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6339-87-3 | Thiophene-2-sulfonamide
CAS No: 6339-87-3 Catalog No: AG003HY1 MDL No:MFCD00185853
Product Description
Catalog Number:
AG003HY1
Chemical Name:
Thiophene-2-sulfonamide
CAS Number:
6339-87-3
Molecular Formula:
C4H5NO2S2
Molecular Weight:
163.2180
MDL Number:
MFCD00185853
IUPAC Name:
thiophene-2-sulfonamide
InChI:
InChI=1S/C4H5NO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H,(H2,5,6,7)
InChI Key:
KTFDYVNEGTXQCV-UHFFFAOYSA-N
SMILES:
NS(=O)(=O)c1cccs1
NSC Number:
42521
RTECS Number:
XN0294000
Properties
Complexity:
181
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
162.976g/mol
Formal Charge:
0
Heavy Atom Count:
9
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
163.209g/mol
Monoisotopic Mass:
162.976g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
96.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3
Literature
| Title | Journal |
|---|---|
| Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. | Journal of medicinal chemistry 20140522 |
| The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. | The EMBO journal 20120516 |
| Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors. | Journal of medicinal chemistry 20120308 |
| BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells. | Journal of biomedical science 20110101 |
| Drug development for Alzheimer's disease: recent progress. | Experimental neurobiology 20101201 |
| Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. | Alzheimer's research & therapy 20100101 |
| Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring. | Bioorganic & medicinal chemistry letters 20041220 |
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