200,000+ products from a single source!
sales@angenechem.com
60559-98-0 | N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE
CAS No: 60559-98-0 Catalog No: AG00EB3I MDL No:
Product Description
Catalog Number:
AG00EB3I
Chemical Name:
N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE
CAS Number:
60559-98-0
Molecular Formula:
C12H17N5
Molecular Weight:
231.2969
IUPAC Name:
1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-ylguanidine
InChI:
InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
InChI Key:
HKZNADVVGXKQDL-UHFFFAOYSA-N
SMILES:
N#CN/C(=N\C(CC)(C)C)/Nc1cccnc1
Properties
Complexity:
312
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
231.148g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
231.303g/mol
Monoisotopic Mass:
231.148g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
73.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1
Literature
| Title | Journal |
|---|---|
| Different potassium channels are involved in relaxation of rat renal artery induced by P1075. | Basic & clinical pharmacology & toxicology 20120701 |
| ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye. | Investigative ophthalmology & visual science 20110801 |
| The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary artery. | Journal of cardiovascular pharmacology 20110601 |
| Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: effects on ligand binding and channel activity. | Naunyn-Schmiedeberg's archives of pharmacology 20100601 |
| Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. | Bioorganic & medicinal chemistry 20090115 |
| Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel. | Cardiovascular research 20081201 |
| Potassium fluxes, energy metabolism, and oxygenation in intact diabetic rat hearts under normal and stress conditions. | Canadian journal of physiology and pharmacology 20081001 |
| Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2. | The Journal of physiology 20080701 |
| K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries. | British journal of pharmacology 20080501 |
| GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. | Basic research in cardiology 20070701 |
| Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener. | Journal of medicinal chemistry 20061116 |
| Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs. | European journal of pharmacology 20060217 |
| P-1075 exerts diverse modulatory effects on mitochondrial ATP-sensitive K+ channels in rabbit ventricular myocytes. | Journal of cardiovascular pharmacology 20060201 |
| Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression. | European journal of pharmacology 20051031 |
| Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress. | Journal of molecular and cellular cardiology 20051001 |
| Lipids modulate ligand binding to sulphonylurea receptors. | British journal of pharmacology 20050801 |
| Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels. | International heart journal 20050701 |
| Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line. | Journal of cardiovascular pharmacology 20050101 |
| Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in renovascular hypertensive rat aorta. | Acta pharmacologica Sinica 20050101 |
| In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892. | British journal of pharmacology 20040901 |
| Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions. | Journal of medicinal chemistry 20040603 |
| Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075. | British journal of pharmacology 20040401 |
| Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. | Journal of medicinal chemistry 20040226 |
| Sarcolemmal and mitochondrial effects of a KATP opener, P-1075, in 'polarized' and 'depolarized' Langendorff-perfused rat hearts. | Biochimica et biophysica acta 20031203 |
| Selective ATP-sensitive potassium channel openers: fact or fiction. | Journal of molecular and cellular cardiology 20030901 |
| P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. | Journal of molecular and cellular cardiology 20030901 |
| Cardioselective sulfonylthiourea HMR 1098 blocks mitochondrial uncoupling induced by a KATP channel opener, P-1075, in beating rat hearts. | Biochimica et biophysica acta 20030714 |
| [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding. | Molecular pharmacology 20030701 |
| Binding and effect of K ATP channel openers in the absence of Mg2+. | British journal of pharmacology 20030501 |
| PNU-83757: a new agent for the treatment of erectile dysfunction. | Current urology reports 20021201 |
| Development of a sensitive bioanalytical method for determination of PNU-83757 in rat, monkey and human plasma: from LC-UV to LC-MS/MS. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs). | Bioorganic & medicinal chemistry letters 20020603 |
| The efficacy, safety and tolerability of intracavernous PNU-83757 for the treatment of erectile dysfunction. | The Journal of urology 20020601 |
| Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts. | Journal of molecular and cellular cardiology 20020401 |
| KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects. | Naunyn-Schmiedeberg's archives of pharmacology 20020301 |
| Interaction of K(ATP) channel modulators with sulfonylurea receptor SUR2B: implication for tetramer formation and allosteric coupling of subunits. | Molecular pharmacology 20020201 |
| Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells. | Bioorganic & medicinal chemistry letters 20010709 |
| Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes. | Molecular pharmacology 20010701 |
| Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells. | The Journal of pharmacology and experimental therapeutics 20010301 |
| Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. | Molecular pharmacology 20010201 |
| Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes. | Journal of pharmacological and toxicological methods 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.