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665-66-7

665-66-7 | Amantadine hydrochloride

CAS No: 665-66-7 Catalog No: AG003NTJ MDL No:MFCD00074723

Product Description

Catalog Number:
AG003NTJ
Chemical Name:
Amantadine hydrochloride
CAS Number:
665-66-7
Molecular Formula:
C10H18ClN
Molecular Weight:
187.7096
MDL Number:
MFCD00074723
IUPAC Name:
adamantan-1-amine;hydrochloride
InChI:
InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
InChI Key:
WOLHOYHSEKDWQH-UHFFFAOYSA-N
SMILES:
NC12CC3CC(C2)CC(C1)C3.Cl
EC Number:
211-560-2
UNII:
M6Q1EO9TD0

Properties

Complexity:
144  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
187.113g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
187.711g/mol
Monoisotopic Mass:
187.113g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
26A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Randomized, placebo-controlled trial of ADS-5102 (amantadine) extended-release capsules for levodopa-induced dyskinesia in Parkinson's disease (EASE LID 3). Movement disorders : official journal of the Movement Disorder Society 20171201
Potentiation of azole antifungals by 2-adamantanamine. Antimicrobial agents and chemotherapy 20130801
Determination of amantadine and rimantadine using a sensitive fluorescent probe. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121201
Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson's disease: role of NMDA vs. 5-HT1A receptors. The European journal of neuroscience 20121101
Comparison of the effect of aspirin and amantadine for the treatment of fatigue in multiple sclerosis: a randomized, blinded, crossover study. Neurological research 20121101
Neuro-ophthalmology of subacute sclerosing panencephalitis: two cases and a review of the literature. Current opinion in ophthalmology 20121101
Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats. European journal of pharmacology 20121015
Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents. Antiviral research 20121001
Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology 20120807
N-Methyl-D-Aspartate antagonists in levodopa induced dyskinesia: a meta-analysis. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20120701
Amantadine for severe traumatic brain injury. The New England journal of medicine 20120621
Amantadine for severe traumatic brain injury. The New England journal of medicine 20120621
Treatment of Parkinson disease: a 64-year-old man with motor complications of advanced Parkinson disease. JAMA 20120606
Photochemical synthesis of N-adamantylhomoallylamines through addition of cyclic olefins to imines catalyzed by alumina grafted cadmium sulfide. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120601
Midbrain tremor: a tremor resistant to treatment. Acta neurologica Belgica 20120601
Carnitine for fatigue in multiple sclerosis. The Cochrane database of systematic reviews 20120516
Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies. Annals of internal medicine 20120403
The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine. Molecular pharmaceutics 20120402
Effect of amantadine on oxymorphone-induced thermal antinociception in cats. Journal of veterinary pharmacology and therapeutics 20120401
Molecular imaging of cell death in an experimental model of Parkinson's disease with a novel apoptosis-targeting peptide. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20120401
Amantadine for the treatment of refractory absence seizures in children. Pediatric neurology 20120401
Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein. Journal of medicinal chemistry 20120308
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis. Leukemia 20120301
The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine. Neuropharmacology 20120301
Beneficial effect of amantadine on postoperative pain reduction and consumption of morphine in patients subjected to elective spine surgery. Pain medicine (Malden, Mass.) 20120301
Placebo-controlled trial of amantadine for severe traumatic brain injury. The New England journal of medicine 20120301
The 'blue' side of glutamatergic neurotransmission: NMDA receptor antagonists as possible novel therapeutics for major depression. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20120301
Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study. The Journal of clinical psychiatry 20120201
Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats. Neuropharmacology 20120201
Amantadine and rimantadine for influenza A in children and the elderly. The Cochrane database of systematic reviews 20120118
Recognition-mediated light-up of thiazole orange with cucurbit[8]uril: exchange and release by chemical stimuli. The journal of physical chemistry. B 20120112
Phosphonium-containing polyelectrolytes for nonviral gene delivery. Biomacromolecules 20120109
Antiviral drugs for influenza. The Medical letter on drugs and therapeutics 20120109
Likely amantadine-induced livedo reticularis in a child. Pediatric dermatology 20120101
[Prevention of postoperative hyperalgesia]. Annales francaises d'anesthesie et de reanimation 20120101
Updates in the medical management of Parkinson disease. Cleveland Clinic journal of medicine 20120101
Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses. PloS one 20120101
[A genetic analysis of A H1N1 pandemic influenza virus in the course of the epidemic]. Terapevticheskii arkhiv 20120101
Bilateral corneal edema secondary to amantadine in the pediatric population: a case report. Boletin de la Asociacion Medica de Puerto Rico 20120101
[Mexidant increases the effectiveness of levadopa treatment of Parkinson's disease]. Eksperimental'naia i klinicheskaia farmakologiia 20120101
Description of antiviral treatment among adults hospitalized with influenza before and during the 2009 pandemic: United States, 2005-2009. The Journal of infectious diseases 20111215
Discovery of potential M2 channel inhibitors based on the amantadine scaffold via virtual screening and pharmacophore modeling. Molecules (Basel, Switzerland) 20111208
Dopamine agonists for the treatment of cocaine dependence. The Cochrane database of systematic reviews 20111207
Spectroscopic analyses on interaction of Amantadine-Salicylaldehyde, Amantadine-5-Chloro-Salicylaldehyde and Amantadine-o-Vanillin Schiff-Bases with bovine serum albumin (BSA). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201
Westphal variant Huntington disease and refractory catatonia: a case report. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 20111201
Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008. Revista panamericana de salud publica = Pan American journal of public health 20111201
Drug carriers based on cyclodextrin inclusion complexes for the controlled release of hydrophobic drugs. Journal of controlled release : official journal of the Controlled Release Society 20111130
Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20111101
Nasogastric medication for perioperative Parkinson's rigidity during anaesthesia emergence. Anaesthesia and intensive care 20111101
Analysis of amantadine in biological fluids using hollow fiber-based liquid-liquid-liquid microextraction followed by corona discharge ion mobility spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111015
An improved model to investigate the efficacy of antidyskinetic agents in hemiparkinsonian rats. Fundamental & clinical pharmacology 20111001
Clinical features of nine patients with alternating hemiplegia of childhood. Journal of paediatrics and child health 20111001
Synthesis, evaluation and application of polycyclic fluorescent analogues as N-methyl-D-aspartate receptor and voltage gated calcium channel ligands. European journal of medicinal chemistry 20111001
Antiviral drugs for viruses other than human immunodeficiency virus. Mayo Clinic proceedings 20111001
Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology 20110901
Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels. Journal of neurochemistry 20110901
Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. Journal of the American Chemical Society 20110803
Comparison of the efficacies of amantadine treatment of swine-origin influenza virus A H1N1 and seasonal influenza H1N1 and H3N2 in Japan (2008-2009). Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110801
Pharmacologic treatments for fatigue associated with palliative care. Clinical journal of oncology nursing 20110801
Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel. Hepatology (Baltimore, Md.) 20110701
How do aminoadamantanes block the influenza M2 channel, and how does resistance develop? Journal of the American Chemical Society 20110629
The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury. Experimental neurology 20110601
Drug therapies for tardive dyskinesia: Part 1. Journal of psychosocial nursing and mental health services 20110601
Milestones in Parkinson's disease therapeutics. Movement disorders : official journal of the Movement Disorder Society 20110501
Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. Journal of medicinal chemistry 20110428
Management of punding in Parkinson's disease: an open-label prospective study. Journal of neurology 20110401
Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus. Biochimica et biophysica acta 20110201
Resistance characteristics of influenza to amino-adamantyls. Biochimica et biophysica acta 20110201
Emergence of amantadine-resistant avian influenza H5N1 virus in India. Virus genes 20110201
Functional reconstitution of influenza A M2(22-62). Biochimica et biophysica acta 20110201
Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino-β-cyclodextrin)-7-nitrobenzofuran (NBD-β-CyD). International journal of pharmaceutics 20110117
Quantitative analysis of influenza M2 channel blockers. Biochimica et biophysica acta 20110101
Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review. The Journal of infection 20110101
Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs. Neuropharmacology 20110101
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. Carcinogenesis 20110101
Medical therapies for concussion. Clinics in sports medicine 20110101
Dropped head associated with amantadine in Parkinson disease. Clinical neuropharmacology 20110101
Pharmacological and electrical stimulation in chronic disorders of consciousness: new insights and future directions. Brain injury 20110101
Sudden onset of amantadine-induced reversible bilateral corneal edema in an elderly patient: case report and literature review. Japanese journal of ophthalmology 20110101
[The 2009 pandemic influenza in Russia. I. Diagnosis and molecular biological characteristics of the virus]. Voprosy virusologii 20110101
[A comparative study of hemantane and amantadine effects on dopamine transporter expression in brain of normal and MPTP-treated C57BL/6 mice]. Eksperimental'naia i klinicheskaia farmakologiia 20110101
[New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine]. Voprosy virusologii 20110101
Phylogenetic analysis of an off-seasonal influenza virus A (H3N2) in Niigata, Japan, 2010. Japanese journal of infectious diseases 20110101
[Comparative study of amantadine and hemantane effects on development of levodopa-induced dyskinesia in rat model of parkinsonian syndrome]. Eksperimental'naia i klinicheskaia farmakologiia 20110101
Molecular mechanisms of l-DOPA-induced dyskinesia. International review of neurobiology 20110101
Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A virus. PloS one 20110101
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study. Annals of neurology 20101201
Pharmacological treatments for fatigue associated with palliative care. The Cochrane database of systematic reviews 20101110
DNA damage in brain cells and behavioral deficits in mice after treatment with high doses of amantadine. Journal of applied toxicology : JAT 20101101
Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran. Antiviral research 20101101
Inhibition of influenza virus replication by plant-derived isoquercetin. Antiviral research 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Amantadine versus methylphenidate in children and adolescents with attention deficit/hyperactivity disorder: a randomized, double-blind trial. Human psychopharmacology 20101101
Differential pharmacological responses of catatonia-like signs in frontotemporal dementia. Neurocase 20101001
Isolated delusional syndrome in Parkinson's Disease. Parkinsonism & related disorders 20100901
Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants. Chemosphere 20100901
Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PLoS pathogens 20100901
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[Naturally occurring oseltamivir resistance in influenza A]. Ugeskrift for laeger 20100809
Transient amantadine-induced musical hallucinations in a patient with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20100730
Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system. Journal of cellular physiology 20100701
Amantadine-associated corneal edema. Parkinsonism & related disorders 20100701
Pathway to lamellar bodies for surfactant protein A. American journal of physiology. Lung cellular and molecular physiology 20100701
Antiviral drug susceptibilities of seasonal human influenza viruses in Lebanon, 2008-09 season. Journal of medical virology 20100701
Progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) with fatal outcome, after the manifestation of an ampullary adenocarcinoma. Pancreas 20100701
NMR studies of p7 protein from hepatitis C virus. European biophysics journal : EBJ 20100601
Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application. Electrophoresis 20100601
The susceptibility of magpies to a highly pathogenic avian influenza virus subtype H5N1. Poultry science 20100601
Use of the glutamate NMDA receptor antagonist PK-Merz in acute stroke. Neuroscience and behavioral physiology 20100601
Oseltamivir-resistant influenza viruses A (H1N1) during 2007-2009 influenza seasons, Japan. Emerging infectious diseases 20100601
Improvement of mutism in a catatonic schizophrenia case by add-on treatment with amantadine. Pharmacopsychiatry 20100601
Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor. Organic & biomolecular chemistry 20100521
Antiviral drug profile of seasonal influenza viruses circulating in Portugal from 2004/2005 to 2008/2009 winter seasons. Antiviral research 20100501
Maternal and neonatal outcomes after antepartum treatment of influenza with antiviral medications. Obstetrics and gynecology 20100401
LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds. Anticancer research 20100401
Excessive daytime somnolence in spinocerebellar ataxia type 1. Journal of the neurological sciences 20100315
Effects of amantadine on circulating neurotransmitters in healthy subjects. Journal of neural transmission (Vienna, Austria : 1996) 20100301
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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature 20100204
Amantadine augmentation for refractory obsessive-compulsive disorder: a case report. Journal of clinical psychopharmacology 20100201
Oseltamivir- and amantadine-resistant influenza virus A (H1N1). Emerging infectious diseases 20100101
Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique. PM & R : the journal of injury, function, and rehabilitation 20100101
Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PloS one 20100101
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A case of schizophrenia with dysphagia successfully treated by a multidimensional approach. General hospital psychiatry 20100101
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A retrospective study of 34 catatonic patients: analysis of clinical care and treatment. General hospital psychiatry 20100101
Effects of amantadine on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. Clinical neuropharmacology 20100101
Amantadine for dyskinesias in Parkinson's disease: a randomized controlled trial. PloS one 20100101
Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry 20091222
Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand. Biochemical and biophysical research communications 20091218
Room tilt illusion in Parkinson's disease: loss of spatial reference frames? Journal of the neurological sciences 20091215
Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs. Metabolic brain disease 20091201
Antiviral treatment and prophylaxis of influenza virus in children. Pediatric annals 20091201
Bilateral reversible corneal edema associated with amantadine use. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091201
Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel. Biophysical journal 20091115
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Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. American journal of physiology. Cell physiology 20091001
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Impact of early pharmacological treatment on cognitive and behavioral outcome after traumatic brain injury in adults: a meta-analysis. Journal of clinical psychopharmacology 20091001
Potentiometric determination of trace amounts of amantadine using a modified carbon-paste electrode. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20091001
Protein kinase inhibition differentially regulates organic cation transport. Canadian journal of physiology and pharmacology 20091001
[The use of antiparkinsonism drugs in 92 cases in Xi'an city]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20091001
Novel use of amantadine: to treat hiccups. Journal of pain and symptom management 20090901
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Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. Journal of the American Chemical Society 20090617
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Effect of amantadine on the sleep-wake cycle of an inpatient with brain injury. Brain injury 20090601
Amantadine-associated corneal edema. Ophthalmology 20090601
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Altered mental status in a transplant patient. Amantadine toxicity. Kidney international 20090101
Applying the Milwaukee protocol to treat canine rabies in Equatorial Guinea. Scandinavian journal of infectious diseases 20090101
Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis. BMC psychiatry 20090101
Rapid simultaneous determination of paracetamol, amantadine hydrochloride, caffeine and chlorpheniramine maleate in human plasma by liquid chromatography/tandem mass spectrometry. Arzneimittel-Forschung 20090101
Syndrome of inappropriate antidiuretic hormone secretion possibly associated with amantadine therapy in Parkinson disease. Clinical neuropharmacology 20090101
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[Amantadine sulfate (PK-Merz) in the treatment of ischemic stroke: a clinical-experimental study]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101
Effect of repeated co-treatment with fluoxetine and amantadine on the behavioral reactivity of the central dopamine and serotonin system in rats. Pharmacological reports : PR 20090101
Clinical and basal aspects of anemia during antiviral therapy for hepatitis C. Annals of hepatology 20090101
Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PloS one 20090101
Does amantadine have favourable effects on fatigue in Persian patients suffering from multiple sclerosis? Neurologia i neurochirurgia polska 20090101
Effect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test. Pharmacological reports : PR 20090101
Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test. Pharmacological reports : PR 20090101
Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood. Pharmacological reports : PR 20090101
Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology (Baltimore, Md.) 20081201
Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo. Journal of hepatology 20081201
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Hiccups and dopamine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081115
Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection. Hepatology (Baltimore, Md.) 20081101
Amantadine for migraine. Headache 20081001
How amantadine and rimantadine inhibit proton transport in the M2 protein channel. Journal of molecular graphics & modelling 20081001
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Antivirals and influenza: frequency of resistance. The Pediatric infectious disease journal 20081001
Design and synthesis of bioactive 1,2-annulated adamantane derivatives. Organic & biomolecular chemistry 20080907
Amantadine-associated corneal edema potentially irreversible even after cessation of the medication. Ophthalmology 20080901
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin. The Journal of general virology 20080901
Cardiotoxicity after massive amantadine overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20080901
Potentiation of morphine-induced conditioned place preference with concurrent use of amantadine and fluvoxamine by the intraperitoneal and intracerebroventricular injection in rat. Behavioural brain research 20080719
Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. The Journal of biological chemistry 20080606
Antiviral drugs for the control of pandemic influenza virus. Annals of the Academy of Medicine, Singapore 20080601
Fatal intoxication using amantadine and pramipexole in a uremic patient. Acta neurologica Taiwanica 20080601
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder. European journal of pharmacology 20080531
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[Influenza]. La Revue du praticien 20080227
Stimulation of suicidal erythrocyte death by amantadine. European journal of pharmacology 20080226
Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers. Biophysical journal 20080215
Measuring the effect of amantadine in chronic anoxic minimally conscious state. Journal of neurology, neurosurgery, and psychiatry 20080201
Amantadine enhancement of arousal and cognition after traumatic brain injury. The Annals of pharmacotherapy 20080201
Structural basis for the function and inhibition of an influenza virus proton channel. Nature 20080131
[The use of Stalevo in Hungary for patients with Parkinson disease and its effect on the quality of life]. Ideggyogyaszati szemle 20080130
Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons. Neuroscience 20080124
Amantadine and rimantadine for influenza A in children and the elderly. The Cochrane database of systematic reviews 20080123
Amantadine may reverse punding in Parkinson's disease--observation in a patient. Movement disorders : official journal of the Movement Disorder Society 20080101
Amantadine-induced serotonin syndrome in a patient with renal failure. The American journal of emergency medicine 20080101
Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine. Journal of inorganic biochemistry 20080101
Amantadine in a multimodal analgesic regimen for alleviation of refractory osteoarthritis pain in dogs. Journal of veterinary internal medicine 20080101
Pharmacological treatment of neurobehavioural sequelae of traumatic brain injury. European journal of anaesthesiology. Supplement 20080101
Do pediatricians manage influenza differently than internists? BMC pediatrics 20080101
A case of temporary finger tremors due to amantadine withdrawal. The Journal of neuropsychiatry and clinical neurosciences 20080101
[Use of amantadine sulfate (PK-MERZ) during emergence from coma: results of a multicenter study]. Anesteziologiia i reanimatologiia 20080101
Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial. The American journal on addictions 20080101
The history and treatment of a bipolar patient diagnosed with Borna disease virus infection. Case report. APMIS. Supplementum 20080101
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Open-label amantadine in children with attention-deficit/hyperactivity disorder. Journal of child and adolescent psychopharmacology 20071001
A change in the effectiveness of amantadine for the treatment of influenza over the 2003-2004, 2004-2005, and 2005-2006 influenza seasons in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20071001
New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Journal of pharmaceutical and biomedical analysis 20070903
Neuraminidase inhibitor susceptibility of porcine H3N2 influenza A viruses isolated in Germany between 1982 and 1999. Antiviral research 20070901
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Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein. Protein science : a publication of the Protein Society 20070901
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Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis. Bulletin of experimental biology and medicine 20070801
19F NMR detection of the complex between amantadine and the receptor portion of the influenza A M2 ion channel in DPC micelles. Bioorganic & medicinal chemistry letters 20070715
Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. The Journal of infectious diseases 20070715
The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain. Biophysical journal 20070701
Amantadine treatment of hemispatial neglect: a double-blind, placebo-controlled study. American journal of physical medicine & rehabilitation 20070701
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Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS). Multiple sclerosis (Houndmills, Basingstoke, England) 20070601
Low dose oral combination chemoprophylaxis with oseltamivir and amantadine for influenza A virus infections in mice. Journal of chemotherapy (Florence, Italy) 20070601
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Levodopa 'drug holiday' with amantadine infusions as a treatment of complications in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20070515
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Combination therapy with ribavirin and amantadine in renal transplant patients with chronic hepatitis C virus infection is not superior to ribavirin alone. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070501
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Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study. Journal of pharmaceutical and biomedical analysis 20070312
Effect of early administration of the N-methyl-d-aspartate receptor antagonist amantadine on the development of postmastectomy pain syndrome: a prospective pilot study. The journal of pain : official journal of the American Pain Society 20070301
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A systematic review of the treatment studies in Huntington's disease since 1990. Expert opinion on pharmacotherapy 20070201
Treatment of hyperactivity in children with pervasive developmental disorders. Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc 20070201
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Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro. The Journal of biological chemistry 20061201
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A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. Drug and alcohol dependence 20061108
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Excellent response to apomorphine in Parkinsonism with optic atrophy unresponsive to oral antiparkinsonian medication. Movement disorders : official journal of the Movement Disorder Society 20060901
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An off-seasonal amantadine-resistant H3N2 influenza outbreak in Japan. The Tohoku journal of experimental medicine 20060901
EFNS guideline on diagnosis and management of post-polio syndrome. Report of an EFNS task force. European journal of neurology 20060801
NH4+ modulates renal tubule amantadine transport independently of intracellular pH changes. European journal of pharmacology 20060710
Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells. Gynecologic oncology 20060701
Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants. Antiviral research 20060701
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Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. The Journal of infectious diseases 20060615
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Effect of amantadine and imipramine on immunological parameters of rats subjected to a forced swimming test. The international journal of neuropsychopharmacology 20060601
Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors. Medical microbiology and immunology 20060601
The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601
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Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent. Biomedical chromatography : BMC 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Archives of pharmacal research 20060501
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Amantadine sulfate reduces experimental sensitization and pain in chronic back pain patients. Anesthesia and analgesia 20060301
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Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. Neuroscience letters 20060220
Comparative anti-tumor efficacy of two orally administered platinum(IV) drugs in nude mice bearing human tumor xenografts. Anti-cancer drugs 20060201
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Efficacy and safety of high-dose cabergoline in Parkinson's disease. Acta neurologica Scandinavica 20060101
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Combating influenza with antiviral therapy in the pediatric population. Pharmacotherapy 20060101
Biochemical and clinical improvement of cytotoxic state by amantadine sulphate. Cellular and molecular neurobiology 20060101
Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury. NeuroRehabilitation 20060101
Amantadine and memantine in catatonic schizophrenia. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20060101
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[Two cases of tardive Tourette syndrome]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20060101
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[Antiviral etiotropic chemicals: efficacy against influenza A viruses A subtype H5N1]. Voprosy virusologii 20060101
Determination of amantadine sulfate in sodium chloride injection by capillary gas chromatography. PDA journal of pharmaceutical science and technology 20060101
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Pathways for clearance of surfactant protein A from the lung. American journal of physiology. Lung cellular and molecular physiology 20051201
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Antiviral drugs for prophylaxis and treatment of influenza. The Medical letter on drugs and therapeutics 20051121
Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies. Biomedical chromatography : BMC 20051101
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A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients. International clinical psychopharmacology 20051101
The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values. Psychopharmacology 20051001
The spectrum of differential diagnosis in neurological patients with livedo reticularis and livedo racemosa. A literature review. Journal of neurology 20051001
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Determination of serum amantadine by liquid chromatography-tandem mass spectrometry. Clinica chimica acta; international journal of clinical chemistry 20050901
High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias. Parkinsonism & related disorders 20050901
Preventive strategies for aspiration pneumonia in elderly disabled persons. The Tohoku journal of experimental medicine 20050901
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity. Anesthesia and analgesia 20050901
Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapine. The American journal of psychiatry 20050901
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Treatment of progressive supranuclear palsy and corticobasal degeneration. Movement disorders : official journal of the Movement Disorder Society 20050801
Rimantadine in Parkinson's disease patients experiencing peripheral adverse effects from amantadine: report of a case series. Movement disorders : official journal of the Movement Disorder Society 20050701
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. British journal of pharmacology 20050701
Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia. Experimental neurology 20050701
Preclinical anti-tumor activity of a new oral platinum(IV) drug LA-12. Anti-cancer drugs 20050701
Ocular complications of neurological therapy. European journal of neurology 20050701
Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: a study using positron emission tomography (PET). Brain injury 20050701
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Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus. The Journal of biological chemistry 20050603
Amantadine inhibits hepatitis A virus internal ribosomal entry site-mediated translation in human hepatoma cells. Biochemical and biophysical research communications 20050603
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Amantadine monotherapy is ineffective in the treatment of hepatitis C virus recurrence in the post-liver transplantation setting. Transplantation proceedings 20050501
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Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug metabolism and disposition: the biological fate of chemicals 20050401
Improved neurological function after Amantadine treatment in two patients with brain injury. The Journal of emergency medicine 20050401
Peginterferon alpha-2a combination therapies in chronic hepatitis C patients who relapsed after or had a viral breakthrough on therapy with standard interferon alpha-2b plus ribavirin: a pilot study of efficacy and safety. Digestive diseases and sciences 20050401
The potential anti-hBV effect of amantadine in combination with ursodeoxycholic acid and biphenyl dimethyl dicarboxylate in hepG2 2.2.15 cells. Archives of pharmacal research 20050401
Simultaneous determination of the binding of amantadine and its analogues to synthetic melanin by liquid chromatography after precolumn derivatization with dansyl chloride. Journal of chromatographic science 20050401
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function. Journal of molecular biology 20050318
Statement on travel, influenza, and prevention. Canada communicable disease report = Releve des maladies transmissibles au Canada 20050315
Simultaneous non-destructive determination of two components of combined paracetamol and amantadine hydrochloride in tablets and powder by NIR spectroscopy and artificial neural networks. Journal of pharmaceutical and biomedical analysis 20050309
'Levodopa phobia': a new iatrogenic cause of disability in Parkinson disease. Neurology 20050308
Economic evaluation of oseltamivir phosphate for postexposure prophylaxis of influenza in long-term care facilities. Journal of the American Geriatrics Society 20050301
Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study. Archives of physical medicine and rehabilitation 20050301
Effect of amantadine on motor memory consolidation in humans. Behavioural pharmacology 20050301
Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels. The Journal of membrane biology 20050301
Triple antiviral therapy with amantadine for IFN-ribavirin nonresponders with recurrent posttransplantation hepatitis C. Transplantation 20050215
A simple rodent assay for the in vivo identification of agents with potential to reduce levodopa-induced dyskinesia in Parkinson's disease. Experimental neurology 20050201
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro. Biochemical pharmacology 20050201
Development of novel therapies for Huntington's disease: hope and challenge. Acta pharmacologica Sinica 20050201
Antiviral drugs for prophylaxis and treatment of influenza. Obstetrics and gynecology 20050201
An ionizable chromophoric reagent for the analysis of primary amine-containing drugs by capillary electrophoresis. Electrophoresis 20050201
Amantadine for weight gain associated with olanzapine treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101
MK801 and amantadine exert different effects on subthalamic neuronal activity in a rodent model of Parkinson's disease. Experimental neurology 20050101
Other pharmacological treatments for motor complications and dyskinesias. Movement disorders : official journal of the Movement Disorder Society 20050101
[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound]. Molekuliarnaia biologiia 20050101
Simple fluorimetric method for determination of certain antiviral drugs via their oxidation with cerium (IV). Farmaco (Societa chimica italiana : 1989) 20050101
Dexamethasone reduces locomotor stimulation induced by dopamine agonists in mice. Pharmacological reports : PR 20050101
Effects of donepezil on compulsive hypersexual behavior in Parkinson disease: a single case study. American journal of therapeutics 20050101
Alternatives to levodopa in the initial treatment of early Parkinson's disease. Drugs & aging 20050101
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Amantadine partition and localization in phospholipid membrane: a solution NMR study. Biochemical and biophysical research communications 20041105
Reversible amantadine-induced corneal edema in an adolescent. Cornea 20041101
Adverse effects of amantadine and oseltamivir used during respiratory outbreaks in a center for developmentally disabled adults. Infection control and hospital epidemiology 20041101
Pandemic influenza: is an antiviral response realistic? The Pediatric infectious disease journal 20041101
Single-dose pharmacokinetics of a novel oral platinum cytostatic drug ([OC-6-43]-bis[acetato][1-adamantylamine]amminedichloroplatinum [IV]) in pigs. Methods and findings in experimental and clinical pharmacology 20041101
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Antiviral treatment and prophylaxis of influenza in primary care: German recommendations. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20041001
Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations. Movement disorders : official journal of the Movement Disorder Society 20041001
Avian influenza should be ruffling our feathers. The Lancet. Infectious diseases 20041001
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A young onset Parkinson's patient: a case study. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20041001
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Molecular cell 20040924
Interaction between an amantadine analogue and the transmembrane portion of the influenza A M2 protein in liposomes probed by 1H NMR spectroscopy of the ligand. Journal of medicinal chemistry 20040923
Functional map of TEA transport activity in isolated rabbit renal proximal tubules. American journal of physiology. Renal physiology 20040901
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Proton conductance of influenza virus M2 protein in planar lipid bilayers. Biophysical journal 20040901
Restoration of femoral GM-CFC progenitors in sublethally irradiated mice of various ages treated with liposomal adamantylamide dipeptide. International immunopharmacology 20040801
Bitterness evaluation of medicines for pediatric use by a taste sensor. Chemical & pharmaceutical bulletin 20040801
Peginterferon alpha-2b plus ribavirin with or without amantadine [correction of amantidine] for the treatment of non-responders to standard interferon and ribavirin. Antiviral therapy 20040801
Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics 20040701
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Influenza outbreaks in aged-care facilities: staff vaccination and the emerging use of antiviral therapy. The Medical journal of Australia 20040621
New platinum(IV) complex with adamantylamine ligand as a promising anti-cancer drug: comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum(IV) complexes. Anti-cancer drugs 20040601
Amantadine therapy for chronic hepatitis C: a dose escalation study. The American journal of gastroenterology 20040601
Quality of life in Polish patients with long-lasting Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20040601
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Amantadine therapy in renal transplant patients with hepatitis C virus infection. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040501
A combinatorial therapy for pneumonia in elderly people. Journal of the American Geriatrics Society 20040501
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Open label study of the effect of amantadine on weight gain induced by olanzapine. Psychiatry and clinical neurosciences 20040401
Crystal structure of the supramolecular linear polymer formed by the self-assembly of mono-6-deoxy-6-adamantylamide-beta-cyclodextrin. Acta crystallographica. Section B, Structural science 20040401
Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against otitis media and lung infection by nontypeable Haemophilus influenzae. The Journal of infectious diseases 20040401
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Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine. The European journal of neuroscience 20040401
Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial. Journal of the neurological sciences 20040315
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