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6228-73-5 | Cyclopropanecarboxamide
CAS No: 6228-73-5 Catalog No: AG003P6S MDL No:MFCD00013729
Product Description
Catalog Number:
AG003P6S
Chemical Name:
Cyclopropanecarboxamide
CAS Number:
6228-73-5
Molecular Formula:
C4H7NO
Molecular Weight:
85.1045
MDL Number:
MFCD00013729
IUPAC Name:
cyclopropanecarboxamide
InChI:
InChI=1S/C4H7NO/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)
InChI Key:
AIMMVWOEOZMVMS-UHFFFAOYSA-N
SMILES:
NC(=O)C1CC1
EC Number:
228-332-3
UNII:
NA7A3S4MUT
NSC Number:
402033
Properties
Complexity:
75.6
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
85.053g/mol
Formal Charge:
0
Heavy Atom Count:
6
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
85.106g/mol
Monoisotopic Mass:
85.053g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
43.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.4
Literature
| Title | Journal |
|---|---|
| Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist. | Journal of medicinal chemistry 20150611 |
| Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator. | Bioorganic & medicinal chemistry letters 20130301 |
| Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones. | Organic & biomolecular chemistry 20120621 |
| Highly asymmetric intramolecular cyclopropanation of acceptor-substituted diazoacetates by Co(II)-based metalloradical catalysis: iterative approach for development of new-generation catalysts. | Journal of the American Chemical Society 20111005 |
| Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors. | Bioorganic & medicinal chemistry letters 20110915 |
| Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators. | Journal of medicinal chemistry 20110113 |
| Identification of a new biaryl scaffold generating potent renin inhibitors. | Bioorganic & medicinal chemistry letters 20101001 |
| Synthesis, antifungal activities and 3D-QSAR study of N-(5-substituted-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides. | European journal of medicinal chemistry 20090701 |
| Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge. | Bioorganic & medicinal chemistry letters 20090301 |
| Potential energy scans and vibrational assignments of cyclopropanecarboxylic acid and cyclopropanecarboxamide. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081215 |
| Effect of Maillard reacted peptides on human salt taste and the amiloride-insensitive salt taste receptor (TRPV1t). | Chemical senses 20080901 |
| Modifications of antiepileptic drugs for improved tolerability and efficacy. | Perspectives in medicinal chemistry 20080101 |
| Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series. | Bioorganic & medicinal chemistry letters 20070701 |
| Design, synthesis and melatoninergic potency of new N-acyl 8,9-dihydro-4-methoxy-7H-2-benzo[de]quinolinalkanamines. | Bioorganic chemistry 20070401 |
| High affinity electrophilic and photoactivatable covalent endocannabinoid probes for the CB1 receptor. | Journal of medicinal chemistry 20051006 |
| Convergent approach to (E)-alkene and cyclopropane peptide isosteres. | Organic letters 20050106 |
| Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). | Bioorganic & medicinal chemistry letters 20031117 |
| Sequential elimination-cyclopropanation reactions promoted by samarium: highly diastereoselective synthesis of cyclopropylamides. | The Journal of organic chemistry 20030207 |
| Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists. | Bioorganic & medicinal chemistry letters 20010423 |
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