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68592-15-4 | 4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol
CAS No: 68592-15-4 Catalog No: AG0036QD MDL No:
Product Description
Catalog Number:
AG0036QD
Chemical Name:
4'-Methoxy-3',5-di-2-propen-1-yl[1,1'-biphenyl]-2-ol
CAS Number:
68592-15-4
Molecular Formula:
C19H20O2
Molecular Weight:
280.3609
IUPAC Name:
2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
InChI:
InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
InChI Key:
OQFHJKZVOALSPV-UHFFFAOYSA-N
SMILES:
C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)OC)O
NSC Number:
293101
Properties
Complexity:
339
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
280.146g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
280.367g/mol
Monoisotopic Mass:
280.146g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
29.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.3
Literature
| Title | Journal |
|---|---|
| Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis. | Anticancer research 20121001 |
| 4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity. | The Journal of nutritional biochemistry 20120701 |
| In vitro growth inhibition of human cancer cells by novel honokiol analogs. | Bioorganic & medicinal chemistry 20120515 |
| Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production. | Bioorganic & medicinal chemistry 20120501 |
| 4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity. | Journal of Alzheimer's disease : JAD 20120101 |
| Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. | Journal of neuroinflammation 20120101 |
| Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship. | Journal of medicinal chemistry 20111013 |
| Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. | Chemistry & biology 20110826 |
| Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship. | Journal of medicinal chemistry 20110811 |
| 4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase. | The Journal of nutritional biochemistry 20110501 |
| 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. | Free radical biology & medicine 20110101 |
| Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx. | Journal of medicinal food 20110101 |
| 4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease. | Journal of Alzheimer's disease : JAD 20110101 |
| The hair growth promoting effect of 4-O-methylhonokiol. | European journal of dermatology : EJD 20110101 |
| Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. | Pharmacology, biochemistry, and behavior 20100301 |
| Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation. | Neurochemical research 20091201 |
| Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected]. | Chemico-biological interactions 20090814 |
| Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity. | Journal of natural medicines 20090701 |
| Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. | Bioorganic & medicinal chemistry 20090701 |
| Cytotoxic lignans from the stem bark of Magnolia officinalis. | Journal of natural products 20071001 |
| Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. | Bioorganic & medicinal chemistry letters 20040517 |
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