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Home > Nitro Compounds > 609-39-2
609-39-2 | 2-Nitrofuran
CAS No: 609-39-2 Catalog No: AG003HSO MDL No:MFCD00013442
Product Description
Catalog Number:
AG003HSO
Chemical Name:
2-Nitrofuran
CAS Number:
609-39-2
Molecular Formula:
C4H3NO3
Molecular Weight:
113.0715
MDL Number:
MFCD00013442
IUPAC Name:
2-nitrofuran
InChI:
InChI=1S/C4H3NO3/c6-5(7)4-2-1-3-8-4/h1-3H
InChI Key:
FUBFWTUFPGFHOJ-UHFFFAOYSA-N
SMILES:
[O-][N+](=O)c1ccco1
UNII:
17EZI4D981
NSC Number:
59983
Properties
Complexity:
97.9
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
113.011g/mol
Formal Charge:
0
Heavy Atom Count:
8
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
113.072g/mol
Monoisotopic Mass:
113.011g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
59A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.7
Literature
| Title | Journal |
|---|---|
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| Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase. | Bioorganic & medicinal chemistry 20110115 |
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| An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents. | PloS one 20110101 |
| Mycobacterium tuberculosis acg gene is required for growth and virulence in vivo. | PloS one 20110101 |
| Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. | PloS one 20110101 |
| [Development and use of test systems for the evaluation of sensitivity of Trichomonas vaginalisto preparations of the 5-nitroimidazole and 5-nitrofuran groups]. | Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101 |
| Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi. | Parasites & vectors 20110101 |
| Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. | Scientific reports 20110101 |
| 2,3-Dibromo-3-(5-nitro-2-fur-yl)-1-(4-nitro-phen-yl)propan-1-one. | Acta crystallographica. Section E, Structure reports online 20101201 |
| 2,3-Dibromo-1-(4-chloro-phen-yl)-3-(5-nitro-2-fur-yl)propan-1-one. | Acta crystallographica. Section E, Structure reports online 20101201 |
| 3-(5-Nitro-2-fur-yl)-1-phenyl-prop-2-yn-1-one. | Acta crystallographica. Section E, Structure reports online 20101101 |
| Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine. | Parasitology research 20100901 |
| (4-Chloro-phen-yl)[1-(4-methoxy-phen-yl)-3-(5-nitro-2-fur-yl)-1H-pyrazol-4-yl]methanone. | Acta crystallographica. Section E, Structure reports online 20100501 |
| Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives. | Bioorganic & medicinal chemistry 20100101 |
| Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones. | European journal of medicinal chemistry 20091201 |
| (4-Methyl-phen-yl)[3-(5-nitro-2-fur-yl)-1-phenyl-1H-pyrazol-4-yl]methanone. | Acta crystallographica. Section E, Structure reports online 20091201 |
| 5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: preliminary in vivo studies. | European journal of medicinal chemistry 20091001 |
| E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954. | British journal of cancer 20090616 |
| 5-Nitrofuran-2-yl derivatives: synthesis and inhibitory activities against growing and dormant mycobacterium species. | Bioorganic & medicinal chemistry letters 20090215 |
| Preliminary evaluation of the toxicity of some synthetic furan derivatives in two cell lines and Artemia salina. | Journal of applied toxicology : JAT 20090101 |
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| Genetic architecture of intrinsic antibiotic susceptibility. | PloS one 20090101 |
| Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae. | BMC microbiology 20090101 |
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| ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080801 |
| Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines. | Bioorganic & medicinal chemistry 20080415 |
| Thiosemicarbazones active against Clostridium difficile. | Bioorganic & medicinal chemistry letters 20080301 |
| Insight into the bioreductive mode of action of antitrypanosomal 5-nitrofuryl containing thiosemicarbazones. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20080101 |
| Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents. | Journal of inorganic biochemistry 20080101 |
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| Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design. | Drug target insights 20070101 |
| Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of Nifurtimox, an antitrypanosomiasis drug. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20060701 |
| New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies. | European journal of medicinal chemistry 20060401 |
| Conformational analyses and docking studies of a series of 5-nitrofuran- and 5-nitrothiophen-semicarbazone derivatives in three possible binding sites of trypanothione and glutathione reductases. | Journal of molecular graphics & modelling 20060301 |
| In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones. | Bioorganic & medicinal chemistry 20040915 |
| Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design. | European journal of medicinal chemistry 20040501 |
| Analysis of 5-nitrofuran derivatives in biological objects. | Bulletin of experimental biology and medicine 20030101 |
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