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Home > Indoles and Oxindole > 700-06-1
700-06-1 | (1H-Indol-3-yl)methanol
CAS No: 700-06-1 Catalog No: AG003R07 MDL No:MFCD00005632
Product Description
Catalog Number:
AG003R07
Chemical Name:
(1H-Indol-3-yl)methanol
CAS Number:
700-06-1
Molecular Formula:
C9H9NO
Molecular Weight:
147.1739
MDL Number:
MFCD00005632
IUPAC Name:
1H-indol-3-ylmethanol
InChI:
InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChI Key:
IVYPNXXAYMYVSP-UHFFFAOYSA-N
SMILES:
OCc1c[nH]c2c1cccc2
EC Number:
211-836-2
UNII:
C11E72455F
NSC Number:
525801
Properties
Complexity:
138
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
147.068g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
147.177g/mol
Monoisotopic Mass:
147.068g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
36A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1
Literature
| Title | Journal |
|---|---|
| Indole-3-Carbinol (I3C) enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin (DOX) through inhibition of NF-κβ, blocking angiogenesis and regulation of mitochondrial apoptotic pathway. | Chemico-biological interactions 20180625 |
| Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. | Toxicology in vitro : an international journal published in association with BIBRA 20180201 |
| Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201 |
| The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome. | Chemico-biological interactions 20170801 |
| Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells. | Archives of toxicology 20170501 |
| In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. | Pharmacology research & perspectives 20170401 |
| Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. | Journal of hypertension 20161001 |
| Global gene expression and morphological alterations in the mammary gland after gestational exposure to bisphenol A, genistein and indole-3-carbinol in female Sprague-Dawley offspring. | Toxicology and applied pharmacology 20160715 |
| The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review. | Gene 20150510 |
| Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. | Chemico-biological interactions 20140325 |
| Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital. | The Journal of toxicological sciences 20140201 |
| 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. | Toxicological sciences : an official journal of the Society of Toxicology 20140101 |
| Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. | Toxicology and applied pharmacology 20140101 |
| Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats. | Reproductive toxicology (Elmsford, N.Y.) 20140101 |
| Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver. | The Journal of toxicological sciences 20130101 |
| Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression. | Investigational new drugs 20121201 |
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. | Molecular and cellular endocrinology 20121105 |
| Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling. | Molecular carcinogenesis 20121101 |
| In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways. | Molecular carcinogenesis 20121001 |
| Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension. | The American journal of the medical sciences 20121001 |
| Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16(Ink4a)) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats. | Toxicology 20120928 |
| 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. | Toxicology and applied pharmacology 20120915 |
| Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages. | Food chemistry 20120915 |
| In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol. | Journal of agricultural and food chemistry 20120808 |
| Modulation of carcinogen metabolizing cytochromes P450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. | Phytotherapy research : PTR 20120801 |
| Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines. | Nutrition and cancer 20120801 |
| Diindolilmethane (DIM) selectively inhibits cancer stem cells. | Biochemical and biophysical research communications 20120720 |
| [EGFR-dependent impact of indol-3-carbinol on radiosensitivity of lung cancer cells]. | Zhongguo fei ai za zhi = Chinese journal of lung cancer 20120720 |
| Emerging roles for modulation of microRNA signatures in cancer chemoprevention. | Current cancer drug targets 20120701 |
| The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: chemistry and metabolism in Leptosphaeria maculans. | Bioorganic & medicinal chemistry 20120701 |
| Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. | Clinical and experimental pharmacology & physiology 20120701 |
| Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. | Toxicologic pathology 20120601 |
| Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512 |
| B-DIM impairs radiation-induced survival pathways independently of androgen receptor expression and augments radiation efficacy in prostate cancer. | Cancer letters 20120501 |
| 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest. | Oncology reports 20120501 |
| The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism. | Animal : an international journal of animal bioscience 20120501 |
| Effect of the pasteurization process on the contents of ascorbigen, indole-3-carbinol, indole-3-acetonitrile, and 3,3'-diindolylmethane in fermented cabbage. | Journal of agricultural and food chemistry 20120411 |
| Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals. | Molecular carcinogenesis 20120301 |
| Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy. | Journal of the American Society of Nephrology : JASN 20120301 |
| Synthesis and evaluation of the cytotoxicities of tetraindoles: observation that the 5-hydroxy tetraindole (SK228) induces G₂ arrest and apoptosis in human breast cancer cells. | Journal of medicinal chemistry 20120223 |
| The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling. | Chemico-biological interactions 20120205 |
| Direct interactions between intestinal immune cells and the diet. | Cell cycle (Georgetown, Tex.) 20120201 |
| Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment. | British journal of cancer 20120117 |
| The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120101 |
| Imatinib ameliorates renal morphological changes in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. | American journal of physiology. Renal physiology 20120101 |
| Tumor angiogenesis as a target for dietary cancer prevention. | Journal of oncology 20120101 |
| The indolic diet-derivative, 3,3'-diindolylmethane, induced apoptosis in human colon cancer cells through upregulation of NDRG1. | Journal of biomedicine & biotechnology 20120101 |
| The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. | Journal of oncology 20120101 |
| Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis. | Pulmonary medicine 20120101 |
| Novel targets for detection of cancer and their modulation by chemopreventive natural compounds. | Frontiers in bioscience (Elite edition) 20120101 |
| Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). | BMC medicine 20120101 |
| Ecologically appropriate xenobiotics induce cytochrome P450s in Apis mellifera. | PloS one 20120101 |
| Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells. | Marine drugs 20120101 |
| Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells. | PloS one 20120101 |
| 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. | PloS one 20120101 |
| Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. | PloS one 20120101 |
| Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid. | PloS one 20120101 |
| The safety of cruciferous plants in humans: a systematic review. | Journal of biomedicine & biotechnology 20120101 |
| 3,3'Diindolylmethane suppresses vascular smooth muscle cell phenotypic modulation and inhibits neointima formation after carotid injury. | PloS one 20120101 |
| Cigarette smoke exposure-associated alterations to non-coding RNA. | Frontiers in genetics 20120101 |
| 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. | PloS one 20120101 |
| Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat. | PloS one 20120101 |
| AHR and the Transcriptional Regulation of Type-17/22 ILC. | Frontiers in immunology 20120101 |
| Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgA. | Frontiers in immunology 20120101 |
| Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury. | Frontiers in physiology 20120101 |
| Current knowledge on pancreatic cancer. | Frontiers in oncology 20120101 |
| Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt(+) Innate Lymphoid Cells and Intraepithelial Lymphocytes. | Frontiers in immunology 20120101 |
| Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines. | PloS one 20120101 |
| Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats. | The journal of medical investigation : JMI 20120101 |
| Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo. | PloS one 20120101 |
| Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway. | Medical oncology (Northwood, London, England) 20111201 |
| Cancer chemoprevention by targeting the epigenome. | Current drug targets 20111201 |
| Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. | International journal of obesity (2005) 20111201 |
| Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. | Cancer letters 20111201 |
| Interaction of cruciferous phytoanticipins with plant fungal pathogens: indole glucosinolates are not metabolized but the corresponding desulfo-derivatives and nitriles are. | Phytochemistry 20111201 |
| Dietary ligands of the aryl hydrocarbon receptor induce anti-inflammatory and immunoregulatory effects on murine dendritic cells. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats. | Journal of hypertension 20111201 |
| Indole-3-carbinol and ultraviolet B induce apoptosis of human melanoma cells via down-regulation of MITF. | Die Pharmazie 20111201 |
| Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway. | The Journal of pharmacology and experimental therapeutics 20111101 |
| Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome. | Journal of hypertension 20111101 |
| Indole-3-carbinol inhibits telomerase activity and gene expression in prostate cancer cell lines. | Anticancer research 20111101 |
| 3,3'-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice. | Toxicology letters 20111010 |
| Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells. | Archives of toxicology 20111001 |
| Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1. | Anticancer research 20111001 |
| Induction of cancer cell death by isoflavone: the role of multiple signaling pathways. | Nutrients 20111001 |
| Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. | The Prostate 20110915 |
| Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats. | Archives of toxicology 20110901 |
| Effectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110901 |
| Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: is DIM a substitute for I3C? | Oncology reports 20110901 |
| Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells. | Carcinogenesis 20110901 |
| Adjuvant therapy for laryngeal papillomatosis. | Acta dermatovenerologica Alpina, Pannonica, et Adriatica 20110901 |
| LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli. | Journal of agricultural and food chemistry 20110810 |
| 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. | Free radical research 20110801 |
| Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. | Journal of hypertension 20110801 |
| [Therapeutic effect of indole-3-carbinol on pig serum-induced hepatic fibrosis in rats]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110801 |
| Dimer radical cations of indole and indole-3-carbinol: localized and delocalized radical cations of diindolylmethane. | The journal of physical chemistry. A 20110707 |
| Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. | Biopharmaceutics & drug disposition 20110701 |
| MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease. | Immune network 20110601 |
| Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine. | Toxicology 20110510 |
| RuCl₃·3H₂O catalyzed reactions: facile synthesis of bis(indolyl)methanes under mild conditions. | Molecules (Basel, Switzerland) 20110509 |
| Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension. | The American journal of the medical sciences 20110501 |
| Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. | Carcinogenesis 20110401 |
| Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice. | Nutrition (Burbank, Los Angeles County, Calif.) 20110401 |
| Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. | The British journal of nutrition 20110301 |
| Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. | Toxicological sciences : an official journal of the Society of Toxicology 20110301 |
| Treatment of recurrent respiratory papillomatosis lung involvement by cidofovir infusion. | Scandinavian journal of infectious diseases 20110201 |
| Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension. | American journal of physiology. Renal physiology 20110201 |
| 3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate model. | Molecular carcinogenesis 20110201 |
| Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway. | European journal of pharmacology 20110115 |
| Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. | The Journal of physiology 20110101 |
| Bioactive food components and cancer-specific metabonomic profiles. | Journal of biomedicine & biotechnology 20110101 |
| Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells. | Journal of Cancer 20110101 |
| Defined plant extracts can protect human cells against combined xenobiotic effects. | Journal of occupational medicine and toxicology (London, England) 20110101 |
| Estrogen induced metastatic modulators MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in thyroid cancer. | PloS one 20110101 |
| Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner. | Nutrition journal 20110101 |
| The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines. | Breast cancer research : BCR 20110101 |
| Therapeutic Implications of Targeting AKT Signaling in Melanoma. | Enzyme research 20110101 |
| Medical interventions for high grade vulval intraepithelial neoplasia. | The Cochrane database of systematic reviews 20110101 |
| Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. | PloS one 20110101 |
| Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. | PloS one 20110101 |
| Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin. | Oncology research 20110101 |
| How to reduce your cancer risk: mechanisms and myths. | International journal of general medicine 20110101 |
| Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. | BMC cancer 20110101 |
| Oral carcinogenesis and oral cancer chemoprevention: a review. | Pathology research international 20110101 |
| Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment. | PloS one 20110101 |
| Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic. | Mutation research 20110101 |
| Adipocyte-derived factor as a modulator of oxidative estrogen metabolism: implications for obesity and estrogen-dependent breast cancer. | In vivo (Athens, Greece) 20110101 |
| Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells. | Molecular cancer 20110101 |
| Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice. | Bioscience, biotechnology, and biochemistry 20110101 |
| Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells. | Nutrition and cancer 20110101 |
| Understanding carcinogenesis for fighting oral cancer. | Journal of oncology 20110101 |
| Indole-3-carbinol generates reactive oxygen species and induces apoptosis. | Biological & pharmaceutical bulletin 20110101 |
| Nigerian foodstuffs with prostate cancer chemopreventive polyphenols. | Infectious agents and cancer 20110101 |
| Selenium and lung cancer: a systematic review and meta analysis. | PloS one 20110101 |
| The role of tobacco-derived carcinogens in pancreas cancer. | ISRN oncology 20110101 |
| Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity. | Molecular biology international 20110101 |
| Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection. | International journal of biological sciences 20110101 |
| Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. | The Journal of toxicological sciences 20110101 |
| Effect of Turkish propolis extracts on proteome of prostate cancer cell line. | Proteome science 20110101 |
| Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons. | PloS one 20110101 |
| Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. | Clinical epigenetics 20110101 |
| [The results of adjuvant therapy of juvenile recurring respiratory papillomatosis with the use of indole-3-carbinol]. | Vestnik otorinolaringologii 20110101 |
| THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue. | Frontiers in endocrinology 20110101 |
| Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices. | Clinical and experimental pharmacology & physiology 20101201 |
| Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. | Anticancer research 20101201 |
| Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. | The American journal of the medical sciences 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro. | Oral oncology 20101001 |
| Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. | Carcinogenesis 20100901 |
| Inhibition of cancer cell invasion and metastasis by genistein. | Cancer metastasis reviews 20100901 |
| Effects of lycopene, indole-3-carbinol, and luteolin on nitric oxide production and iNOS expression are organ-specific in rats. | Arhiv za higijenu rada i toksikologiju 20100901 |
| 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells. | Chemico-biological interactions 20100805 |
| Effects of combined treatment with resveratrol and indole-3-carbinol. | Bulletin of experimental biology and medicine 20100801 |
| Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol. | Journal of agricultural and food chemistry 20100728 |
| Radicals and radical ions derived from indole, indole-3-carbinol and diindolylmethane. | The journal of physical chemistry. A 20100701 |
| 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. | Molecular carcinogenesis 20100701 |
| A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation. | Cancer prevention research (Philadelphia, Pa.) 20100701 |
| Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells. | Cancer research 20100615 |
| Automated generation and reactions of 3-hydroxymethylindoles in continuous-flow microreactors. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100611 |
| Synthesis and biological evaluation of a gamma-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b':7,8-b'':10,11-b''']tetraindole (CTet). | Molecules (Basel, Switzerland) 20100604 |
| The renin-angiotensin system as a primary cause of polyarteritis nodosa in rats. | Journal of cellular and molecular medicine 20100601 |
| Diet, microRNAs and prostate cancer. | Pharmaceutical research 20100601 |
| Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy. | Current drug targets 20100601 |
| Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. | Pharmaceutical research 20100601 |
| Transient induction of ANG II-dependent malignant hypertension causes sustained elevation of blood pressure and augmentation of the pressor response to ANG II in CYP1A1-REN2 transgenic rats. | The American journal of the medical sciences 20100601 |
| Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis. | Recent patents on food, nutrition & agriculture 20100601 |
| Cancer prevention with natural compounds. | Seminars in oncology 20100601 |
| Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. | Cancer chemotherapy and pharmacology 20100501 |
| The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20100501 |
| Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents. | Mini reviews in medicinal chemistry 20100501 |
| The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker. | International journal of andrology 20100401 |
| Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. | Molecular biology of the cell 20100401 |
| AT1 receptor blockade prevents the increase in blood pressure and the augmentation of intrarenal ANG II levels in hypertensive Cyp1a1-Ren2 transgenic rats fed with a high-salt diet. | The American journal of the medical sciences 20100401 |
| Dioxin-induced changes in epididymal sperm count and spermatogenesis. | Environmental health perspectives 20100401 |
| Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats. | Journal of hypertension 20100301 |
| Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301 |
| Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. | Experimental dermatology 20100201 |
| Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. | Carcinogenesis 20100201 |
| Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. | Carcinogenesis 20100201 |
| The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100101 |
| Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. | Cancer prevention research (Philadelphia, Pa.) 20100101 |
| Indole-3-carbinol inhibits nasopharyngeal carcinoma. | International journal of toxicology 20100101 |
| Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. | Mediators of inflammation 20100101 |
| Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study. | BMC cancer 20100101 |
| Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. | Molecular cancer 20100101 |
| Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. | Therapeutics and clinical risk management 20100101 |
| Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments. | In vivo (Athens, Greece) 20100101 |
| Redox regulation in cancer: a double-edged sword with therapeutic potential. | Oxidative medicine and cellular longevity 20100101 |
| Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. | Oxidative medicine and cellular longevity 20100101 |
| 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. | BMC cancer 20100101 |
| Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei). | Marine drugs 20100101 |
| Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial. | Breast cancer : basic and clinical research 20100101 |
| [Approaches to raising efficacy of treatment of patients with chronic prostatitis associated with intracellular infections]. | Urologiia (Moscow, Russia : 1999) 20100101 |
| Minireview: modulation of hormone receptor signaling by dietary anticancer indoles. | Molecular endocrinology (Baltimore, Md.) 20091201 |
| Cellular signaling perturbation by natural products. | Cellular signalling 20091101 |
| Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. | Cancer treatment reviews 20091101 |
| Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. | Molecular pharmacology 20091101 |
| Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism. | American journal of physiology. Heart and circulatory physiology 20091101 |
| tert-Butyl 3-[2,2-bis-(ethoxy-carbon-yl)vin-yl]-2-bromo-methyl-1H-indole-1-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20091101 |
| The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract. | Drug metabolism and disposition: the biological fate of chemicals 20091001 |
| OSU-A9, a potent indole-3-carbinol derivative, suppresses breast tumor growth by targeting the Akt-NF-kappaB pathway and stress response signaling. | Carcinogenesis 20091001 |
| [Effects of indole-3-carbinol on the outcome of tumor and the changes of anti-oxidative system in null mice grafted with nasopharyngeal carcinoma]. | Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20091001 |
| 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. | Inflammatory bowel diseases 20090801 |
| Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. | Cancer research 20090801 |
| Dietary chemopreventive phytochemicals: too little or too much? | Cancer prevention research (Philadelphia, Pa.) 20090701 |
| Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. | The Journal of biological chemistry 20090605 |
| Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades. | Clinical immunology (Orlando, Fla.) 20090601 |
| The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract. | Journal of applied microbiology 20090601 |
| 3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells. | Cancer prevention research (Philadelphia, Pa.) 20090601 |
| Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity. | International journal of cancer 20090515 |
| Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells. | Journal of cellular physiology 20090401 |
| Evaluation of indole-based probes for high-throughput screening of drug binding to human serum albumin: Analysis by high-performance affinity chromatography. | Journal of separation science 20090401 |
| Effect of boiling on the content of ascorbigen, indole-3-carbinol, indole-3-acetonitrile, and 3,3'-diindolylmethane in fermented cabbage. | Journal of agricultural and food chemistry 20090325 |
| Pharmacotherapy of recurrent respiratory papillomatosis: an expert opinion. | Expert opinion on pharmacotherapy 20090301 |
| Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats. | Journal of hypertension 20090301 |
| Medical treatment of cervical intraepithelial neoplasia II, III: an update review. | International journal of clinical oncology 20090201 |
| Indole-3-carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells. | Journal of agricultural and food chemistry 20090114 |
| Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. | The Journal of nutrition 20090101 |
| Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol. | Retrovirology 20090101 |
| Ascorbigen: chemistry, occurrence, and biologic properties. | Clinics in dermatology 20090101 |
| CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability. | Molecular vision 20090101 |
| Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. | BMC cancer 20090101 |
| Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. | BMC genomics 20090101 |
| Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. | BMC gastroenterology 20090101 |
| Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension. | Vascular pharmacology 20090101 |
| Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin. | Breast cancer : basic and clinical research 20090101 |
| Urinary estrogen metabolites and prostate cancer: a case-control study and meta-analysis. | Journal of experimental & clinical cancer research : CR 20090101 |
| Changes in hippocampal metabolites after effective treatment for fibromyalgia: a case study. | The Clinical journal of pain 20090101 |
| A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. | Molecular cancer 20090101 |
| Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system. | Neuro endocrinology letters 20090101 |
| Loquat (Eriobotrya japonica) extracts suppress the adhesion, migration and invasion of human breast cancer cell line. | Nutrition research and practice 20090101 |
| [Effects of indol-3-carbinol and epigallocatexin-3-gallate on alteration and reparation in affected urethra of experimental animals]. | Urologiia (Moscow, Russia : 1999) 20090101 |
| The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. | Proceedings of the National Academy of Sciences of the United States of America 20081216 |
| Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. | Cancer prevention research (Philadelphia, Pa.) 20081201 |
| BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR. | Cancer chemotherapy and pharmacology 20081101 |
| Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. | Cancer letters 20081008 |
| Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt. | The Journal of veterinary medical science 20081001 |
| Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells. | Gynecologic oncology 20080901 |
| Aflatoxin B1 detoxification by CYP321A1 in Helicoverpa zea. | Archives of insect biochemistry and physiology 20080901 |
| Cancer is a preventable disease that requires major lifestyle changes. | Pharmaceutical research 20080901 |
| Mechanism of decreased susceptibility for Gram-negative bacteria and synergistic effect with ampicillin of indole-3-carbinol. | Biological & pharmaceutical bulletin 20080901 |
| Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801 |
| Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis. | Bioscience, biotechnology, and biochemistry 20080801 |
| Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. | Environmental health perspectives 20080801 |
| AH receptor agonist activity in human blood measured with a cell-based bioassay: evidence for naturally occurring AH receptor ligands in vivo. | Journal of exposure science & environmental epidemiology 20080701 |
| Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701 |
| 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. | Molecular cancer therapeutics 20080701 |
| Indole-3-carbinol-induced modulation of NF-kappaB signalling is breast cancer cell-specific and does not correlate with cell death. | Breast cancer research and treatment 20080601 |
| Identification of indole glucosinolate breakdown products with antifeedant effects on Myzus persicae (green peach aphid). | The Plant journal : for cell and molecular biology 20080601 |
| Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer. | Expert opinion on therapeutic targets 20080601 |
| 3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo. | The Journal of nutritional biochemistry 20080501 |
| Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines. | Biochemical pharmacology 20080501 |
| Indole-3-carbinol as a chemopreventive and anti-cancer agent. | Cancer letters 20080418 |
| A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers. | Toxicologic pathology 20080401 |
| Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. | Journal of applied toxicology : JAT 20080301 |
| Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301 |
| Indole-3-acetonitrile production from indole glucosinolates deters oviposition by Pieris rapae. | Plant physiology 20080301 |
| Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. | Carcinogenesis 20080301 |
| N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells. | Biochemical pharmacology 20080201 |
| Recurrent respiratory papillomatosis: an overview of current thinking and treatment. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080201 |
| Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities. | Analytical and bioanalytical chemistry 20080201 |
| Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo. | Phytotherapy research : PTR 20080101 |
| Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension. | American journal of physiology. Renal physiology 20080101 |
| Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. | The Journal of steroid biochemistry and molecular biology 20080101 |
| Prorenin and glomerulosclerosis? | Journal of hypertension 20080101 |
| Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis. | Journal of hypertension 20080101 |
| Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. | In vivo (Athens, Greece) 20080101 |
| TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells. | BMC cancer 20080101 |
| Selective androgen receptor modulators in preclinical and clinical development. | Nuclear receptor signaling 20080101 |
| Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells. | Drug design, development and therapy 20080101 |
| Recurrent Respiratory Papillomatosis (RRP)-Juvenile Onset. | Clinical medicine. Oncology 20080101 |
| Syzygium cumini inhibits growth and induces apoptosis in cervical cancer cell lines: a primary study. | Ecancermedicalscience 20080101 |
| Inhibition of amyloid fibrillation of lysozyme by indole derivatives--possible mechanism of action. | The FEBS journal 20071201 |
| Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats. | American journal of physiology. Renal physiology 20071101 |
| Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. | Molecular cancer therapeutics 20071101 |
| Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. | Molecular cancer therapeutics 20071001 |
| In vitro antimicrobial activity and the mode of action of indole-3-carbinol against human pathogenic microorganisms. | Biological & pharmaceutical bulletin 20071001 |
| Short-term modulation of cell proliferation and apoptosis and preventive/therapeutic efficacy of various agents in a mammary cancer model. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070915 |
| Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. | Acta pharmacologica Sinica 20070901 |
| A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells. | Cancer research 20070815 |
| Indole-3-carbinol - induced growth inhibition can be converted to a cytotoxic response in the presence of TPA+Ca(2+) in squamous cell carcinoma cell lines. | FEBS letters 20070807 |
| Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling. | Journal of medicinal chemistry 20070726 |
| Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. | The Journal of clinical investigation 20070702 |
| Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro. | Carcinogenesis 20070701 |
| Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. | Cancer research 20070701 |
| Renal vascular and tubulointerstitial inflammation and proliferation in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. | American journal of physiology. Renal physiology 20070601 |
| A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals. | Nutrition reviews 20070601 |
| The candidacidal activity of indole-3-carbinol that binds with DNA. | IUBMB life 20070601 |
| Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | Toxicological sciences : an official journal of the Society of Toxicology 20070401 |
| Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20070401 |
| Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea. | Journal of chemical ecology 20070301 |
| Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. | Pharmacological research 20070301 |
| Chemopreventive herbal anti-oxidants: current status and future perspectives. | Journal of clinical biochemistry and nutrition 20070301 |
| EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells. | Carcinogenesis 20070201 |
| Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. | Breast cancer research : BCR 20070101 |
| The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells. | Acta biochimica Polonica 20070101 |
| Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. | BMC evolutionary biology 20070101 |
| Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. | Molecular medicine (Cambridge, Mass.) 20070101 |
| Sensitive and robust gene expression changes in fish exposed to estrogen--a microarray approach. | BMC genomics 20070101 |
| 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. | Breast cancer research : BCR 20070101 |
| Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7. | BMC pharmacology 20070101 |
| S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells. | BMC cancer 20070101 |
| Putative cancer chemopreventive agents of dietary origin-how safe are they? | Nutrition and cancer 20070101 |
| Effects of prepubertal indole-3-carbinol treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Sprague-Dawley rats. | In vivo (Athens, Greece) 20070101 |
| Abstracts of papers presented at the 2007 pittsburgh conference. | Journal of automated methods & management in chemistry 20070101 |
| Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. | Biochemical pharmacology 20061215 |
| Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. | Molecular endocrinology (Baltimore, Md.) 20061201 |
| AT1 receptor blockade is superior to conventional triple therapy in protecting against end-organ damage in Cyp1a1-Ren-2 transgenic rats with inducible hypertension. | Journal of hypertension 20061201 |
| Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201 |
| A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands. | Bioorganic & medicinal chemistry letters 20061101 |
| Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. | The American journal of pathology 20061101 |
| Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells. | Cellular and molecular life sciences : CMLS 20061101 |
| Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model. | Molecular cancer therapeutics 20061101 |
| Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status. | Mutation research 20061010 |
| Estrogen receptor alpha as a target for indole-3-carbinol. | The Journal of nutritional biochemistry 20061001 |
| Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake. | Carcinogenesis 20061001 |
| Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. | Carcinogenesis 20061001 |
| Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. | American journal of physiology. Renal physiology 20060901 |
| In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro. | Toxicology in vitro : an international journal published in association with BIBRA 20060801 |
| Indole-3-carbinol alters placental cytochrome P450 1A1 and P-glycoprotein levels in rats: a potential role in intensifying fetal intrauterine growth-retardation produced by tobacco smoke. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060801 |
| Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. | Mutation research 20060725 |
| Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. | Journal of controlled release : official journal of the Controlled Release Society 20060720 |
| British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis. | International journal of pediatric otorhinolaryngology 20060701 |
| Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
| Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20060601 |
| 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. | The Journal of surgical research 20060515 |
| Molecular targets of dietary agents for prevention and therapy of cancer. | Biochemical pharmacology 20060514 |
| Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. | Apoptosis : an international journal on programmed cell death 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. | Cancer research 20060501 |
| Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20060501 |
| Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. | Biochemistry 20060418 |
| Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. | The Prostate 20060401 |
| Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. | Toxicology and applied pharmacology 20060301 |
| Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. | Toxicological sciences : an official journal of the Society of Toxicology 20060301 |
| Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout. | Toxicological sciences : an official journal of the Society of Toxicology 20060301 |
| Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. | Chemical research in toxicology 20060301 |
| Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane. | Molecular cancer therapeutics 20060301 |
| Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. | International journal of cancer 20060215 |
| BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. | British journal of cancer 20060213 |
| 3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. | Biochemical and biophysical research communications 20060210 |
| Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats. | Carcinogenesis 20060201 |
| Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats. | Journal of carcinogenesis 20060101 |
| Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. | Breast cancer research : BCR 20060101 |
| The natural chemopreventive compound indole-3-carbinol: state of the science. | In vivo (Athens, Greece) 20060101 |
| A randomized phase II trial of indole-3-carbinol in the treatment of vulvar intraepithelial neoplasia. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101 |
| A zebrafish assay for identifying neuroprotectants in vivo. | Neurotoxicology and teratology 20060101 |
| Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. | Journal of applied toxicology : JAT 20060101 |
| Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes. | BMC genomics 20060101 |
| Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. | Journal of applied toxicology : JAT 20060101 |
| Modulation of apoptosis by cancer chemopreventive agents. | Mutation research 20051211 |
| Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. | American journal of physiology. Renal physiology 20051201 |
| Recurrent respiratory papillomatosis: pathogenesis to treatment. | Current opinion in otolaryngology & head and neck surgery 20051201 |
| Nutrition and primary prevention of breast cancer: foods, nutrients and breast cancer risk. | European journal of obstetrics, gynecology, and reproductive biology 20051201 |
| Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051201 |
| Indole-3-carbinol. Monograph. | Alternative medicine review : a journal of clinical therapeutic 20051201 |
| 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. | Biochemical and biophysical research communications 20051125 |
| Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. | Carcinogenesis 20051101 |
| [Current therapeutic options for recurrent respiratory papillomatosis]. | HNO 20051101 |
| Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis. | International journal of oncology 20051101 |
| Molecular targets of dietary polyphenols with anti-inflammatory properties. | Yonsei medical journal 20051031 |
| Molecular characterization of the gallate dioxygenase from Pseudomonas putida KT2440. The prototype of a new subgroup of extradiol dioxygenases. | The Journal of biological chemistry 20051021 |
| Characterization of the oxidase activity in mammalian catalase. | The Journal of biological chemistry 20051021 |
| Re: Xue et al. Effects of analogs of indole-3-carbinol cyclic trimerization, etc. Chem. Biol. Interact. 152 (2005) 119. | Chemico-biological interactions 20051020 |
| Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension. | American journal of physiology. Renal physiology 20051001 |
| Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. | Cell cycle (Georgetown, Tex.) 20050901 |
| Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol. | European journal of cancer (Oxford, England : 1990) 20050901 |
| Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. | Toxicology letters 20050814 |
| A phase I study of indole-3-carbinol in women: tolerability and effects. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050801 |
| Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. | Blood 20050715 |
| Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables. | Journal of agricultural and food chemistry 20050629 |
| Prior exposure to indole-3-carbinol decreases the incidence of specific cyclophosphamide-induced developmental defects in mice. | Birth defects research. Part B, Developmental and reproductive toxicology 20050601 |
| Effects of analogs of indole-3-carbinol cyclic trimerization product in human breast cancer cells. | Chemico-biological interactions 20050415 |
| Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. | American journal of physiology. Renal physiology 20050401 |
| 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. | Carcinogenesis 20050401 |
| Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. | Journal of biochemistry and molecular biology 20050331 |
| Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex. | The Journal of biological chemistry 20050311 |
| Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. | Biochemical and biophysical research communications 20050304 |
| Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. | Biochemical and biophysical research communications 20050218 |
| Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis. | Journal of medical virology 20050201 |
| Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol. | Toxicology and applied pharmacology 20050201 |
| Targets for indole-3-carbinol in cancer prevention. | The Journal of nutritional biochemistry 20050201 |
| Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines. | Toxicological sciences : an official journal of the Society of Toxicology 20050101 |
| Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. | Frontiers in bioscience : a journal and virtual library 20050101 |
| Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. | Oncology reports 20050101 |
| Innovative agents in cancer prevention. | Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20050101 |
| Red maca (Lepidium meyenii) reduced prostate size in rats. | Reproductive biology and endocrinology : RB&E 20050101 |
| Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. | Cancer research 20050101 |
| Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo. | Molecular medicine (Cambridge, Mass.) 20050101 |
| Surgical procedures for voice restoration. | GMS current topics in otorhinolaryngology, head and neck surgery 20050101 |
| Cell signaling pathways altered by natural chemopreventive agents. | Mutation research 20041102 |
| Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism. | Carcinogenesis 20041101 |
| Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma. | International journal of cancer 20041010 |
| Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15(INK4b) gene. | FEBS letters 20041008 |
| Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3'-diindolylmethane through the mitochondrial pathway. | British journal of cancer 20041004 |
| Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001 |
| Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosis. | Antiviral research 20040901 |
| An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. | British journal of cancer 20040802 |
| Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040801 |
| Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells. | Carcinogenesis 20040701 |
| Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. | Toxicology and applied pharmacology 20040701 |
| Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601 |
| Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results. | Journal of voice : official journal of the Voice Foundation 20040601 |
| Inhibition of MUC1 expression by indole-3-carbinol. | International journal of cancer 20040510 |
| Protective effects of indole-3-carbinol on cyclophosphamide-induced clastogenecity in mouse bone marrow cells. | Human & experimental toxicology 20040501 |
| Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. | Integrative cancer therapies 20040301 |
| Lack of an inducible effect of dietary soy isoflavones on the mRNA abundance of hepatic cytochrome P-450 isozymes in rats. | Bioscience, biotechnology, and biochemistry 20040301 |
| Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay. | Free radical research 20040301 |
| Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro. | Cell stress & chaperones 20040301 |
| Established and potential strategies against papillomavirus infections. | The Journal of antimicrobial chemotherapy 20040201 |
| Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. | Anticancer research 20040101 |
| Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. | Cancer detection and prevention 20040101 |
| Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases. | Anticancer research 20040101 |
| Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. | Nutrition and cancer 20040101 |
| Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101 |
| Apoptosis in cervical cancer cells: implications for adjunct anti-estrogen therapy for cervical cancer. | Anticancer research 20040101 |
| Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci. | Nutrition and cancer 20040101 |
| Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. | Cancer 20031201 |
| Broccoli compound inhibits HSV. | AIDS patient care and STDs 20031101 |
| A selective irreversible inhibitor targeting a PDZ protein interaction domain. | Journal of the American Chemical Society 20031008 |
| Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. | Journal of the American College of Nutrition 20031001 |
| Chemoprevention of gastrointestinal malignancies. | ANZ journal of surgery 20030901 |
| The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801 |
| Arsenate reduction in human erythrocytes and rats--testing the role of purine nucleoside phosphorylase. | Toxicological sciences : an official journal of the Society of Toxicology 20030701 |
| Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats. | Toxicological sciences : an official journal of the Society of Toxicology 20030701 |
| Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. | The Journal of biological chemistry 20030606 |
| Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. | FEBS letters 20030605 |
| Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030601 |
| Phase II in vitro metabolism of 3-methylindole metabolites in porcine liver. | Xenobiotica; the fate of foreign compounds in biological systems 20030501 |
| Cervical dysplasia: early intervention. | Alternative medicine review : a journal of clinical therapeutic 20030501 |
| Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425 |
| Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. | Molecular carcinogenesis 20030401 |
| The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. | ANZ journal of surgery 20030301 |
| Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. | Cancer letters 20030128 |
| Convenient synthesis of 5,6,11,12,17,18- hexahydrocyclononal[1,2-b:4,5-b':7,8-b'']triindole, a novel phytoestrogen. | The Journal of organic chemistry 20030110 |
| Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line. | BMC cancer 20030101 |
| The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. | Toxicologic pathology 20030101 |
| Antigenotoxic potential of certain dietary constituents. | Teratogenesis, carcinogenesis, and mutagenesis 20030101 |
| Chemoprevention of colon cancer by Korean food plant components. | Mutation research 20030101 |
| Mechanism-based in vitro screening of potential cancer chemopreventive agents. | Mutation research 20030101 |
| Beneficial and adverse effects of chemopreventive agents. | Mutation research 20030101 |
| Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. | Nutrition and cancer 20030101 |
| Chapter 17: Genital human papillomavirus infections--current and prospective therapies. | Journal of the National Cancer Institute. Monographs 20030101 |
| Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas. | Anticancer research 20030101 |
| Role of salicylic acid in systemic resistance induced by Pseudomonas fluorescens against Fusarium oxysporum f. sp. ciceri in chickpea. | Microbiological research 20030101 |
| Comparative molecular field analysis of substrates for an aryl sulfotransferase based on catalytic mechanism and protein homology modeling. | Journal of medicinal chemistry 20021205 |
| Differential effects of vegetable-derived indoles on the induction of quinone reductase in hepatoma cells. | Journal of nutritional science and vitaminology 20021201 |
| Plant-derived biomolecules in fermented cabbage. | Journal of agricultural and food chemistry 20021106 |
| Why phase II trials in cervical chemoprevention are negative: what have we learned? | Cancer causes & control : CCC 20021101 |
| Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. | Molecular cancer therapeutics 20021101 |
| Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol-. Certain health supplements may cause both carcinogenic and anticarcinogenic effects. | Carcinogenesis 20021001 |
| Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. | Journal of cancer research and clinical oncology 20021001 |
| Endocrine disruption by indole-3-carbinol and tamoxifen: blockage of ovulation. | Toxicology and applied pharmacology 20020915 |
| Plant allelochemicals differentially regulate Helicoverpa zea cytochrome P450 genes. | Insect molecular biology 20020801 |
| Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol. | Biochemical pharmacology 20020801 |
| Pharmacotherapy of recurrent respiratory papillomatosis. | Expert opinion on pharmacotherapy 20020801 |
| Multiple molecular targets of indole-3-carbinol, a chemopreventive anti-estrogen in breast cancer. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20020801 |
| Tissue distribution and chemical induction of multiple drug resistance genes in rats. | Drug metabolism and disposition: the biological fate of chemicals 20020701 |
| Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020401 |
| Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites. | Alternative medicine review : a journal of clinical therapeutic 20020401 |
| Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. | Biochemical pharmacology 20020315 |
| Therapy for recurrent respiratory papillomatosis. | Antiviral therapy 20020301 |
| The 19th International Papillomavirus Conference. | Antiviral therapy 20020301 |
| Fate of indole-3-carbinol in cultured human breast tumor cells. | Chemical research in toxicology 20020201 |
| Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. | Carcinogenesis 20020201 |
| Steroid hormone mimics: molecular mechanisms of cell growth and apoptosis in normal and malignant mammary epithelial cells. | The Journal of steroid biochemistry and molecular biology 20020201 |
| Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. | The Journal of pharmacology and experimental therapeutics 20020101 |
| Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. | The Journal of pharmacology and experimental therapeutics 20020101 |
| Lack of chemoprevention of indole-3-carbinol in N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. | IARC scientific publications 20020101 |
| Anti-metastatic activities of all-trans retinoic acid, indole-3-carbinol and (+)-catechin in Dunning rat invasive prostate adenocarcinoma cells. | Anticancer research 20020101 |
| A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction. | Journal of pharmacological and toxicological methods 20020101 |
| Transplacental exposure to indole-3-carbinol induces sex-specific expression of CYP1A1 and CYP1B1 in the liver of Fischer 344 neonatal rats. | Toxicological sciences : an official journal of the Society of Toxicology 20011201 |
| Prevention and treatment of cancer with indole-3-carbinol. | Alternative medicine review : a journal of clinical therapeutic 20011201 |
| Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. | Carcinogenesis 20011101 |
| Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. | The Journal of biological chemistry 20010928 |
| Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells. | Mutation research 20010901 |
| Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20010901 |
| Post-initiation treatment of Indole-3-carbinol did not suppress N-methyl-N-nitrosourea induced mammary carcinogenesis in rats. | Cancer letters 20010828 |
| Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. | Cancer research 20010815 |
| Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats. | Drug metabolism and disposition: the biological fate of chemicals 20010801 |
| Indole-3-carbinol modulation of hepatic monooxygenases CYP1A1, CYP1A2 and FMO1 in guinea pig, mouse and rabbit. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010801 |
| Detection and characterization of DNA adducts of 3-methylindole. | Chemical research in toxicology 20010801 |
| The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. | Toxicology and applied pharmacology 20010715 |
| Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20010701 |
| Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. | The Journal of biological chemistry 20010622 |
| Oxidations of 17beta-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or beta-naphthoflavone. | Canadian journal of physiology and pharmacology 20010601 |
| Risk reduction for DDT toxicity and carcinogenesis through dietary modification. | The journal of the Royal Society for the Promotion of Health 20010601 |
| Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats. | Bulletin of experimental biology and medicine 20010601 |
| Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. | Oncogene 20010524 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. | Toxicological sciences : an official journal of the Society of Toxicology 20010501 |
| The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. | Cancer research 20010415 |
| Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats. | Journal of toxicology and environmental health. Part A 20010406 |
| Molecular biology of the Ah receptor and its role in carcinogenesis. | Toxicology letters 20010331 |
| Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. | Breast cancer research and treatment 20010301 |
| 3,3'-diindolylmethane, a major condensation product of indole-3-carbinol, is a potent estrogen in the rainbow trout. | Toxicology and applied pharmacology 20010201 |
| Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. | Carcinogenesis 20010201 |
| beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. | Carcinogenesis 20010201 |
| Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes. | Chemico-biological interactions 20010130 |
| Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins. | The Journal of general virology 20010101 |
| Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. | Environmental toxicology 20010101 |
| Effects of binary mixtures of six xenobiotics on hormone concentrations and morphometric endpoints of northern bobwhite quail (Colinus virginianus). | Chemosphere 20010101 |
| Unsymmetrical methylene derivatives of indoles as antiproliferative agents. | European journal of medicinal chemistry 20010101 |
| Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions. | Advances in experimental medicine and biology 20010101 |
| Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. | Lupus 20010101 |
| Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia. | In vitro & molecular toxicology 20010101 |
| Cruciferous vegetables and cancer prevention. | Nutrition and cancer 20010101 |
| Abrogation of estrogen-mediated cellular and biochemical effects by indole-3-carbinol. | Nutrition and cancer 20010101 |
| Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol. | Nutrition and cancer 20010101 |
| Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells. | The Journal of nutrition 20001201 |
| Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase. | Biochemistry 19990720 |
| Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1. | The Biochemical journal 19981101 |
| Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers. | Carcinogenesis 19981001 |
| Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. | Carcinogenesis 19980901 |
| Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds. | The Journal of biological chemistry 19971226 |
| Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. | The Journal of biological chemistry 19971212 |
| Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. | Carcinogenesis 19970901 |
| Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. | Biochemical pharmacology 19930309 |
| Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Proceedings of the National Academy of Sciences of the United States of America 19911101 |
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