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704-00-7 | 1,2-Diacetylbenzene
CAS No: 704-00-7 Catalog No: AG003DDB MDL No:
Product Description
Catalog Number:
AG003DDB
Chemical Name:
1,2-Diacetylbenzene
CAS Number:
704-00-7
IUPAC Name:
1-(2-acetylphenyl)ethanone
InChI:
InChI=1S/C10H10O2/c1-7(11)9-5-3-4-6-10(9)8(2)12/h3-6H,1-2H3
InChI Key:
LVQFKRXRTXCQCZ-UHFFFAOYSA-N
EC Number:
211-877-6
Properties
Complexity:
174
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
162.068g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
162.188g/mol
Monoisotopic Mass:
162.068g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
34.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1
Literature
| Title | Journal |
|---|---|
| Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice. | Toxicology letters 20170905 |
| Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin. | Journal of molecular neuroscience : MN 20120701 |
| Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. | Chemico-biological interactions 20111115 |
| Therapeutic effect of the combined use of growth hormone releasing peptide-6 and epidermal growth factor in an axonopathy model. | Neurotoxicity research 20110101 |
| Yields of glyoxal and ring-cleavage co-products from the OH radical-initiated reactions of naphthalene and selected alkylnaphthalenes. | Environmental science & technology 20091115 |
| New insights into mechanisms of gamma-diketone-induced axonopathy. | Neurochemical research 20091101 |
| Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. | Toxicological sciences : an official journal of the Society of Toxicology 20090201 |
| Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene. | Toxicological sciences : an official journal of the Society of Toxicology 20080901 |
| Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress. | Toxicology 20080114 |
| Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport. | Neurochemical research 20071201 |
| Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells. | Journal of toxicology and environmental health. Part A 20070801 |
| A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat. | Journal of toxicology and environmental health. Part A 20070101 |
| Monocyclic and dicyclic hydrocarbons: structural requirements for proximal giant axonopathy. | Acta neuropathologica 20060901 |
| Kinetics and products of photolysis and reaction with OH radicals of a series of aromatic carbonyl compounds. | Environmental science & technology 20060901 |
| A new murine model of giant proximal axonopathy. | Acta neuropathologica 20050401 |
| Chromogenic derivatives of AHTN (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040501 |
| Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. | Toxicology and applied pharmacology 20020815 |
| Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. | Journal of the American Chemical Society 20020320 |
| Aromatic as well as aliphatic hydrocarbon solvent axonopathy. | International journal of hygiene and environmental health 20020301 |
| 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. | Toxicology and applied pharmacology 20011201 |
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