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6890-08-0 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE
CAS No: 6890-08-0 Catalog No: AG00FDF9 MDL No:MFCD00835191
Product Description
Catalog Number:
AG00FDF9
Chemical Name:
2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE
CAS Number:
6890-08-0
MDL Number:
MFCD00835191
IUPAC Name:
2-hydroxy-4H-isoquinoline-1,3-dione
InChI:
InChI=1S/C9H7NO3/c11-8-5-6-3-1-2-4-7(6)9(12)10(8)13/h1-4,13H,5H2
InChI Key:
ZXAICCBFIBBVAR-UHFFFAOYSA-N
Properties
Complexity:
251
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
177.043g/mol
Formal Charge:
0
Heavy Atom Count:
13
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
177.159g/mol
Monoisotopic Mass:
177.043g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
57.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.3
Literature
| Title | Journal |
|---|---|
| 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. | ACS chemical biology 20130101 |
| Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. | ACS chemical biology 20120316 |
| Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function. | Journal of medicinal chemistry 20110324 |
| 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. | European journal of medicinal chemistry 20110201 |
| Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold. | Bioorganic & medicinal chemistry letters 20101115 |
| Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. | Journal of medicinal chemistry 20081225 |
| Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs). | Biochemical and biophysical research communications 20070112 |
| Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides. | Biochemical and biophysical research communications 20040430 |
| Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. | Journal of medicinal chemistry 20030327 |
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