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6681-15-8 | Jatrorrhizine chloride
CAS No: 6681-15-8 Catalog No: AG006R07 MDL No:MFCD00238625
Product Description
Catalog Number:
AG006R07
Chemical Name:
Jatrorrhizine chloride
CAS Number:
6681-15-8
Molecular Formula:
C20H20ClNO4
Molecular Weight:
373.8301
MDL Number:
MFCD00238625
IUPAC Name:
2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol;chloride
InChI:
InChI=1S/C20H19NO4.ClH/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3;/h4-5,8-11H,6-7H2,1-3H3;1H
InChI Key:
JKMUUZMCSNHBAX-UHFFFAOYSA-N
SMILES:
COc1cc2c(cc1O)CC[n+]1c2cc2ccc(c(c2c1)OC)OC.[Cl-]
Properties
Complexity:
461
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
373.108g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
373.833g/mol
Monoisotopic Mass:
373.108g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
51.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy. | Analytica chimica acta 20121017 |
| Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase. | Phytotherapy research : PTR 20120901 |
| Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection. | Analytica chimica acta 20120806 |
| Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids. | Archives of pharmacal research 20120601 |
| Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate. | Biopharmaceutics & drug disposition 20120401 |
| Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. | The Journal of pharmacy and pharmacology 20120301 |
| Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method. | Journal of pharmaceutical and biomedical analysis 20120223 |
| Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography-electrospray ionization-mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20111215 |
| Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. | Medicinal research reviews 20111101 |
| Micelle to solvent stacking of two alkaloids in nonaqueous capillary electrophoresis. | Journal of chromatography. A 20110826 |
| The effects of jatrorrhizine on contractile responses of rat ileum. | European journal of pharmacology 20110801 |
| Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids. | Talanta 20110715 |
| Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells. | Neuroscience letters 20110712 |
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. | European journal of medicinal chemistry 20110401 |
| Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. | Xenobiotica; the fate of foreign compounds in biological systems 20110401 |
| Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. | Journal of translational medicine 20110101 |
| Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. | Journal of pharmaceutical and biomedical analysis 20101102 |
| [Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801 |
| Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells. | Journal of ethnopharmacology 20100504 |
| [Simultaneous determination of the five alkaloids in Rhizoma Coptidis by nonaqueous capillary electrophoresis]. | Se pu = Chinese journal of chromatography 20100401 |
| [In situ intestinal absorption kinetics of berberine and jatrorrhizine from extractive Rhizoma Coptidis in rats]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301 |
| The application of digital image recognition to the analysis of two-dimensional fingerprints. | Analytica chimica acta 20100111 |
| [Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101 |
| [Effects of extracts and active components of Rhizoma Coptidis on contraction of circular smooth muscle isolated from guinea pig gastric antrum]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901 |
| [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501 |
| [Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201 |
| Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives. | Journal of Asian natural products research 20090101 |
| Development of a rapid resolution liquid chromatographic method for simultaneous analysis of four alkaloids in Rhizoma coptidis under different cultivation conditions. | Journal of AOAC International 20090101 |
| Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection. | Phytochemical analysis : PCA 20090101 |
| Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells. | Immunopharmacology and immunotoxicology 20090101 |
| LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine. | Biomedical chromatography : BMC 20081201 |
| [Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient]. | Ying yong sheng tai xue bao = The journal of applied ecology 20080701 |
| Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. | Journal of mass spectrometry : JMS 20080301 |
| Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301 |
| [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080301 |
| Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives. | Planta medica 20080201 |
| High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs. | Journal of separation science 20070401 |
| Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
| [Quality analysis and evaluation of Rhizoma Coptidis under different cultivation conditions]. | Yao xue xue bao = Acta pharmaceutica Sinica 20061001 |
| [Determination of 3 kinds of components in huanglian jiedu decoction by HPLC under different UV wavelengths]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001 |
| [Liquid chromatography-tandem electrospray ionization ion trap mass spectrometric assay for the metabolites of jatrorrhizine in rat urine]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060901 |
| Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA. | Bioorganic & medicinal chemistry 20060701 |
| Nonaqueous capillary electrophoresis coupled with laser-induced native fluorescence detection for the analysis of berberine, palmatine, and jatrorrhizine in Chinese herbal medicines. | Journal of separation science 20060601 |
| [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060401 |
| Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum. | Electrophoresis 20050901 |
| [Chemical constituents from Corydalis humosa]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701 |
| [Quality assessment of Coptis chinensis in China]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401 |
| Binding of the bioactive component jatrorrhizine to human serum albumin. | Biochimica et biophysica acta 20050211 |
| Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis. | Journal of separation science 20050101 |
| Hypoglycemic activity of jatrorrhizine. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101 |
| [Establishment of the control substance of plant drug and fingerprints of Coptis chinensis]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201 |
| Structural elucidation and identification of alkaloids in Rhizoma Coptidis by electrospray ionization tandem mass spectrometry. | Journal of mass spectrometry : JMS 20041101 |
| Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium. | Phytotherapy research : PTR 20040801 |
| Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. | Phytotherapy research : PTR 20040801 |
| [Distribution of four alkaloids in plants of Berberis]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201 |
| [Determination of four alkaloids in Berberis plants by HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201 |
| High-performance capillary electrophoresis for determining the contents of berberine, jatrorrhizine and palmatine in Gegenqinlian decoction. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030701 |
| [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701 |
| Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. | Planta medica 20020301 |
| Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration. | Acta pharmacologica Sinica 20020101 |
| Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. | BMC complementary and alternative medicine 20020101 |
| [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901 |
| Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | Journal of natural products 19910101 |
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