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59804-37-4

59804-37-4 | 2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide

CAS No: 59804-37-4 Catalog No: AG00IKIF MDL No:MFCD00083502

Product Description

Catalog Number:
AG00IKIF
Chemical Name:
2H-Thieno[2,3-e]-1,2-thiazine-3-carboxamide,4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
CAS Number:
59804-37-4
Molecular Formula:
C13H11N3O4S2
Molecular Weight:
337.3741
MDL Number:
MFCD00083502
IUPAC Name:
4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
InChI:
InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
InChI Key:
LZNWYQJJBLGYLT-UHFFFAOYSA-N
SMILES:
O=C(C1=C(O)c2sccc2S(=O)(=O)N1C)Nc1ccccn1
UNII:
Z1R9N0A399
NSC Number:
758397

Properties

Complexity:
599  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
337.019g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
337.368g/mol
Monoisotopic Mass:
337.019g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
136A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1  

Literature

Title Journal
Preparation, structural analysis, and properties of tenoxicam cocrystals. International journal of pharmaceutics 20121015
Comparing the efficacy of intravenous tenoxicam, lornoxicam, and dexketoprofen trometamol for the treatment of renal colic. The American journal of emergency medicine 20121001
Recompression and adjunctive therapy for decompression illness. The Cochrane database of systematic reviews 20120516
Preparation and structural characterization of amorphous spray-dried dispersions of tenoxicam with enhanced dissolution. Journal of pharmaceutical sciences 20120201
The efficacy of paracetamol versus tenoxicam on postoperative pain and morphine consumption after abdominal hysterectomy: a placebo-controlled, randomized study. Clinical and experimental obstetrics & gynecology 20120101
Effect of lipid molecule headgroup mismatch on non steroidal anti-inflammatory drugs induced membrane fusion. Langmuir : the ACS journal of surfaces and colloids 20111220
Tautomeric ratio and prototropic equilibrium constants of tenoxicam, a 1H and 13C NMR theoretical and experimental study. The journal of physical chemistry. B 20111124
Development of novel transdermal self-adhesive films for tenoxicam, an anti-inflammatory drug. Life sciences 20110926
Evaluation of tenoxicam on prevention of arachnoiditis in rat laminectomy model. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20110801
Enzymatic probing of model lipid membranes: phospholipase A2 activity toward monolayers modified by oxicam NSAIDs. The journal of physical chemistry. B 20110728
Effectiveness of tenoxicam and ibuprofen for pain prevention following endodontic therapy in comparison to placebo: a randomized double-blind clinical trial. Journal of oral science 20110601
Proniosomes as a carrier system for transdermal delivery of tenoxicam. International journal of pharmaceutics 20110227
Clinical management of angioneurotic oedema patient post-orthognathic surgery. International journal of oral and maxillofacial surgery 20110101
Photoclinic. Fixed drug eruption. Archives of Iranian medicine 20110101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry 20101101
Recompression and adjunctive therapy for decompression illness: a systematic review of randomized controlled trials. Anesthesia and analgesia 20100901
Effect of tenoxicam on rat liver tissue. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20100601
Intra-articular injection of tenoxicam following temporomandibular joint arthrocentesis: a pilot study. International journal of oral and maxillofacial surgery 20100501
A double-blind randomised controlled study comparing subacromial injection of tenoxicam or methylprednisolone in patients with subacromial impingement. The Journal of bone and joint surgery. British volume 20100101
[Turbidimetric determination of tenoxicam using molybdophosphoric acid]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101
Epidural versus intravenous fentanyl for postoperative analgesia following orthopedic surgery: randomized controlled trial. Sao Paulo medical journal = Revista paulista de medicina 20100101
[Construction and characterization of a selective membrane electrode for tenoxicam determination]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101
Non-steroidal anti-inflammatory drug induced membrane fusion: concentration and temperature effects. The journal of physical chemistry. B 20091224
Determination of pKa values of tenoxicam from 1H NMR chemical shifts and of oxicams from electrophoretic mobilities (CZE) with the aid of programs SQUAD and HYPNMR. Talanta 20091215
Determination of pKa values of nonsteroidal antiinflammatory drug-oxicams by RP-HPLC and their analysis in pharmaceutical dosage forms. Journal of separation science 20090901
Combination therapy with doxazosin and tenoxicam for the management of lower urinary tract symptoms. Urology 20090801
Effect of some analgesics on paraoxonase-1 purified from human serum. Journal of enzyme inhibition and medicinal chemistry 20090801
Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study. Journal of enzyme inhibition and medicinal chemistry 20090401
Interaction of Oxicam NSAIDs with lipid monolayer: anomalous dependence on drug concentration. Colloids and surfaces. B, Biointerfaces 20090401
Improving tenoxicam solubility and bioavailability by cosolvent system. AAPS PharmSciTech 20090301
Tenoxicam controls pain without altering orthodontic movement of maxillary canines. Orthodontics & craniofacial research 20090201
Pharmacogenetic relevance of the CYP2C9*3 allele in a tenoxicam bioequivalence study performed on Spaniards. Pharmacological research 20090101
Single dose oral tenoxicam for acute postoperative pain in adults. The Cochrane database of systematic reviews 20090101
[Ultraviolet spectrophotometric determination of tenoxicam using iodine solution as reagent]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20090101
Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDS. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201
The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081115
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry 20081113
Analysis of meloxicam by high-performance liquid chromatography with cloud-point extraction. Analytical and bioanalytical chemistry 20081101
Tenoxicam modulates antioxidant redox system and lipid peroxidation in rat brain. Neurochemical research 20080901
Membrane fusion: a new function of non steroidal anti-inflammatory drugs. Biophysical chemistry 20080901
Anesthetic management of a patient with Seckel syndrome and implanted pacemaker. Paediatric anaesthesia 20080701
Lornoxicam in extracorporeal shock-wave lithotripsy; comparison with tenoxicam and placebo in terms of analgesic consumption. Scandinavian journal of urology and nephrology 20080101
Pharmacokinetics of formulated tenoxicam transdermal delivery systems. The Journal of pharmacy and pharmacology 20080101
[Use of drugs in renal impairment]. Der Internist 20080101
Comparison of analgesic and anti-inflammatory efficacy of selective and non-selective cyclooxygenase-2 inhibitors in dental implant surgery. Journal of periodontology 20071201
Intra-articular injection of tenoxicam in osteoarthritic knee joints with effusion. Orthopedics 20071201
Uranyl binary and ternary chelates of tenoxicam Synthesis, spectroscopic and thermal characterization of ternary chelates of tenoxicam and alanine with transition metals. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101
Comparison of effects of preoperatively administered lornoxicam and tenoxicam on morphine consumption after laparoscopic cholecystectomy. European journal of anaesthesiology 20070801
In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses. Osteoarthritis and cartilage 20070501
Recompression and adjunctive therapy for decompression illness. The Cochrane database of systematic reviews 20070418
Effects of diclofenac and tenoxicam on distraction osteogenesis. Archives of orthopaedic and trauma surgery 20070401
Fast RPLC-UV method on short sub-two microns particles packed column for the assay of tenoxicam in plasma samples. Journal of pharmaceutical and biomedical analysis 20070312
Study of hydroxy propyl guar derivative for its gelling property and it's use in the formulation of tenoxicam gels. Pakistan journal of pharmaceutical sciences 20070101
[Microspeciation of amphoteric molecules of unusual acid-base properties]. Acta pharmaceutica Hungarica 20070101
CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug metabolism and disposition: the biological fate of chemicals 20061201
Indirect flow-injection spectrophotometric determination of meloxicam, tenoxicam and piroxicam in pharmaceutical formulations. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20061201
Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems. Fundamental & clinical pharmacology 20060801
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Synthesis and thermal characterization of new ternary chelates of piroxicam and tenoxicam with glycine and DL-phenylalanine and some transition metals. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060501
Spectrofluorimetric and spectrophotometric stability-indicating methods for determination of some oxicams using 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD-Cl). Chemical & pharmaceutical bulletin 20060501
Comparison of intra-articular tenoxicam and oral tenoxicam for pain and physical functioning in osteoarthritis of the knee. Clinical rheumatology 20060201
Intraperitoneal tenoxicam to prevent abdominal adhesion formation in a rat peritonitis model. Surgery today 20060101
Simultaneous determination of piroxicam, meloxicam and tenoxicam in human plasma by liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105
Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaine. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20051101
Modulation of Tenoxicam release from hydrophilic matrix: modulator membrane versus rate-controlling membrane. Chemical & pharmaceutical bulletin 20050901
Differential analgesic effect of tenoxicam on post-cesarean uterine cramping pain between primiparous and multiparous women. Journal of the Formosan Medical Association = Taiwan yi zhi 20050901
Enhanced bioavailability of piroxicam via salt formation with ethanolamines. International journal of pharmaceutics 20050613
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models. Xenobiotica; the fate of foreign compounds in biological systems 20050601
Tenoxicam exerts a neuroprotective action after cerebral ischemia in rats. Neurochemical research 20050101
[Effects of tenoxicam on abdominal wall healing: experimental study in rats]. Acta cirurgica brasileira 20050101
In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis. Annals of clinical and laboratory science 20050101
Effects of non-steroid anti-inflammatory drugs in membrane bilayers. Chemistry and physics of lipids 20041201
A randomized crossover trial of tenoxicam compared with rofecoxib for postoperative dental pain control. Anaesthesia and intensive care 20041201
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury. Life sciences 20041008
Clinical tolerability of perioperative tenoxicam in 1001 patients--a prospective, controlled, double-blind, multi-centre study. Pain 20041001
Polarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol-water mixture. Journal of pharmaceutical and biomedical analysis 20040921
Compatibility and stability of ceftazidime sodium and tenoxicam in 5% dextrose injection. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040915
Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy. Acta anaesthesiologica Scandinavica 20040901
Independent lesions of fixed drug eruption caused by trimethoprim-sulfamethoxazole and tenoxicam in the same patient: a rare case of polysensitivity. Journal of the American Academy of Dermatology 20040801
CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians. Clinical pharmacology and therapeutics 20040701
Clinical inquiries. What is the best therapy for superficial thrombophlebitis? The Journal of family practice 20040701
Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug metabolism and disposition: the biological fate of chemicals 20040501
Quantitative determination of Piroxicam by TLC-MALDI TOF MS. Journal of pharmaceutical and biomedical analysis 20040401
Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents. Bioorganic & medicinal chemistry 20040301
The reactions of oxicam and sulfoanilide non steroidal anti-inflammatory drugs with hypochlorous acid: determination of the rate constants with an assay based on the competition with para-aminobenzoic acid chlorination and identification of some oxidation products. Free radical research 20040301
Spectrofluorimetric determination of 2-aminopyridine as a potential impurity in piroxicam and tenoxicam within the pharmacopoeial limit. Journal of pharmaceutical and biomedical analysis 20040127
Stability-indicating chromatographic methods for the determination of some oxicams. Journal of AOAC International 20040101
Intra-articular injection of tenoxicam in rats: assessment of the local effects on the articular cartilage and synovium. The Journal of international medical research 20040101
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. Inflammopharmacology 20040101
The detection of piroxicam, tenoxicam and their metabolites in equine urine by electrospray ionisation ion trap mass spectrometry. Rapid communications in mass spectrometry : RCM 20040101
The effect of preoperative intravenous use of tenoxicam: a prospective, double-blind, placebo-controlled study. Journal of investigative surgery : the official journal of the Academy of Surgical Research 20040101
A pilot randomized double-blind comparison of a low-molecular-weight heparin, a nonsteroidal anti-inflammatory agent, and placebo in the treatment of superficial vein thrombosis. Archives of internal medicine 20030728
Prolonged cholestasis and ductopenia associated with tenoxicam. Journal of hepatology 20030701
Anti-inflammatory activity and gastric lesions induced by zinc-tenoxicam. Pharmacology 20030601
Speciation study of the anti-inflammatory drug tenoxicam (Htenox) with Cu(II): X-ray crystal structure of [Cu(tenox)(2)(py)(2)].EtOH. Journal of inorganic biochemistry 20030601
Incorporation of NSAIDs in micelles: implication of structural switchover in drug-membrane interaction. Biophysical chemistry 20030501
Structure and drug release of lamellar liquid crystals containing glycerol. International journal of pharmaceutics 20030430
Photophysical studies of oxicam group of NSAIDs: piroxicam, meloxicam and tenoxicam. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030401
Effect of tenoxicam on fracture healing in rat tibiae. Injury 20030201
Differential analgesic effect of tenoxicam on the wound pain and uterine cramping pain after cesarean section. The Clinical journal of pain 20030101
Spectrophotometric and potentiometric determination of piroxicam and tenoxicam in pharmaceutical preparations. Chemical & pharmaceutical bulletin 20030101
Non-pigmenting cutaneous-mucosal fixed drug eruption due to piroxicam. Allergologia et immunopathologia 20030101
Adjunctive treatment of decompression illness with a non-steroidal anti-inflammatory drug (tenoxicam) reduces compression requirement. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 20030101
Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications. The British journal of ophthalmology 20021201
Comparison of efficacy of intraarticular application of tenoxicam, bupivacaine and tenoxicam: bupivacaine combination in arthroscopic knee surgery. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20021101
Solid phases of tenoxicam. Journal of pharmaceutical sciences 20021001
Spectrophotometric determination of piroxicam and tenoxicam in pharmaceutical formulations using alizarin. Journal of pharmaceutical and biomedical analysis 20020720
Comparison of analgesic effects of intra-articular tenoxicam and morphine in anterior cruciate ligament reconstruction. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20020701
Potentiometric and spectrofluorimetric studies on complexation of tenoxicam with some metal ions. Journal of pharmaceutical and biomedical analysis 20020601
Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin. International journal of pharmaceutics 20020402
Intravenous tenoxicam reduces uterine cramps after Cesarean delivery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20020401
Tenoxicam 20 mg or 40 mg after thoracotomy: a prospective, randomized, double-blind, placebo-controlled study. Anaesthesia and intensive care 20020401
Study of the complexation behavior of tenoxicam with cyclodextrins in solution: improved solubility and percutaneous permeability. Drug development and industrial pharmacy 20020301
Clinical experience with Norplant subdermal implant system as long-term contraception during adolescence. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20020301
Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20020101
In vitro percutaneous absorption of tenoxicam from pressure-sensitive adhesive matrices across the hairless mouse skin. Archives of pharmacal research 20011201
Sensitive LC determination of piroxicam after in vitro transdermal permeation studies. Journal of pharmaceutical and biomedical analysis 20011101
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. Immunopharmacology and immunotoxicology 20011101
Single- and multiple-dose pharmacokinetics, kidney tolerability and plasma protein binding of tenoxicam in renally impaired patients and healthy volunteers. Pharmacology & toxicology 20011101
Combined effect of oleic acid and propylene glycol on the percutaneous penetration of tenoxicam and its retention in the skin. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010901
Intranasal delivery of tenoxicam in rat. International journal of pharmaceutics 20010619
Eotaxin expression and eosinophil infiltrate in the liver of patients with drug-induced liver disease. Journal of hepatology 20010401
Timing of pre-emptive tenoxicam is important for postoperative analgesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010201
Interaction of tenoxicam with cyclodextrins and its influence on the in vitro percutaneous penetration of the drug. Drug development and industrial pharmacy 20010101
[Drug-induced aphthae]. Annales de dermatologie et de venereologie 20010101
Piroxicam-induced photodermatitis. Cross-reactivity among oxicams. A case report. Allergologia et immunopathologia 20010101
Piroxicam versus tenoxicam in spine surgery: a placebo controlled study. Acta anaesthesiologica Belgica 20010101
Intravenous tenoxicam for analgesia following laparoscopic cholecystectomy. Anaesthesia and intensive care 19980201
Orthostatic hypotension during postoperative continuous thoracic epidural bupivacaine-morphine in patients undergoing abdominal surgery. Anesthesia and analgesia 19961101
Acute hepatitis caused by tenoxicam. The Annals of pharmacotherapy 19941101
A comparison of tenoxicam and piroxicam in the treatment of rheumatoid arthritis. The Journal of rheumatology 19920401
Clinical efficacy and tolerability of tenoxicam in African patients with osteoarthritis, rheumatoid arthritis, tendinitis and/or bursitis: an open study. Current medical research and opinion 19910101
Comparative biochemical pharmacology of the oxicams. Scandinavian journal of rheumatology. Supplement 19870101

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