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695-53-4 | 5,5-Dimethyloxazolidine-2,4-dione
CAS No: 695-53-4 Catalog No: AG005WIG MDL No:MFCD00005379
Product Description
Catalog Number:
AG005WIG
Chemical Name:
5,5-Dimethyloxazolidine-2,4-dione
CAS Number:
695-53-4
Molecular Formula:
C5H7NO3
Molecular Weight:
129.1140
MDL Number:
MFCD00005379
IUPAC Name:
5,5-dimethyl-1,3-oxazolidine-2,4-dione
InChI:
InChI=1S/C5H7NO3/c1-5(2)3(7)6-4(8)9-5/h1-2H3,(H,6,7,8)
InChI Key:
JYJFNDQBESEHJQ-UHFFFAOYSA-N
SMILES:
O=C1NC(=O)C(O1)(C)C
EC Number:
211-781-4
UNII:
ALU9NPM703
Properties
Complexity:
173
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
129.043g/mol
Formal Charge:
0
Heavy Atom Count:
9
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
129.115g/mol
Monoisotopic Mass:
129.043g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
55.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.1
Literature
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| Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung. | Toxicology 20141204 |
| In utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat. | Toxicological sciences : an official journal of the Society of Toxicology 20141201 |
| Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators. | Journal of medicinal chemistry 20111222 |
| Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. | Birth defects research. Part B, Developmental and reproductive toxicology 20110601 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
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| Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats. | Metabolic brain disease 20080301 |
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| Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. | Reproductive toxicology (Elmsford, N.Y.) 20070701 |
| Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum. | Development, growth & differentiation 20070401 |
| Thoracic skeletal defects and cardiac malformations: a common epigenetic link? | Birth defects research. Part C, Embryo today : reviews 20061201 |
| Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice. | Birth defects research. Part A, Clinical and molecular teratology 20060101 |
| Discriminative power of an assay for automated in vitro screening of teratogens. | Toxicology in vitro : an international journal published in association with BIBRA 20040801 |
| Disruption of bovine oocytes and preimplantation embryos by urea and acidic pH. | Journal of dairy science 20030401 |
| Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? | Epilepsia 20020501 |
| Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. | Alternatives to laboratory animals : ATLA 20020101 |
| The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia. | Journal of clinical pharmacy and therapeutics 20011201 |
| Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis. | The Journal of biological chemistry 20010803 |
| Altering intracellular pH disrupts development and cellular organization in preimplantation hamster embryos. | Biology of reproduction 20010601 |
| Trimethadione N-demethylation by rat liver CYP2E1 in vitro. | Research communications in molecular pathology and pharmacology 19960701 |
| Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat. | Archives of toxicology 19920101 |
| Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. | Annals of neurology 19890601 |
| Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. | Neuroscience letters 19890313 |
| Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy. | The Journal of pediatrics 19760801 |
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