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701-44-0 | 1-methyl-6-oxo-pyridine-3-carboxamide
CAS No: 701-44-0 Catalog No: AG00FDMQ MDL No:MFCD00457283
Product Description
Catalog Number:
AG00FDMQ
Chemical Name:
1-methyl-6-oxo-pyridine-3-carboxamide
CAS Number:
701-44-0
Molecular Formula:
C7H8N2O2
Molecular Weight:
152.1506
MDL Number:
MFCD00457283
IUPAC Name:
1-methyl-6-oxopyridine-3-carboxamide
InChI:
InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)
InChI Key:
JLQSXXWTCJPCBC-UHFFFAOYSA-N
SMILES:
NC(=O)c1ccc(=O)n(c1)C
UNII:
68139USC7W
Properties
Complexity:
266
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
152.059g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
152.153g/mol
Monoisotopic Mass:
152.059g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
63.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1
Literature
| Title | Journal |
|---|---|
| N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity. | Journal of physiology and biochemistry 20120901 |
| Effect of graded levels of niacin supplementation of a semipurified diet on energy and nitrogen balance, growth performance, diarrhea occurrence, and niacin metabolite excretion by growing swine. | Journal of animal science 20120101 |
| 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside triphosphate (4PyTP), a novel NAD metabolite accumulating in erythrocytes of uremic children: a biomarker for a toxic NAD analogue in other tissues? | Toxins 20110601 |
| Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. | Nutrition & metabolism 20110101 |
| Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. | Biomedical chromatography : BMC 20101001 |
| Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. | Molecular bioSystems 20100501 |
| Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100401 |
| Two new megastigmane sulphonoglucosides from Mallotus anisopodus. | Natural product communications 20090701 |
| 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. | Archivum immunologiae et therapiae experimentalis 20080401 |
| Are so-called uremic toxins always toxic? | Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20080101 |
| Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites. | Journal of clinical pharmacology 20070601 |
| Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. | Scandinavian journal of urology and nephrology 20070101 |
| Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure. | Pediatric nephrology (Berlin, Germany) 20060601 |
| Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. | Journal of nutritional science and vitaminology 20060401 |
| Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. | Drug metabolism and disposition: the biological fate of chemicals 20060201 |
| The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325 |
| The effect of N-methyl-2-pyridone-5-carboxamide--A nicotinamide catabolite on poly ADP-rybosylation and oxidative stress injury in endothelial cells. | Nucleosides, nucleotides & nucleic acids 20050101 |
| Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes. | Journal of nutritional science and vitaminology 20041201 |
| An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure. | Nucleosides, nucleotides & nucleic acids 20041001 |
| Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure. | Clinica chimica acta; international journal of clinical chemistry 20030901 |
| N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? | Kidney international. Supplement 20030501 |
| Increase in conversion of tryptophan to niacin in pregnant rats. | Advances in experimental medicine and biology 20030101 |
| Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. | Bioscience, biotechnology, and biochemistry 20020601 |
| Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. | Molecular and cellular biochemistry 20020201 |
| [Effect of feeding with a poisonous mushroom Clitocybe acromelalga on the metabolism of tryptophan-niacin in rats]. | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20010601 |
| The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production. | The American journal of gastroenterology 20010401 |
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