+ channels in transmitter release from mammalian inner hair cells. II. Single-neuron activity. Journal of neurophysiology 20020601
Diminished inibitory action of ethanol on the contraction of gallbladder isolated from chronically ethanol-fed Guinea pigs. Pharmacology 20020501
Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells. American journal of physiology. Heart and circulatory physiology 20020501
Development of a 'mechano-active' scaffold for tissue engineering. Biomaterials 20020501
Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. The Journal of physiology 20020501
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis. Cardiovascular research 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles. American journal of physiology. Heart and circulatory physiology 20020401
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits. American journal of physiology. Regulatory, integrative and comparative physiology 20020401
Electrophysiological effects of phytoestrogen genistein on pacemaker cells in sinoatrial nodes of rabbits. Acta pharmacologica Sinica 20020401
Mechanisms underlying greater sensitivity of neonatal cardiac muscle to volatile anesthetics. Anesthesiology 20020401
Polyamine effects on human myometrial contractility. American journal of obstetrics and gynecology 20020401
The initial inositol 1,4,5-trisphosphate response induced by histamine is strongly amplified by Ca(2+) release from internal stores in smooth muscle. Cell calcium 20020401
Up-regulation of L-type voltage-dependent calcium channels after long term exposure to nicotine in cerebral cortical neurons. The Journal of biological chemistry 20020308
L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the 'slip-mode' phenomenon in cardiac myocytes? Circulation research 20020308
PRL gene expression in individual living mammotropes displays distinct functional pulses that oscillate in a noncircadian temporal pattern. Endocrinology 20020301
Ca2+ buffering function of the sarcoplasmic reticulum is increased in the carotid artery from spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 20020301
Increased Ca2+ buffering function of sarcoplasmic reticulum in small mesenteric arteries from spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 20020301
Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers. Journal of medicinal chemistry 20020214
Calcium channels contribute to the decrease in blood pressure of pregnant rats. American journal of physiology. Heart and circulatory physiology 20020201
Smooth muscle in the annulus fibrosus of the tympanic membrane: physiological effects on sound transmission in the gerbil. Hearing research 20020201
L-type Ca2+ channels in fetal and adult ovine cerebral arteries. American journal of physiology. Regulatory, integrative and comparative physiology 20020101
Electrical activity induced by nitric oxide in canine colonic circular muscle. American journal of physiology. Gastrointestinal and liver physiology 20020101
Self-biting induced by activation of L-type calcium channels in mice: serotonergic influences. Developmental neuroscience 20020101
Vascular smooth muscle sensitivity to varying oxygen tensions, Bay K 8644 and nifedipine. West African journal of medicine 20020101
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20011215
Gonadotropin subunit transcriptional responses to calcium signals in the rat: evidence for regulation by pulse frequency. Biology of reproduction 20011201
Novel marine-derived halogen-containing gramine analogues induce vasorelaxation in isolated rat aorta. European journal of pharmacology 20011130
High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK. European journal of pharmacology 20011102
Intracellular and extracellular calcium utilization during hypoxic vasoconstriction of cyclostome aortas. American journal of physiology. Regulatory, integrative and comparative physiology 20011101
Ca2+ influx mediates enhanced alpha2-adrenergic contraction in aortas from rats treated with NOS inhibitor. American journal of physiology. Heart and circulatory physiology 20011101
Influence of Voltage-sensitive Ca(++) channel drugs on bupivacaine infiltration anesthesia in mice. Anesthesiology 20011101
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. Metabolism: clinical and experimental 20011101
Calcium signalling through nucleotide receptor P2X1 in rat portal vein myocytes. The Journal of physiology 20011015
Contribution of L-type Ca(2+) channels to evoked transmitter release in cultured Xenopus nerve-muscle synapses. The Journal of physiology 20011001
Effects of amlodipine on unitary non-L-type high voltage-activated Ca2+ channel currents in differentiated PC12 cells. Naunyn-Schmiedeberg's archives of pharmacology 20011001
Contribution of Na+/Ca2+ exchanger to the regulation of myogenic tone in isolated rat small arteries. Acta physiologica Scandinavica 20011001
[Effects of Bay K8644 and nifedipine on L-type Ca2+ channels in hypothalamic neurons of rats]. Sheng li xue bao : [Acta physiologica Sinica] 20011001
Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx. Cell type-specific action potential secretion coupling. The Journal of biological chemistry 20010907
E(f)-current contributes to whole-cell calcium current in low calcium in frog sympathetic neurons. Journal of neurophysiology 20010901
Ca(2+) influx is increased in 2-kidney, 1-clip hypertensive rat aorta. Hypertension (Dallas, Tex. : 1979) 20010901
Agonist of dihydropyridine receptors, BayK8644 depresses excitation-contraction coupling in myocytes of guinea pig heart. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20010901
Suppression of Ca2+ influx through L-type voltage-dependent calcium channels by hydroxyl radical in mouse cerebral cortical neurons. Brain research. Molecular brain research 20010815
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815
Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. American journal of physiology. Endocrinology and metabolism 20010701
Role of calcium channels in the spinal transmission of nociceptive information from the mesentery. Pain 20010701
Neural regulation of in vitro giant contractions in the rat colon. American journal of physiology. Gastrointestinal and liver physiology 20010701
H+-ATPase-mediated cytoplasmic pH-responses associated with elevation of cytoplasmic calcium in cultured rabbit nonpigmented ciliary epithelium. The Journal of membrane biology 20010701
alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. The Journal of biological chemistry 20010622
Hormonal regulation of the human ghrelin receptor gene transcription. Biochemical and biophysical research communications 20010615
5-Hydroxytryptamine stimulates net Ca2+ flux in the ventricular muscle of a mollusc (Busycon canaliculatum) during cardioexcitation. The Biological bulletin 20010601
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons. The European journal of neuroscience 20010601
Angiotensin II priming of aldosterone secretion with agents that enhance Ca(2+) influx. Molecular and cellular endocrinology 20010525
Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. Behavioural brain research 20010501
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture. American journal of physiology. Cell physiology 20010501
Sites and ionic mechanisms of hypoxic vasoconstriction in frog skin. American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Calcium buffering of resting, voltage-dependent Ca2+ influx by sarcoplasmic reticulum in femoral arteries from spontaneously hypertensive rats at prehypertensive stage. Hypertension research : official journal of the Japanese Society of Hypertension 20010501
Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. The Journal of biological chemistry 20010427
Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: involvement of region-specific voltage-dependent calcium channels. Journal of neurochemistry 20010401
L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation. Basic research in cardiology 20010401
Effect of beta-estradiol on voltage-gated Ca(2+) channels in rat hippocampal neurons: a comparison with dehydroepiandrosterone. European journal of pharmacology 20010330
Activation of purified cardiac ryanodine receptors by dihydropyridine agonists. American journal of physiology. Heart and circulatory physiology 20010301
Regulation of Ca2+-sensitive adenylyl cyclase in gonadotropin-releasing hormone neurons. Molecular endocrinology (Baltimore, Md.) 20010301
Signalling mechanisms underlying the myogenic response in human subcutaneous resistance arteries. Cardiovascular research 20010301
The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons. Epilepsy research 20010301
Mechanism of CGRP-induced relaxation in rat intramural coronary arteries. British journal of pharmacology 20010301
Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors. British journal of pharmacology 20010301
Differential effects of agonists of aldosterone secretion on steroidogenic acute regulatory phosphorylation. Molecular and cellular endocrinology 20010227
Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles. Circulation research 20010216
Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation. Circulation 20010206
Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterology 20010201
Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. Journal of neurophysiology 20010201
Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor. American journal of obstetrics and gynecology 20010201
Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials. Pflugers Archiv : European journal of physiology 20010201
Comparative study of the molecular and functional expression of L-type Ca2+ channels and large-conductance, Ca2+-activated K+ channels in rabbit aorta and vas deferens smooth muscle. Pflugers Archiv : European journal of physiology 20010201
Downregulation of the voltage-dependent calcium channel (VDCC) beta-subunit mRNAs in pancreatic islets of type 2 diabetic rats. Biochemical and biophysical research communications 20010126
Dependence of soluble guanylyl cyclase activity on calcium signaling in pituitary cells. The Journal of biological chemistry 20010105
Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. American journal of physiology. Lung cellular and molecular physiology 20010101
Voltage-activated Ca2+ channels and ionotropic GABA receptors localized at axon terminals of mammalian retinal bipolar cells. Visual neuroscience 20010101
Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E). Journal of cellular biochemistry 20010101
The influence of nifedipine (calcium channel blocker) and Bay-K-8644 (calcium channel agonist) on the development of experimental acute pancreatitis. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20010101
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. The Journal of biological chemistry 20001215
D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience 20001215
Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell 20000707
Structure and functional characterization of a novel human low-voltage activated calcium channel. Journal of neurochemistry 19990201
The effects of 4-aminopyridine and Bay K 8644 on verapamil-induced cardiovascular toxicity in anesthetized rats. Journal of toxicology. Clinical toxicology 19980101
Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. Molecular endocrinology (Baltimore, Md.) 19970501
Anticonvulsant activity of 5,7DCKA, NBQX, and felbamate against some chemoconvulsants in DBA/2 mice. Pharmacology, biochemistry, and behavior 19961001
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