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6724-53-4 | PerheXiline Maleate Salt
CAS No: 6724-53-4 Catalog No: AG003TNJ MDL No:MFCD00057329
Product Description
Catalog Number:
AG003TNJ
Chemical Name:
PerheXiline Maleate Salt
CAS Number:
6724-53-4
MDL Number:
MFCD00057329
IUPAC Name:
(Z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine
InChI:
InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key:
JDZOTSLZMQDFLG-BTJKTKAUSA-N
EC Number:
229-775-5
NSC Number:
758409
Properties
Complexity:
364
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
393.288g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
393.568g/mol
Monoisotopic Mass:
393.288g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
86.6A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Why are most phospholipidosis inducers also hERG blockers? | Archives of toxicology 20171201 |
| A case series of concomitant treatment of perhexiline with amiodarone. | Therapeutic drug monitoring 20120401 |
| Hypoglycaemia after treatment with perhexiline maleate: a case report. | The New Zealand medical journal 20110304 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101 |
| Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation. | Toxicology in vitro : an international journal published in association with BIBRA 20080901 |
| Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia. | Pharmacogenetics and genomics 20070501 |
| Metabolic therapeutics in angina pectoris: history revisited with perhexiline. | European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102. | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020301 |
| [Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis]. | Ryoikibetsu shokogun shirizu 20010101 |
| Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy. | Therapeutic drug monitoring 19961201 |
| Perhexiline maleate-induced hepatitis. | Hepato-gastroenterology 19910801 |
| Torsade de pointes associated with perhexiline maleate therapy. | Australian and New Zealand journal of medicine 19901201 |
| [Myopathy caused by perhexiline maleate]. | Neurologia (Barcelona, Spain) 19870101 |
| Severe ocular side effects of perhexilene maleate: case report. | The British journal of ophthalmology 19840801 |
| Perhexilene neuropathy: a report of two cases. | Australian and New Zealand journal of medicine 19831001 |
| Perhexiline maleate induced cirrhosis. | Pathology 19830401 |
| Cirrhosis of the liver following therapy with perhexiline maleate. | The New Zealand medical journal 19830323 |
| [Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]. | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19830106 |
| Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation. | American heart journal 19830101 |
| Papilledema without peripheral neuropathy in a patient taking perhexiline maleate. | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 19820801 |
| Perhexiline hepatitis and HLA-B8. | Lancet (London, England) 19820710 |
| Adverse effects of perhexiline. | Lancet (London, England) 19820227 |
| Impaired oxidation of debrisoquine in patients with perhexiline neuropathy. | British medical journal (Clinical research ed.) 19820130 |
| [Perhexiline maleate-induced cirrhosis]. | Acta gastro-enterologica Belgica 19820101 |
| Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes. | Clinical toxicology 19811201 |
| Liver disease induced by perhexiline maleate. | The Medical journal of Australia 19811114 |
| Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy. | Journal of the American Geriatrics Society 19810601 |
| [Perhexiline maleate induced cirrhosis (author's transl)]. | Acta gastro-enterologica Belgica 19810101 |
| [Polyneuritis after use of perhexiline maleate: quantimetric and ultrastructural study (author's transl)]. | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19801101 |
| Toxic polyneuritis and toxic hepatitis related to long-term perhexiline maleate therapy. | American heart journal 19800801 |
| Peripheral neuropathy due to perhexilene maleate. | Journal of the neurological sciences 19800601 |
| Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid). | British heart journal 19800401 |
| [Complications after perhexiline maleate and amiodarone chlorhydrate treatment in a same patient: hypoglycemia, polyneuritis and hyperthyroidism (author's transl)]. | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19800201 |
| Perhexiline maleate-associated hepatic injury prevalence and characteristics. | Digestion 19800101 |
| [Neuropathies due to perhexiline maleate and their electromyographic diagnosis]. | Journal belge de medecine physique et de rehabilitation. = Belgisch tijdschrift voor fysische geneeskunde en rehabilitatie 19800101 |
| Prevalence of perhexiline maleate neurotoxicosis. | The Medical journal of Australia 19791020 |
| Perhexiline maleate in the treatment of severe angina pectoris. | The Medical journal of Australia 19790602 |
| Perhexiline maleate and peripheral neuropathy. | Neurology 19790501 |
| Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy. | Journal of the neurological sciences 19790401 |
| [Acute hepatic failure due to perhexiline maleate]. | La Nouvelle presse medicale 19790210 |
| Perhexiline maleate-induced cirrhosis. | Gastroenterology 19790101 |
| Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy. | European journal of clinical pharmacology 19781127 |
| Polyneuropathy with normal metabolism of perhexiline maleate. | Annals of neurology 19781001 |
| [Cirrhogenic hepatitis due to perhexiline maleate: general review based upon one new case with ultrastructural study (author's transl)]. | Annales de medecine interne 19781001 |
| Prevalence of latent perhexiline neuropathy. | British medical journal 19780520 |
| Perhexilene mimicking bronchial carcinoma. | Lancet (London, England) 19780415 |
| Perhexilline-induced neuropathy. | British medical journal 19780401 |
| [Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)]. | La Nouvelle presse medicale 19780311 |
| Perhexiline neuropathy: a clinicopathological study. | Annals of neurology 19780301 |
| [Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)]. | Revue neurologique 19780201 |
| Raised intracranial pressure due to perhexiline maleate. | British medical journal 19780107 |
| Perhexiline maleate-induced hepatitis. | Digestion 19780101 |
| [Post-arteriographic thrombosis of the ophthalmic veins in 2 cases of peripheral neuropathy with central neurological signs due to perhexiline maleate]. | La Nouvelle presse medicale 19771112 |
| [Peripheral neuropathies due to perhexiline maleate (author's transl)]. | Annales de cardiologie et d'angeiologie 19771101 |
| [Hepatitis due to perhexiline maleate. Development of cirrhosis after interruption of the drug. Report of two cases (author's transl)]. | Gastroenterologie clinique et biologique 19771001 |
| Peripheral and autonomic neuropathy after treatment with perhexiline maleate. | British medical journal 19770910 |
| Peripheral-nerve lipid abnormalities in patients on perhexiline maleate. | Lancet (London, England) 19770611 |
| Proximal myopathy after perhexiline maleate treatment. | British medical journal 19770521 |
| [Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)]. | Acta neuropathologica 19770429 |
| Liver ganglioside storage after perhexiline maleate. | Lancet (London, England) 19770226 |
| [A case of polyneuropathy caused by perhexiline maleate]. | Revue d'oto-neuro-ophtalmologie 19770101 |
| [Slow and incomplete regression of peripheral neuropathy due to perhexiline maleate]. | Annales de cardiologie et d'angeiologie 19770101 |
| [Oedematous optic neuropathy from Perhexilline maleate associated with peripheral polyneuropathy (author's transl)]. | Archives d'ophtalmologie 19770101 |
| [Ocular complications of PEXID]. | Bulletin des societes d'ophtalmologie de France 19770101 |
| [A case of polyradiculoneuritis following prolonged treatment with perhexiline maleate]. | La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19761109 |
| Polyneuropathy after perhexiline maleate therapy. | British medical journal 19760522 |
| [Peripheral neuropathies caused by perhexiline maleate. Apropos of 7 cases]. | Coeur et medecine interne 19760101 |
| [Letter: Equilibrium disorders induced by perhexiline maleate]. | La Nouvelle presse medicale 19741026 |
| Perhexiline maleate, a new anti-anginal drug, evaluated by 'modified double blind double cross over study'. | Angiology 19740601 |
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