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638-94-8 | Desonide
CAS No: 638-94-8 Catalog No: AG003AX4 MDL No:MFCD00866151
Product Description
Catalog Number:
AG003AX4
Chemical Name:
Desonide
CAS Number:
638-94-8
Molecular Formula:
C24H32O6
Molecular Weight:
416.5073
MDL Number:
MFCD00866151
IUPAC Name:
(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
InChI:
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
InChI Key:
WBGKWQHBNHJJPZ-LECWWXJVSA-N
SMILES:
OCC(=O)[C@@]12OC(O[C@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)(C)C
EC Number:
211-351-6
UNII:
J280872D1O
Properties
Complexity:
873
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
8
Defined Bond Stereocenter Count:
0
Exact Mass:
416.22g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
416.514g/mol
Monoisotopic Mass:
416.22g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
93.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
Literature
| Title | Journal |
|---|---|
| Golimumab-exacerbated subacute cutaneous lupus erythematosus. | Archives of dermatology 20121001 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Generalized granuloma annulare in infancy following bacillus calmette-guerin vaccination. | Annals of dermatology 20111201 |
| Randomized Controlled Trial of Desonlde Hydrogel 0.05% versus Desonide Ointment 0.05% in the Treatment of Mild-to-moderate Atopic Dermatitis. | The Journal of clinical and aesthetic dermatology 20111101 |
| Allergic contact dermatitis caused by methylphenidate. | Contact dermatitis 20110901 |
| Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801 |
| Practical advantages of desonide hydrogel in the management of atopic dermatitis. Introduction. | Cutis 20110701 |
| Moisturizing advantages of desonide hydrogel in treating atopic dermatitis. | Cutis 20110701 |
| Self-reported participant experience with desonide hydrogel in the treatment of mild to moderate atopic dermatitis. | Cutis 20110701 |
| The importance of vehicle properties to patients with atopic dermatitis. | Cutis 20110701 |
| Fox-Fordyce Disease (Apocrine Miliaria). | Journal of pediatric and adolescent gynecology 20110601 |
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| Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | Analytical and bioanalytical chemistry 20100401 |
| Good adherence and early efficacy using desonide hydrogel for atopic dermatitis: results from a program addressing patient compliance. | Journal of drugs in dermatology : JDD 20100401 |
| Lenalidomide-induced acute acneiform folliculitis of the head and neck: not only the anti-EGF receptor agents. | Dermatology (Basel, Switzerland) 20100101 |
| Vitiligo after diphencyprone for alopecia areata. | Dermatology research and practice 20100101 |
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| Rhabdomyomatous mesenchymal hamartoma: clinical overview and report of a case with spontaneous regression. | The West Indian medical journal 20091201 |
| Manifestations of cutaneous sarcoidosis: a case report of an African American woman. | Journal of the National Medical Association 20090601 |
| A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples. | Indian journal of pharmacology 20090401 |
| Treatment of scalp and facial seborrheic dermatitis with desonide hydrogel 0.05%. | The Journal of clinical and aesthetic dermatology 20090201 |
| [Streptococcal perianal dermatitis and guttate psoriasis]. | Annales de dermatologie et de venereologie 20090101 |
| Drugs associated with more suicidal ideations are also associated with more suicide attempts. | PloS one 20090101 |
| Inflammation of actinic keratosis with combination of alkylating and taxane agents: a case report. | Cases journal 20090101 |
| An investigator-blind, randomized, 4-week, parallel-group, multicenter pilot study to compare the safety and efficacy of a nonsteroidal cream (Promiseb Topical Cream) and desonide cream 0.05% in the twice-daily treatment of mild to moderate seborrheic dermatitis of the face. | Clinics in dermatology 20090101 |
| What's your assessment? Severe seborrheic dermatitis. | Dermatology nursing 20081201 |
| Direct injection LC/ESI-MS horse urine analysis for the quantification and identification of threshold substances for doping control. I. Determination of hydrocortisone. | Journal of mass spectrometry : JMS 20080901 |
| Nephrotic state as a risk factor for developing posterior reversible encephalopathy syndrome in paediatric patients with nephrotic syndrome. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080801 |
| Desonide foam 0.05%: safety in children as young as 3 months. | Journal of the American Academy of Dermatology 20080801 |
| Desonide: a review of formulations, efficacy and safety. | Expert opinion on investigational drugs 20080701 |
| Worrisome perioral rash on a young boy. Lip-licker's dermatitis. | JAAPA : official journal of the American Academy of Physician Assistants 20080501 |
| Desonide foam: a review. | Drugs of today (Barcelona, Spain : 1998) 20080101 |
| New and emerging trends in the treatment of atopic dermatitis. | Patient preference and adherence 20080101 |
| Adverse cutaneous drug reaction. | Indian journal of dermatology 20080101 |
| Fixed drug eruption induced by atenolol. | Clinical, cosmetic and investigational dermatology 20080101 |
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| Ketoconazole gel 2% in the treatment of moderate to severe seborrheic dermatitis. | Cutis 20070601 |
| Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis. | Journal of drugs in dermatology : JDD 20070201 |
| Verdeso (desonide) Foam, 0.05%. | Skinmed 20070101 |
| Periorbital cutaneous neonatal lupus. | Skinmed 20070101 |
| Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis. | Pediatric dermatology 20070101 |
| Desonide gel. | Skinmed 20070101 |
| Corticosteroid therapy in the treatment of pediatric patients with atopic dermatitis. | GMS health technology assessment 20070101 |
| Photochemistry of desonide, a non-fluorinated steroidal anti-inflammatory drug. | Chemical & pharmaceutical bulletin 20060601 |
| Erythematous scaling eyelids: patient history, exposure to allergens and irritants are keys to diagnosis. | Postgraduate medicine 20050601 |
| Rapid resolution of a common problem. | The American journal of medicine 20050501 |
| [Connubial contact dermatitis to an inhaled corticosteroid]. | Annales de dermatologie et de venereologie 20050201 |
| Seborrheic dermatitis. | Skinmed 20050101 |
| Comparison of the analysis of corticosteroids using different techniques. | Analytical and bioanalytical chemistry 20050101 |
| Corneofungimetry bioassay on Malassezia spp. under ketoconazole and desonide influences. | Skin pharmacology and physiology 20050101 |
| Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare. | Journal of the European Academy of Dermatology and Venereology : JEADV 20040901 |
| Overview on desonide 0.05%: a clinical safety profile. | Journal of drugs in dermatology : JDD 20040101 |
| Steroid therapy altered serum levels of CCL2 and CCL5 chemokines in multiple sclerosis patients during relapse. | European neurology 20040101 |
| Efficacy of desonide 0.05% cream and lotion in steroid-responsive dermatoses in Indian patients: a post-marketing surveillance study. | Indian journal of dermatology, venereology and leprology 20040101 |
| Efficacy, cutaneous tolerance and cosmetic acceptability of desonide 0.05% lotion (Desowen) versus vehicle in the short-term treatment of facial atopic or seborrhoeic dermatitis. | The Australasian journal of dermatology 20020801 |
| Evaluation of cross-reactivity between budesonide and desonide. | Contact dermatitis 20020801 |
| Efficacy and safety of desonide phosphate for the treatment of allergic conjunctivitis. | Cornea 20020701 |
| A double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis. | Dermatology (Basel, Switzerland) 20020101 |
| Allergic contact dermatitis from topical corticosteroids. | Contact dermatitis 19890801 |
| Clinical comparison of alclometasone dipropionate and desonide ointments (0.05%) in the management of psoriasis. | The Journal of international medical research 19820101 |
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