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68-89-3

68-89-3 | Dipyrone

CAS No: 68-89-3 Catalog No: AG006FYJ MDL No:MFCD00020783

Product Description

Catalog Number:
AG006FYJ
Chemical Name:
Dipyrone
CAS Number:
68-89-3
Molecular Formula:
C13H16N3NaO4S
Molecular Weight:
333.3386
MDL Number:
MFCD00020783
IUPAC Name:
sodium;[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate
InChI:
InChI=1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1
InChI Key:
DJGAAPFSPWAYTJ-UHFFFAOYSA-M
SMILES:
CN(c1c(C)n(n(c1=O)c1ccccc1)C)CS(=O)(=O)[O-].[Na+]
EC Number:
200-694-7
UNII:
VSU62Z74ON

Properties

Complexity:
552  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
333.076g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
333.338g/mol
Monoisotopic Mass:
333.076g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
92.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in mice. Chemico-biological interactions 20130925
High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis 20121201
Factors associated with intolerance after refeeding in mild acute pancreatitis. Pancreas 20121101
Involvement of PGE2 and RANTES in Staphylococcus aureus-induced fever in rats. Journal of applied physiology (Bethesda, Md. : 1985) 20121101
Hypernociception and wound healing after application of cyanoacrylate ester as a tissue adhesive in rats. Oral surgery, oral medicine, oral pathology and oral radiology 20121101
Evaluation of the endogenous cannabinoid system in mediating the behavioral effects of dipyrone (metamizol) in mice. Behavioural pharmacology 20121001
Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms. part II: furoxan derivatives. Journal of medicinal chemistry 20120913
Dexamethasone versus ondansetron in combination with dexamethasone for the prophylaxis of postoperative vomiting in pediatric outpatients: a double-blind, randomized, placebo-controlled clinical trial. Paediatric anaesthesia 20120901
Antinociceptive and anti-inflammatory activities of crude methanolic extract of red alga Bryothamnion triquetrum. Marine drugs 20120901
Importance of MS selectivity and chromatographic separation in LC-MS/MS-based methods when investigating pharmaceutical metabolites in water. Dipyrone as a case of study. Journal of mass spectrometry : JMS 20120801
The effect of paracetamol, metamizole sodium and ibuprofen on postoperative hemorrhage following pediatric tonsillectomy. International journal of pediatric otorhinolaryngology 20120701
Oral administration of an anti-inflammatory does not compromise the efficacy of intra-testicular injection of zinc gluconate as a contraceptive for dogs. Animal reproduction science 20120601
IgE-mediated metamizol allergy and the usefulness of the cellular allergen stimulation test. European annals of allergy and clinical immunology 20120601
Dipyrone attenuates acute sickness response to lipopolysaccharide in mice. Neuroscience letters 20120510
Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain. Naunyn-Schmiedeberg's archives of pharmacology 20120501
Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats. European journal of pain (London, England) 20120501
[Pharmacokinetics interaction between methadone and metamizole: study of 53 cases]. Medicina clinica 20120428
Near-infrared spectrometric determination of dipyrone in closed ampoules. Talanta 20120415
The role of inflammation and COX-derived prostanoids in the effects of bradykinin on isolated rat aorta and urinary bladder. Inflammation 20120401
[Lupus, Graves' disease, and vasculitis: a case report]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20120301
[Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20120301
Analgesic effectiveness of dipyrone (metamizol) for postoperative pain after herniorrhaphy: a randomized, double-blind, dose-response study. Pain practice : the official journal of World Institute of Pain 20120201
Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. Scandinavian journal of urology and nephrology 20120201
Efficacy and tolerability of combined dipyrone, isometheptene and caffeine in the treatment of mild-to-moderate primary headache episodes. Expert review of neurotherapeutics 20120201
Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium(IV) system and flow-injection analysis. Luminescence : the journal of biological and chemical luminescence 20120101
Novel bioactive metabolites of dipyrone (metamizol). Bioorganic & medicinal chemistry 20120101
[Continuous propofol perfusion in critically ill children]. Medicina intensiva 20120101
Difficulty in diagnosing oral paracoccidioidomycosis after topical nystatin usage. General dentistry 20120101
[Metamizole in postoperative pain management]. Nederlands tijdschrift voor geneeskunde 20120101
A randomized, double-blind, controlled trial on non-opioid analgesics and opioid consumption for postoperative pain relief after laparoscopic cholecystectomy. Acta anaesthesiologica Belgica 20120101
Postoperative pain management at Tirana university hospital center -Mother Teresa-, Tirana, Albania. Journal of biological regulators and homeostatic agents 20120101
Anaphylaxis due to sulpiride and sensitization to metamizole. Journal of investigational allergology & clinical immunology 20120101
Intrapleural analgesia after endoscopic thoracic sympathectomy. Acta cirurgica brasileira 20111201
Dipyrone inhibits neuronal cell death and diminishes hypoxic/ischemic brain injury. Neurosurgery 20111001
Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models. Pharmacology, biochemistry, and behavior 20111001
Cobalt phthalocyanine as a biomimetic catalyst in the amperometric quantification of dipyrone using FIA. Talanta 20110930
[Pupillary block acute glaucoma due to acrylic intraocular lens posterior dislocation after Nd:YAG capsulotomy]. Archivos de la Sociedad Espanola de Oftalmologia 20110901
Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms. Journal of medicinal chemistry 20110825
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. Molecules (Basel, Switzerland) 20110815
Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110801
The use of different doses of metamizol for post-operative analgesia in dogs. Veterinary anaesthesia and analgesia 20110701
Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri. Reproductive biomedicine online 20110701
[Synergistic combination therapy in osteoporosis. Strategies against painful bone loss]. MMW Fortschritte der Medizin 20110512
Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. Journal of natural products 20110425
[Postoperative pain management after ambulatory surgery. A survey of anaesthesiologists]. Schmerz (Berlin, Germany) 20110401
[Medical management of acute renal colic - there is more than hydration and Buscopan®...]. Praxis 20110302
Subchronic effects of dipyrone on the fish species Rhamdia quelen. Ecotoxicology and environmental safety 20110301
The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus. British journal of pharmacology 20110301
Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial. European journal of anaesthesiology 20110201
The role of metamizol induction for the detection of perfusion reversibility on thallium-201 myocardial perfusion scintigraphy. Nuclear medicine communications 20110201
[Estimation of postoperative pain after tonsillectomy in adults using QUIPS: an instrument to improve postoperative pain management]. Laryngo- rhino- otologie 20110201
[17-year-old patient with neutropenia and fever during therapy with analgesics]. Deutsche medizinische Wochenschrift (1946) 20110201
Comparison of dipyrone/propofol versus fentanyl/propofol anaesthesia during surgery in rabbits. Laboratory animals 20110101
Antipyretic effect of ibuprofen and dipyrone in febrile children. Jornal de pediatria 20110101
Standardized antipyretic treatment in stroke: a pilot study. Cerebrovascular diseases (Basel, Switzerland) 20110101
Effective fever control in acute stroke: still wanted! Cerebrovascular diseases (Basel, Switzerland) 20110101
Metamizole is not as safe as we think or assume. Turkish neurosurgery 20110101
Opioid sensitivity of nucleus raphe magnus ater analgesia by nonsteroidal anti-inflammatory drugs. Georgian medical news 20110101
Acute kidney injury associated with metamizole sodium ingestion. Renal failure 20110101
Effect of Buscopan compositum on the motility of the duodenum, cecum and left ventral colon in healthy conscious horses. Berliner und Munchener tierarztliche Wochenschrift 20110101
Efficiency of postoperative pain management after gynecologic oncological surgeries with the use of morphine + acetaminophen + ketoprofen versus morphine + metamizol + ketoprofen. European journal of gynaecological oncology 20110101
Epidural and opioid analgesia following the Nuss procedure. Medical science monitor : international medical journal of experimental and clinical research 20110101
N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101201
Population pharmacokinetic analysis of the active product of dipyrone. International journal of clinical pharmacology and therapeutics 20101201
[Chronic dizziness in a pain patient--pharmacogenomic identification of tramadol as cause]. Die Rehabilitation 20101201
Assessment of early post-operative pain following septorhinoplasty. The Journal of laryngology and otology 20101101
Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives. European journal of medicinal chemistry 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
[Quality of over-the-counter medicines: a study with dipyrone brands commercialized in a drugstore in Cascavel city (Paraná, Brazil)]. Ciencia & saude coletiva 20101101
Effect of metamizol on morphine pharmacokinetics and pharmacodynamics after acute and subchronic administration in arthritic rats. European journal of pharmacology 20101025
Antinociceptive effect of methanol extract of Capparis ovata in mice. Pharmaceutical biology 20101001
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. European journal of obstetrics, gynecology, and reproductive biology 20100901
[A non-abscess-forming inflammation of the corpora cavernosa in a diabetic patient - case report]. Aktuelle Urologie 20100901
Immediate rhinoconjunctivitis induced by metamizole: an allergic reaction? Allergy 20100801
Graphite-epoxy electrodes modified with functionalised carbon nanotubes and chitosan for the rapid electrochemical determination of dipyrone. Combinatorial chemistry & high throughput screening 20100801
Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS). Water research 20100801
Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety. European journal of medicinal chemistry 20100601
[Antipyretic strategies for acute stroke: a nationwide survey among German stroke units]. Der Nervenarzt 20100601
Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery. European journal of anaesthesiology 20100501
[Urolithiasis]. MMW Fortschritte der Medizin 20100422
Synergism between COX-3 inhibitors in two animal models of pain. Inflammopharmacology 20100401
Elevated urinary biopyrrin excretion and oxidative bilirubin metabolism during 24-hour ultramarathon running. Rinsho byori. The Japanese journal of clinical pathology 20100401
Transient renal insufficiency following dipyrone overdose. Archives of disease in childhood 20100301
Tolerance induced by non-opioid analgesic microinjections into rat's periaqueductal gray and nucleus raphe. Georgian medical news 20100301
Analgesic and antiinflammatory activity of Morinda citrifolia L. (Noni) fruit. Phytotherapy research : PTR 20100101
Postoperative and preincisional electrical nerve stimulation TENS reduce postoperative opioid requirement after major spinal surgery. Journal of neurosurgical anesthesiology 20100101
Effects of postoperative analgesia on acute phase response in thoracic surgery. Medicinski arhiv 20100101
Postoperative pain and respiratory function in patients treated with electroacupuncture following coronary surgery. Neurosciences (Riyadh, Saudi Arabia) 20100101
Individual variability of response and non-response to acetyl salicylic acid after cardiac surgery. Platelets 20100101
Single dose dipyrone for acute postoperative pain. The Cochrane database of systematic reviews 20100101
Update on the incidence of metamizole sodium-induced blood dyscrasias in Poland. The Journal of international medical research 20100101
Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-sensitive afferent pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20091101
Cardiovascular effects of dipyrone and propofol on hemodynamic function in rabbits. American journal of veterinary research 20091101
The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study. Acta neurologica Scandinavica 20091001
Drug/nutrition interaction in the developing brain: dipyrone enhances spreading depression in rats. Experimental neurology 20091001
Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing. Journal of proteome research 20091001
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole. Bioorganic & medicinal chemistry 20090915
Sciatic injection injuries in adults: is dipyrone a foe to nerve? Acta neurologica Belgica 20090901
[Adverse events associated with tramadol and dipirona administration in a level III hospital]. Biomedica : revista del Instituto Nacional de Salud 20090901
Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats. European journal of pharmacology 20090815
The effective duration of analgesia after intrathecal morphine in patients without additional opioid analgesia: a randomized double-blind multicentre study on orthopaedic patients. European journal of anaesthesiology 20090801
Immunoglobulin E-mediated immediate allergic reactions to dipyrone: value of basophil activation test in the identification of patients. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090801
Analgesic efficacy of lysine clonixinate, paracetamol and dipyrone in lower third molar extraction: a randomized controlled trial. Medicina oral, patologia oral y cirugia bucal 20090801
Paracetamol versus metamizol in the treatment of postoperative pain after breast surgery: a randomized, controlled trial. European journal of anaesthesiology 20090801
[Influence of acupuncture on postoperative pain, nausea and vomiting after visceral surgery : a prospective, randomized comparative study of metamizole and standard treatment]. Schmerz (Berlin, Germany) 20090801
Necrotising fasciitis caused by adulterated traditional Asian medicine: a case report. Journal of orthopaedic surgery (Hong Kong) 20090801
Can metamizol play a role in nuclear medicine practice? European journal of nuclear medicine and molecular imaging 20090701
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS). Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601
Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats. American journal of physiology. Regulatory, integrative and comparative physiology 20090501
[Early results of surgical treatment of haemorrhoids at use of harmonic scalpel]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090501
Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma. Bioanalysis 20090501
D-propoxyphene and dipyrone co-administration produces greater antinociception and fewer adverse effects than single treatments in rats. European journal of pharmacology 20090401
[Agranulocytosis from metamizole: a potential problem for the British population]. Revista clinica espanola 20090401
Dipyrone use during pregnancy and adverse perinatal events. Archives of gynecology and obstetrics 20090301
Dipyrone increases the blood flow of arterial dorsal skin flaps: are prospective studies always properly designed? Aesthetic plastic surgery 20090301
Determination of tramadol, metamizole, ropivacaine, and bupivacaine in analgesic mixture samples by HPLC with DAD detection. Journal of chromatographic science 20090301
Tolerance to non-opioid analgesics in PAG involves unresponsiveness of medullary pain-modulating neurons in male rats. The European journal of neuroscience 20090301
[Evaluation of the analgesic effects of the lumiracoxib compared with placebo in the 24 first postoperative hours]. Revista do Colegio Brasileiro de Cirurgioes 20090201
Cooling therapy for acute stroke. The Cochrane database of systematic reviews 20090121
Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic. Pharmacology, biochemistry, and behavior 20090101
Drug enhancement of myocardial tracer uptake during myocardial perfusion imaging. European journal of nuclear medicine and molecular imaging 20090101
Synthesis and pharmacological evaluation of N-(dimethylamino)ethyl derivatives of benzo- and pyridopyridazinones. Archiv der Pharmazie 20090101
The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice. The International journal of neuroscience 20090101
[Comparison of sublingual ketorolac vs. IV metamizole in the management of pain after same-day surgery]. Cirugia y cirujanos 20090101
[Scorpionism caused by Tityus pusillus Pocock, 1893 (Scorpiones; Buthidae) in State of Pernambuco]. Revista da Sociedade Brasileira de Medicina Tropical 20090101
Advise against metamizole. Deutsches Arzteblatt international 20090101
[Study of the ocular findings in Stevens-Johnson syndrome patients from a tertiary ophthalmologic center]. Arquivos brasileiros de oftalmologia 20090101
[Safety of metamizole and paracetamol for acute pain treatment]. Anestezjologia intensywna terapia 20090101
[Comparison of the analgesic effect between 90 mg etoricoxib and dipyrone after exeresis of primary pterygium with conjunctival autograft]. Arquivos brasileiros de oftalmologia 20090101
Influence of oxcarbazepine on the antinociceptive action of morphine and metamizole in mice. Acta poloniae pharmaceutica 20090101
[Management of anxiety associated with oral surgery]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20090101
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice. Life sciences 20081121
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. Pharmacology, biochemistry, and behavior 20081101
[Leeches, phytotherapy and physiotherapy in osteo-arthrosis of the knee--a geriatric case study]. Forschende Komplementarmedizin (2006) 20081001
Synthesis of new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}-thiourea and urea derivatives with anti-nociceptive activity. Bioorganic & medicinal chemistry 20080915
Dipyrone increases the blood flow of arterial dorsal skin flaps. Aesthetic plastic surgery 20080901
Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion. Circulation journal : official journal of the Japanese Circulation Society 20080901
99mTc sestamibi myocardial perfusion scintigraphy with the novel use of metamizol for the detection of perfusion reversibility. European journal of nuclear medicine and molecular imaging 20080801
Design and microwave-assisted synthesis of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles: novel agents with analgesic and anti-inflammatory properties. European journal of medicinal chemistry 20080601
Femoral nerve blockade administered preclinically for pain relief in severe knee trauma is more feasible and effective than intravenous metamizole: a randomized controlled trial. The Journal of trauma 20080601
Lysine clonixinate versus dipyrone (metamizole) for the acute treatment of severe migraine attacks: a single-blind, randomized study. Arquivos de neuro-psiquiatria 20080601
[Intrauterine closure of the ductus arteriosus probably associated with the taking of metamizole during the third trimester]. Anales de pediatria (Barcelona, Spain : 2003) 20080601
Systemic effects of isolated brain injury: an experimental animal study. Neurological research 20080601
Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products. Water research 20080501
Study of non-opioid analgesics tolerance in young and adult rats. Georgian medical news 20080501
Life-threatening bite injury of the lower lip after use of metamizole. Oral and maxillofacial surgery 20080501
Occurrence, fate and assessment of polar metamizole (dipyrone) residues in hospital and municipal wastewater. Chemosphere 20080401
[Intrathecal morphine in orthopaedic surgery patients. Optimised dose in patients receiving dipyrone]. Der Anaesthesist 20080401
Tepid sponging plus dipyrone versus dipyrone alone for reducing body temperature in febrile children. Sao Paulo medical journal = Revista paulista de medicina 20080306
Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplasty: a prospective, randomized, double-blind, placebo-controlled study. European journal of anaesthesiology 20080301
Extralabel use of nonsteroidal anti-inflammatory drugs in cattle. Journal of the American Veterinary Medical Association 20080301
Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone. Journal of clinical anesthesia 20080301
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. British journal of pharmacology 20080201
[Chikungunya: fever and joint pains after vacation in a tropical area]. Deutsche medizinische Wochenschrift (1946) 20080201
Pyrazolinone analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis. Journal of thrombosis and haemostasis : JTH 20080101
Efficacy and tolerance of metamizole versus morphine for acute pancreatitis pain. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20080101
Lipomatous metaplasia after severe and chronic cutaneous inflammation. Dermatology (Basel, Switzerland) 20080101
[Characterization of chronic pain and analgesic approaches among community-dwelling elderly]. Revista da Associacao Medica Brasileira (1992) 20080101
Parecoxib versus dipyrone (metamizole) for postoperative pain relief after hysterectomy : a prospective, single-centre, randomized, double-blind trial. Clinical drug investigation 20080101
Singlet oxygen scavenging activity of non-steroidal anti-inflammatory drugs. Redox report : communications in free radical research 20080101
[Synergism of caffeine on antinociceptive effects of metamizole]. Cirugia y cirujanos 20080101
[Estimated methods of predicting risk of analgetic interstitial renal disease]. Terapevticheskii arkhiv 20080101
Antibiotic use in post-adenotonsillectomy morbidity: a randomized prospective study. Brazilian journal of otorhinolaryngology 20080101
[Is the assessment of serum creatinine reliable?]. Casopis lekaru ceskych 20080101
Ketoprofen is superior to metamizole in relieving postoperative pain after head and neck tumor operation. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20080101
Usefulness of intradermal test and patch test in the diagnosis of nonimmediate reactions to metamizol. Allergy 20071201
Flow-injection spectrophotometric determination of novalgin in pharmaceuticals using micellar medium. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20071201
The effects of some nonsteroidal anti-inflammatory drugs on experimental induced gastric ulcers in rats. Inflammopharmacology 20071201
Adjunct dipyrone in association with oral morphine for cancer-related pain: the sooner the better. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20071101
[Analysis of three metabolite residues of dipyrone in bovine muscle and pork muscle using high performance liquid chromatography]. Se pu = Chinese journal of chromatography 20071101
Are false-positive phencyclidine immunoassay instant-view multi-test results caused by overdose concentrations of Ibuprofen, metamizol, and dextromethorphan? Therapeutic drug monitoring 20071001
[Comparison of tramadol, tramadol-metamizol and tramadol-lornoxicam administered by intravenous PCA in management of postoperative pain]. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20071001
Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. Clinical pharmacology and therapeutics 20070901
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070801
Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. European journal of clinical pharmacology 20070801
Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070801
Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070701
Effect of cigarette smoking on serum hydrocodone levels in chronic pain patients. The Journal of the Arkansas Medical Society 20070701
Inhibition of cyclooxygenases by dipyrone. British journal of pharmacology 20070601
Multiple fixed drug eruption due to intradermal test with metamizole. Allergy 20070601
Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome. Journal of gastroenterology and hepatology 20070601
Control of postoperative pain after awake craniotomy with local intradermal analgesia and metamizol. The Israel Medical Association journal : IMAJ 20070501
Dipyrone for acute primary headaches. The Cochrane database of systematic reviews 20070418
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesthesia and analgesia 20070401
[Cost-effectiveness analysis of patient-controlled analgesia compared to continuous elastomeric pump infusion of tramadol and metamizole]. Revista espanola de anestesiologia y reanimacion 20070401
[Stress response under continuous infusion of remifentanil compared to bolus doses of fentanyl assessed by levels of cytokines, C-reactive protein, and cortisol during and after abdominal hysterectomy]. Revista espanola de anestesiologia y reanimacion 20070401
Suicide by multidrug ingestion: hypothesis on the role played by the self-administration of activated charcoal. The American journal of forensic medicine and pathology 20070301
Update on the role of non-opioids for postoperative pain treatment. Best practice & research. Clinical anaesthesiology 20070301
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. Clinical therapeutics 20070301
Dipyrone and acetaminophen: correct dosing by parents? Sao Paulo medical journal = Revista paulista de medicina 20070104
A population-based case-control teratologic study of oral dipyrone treatment during pregnancy. Drug safety 20070101
A nonopioid analgesic acts upon the PAG-RVM axis to reverse inflammatory hyperalgesia. The European journal of neuroscience 20070101
Unilateral conjunctival chemosis as a unique symptom of nonsteroidal anti-inflammatory drug intolerance. Journal of investigational allergology & clinical immunology 20070101
Isobolographic analyses of the gabapentin-metamizol combination after local peripheral, intrathecal and oral administration in the rat. Pharmacology 20070101
Rheumatoid arthritis patients with therapy-induced myelodysplastic syndrome present with long-term remission after recovery. Scandinavian journal of rheumatology 20070101
[Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals]. Eksperimental'naia i klinicheskaia farmakologiia 20070101
Bioactive phenolic compounds from aerial parts of Plinia glomerata. Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101
Simultaneous determination of caffeine, ergotamine, and metamizol in solid pharmaceutical formulation by HPTLC-UV-FLD with mass confirmation by online HPTLC-ESI-MS. Journal of chromatographic science 20070101
Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents. Pharmacology 20070101
Dipyrone improves small airway function in asthmatic patients with moderate obstruction. Journal of investigational allergology & clinical immunology 20070101
Influence of tiagabine on the antinociceptive action of morphine, metamizole and indomethacin in mice. Acta poloniae pharmaceutica 20070101
[Antinociceptive effects of the combination metamizol + morphine in rats with intense pain (arthritic gout-type pain produced with AU)]. Cirugia y cirujanos 20070101
[Comparison of intravenous dipyrone to intravenous metoclopramide in the treatment of acute crisis of migraine: randomized clinical trial]. Arquivos de neuro-psiquiatria 20061201
[Fulminant pancreatitis--internal point of view]. Praxis 20061129
[Agranulocytosis in a patient treated with metamizole and clopidogrel]. Praxis 20061108
Considerations about the theoretically expected crushing strength of tablets from binary powder mixtures: double layer tablets versus arithmetic additivity rule. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061101
Analgesics for pain after traumatic or orthopaedic surgery: what is the evidence--a systematic review. European journal of clinical pharmacology 20061101
Effect of antipyrine on the gastric emptying of liquid in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20061101
Multiple endocrine neoplasia-like syndrome in a horse. The Veterinary record 20061014
Paediatric cancer pain management using the WHO analgesic ladder--results of a prospective analysis from 2265 treatment days during a quality improvement study. European journal of pain (London, England) 20061001
Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients. Archives of medical research 20061001
Clinical equivalence of IV paracetamol compared to IV dipyrone for postoperative analgesia after surgery for breast cancer. Current medical research and opinion 20061001
Dipyrone-induced oligohydramnios and ductus arteriosus restriction. The Israel Medical Association journal : IMAJ 20061001
Endogenous opioids are involved in morphine and dipyrone analgesic potentiation in the tail flick test in rats. European journal of pharmacology 20060928
[Medical liability in diagnostic errors. Judgement of the High Court of Koblenz on 29.06.2006]]. Deutsche medizinische Wochenschrift (1946) 20060922
Dipyrone (metamizole) metabolites interfere with HPLC analysis of plasma catecholamines but not with the determination of urinary catecholamines. Clinical chemistry 20060901
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Metamizole use among Hispanics in Miami: report of a survey conducted in a primary care setting. Southern medical journal 20060901
Pattern of dipyrone exposure in Texas, 1998 to 2004. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20060901
Prediction of tablet hardness based on near infrared spectra of raw mixed powders by chemometrics. Journal of pharmaceutical sciences 20060701
The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiscectomy. Anesthesia and analgesia 20060701
Pharmacodynamics and potential toxicity of intranasally administered dipyrone. Biological & pharmaceutical bulletin 20060701
[Intraoperative bronchospasm during paranasal sinus surgery -- indicator of aspirin intolerance syndrome?]. Laryngo- rhino- otologie 20060601
The Ginkgo biloba extract, EGb 761, fails to reduce brain infarct size in rats after transient, middle cerebral artery occlusion in conditions of unprevented, ischemia-induced fever. Phytotherapy research : PTR 20060601
Antipyretic efficacy and tolerability of oral ibuprofen, oral dipyrone and intramuscular dipyrone in children: a randomized controlled trial. Sao Paulo medical journal = Revista paulista de medicina 20060504
Does dipyrone have any effect on respiratory function in COPD patients? Respiratory medicine 20060501
Characterization of oxalic acid derivatives as new metabolites of metamizol (dipyrone) in incubated hen's egg and human. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060501
Dipyrone-induced granulocytopenia: a case for awareness. Pharmacotherapy 20060301
[Acute intermittent porphyria and oral contraception. Case report]. Ginekologia polska 20060301
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives. Free radical biology & medicine 20060215
Use of patch test in fixed drug eruption due to metamizole (Nolotil). Contact dermatitis 20060201
Antinociceptive activity of 3-O-beta-d-glucopyranosyl-23,24-dihydrocucurbitacin F from Hintonia standleyana (Rubiaceae). Pharmacology, biochemistry, and behavior 20060201
[Postoperative pain management in clinics of otolaryngology]. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20060101
Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species. Redox report : communications in free radical research 20060101
[Parotid phlegmon with involvement of both lobes. Report of a case]. Anales otorrinolaringologicos ibero-americanos 20060101
Airway smooth muscle relaxations induced by dipyrone. Pharmacology 20060101
Intraperitoneal bupivacaine for postoperative pain relief after laparoscopic cholecystectomy. Pain medicine (Malden, Mass.) 20060101
[First record of scorpionism caused by Tityus adrianoi Lourenço (Scorpiones: Buthidae)]. Revista da Sociedade Brasileira de Medicina Tropical 20060101
[Comparative efficiency study, safety and usage of tested drugs in patients with renal colic]. Medicinski arhiv 20060101
Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. The Journal of pharmacology and experimental therapeutics 20051201
[Effectiveness of early dipyrone administration on severity of dengue virus infection in a prospective cohort]. Enfermedades infecciosas y microbiologia clinica 20051201
[Rational diagnostic and therapy of renal colic in the year 2005--what's new?]. Zentralblatt fur Chirurgie 20051201
Dipyrone: The ban, the justification. African journal of medicine and medical sciences 20051201
Intraoperative metamizol as cause for acute anaphylactic collapse. European journal of anaesthesiology 20051001
A comparison between IV paracetamol and IV metamizol for postoperative analgesia after retinal surgery. Current medical research and opinion 20051001
[Clinical biochemical evaluation of central fatigue with 24-hour continuous exercise]. Rinsho byori. The Japanese journal of clinical pathology 20050901
Neutropenia, agranulocytosis and dipyrone. Sao Paulo medical journal = Revista paulista de medicina 20050901
[Postoperative pain therapy after tonsillectomy in children. An observational study for 7 days]. HNO 20050801
Metamizol acts as an ATP sensitive potassium channel opener to inhibit the contracting response induced by angiotensin II but not to norepinephrine in rat thoracic aorta smooth muscle. Vascular pharmacology 20050801
Pro-drugs in in vitro experiments. Anesthesia and analgesia 20050801
[Systemic hypertension at emergency units. The use of symptomatic drugs as choice for management]. Arquivos brasileiros de cardiologia 20050801
Safety of mixture of morphine with ketamine for postoperative patient-controlled analgesia: an audit with 1026 patients. Acta anaesthesiologica Scandinavica 20050701
Antinociception induced by intravenous dipyrone (metamizol) upon dorsal horn neurons: involvement of endogenous opioids at the periaqueductal gray matter, the nucleus raphe magnus, and the spinal cord in rats. Brain research 20050628
[Open heart tricuspid valve replacement in a heroin addict Anaesthesiological management]. Der Anaesthesist 20050601
Drug hypersensitivities: which room for biological tests? European annals of allergy and clinical immunology 20050601
Dipyrone and blood dyscrasia revisited: 'non-evidence based medicine'. Sao Paulo medical journal = Revista paulista de medicina 20050502
Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds. Journal of ethnopharmacology 20050408
Intravenous ketoprofen in postoperative pain treatment after major abdominal surgery. World journal of surgery 20050401
Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus. Toxicon : official journal of the International Society on Toxinology 20050401
Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study. European journal of obstetrics, gynecology, and reproductive biology 20050401
Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis. Parasite (Paris, France) 20050301
[Dual agranulocytosis episode likely resulting from metamizole use]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050301
Agranulocytosis associated with dipyrone (metamizol). European journal of clinical pharmacology 20050101
Peristalsis in the Guinea pig small intestine in vitro is impaired by acetaminophen but not aspirin and dipyrone. Anesthesia and analgesia 20050101
Absence of re-epithelialization in a fatal case of toxic epidermal necrolysis: is hyperbilirubinemia a culprit? Archives of dermatology 20050101
Effect of the GABAB agonist baclofen on dipyrone-induced delayed gastric emptying in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050101
[Agranulocytosis induced by metamizole and its management with granulocyte growth factor]. Vojnosanitetski pregled 20050101
[Metamizole and pseudo-ephedrine induced acute generalized exanthematous pustulosis]. Annales de dermatologie et de venereologie 20050101
Simultaneous determination of residues of dipyrone and its major metabolites in milk, bovine muscle, and porcine muscle by liquid chromatography/mass spectrometry. Journal of AOAC International 20050101
Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database. Drug safety 20050101
Pancreatitis due to codeine. Allergologia et immunopathologia 20050101
[Use of analgesics and aspirin in a Spanish multicenter study]. Gaceta sanitaria 20050101
[A possible protocol for postoperative management in laparoscopic cholecystectomy]. Chirurgia (Bucharest, Romania : 1990) 20050101
Influence of antipyretic drugs on the labeling of blood elements with technetium-99m. Acta biologica Hungarica 20050101
Antinociceptive effect of selected Mexican traditional medicinal species. Proceedings of the Western Pharmacology Society 20050101
The effectiveness of analgesics in traumatic injuries of the extremities. Advances in therapy 20050101
Comparison of the effects on spinal reflexes of acetylsalicylate and metamizol in spinalized and normal rats. Acta medica (Hradec Kralove) 20050101
Involvement of cholecystokinin in the opioid tolerance induced by dipyrone (metamizol) microinjections into the periaqueductal gray matter of rats. Pain 20041101
Dipyrone potentiates morphine-induced antinociception in dipyrone-treated and morphine-tolerant rats. European journal of pharmacology 20041011
Non-oliguric acute renal failure and abortion induced by metamizol overdose. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041001
Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041001
A prospective study of the incidence of agranulocytosis and aplastic anemia associated with the oral use of metamizole sodium in Poland. Medical science monitor : international medical journal of experimental and clinical research 20040901
The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040901
Sequential supraclavicular brachial plexus block and intravenous regional anaesthesia for upper limb surgery. European journal of anaesthesiology 20040901
Alpha 2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone. European journal of pharmacology 20040802
Effort-reward imbalance and physical health among Japanese workers in a recently downsized corporation. International archives of occupational and environmental health 20040801
Delayed reaction urticaria due to trimebutine. Allergy 20040701
Topical provocation in fixed drug eruption due to metamizol and naproxen. Clinical and experimental dermatology 20040701
Comparison of cizolirtine citrate and metamizol sodium in the treatment of adult acute renal colic: a randomized, double-blind, clinical pilot study. Clinical therapeutics 20040701
Metamizole sodium-induced severe aplastic anemia and its recovery with a short-course steroid therapy. Pediatric hematology and oncology 20040601
Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm. Indian journal of experimental biology 20040601
Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam. Digestive diseases and sciences 20040601
Characterization of the role of physicochemical factors on the hydrolysis of dipyrone. Journal of pharmaceutical and biomedical analysis 20040528
Tetracycline compound placement to prevent dry socket: a postoperative study of 200 impacted mandibular third molars. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20040501
Metamizol as a cause of postoperative erythroderma. Contact dermatitis 20040501
[Bone marrow aplasia following dipyrone treatment in a patient with Crohn's disease receiving long-term methotrexate]. Gastroenterologie clinique et biologique 20040501
[Drug-induced headache and pain reduction medication with amitriptyline in an 11-year old pupil]. Der Nervenarzt 20040501
Evidence for the involvement of metabotropic glutamatergic, neurokinin 1 receptor pathways and protein kinase C in the antinociceptive effect of dipyrone in mice. Brain research 20040402
Controlled-release oxycodone is better tolerated than intravenous tramadol/metamizol for postoperative analgesia after retinal-surgery. Current eye research 20040401
Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Intensive care medicine 20040301
An electronic pressure-meter nociception paw test for rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040301
An electronic pressure-meter nociception paw test for mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20040301
[Severe anaphylactic reaction to metamizol during subarachnoid anesthesia]. Revista espanola de anestesiologia y reanimacion 20040301
[Two cases of anaphylactic shock after metamizol given during postoperative recovery]. Revista espanola de anestesiologia y reanimacion 20040301
[Selective quantitation of analgin by flow injection chemiluminescence method]. Guang pu xue yu guang pu fen xi = Guang pu 20040201
Does preoperative administration of metamizol (Novalgin) affect postoperative body weight and duration of recovery from ketamine-xylazine anaesthesia in mice undergoing embryo transfer: a preliminary report. Laboratory animals 20040101
Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report. Journal of orofacial pain 20040101
[Consensus of a group of Mexican experts: efficacy and safety of metamizol (Dipirone)]. Gaceta medica de Mexico 20040101
Dipyrone overdose. Journal of toxicology. Clinical toxicology 20040101
Use of a complex approach for assessment of metamizole sodium and acetylsalicylic acid toxicity, genotoxicity and cytotoxicity. Journal of applied toxicology : JAT 20040101
Influence of sertraline on the antinociceptive effect of morphine, metamizol and indomethacin in mice. Acta poloniae pharmaceutica 20040101
[Anaphylactic reaction versus carcinoid crisis: the role of octreotide as a vasoconstrictor]. Revista espanola de anestesiologia y reanimacion 20040101
[Is allergy to nonsteroidal antiinflamatory drugs common in surgical patients?]. Revista espanola de anestesiologia y reanimacion 20040101
The efficacy and safety of dipyrone (Novalgin) tablets in the treatment of acute migraine attacks: a double-blind, cross-over, randomized, placebo-controlled, multi-center study. Functional neurology 20040101
Synergistic interaction between gabapentin and metamizol in the rat formalin test. Proceedings of the Western Pharmacology Society 20040101
[Sensitivity to tonic pain and analgin in two lines of mice with knockout genotype]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20040101
The effect of gabapentin on antinociceptive action of analgesics. Acta poloniae pharmaceutica 20040101
Specific site involvement in fixed drug eruption. Journal of the American Academy of Dermatology 20031201
Nandrolone modulates the non-opioid and opioid analgesia and tolerance/dependence: role of sexual dimorphism. Archives of physiology and biochemistry 20031201
Linear regression analysis and its application to the multivariate spectral calibrations for the multiresolution of a ternary mixture of caffeine, paracetamol and metamizol in tablets. Journal of pharmaceutical and biomedical analysis 20031124
Inhibition of spinal reflexes by acetylsalicylate and metamizol (dipyrone) in rats. Pharmacology 20031101
[Multifocal brain haemorrhage associated with migraine and medication abuse]. Revista de neurologia 20031101
Associations between oxidative stress levels and total duration of engagement in jobs with exposure to fly ash among workers at municipal solid waste incinerators. Mutagenesis 20031101
Extrapleural regional versus systemic analgesia for relieving postthoracotomy pain: a clinical study of bupivacaine compared with metamizol. The Journal of thoracic and cardiovascular surgery 20031101
Evidence of the effect of dipyrone on the central nervous system as a determinant of delayed gastric emptying observed in rats after its administration. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031001
Flow injection amperometric determination of dipyrone in pharmaceutical formulations using a carbon paste electrode. Farmaco (Societa chimica italiana : 1989) 20031001
Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone? Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030901
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla. Planta medica 20030901
[Children often suffer unnecessary pain. A fever suppository after surgery is not enough!]. MMW Fortschritte der Medizin 20030821
Multi-pumping flow system for the spectrophotometric determination of dipyrone in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis 20030808
Acute renal failure and oligohydramnios induced by magnesium dypirone (metamizol) in a pregnant woman. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030801
Sustained modelling ability of artificial neural networks in the analysis of two pharmaceuticals (dextropropoxyphene and dipyrone) present in unequal concentrations. Analytical and bioanalytical chemistry 20030701
Metamizole-induced acute generalized exanthematous pustulosis. Contact dermatitis 20030701
Morphine and dipyrone co-administration delays tolerance development and potentiates antinociception. European journal of pharmacology 20030523
Determination of dipyrone in pharmaceutical products by flow injection analysis with potentiometric detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030501
Effects of acetylsalicylic acid and metamizol on hyaluronidase activity and sperm characteristics in rams. Animal reproduction science 20030415
'Death due to baclofen and dipyrone ingestion', by de Giovanni N, et all. Forensic science international 20030408
Use of CD63 expression as a marker of in vitro basophil activation and leukotriene determination in metamizol allergic patients. Allergy 20030401
[Anaphylactic cardiocirculatory failure after intraoperative application of dipyrone]. Der Anaesthesist 20030401
Dipyrone and agranulocytosis: what is the risk? Lancet (London, England) 20030315
Effect of adverse drug reactions on length of stay in surgical intensive care units. Critical care medicine 20030301
[Diversity and anti-oxidative effects of bilirubin]. Seikagaku. The Journal of Japanese Biochemical Society 20030301
[Early extubation with caudal morphine after pediatric heart surgery]. Revista espanola de anestesiologia y reanimacion 20030201
Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac. Biochemical pharmacology 20030115
Possible involvement of potassium channels in peripheral antinociception induced by metamizol: lack of participation of ATP-sensitive K+ channels. Pharmacology, biochemistry, and behavior 20030101
Antinociceptive effects of Cremophor EL orally administered to mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030101
[Postoperative analgesia with tramadol and metamizol. Continual infusion versus patient controlled analgesia]. Der Anaesthesist 20030101
Delayed skin reactions to metamizol. Allergy 20030101
[Combined premedication at adenectomy in children]. Anesteziologiia i reanimatologiia 20030101
Interaction between metamizol and tramadol in a model of acute visceral pain in rats. European journal of pain (London, England) 20030101
[Basophil activation test in the diagnosis of allergy to medicines]. Anales del sistema sanitario de Navarra 20030101
Influence of felbamate on the antinociceptive action of morphine, metamizol and indomethacin in mice. Acta poloniae pharmaceutica 20030101
[Ketorolac vs metamizol preemptive analgesia in children]. Cirugia y cirujanos 20030101
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test. Liver 20021201
Gastrointestinal tolerability of metamizol, acetaminophen, and diclofenac in subchronic treatment in rats. Digestive diseases and sciences 20021201
Pharmacology of systemic analgesics. Best practice & research. Clinical anaesthesiology 20021201
Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol. Journal of pain and symptom management 20021201
Metabolism of metamizol in early stages of the incubated hen's egg. Die Pharmazie 20021201
Dipyrone and agranulocytosis: what is the risk? Lancet (London, England) 20021109
Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice. Pharmacological research 20021101
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proceedings of the National Academy of Sciences of the United States of America 20021015
Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study. Headache 20021001
Intravenous dipyrone for the acute treatment of episodic tension-type headache: a randomized, placebo-controlled, double-blind study. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20021001
[Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients]. Revista espanola de anestesiologia y reanimacion 20021001
Pain research. Enzyme might relieve research headache. Science (New York, N.Y.) 20020920
Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice. European journal of pharmacology 20020913
[Headache and hemodialysis: evaluation of the possible triggering factors and of the treatment]. Arquivos de neuro-psiquiatria 20020901
Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020801
In vitro monitoring sub-nanogram amounts analgin in human urine by its inhibitory of the luminol-periodate chemiluminescence reaction using reagent immobilization release technique. Bioorganic & medicinal chemistry 20020701
Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). European journal of clinical pharmacology 20020701
Bioavailability of two metamizole (dipyrone) solutions as single doses of 2 g versus metamizole capsules. International journal of clinical pharmacology and therapeutics 20020701
Metamizole use by Latino immigrants: a common and potentially harmful home remedy. Pediatrics 20020601
Effects of dipyrone on inflammatory infiltration and oxidative metabolism in gastric mucosa: comparison with acetaminophen and diclofenac. Digestive diseases and sciences 20020601
[Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study]. Arquivos de neuro-psiquiatria 20020601
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. Pharmacological research 20020601
Reproducible identification of the causative drug of a fixed drug eruption by oral provocation and lesional patch testing. Contact dermatitis 20020601
Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone. European journal of pharmacology 20020524
Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors. European journal of pharmacology 20020503
Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia. American journal of physiology. Renal physiology 20020501
Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria. Allergy 20020501
[Postoperative pain therapy in urology. A prospective study]. Der Urologe. Ausg. A 20020501
Hematopoietic growth factors in drug-induced agranulocytosis. The Journal of the Association of Physicians of India 20020501
Metamizol potentiates morphine antinociception but not constipation after chronic treatment. European journal of pharmacology 20020426
To use or not to use dipyrone? Sao Paulo medical journal = Revista paulista de medicina 20020307
Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020101
A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020101
Pharmacokinetics of oleandomycin in dogs after intravenous or oral administration alone and after pretreatment with metamizole or dexamethasone. Veterinary research communications 20020101
Utilization pattern of metamizole in northern Sweden and risk estimates of agranulocytosis. Pharmacoepidemiology and drug safety 20020101
[Instrumental evaluation of sensory thresholds in subjects with different pain sensitivity]. Stomatologiia 20020101
Urticaria - as a problem. Allergologia et immunopathologia 20020101
Metamizole intolerance and bronchial asthma. Allergologia et immunopathologia 20020101
The incidence of metamizole sodium-induced agranulocytosis in Poland. The Journal of international medical research 20020101
Single dose dipyrone for acute renal colic pain. The Cochrane database of systematic reviews 20020101
[Cutaneous changes occurring after taking non-steroidal anti-inflammatory drugs--five-years' retrospective studies]. Przeglad lekarski 20020101
Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric techniques. Journal of pharmaceutical and biomedical analysis 20011201
Amperometric determination of dipyrone in pharmaceutical formulations with a flow cell containing gold electrodes from recordable compact discs. Journal of pharmaceutical sciences 20011201
Doctor, there's a fly in my soup! Angiotensin-converting enzyme inhibitors, endogenous opioids and visual hallucinations. The Israel Medical Association journal : IMAJ 20011201
Death due to baclofen and dipyrone ingestion. Forensic science international 20011115
Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20011101
Antiapoptotic effect of dipyrone on HL-60, Jurkat and Raji cell lines submitted to UV irradiation, arachidonic acid and cycloheximide treatments. International immunopharmacology 20011101
To use or not to use dipyrone? Or maybe, Central Station versus ER? That is the question. Sao Paulo medical journal = Revista paulista de medicina 20011101
[Postoperative pain therapy with hydromorphone and metamizole. A prospective randomized study in intravenous patient-controlled analgesia (PCA)]. Der Anaesthesist 20011001
Moderate alcohol consumption reduces urinary 8-hydroxydeoxyguanosine by inducing of uric acid. Industrial health 20011001
Use of Neo-melubrina, a banned antipyretic drug, in San Diego, California: a survey of patients and providers. The Western journal of medicine 20010901
Oral hygiene and postoperative pain after mandibular third molar surgery. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010901
Generalized reaction after patch testing with metamizol. Contact dermatitis 20010901
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators. European journal of clinical pharmacology 20010901
Tune compounds for electrospray ionisation/in-source collision-induced dissociation with mass spectral library searching. Journal of chromatography. A 20010810
Prohemorrhagic potential of dipyrone, ibuprofen, ketorolac, and aspirin: mechanisms associated with blood flow and erythrocyte deformability. Journal of cardiovascular pharmacology 20010801
Cromolyn sodium suppresses eosinophilic inflammation in patients with aspirin-intolerant asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010801
Effects of metamizol and magnesium sulfate on enzyme activity of glucose 6-phosphate dehydrogenase from human erythrocyte in vitro and rat erythrocyte in vivo. Clinical biochemistry 20010601
[44-year-old patient with thrombocytopenia, multiple organ failure and disseminated intravascular coagulation caused by drug poisoning with paracetamol, metamizole, benzodiazepines and alcohol in attempted suicide]. Der Internist 20010601
Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study. Cephalalgia : an international journal of headache 20010601
[Self medication among patients with musculoskeletal symptoms in Araucanía region]. Revista medica de Chile 20010601
Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: results of a multinational, randomized, modified double-blind study. Clinical pediatrics 20010601
Are we losing good drugs? Clinical pediatrics 20010601
Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids. Brain research 20010330
Effect of antipyretic drugs in children with malaria. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010301
Exanthema to metamizole. Allergy 20010301
The effect of dipyrone on survival of skin flaps. Scandinavian journal of plastic and reconstructive surgery and hand surgery 20010301
Intravenous metamizol (Dipyrone) in acute migraine treatment and in episodic tension-type headache--a placebo-controlled study. Cephalalgia : an international journal of headache 20010301
Response variability to analgesics: a role for non-specific activation of endogenous opioids. Pain 20010215
Postoperative analgesia at home after ambulatory hand surgery: a controlled comparison of tramadol, metamizol, and paracetamol. Anesthesia and analgesia 20010201
Antibiotic-induced NSAID intolerance. Allergy 20010101
Effect of diazepam and midazolam on the antinociceptive effect of morphine, metamizol and indomethacin in mice. Die Pharmazie 20010101
Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: a randomized, double-blind, multicenter study. Regional anesthesia and pain medicine 20010101
[Adequate analgesic sedation: an alternative to general anesthesia in ambulatory settings]. Anesteziologiia i reanimatologiia 20010101
Single-dose dipyrone for acute postoperative pain. The Cochrane database of systematic reviews 20010101
Diclofenac and metamizol in postoperative analgesia in plastic surgery. Acta chirurgiae plasticae 20010101
Cutaneous drug reaction case reports: from the world literature. American journal of clinical dermatology 20010101
Urticaria induced by meperidine allergy. Allergy 20000301
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats. Cancer letters 19990108
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. European journal of pharmacology 19980326
Use of dipyrone during pregnancy and risk of Wilms' tumor. Brazilian Wilms' Tumor Study Group. Epidemiology (Cambridge, Mass.) 19960901
Activation of the arginine-nitric oxide pathway in primary sensory neurons contributes to dipyrone-induced spinal and peripheral analgesia. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19960601
S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance. British journal of pharmacology 19950101
Octreotide dependency and headache: a case report. Cephalalgia : an international journal of headache 19940801
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