200,000+ products from a single source!
sales@angenechem.com
633-65-8 | Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride
CAS No: 633-65-8 Catalog No: AG00IB6S MDL No:MFCD00011939
Product Description
Catalog Number:
AG00IB6S
Chemical Name:
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride
CAS Number:
633-65-8
Molecular Formula:
C20H22ClNO6
Molecular Weight:
407.8448
MDL Number:
MFCD00011939
IUPAC Name:
16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride
InChI:
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChI Key:
VKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES:
COc1c(OC)ccc2c1c[n+]1CCc3c(c1c2)cc1c(c3)OCO1.O.O.[Cl-]
EC Number:
211-195-9
UNII:
UOT4O1BYV8
Properties
Complexity:
488
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
371.092g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
371.817g/mol
Monoisotopic Mass:
371.092g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
40.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing. | The Journal of antimicrobial chemotherapy 20140101 |
| Structural optimization of berberine as a synergist to restore antifungal activity of fluconazole against drug-resistant Candida albicans. | ChemMedChem 20140101 |
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| Synthesis, structure-activity relationship and in vitro anti-mycobacterial evaluation of 13-n-octylberberine derivatives. | European journal of medicinal chemistry 20120601 |
| Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. | Bioorganic & medicinal chemistry 20120415 |
| Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease. | Bioorganic & medicinal chemistry 20111201 |
| Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene. | European journal of medicinal chemistry 20110501 |
| Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect. | Journal of natural products 20110425 |
| Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. | European journal of medicinal chemistry 20110401 |
| Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. | Bioorganic & medicinal chemistry 20110401 |
| Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase. | Bioorganic & medicinal chemistry letters 20101115 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. | Bioorganic & medicinal chemistry 20100901 |
| Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. | Bioorganic & medicinal chemistry letters 20100801 |
| Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. | Bioorganic & medicinal chemistry 20100615 |
| Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones. | European journal of medicinal chemistry 20100601 |
| Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. | Journal of medicinal chemistry 20100513 |
| Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. | Bioorganic & medicinal chemistry 20100201 |
| Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. | Bioorganic & medicinal chemistry letters 20091101 |
| Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. | Bioorganic & medicinal chemistry letters 20091001 |
| Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. | Bioorganic & medicinal chemistry 20090601 |
| Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. | Bioorganic & medicinal chemistry 20090401 |
| Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists. | Bioorganic & medicinal chemistry letters 20090201 |
| Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. | Journal of medicinal chemistry 20090122 |
| Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. | Bioorganic & medicinal chemistry letters 20080815 |
| Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus. | Bioorganic & medicinal chemistry letters 20080801 |
| Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. | Bioorganic & medicinal chemistry 20080401 |
| Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos. | Bioorganic & medicinal chemistry letters 20071001 |
| Antiviral activity of berberine and related compounds against human cytomegalovirus. | Bioorganic & medicinal chemistry letters 20070315 |
| Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents. | Bioorganic & medicinal chemistry letters 20060801 |
| Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. | Journal of natural products 20060701 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Synthesis and antihyperglycemic evaluation of various protoberberine derivatives. | Bioorganic & medicinal chemistry letters 20060301 |
| Metabolites of the 'smoke tree', Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. | Journal of natural products 20060201 |
| A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis. | Journal of natural products 20041101 |
| Xanthones and benzophenones from the stems of Garcinia multiflora. | Journal of natural products 20030801 |
| Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2. | Journal of natural products 19981001 |
| Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. | Journal of natural products 19910101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.