200,000+ products from a single source!
sales@angenechem.com
70-40-6 | 3,3'-diiodothyronine
CAS No: 70-40-6 Catalog No: AG00FEJX MDL No:
Product Description
Catalog Number:
AG00FEJX
Chemical Name:
3,3'-diiodothyronine
CAS Number:
70-40-6
IUPAC Name:
2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid
InChI:
InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)
InChI Key:
CPCJBZABTUOGNM-UHFFFAOYSA-N
Properties
Complexity:
385
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
524.893g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
525.081g/mol
Monoisotopic Mass:
524.893g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
92.8A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1
Literature
| Title | Journal |
|---|---|
| Regioselective deiodination of thyroxine by iodothyronine deiodinase mimics: an unusual mechanistic pathway involving cooperative chalcogen and halogen bonding. | Journal of the American Chemical Society 20120307 |
| Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Management and follow-up of thyroid cancer in pregnant women. | Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20111201 |
| Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation. | The Journal of endocrinology 20110601 |
| Analysis of thyroid hormones in raw and treated waste water. | Journal of chromatography. A 20101015 |
| Analysis of thyroid hormones in serum by liquid chromatography-tandem mass spectrometry. | Analytical and bioanalytical chemistry 20100701 |
| Effects of substitution and high-dose thyroid hormone therapy on deiodination, sulfoconjugation, and tissue thyroid hormone levels in prolonged critically ill rabbits. | Endocrinology 20080801 |
| Iodothyronine deiodinase enzyme activities in bone. | Bone 20080701 |
| Metabolic effects of thyroid hormone derivatives. | Thyroid : official journal of the American Thyroid Association 20080201 |
| Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. | Molecular endocrinology (Baltimore, Md.) 20061101 |
| Differentiation of diiodothyronines using electrospray ionization tandem mass spectrometry. | Journal of mass spectrometry : JMS 20060201 |
| Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. | The Journal of clinical endocrinology and metabolism 20051201 |
| Biochemical mechanisms of thyroid hormone deiodination. | Thyroid : official journal of the American Thyroid Association 20050801 |
| Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens. | The Journal of clinical endocrinology and metabolism 20041101 |
| Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs. | Endocrinology 20040901 |
| A radioimmunoassay for measurement of 3,3'-diiodothyronine sulfate: Studies in thyroidal and nonthyroidal diseases, pregnancy, and fetal/neonatal life. | Metabolism: clinical and experimental 20040401 |
| Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. | The Journal of biological chemistry 20031010 |
| Comparative evaluation of 11 scoring functions for molecular docking. | Journal of medicinal chemistry 20030605 |
| Thyroid hormone transport by the rat fatty acid translocase. | Endocrinology 20030401 |
| Concentrations of seven iodothyronine metabolites in brain regions and the liver of the adult rat. | Endocrinology 20020501 |
| Uptake of triiodothyronine and triiodothyroacetic acid in neonatal rat cardiomyocytes: effects of metabolites and analogs. | The Journal of endocrinology 20020501 |
| Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. | The Journal of endocrinology 20011201 |
| Thyroid hormone transport by the heterodimeric human system L amino acid transporter. | Endocrinology 20011001 |
| Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog. | Archives of biochemistry and biophysics 20010601 |
| Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3'-triiodothyronine content in the human central nervous system. | European journal of endocrinology 20010601 |
| Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain. | The Journal of clinical endocrinology and metabolism 20010601 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.