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70918-17-1 | R-Doxazosin
CAS No: 70918-17-1 Catalog No: AG00FG9K MDL No:
Product Description
Catalog Number:
AG00FG9K
Chemical Name:
R-Doxazosin
CAS Number:
70918-17-1
IUPAC Name:
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone
InChI:
InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)/t20-/m1/s1
InChI Key:
RUZYUOTYCVRMRZ-HXUWFJFHSA-N
UNII:
F6HQ441M9W
Properties
Complexity:
678
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
451.186g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
451.483g/mol
Monoisotopic Mass:
451.186g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5
Literature
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|---|---|
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| A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo. | PloS one 20120101 |
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| Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons? | Journal of translational medicine 20110101 |
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| Magnetic resonance imaging and relaxometry to study water transport mechanisms in a commercially available gastrointestinal therapeutic system (GITS) tablet. | International journal of pharmaceutics 20100915 |
| Enantioselective determination of doxazosin in human plasma by liquid chromatography-tandem mass spectrometry using ovomucoid chiral stationary phase. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100915 |
| Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia. | Molecular cancer 20100101 |
| How do physicians conduct medication reviews? | Journal of general internal medicine 20091201 |
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| [Changes in microcirculation of the urinary bladder in patients with stage II prostatic adenoma depending on the treatment method]. | Urologiia (Moscow, Russia : 1999) 20080101 |
| Epidemiology of viral hepatitis in Sudan. | Clinical and experimental gastroenterology 20080101 |
| [Effects of doxazosin enantiomers on alpha-adrenoceptors of isolated rabbit blood vessels]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070201 |
| Chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats. | Acta pharmacologica Sinica 20061101 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Bioequivalence evaluation of two formulations of doxazosin tablet in healthy thai male volunteers. | Drug development and industrial pharmacy 20051201 |
| Doxazosin gastrointestinal therapeutic system: a review of its use in benign prostatic hyperplasia. | Drugs 20050101 |
| [Viagra effects on polysystemic energy metabolism in stress (an experimental study)]. | Urologiia (Moscow, Russia : 1999) 20040101 |
| [Alfadil and heart failure--clinical conclusions do exist!]. | Lakartidningen 20031204 |
| Massive diltiazem overdose treated with extracorporeal membrane oxygenation. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030701 |
| [Comparative pharmacologic economic efficacy of alpha-adrenoblockers produced by different manufacturing firms for the management of chronic prostatitis]. | Likars'ka sprava 20030101 |
| [The incidence, features of the course, and treatment of arterial hypertension in patients with prostate hyperplasia]. | Likars'ka sprava 20030101 |
| [Possibility of predicting the use of doxazosin in the treatment of arterial hypertension]. | Klinicheskaia meditsina 20030101 |
| Stability-indicating methods for the determination of doxazosin mezylate and celecoxib. | Journal of pharmaceutical and biomedical analysis 20020201 |
| Heart lines. Cardura update. | Harvard heart letter : from Harvard Medical School 20010901 |
| On call. I'm a 76-year-old man with an enlarged prostate. I've been taking Cardura and it's helped a lot, but my doctor stopped it because he said a study found the drug could cause heart failure. Now I'm getting up three or four times a night again. Is Cadura safe? | Harvard men's health watch 20010701 |
| [Doksazozin 'Cardura' in acute urinary retention caused by benign prostatic hyperplasia]. | Urologiia (Moscow, Russia : 1999) 20010101 |
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