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69729-06-2 | L-Leucine, L-phenylalanyl-L-leucyl-L-a-glutamyl-L-a-glutamyl-
CAS No: 69729-06-2 Catalog No: AG005IDN MDL No:
Product Description
Catalog Number:
AG005IDN
Chemical Name:
L-Leucine, L-phenylalanyl-L-leucyl-L-a-glutamyl-L-a-glutamyl-
CAS Number:
69729-06-2
Molecular Formula:
C31H57N7O12
Molecular Weight:
719.8240
IUPAC Name:
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acid
InChI:
InChI=1S/C31H47N5O10/c1-17(2)14-23(35-27(41)20(32)16-19-8-6-5-7-9-19)30(44)34-21(10-12-25(37)38)28(42)33-22(11-13-26(39)40)29(43)36-24(31(45)46)15-18(3)4/h5-9,17-18,20-24H,10-16,32H2,1-4H3,(H,33,42)(H,34,44)(H,35,41)(H,36,43)(H,37,38)(H,39,40)(H,45,46)/t20-,21-,22-,23-,24-/m0/s1
InChI Key:
JNBCIUTTWUUDDX-LSBAASHUSA-N
SMILES:
N[C@H](C(=O)O)Cc1ccccc1.CC(C[C@@H](C(=O)O)N)C.CC(C[C@@H](C(=O)O)N)C.NC(=O)CC[C@@H](C(=O)O)N.NC(=O)CC[C@@H](C(=O)O)N
Properties
Complexity:
1060
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
5
Defined Bond Stereocenter Count:
0
Exact Mass:
649.332g/mol
Formal Charge:
0
Heavy Atom Count:
46
Hydrogen Bond Acceptor Count:
11
Hydrogen Bond Donor Count:
8
Isotope Atom Count:
0
Molecular Weight:
649.742g/mol
Monoisotopic Mass:
649.332g/mol
Rotatable Bond Count:
21
Topological Polar Surface Area:
254A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.6
Literature
| Title | Journal |
|---|---|
| Dual-spray hydrogen/deuterium exchange (HDX) reactions: A new method of probing protein structure. | Rapid communications in mass spectrometry : RCM 20160715 |
| Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. | European journal of biochemistry 20021201 |
| Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state. | Proceedings of the National Academy of Sciences of the United States of America 19970819 |
| Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone. | The Journal of biological chemistry 19950310 |
| Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. | Cancer 19940901 |
| Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae. | The Biochemical journal 19870701 |
| Synthesis and biological properties of new hexapeptide substrates for vitamin K dependent carboxylase. Evidence for X-Pro cis/trans amide bond interconversions in prothrombin precursor fragment 18-23. | Journal of medicinal chemistry 19830601 |
| Vitamin K dependent carboxylation of glutamate residues to gamma-carboxyglutamate in microsomes from spleen and testes: comparison with liver, lung, and kidney. | Biochemistry 19830301 |
| Vitamin K-dependent carboxylase: synthesis of an inhibitor of the glutamyl binding site. | FEBS letters 19830207 |
| Vitamin K-dependent carboxylase. Partial purification and properties of the enzyme-substrate complex. | The Journal of biological chemistry 19821225 |
| Synthesis of two analogs of a cyclic hexapeptide with disulfide bridge corresponding to bovine prothrombin precursor sequence 18-23. Extent of carboxylation by Vitamin K-Dependent carboxylase. | International journal of peptide and protein research 19810701 |
| Synthesis of peptide analogues of prothrombin precursor sequence 5-9. Substrate specificity of vitamin K dependent carboxylase. | Journal of medicinal chemistry 19810601 |
| Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid. | CRC critical reviews in biochemistry 19800101 |
| Vitamin K-dependent gamma-carbon-hydrogen bond cleavage and nonmandatory concurrent carboxylation of peptide-bound glutamic acid residues. | Proceedings of the National Academy of Sciences of the United States of America 19790701 |
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