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67339-62-2 | 2-[2-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)ETHYL]-4,4-DIMETHYL-1,3-(2H,4H)-ISOQUINOLINDIONE DIHYDROCHLORIDE
CAS No: 67339-62-2 Catalog No: AG0062N0 MDL No:
Product Description
Catalog Number:
AG0062N0
Chemical Name:
2-[2-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)ETHYL]-4,4-DIMETHYL-1,3-(2H,4H)-ISOQUINOLINDIONE DIHYDROCHLORIDE
CAS Number:
67339-62-2
Molecular Formula:
C24H31Cl2N3O3
Molecular Weight:
480.4272
IUPAC Name:
2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-4,4-dimethylisoquinoline-1,3-dione
InChI:
InChI=1S/C24H29N3O3/c1-24(2)19-9-5-4-8-18(19)22(28)27(23(24)29)17-14-25-12-15-26(16-13-25)20-10-6-7-11-21(20)30-3/h4-11H,12-17H2,1-3H3
InChI Key:
JFNKXGOEOQCXDM-UHFFFAOYSA-N
SMILES:
COc1ccccc1N1CCN(CC1)CCN1C(=O)c2ccccc2C(C1=O)(C)C.Cl.Cl
UNII:
M7H349ZZ5T
Properties
Complexity:
629
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
407.221g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
407.514g/mol
Monoisotopic Mass:
407.221g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
53.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4
Literature
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| The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat. | European journal of pharmacology 20090801 |
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| Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat. | Neurochemistry international 20071001 |
| Multiplexing G protein-coupled receptors in microarrays: a radioligand-binding assay. | Analytical biochemistry 20070615 |
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| The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. | BMC pharmacology 20070101 |
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| Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain. | Neuroscience 20060811 |
| Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. | European journal of pharmacology 20041011 |
| Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype. | Behavioural brain research 20040831 |
| Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via alpha(1) and alpha(2A) adrenoceptors. | Neuropharmacology 20010901 |
| Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: characterization of alpha2-adrenoceptor. | Neurochemistry international 20010401 |
| Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein. | European journal of pharmacology 20010216 |
| [Interactions between alpha 1, alpha 2 and beta receptors in the blood pressure effects of adrenaline and noradrenaline in the dog]. | Journal de pharmacologie 19830101 |
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