200,000+ products from a single source!

sales@angenechem.com

Home > Amines > 593-56-6

593-56-6

593-56-6 | O-Methylhydroxylamine Hydrochloride

CAS No: 593-56-6 Catalog No: AG0035FK MDL No:MFCD00012951

Product Description

Catalog Number:
AG0035FK
Chemical Name:
O-Methylhydroxylamine Hydrochloride
CAS Number:
593-56-6
Molecular Formula:
CH6ClNO
Molecular Weight:
83.5174
MDL Number:
MFCD00012951
IUPAC Name:
O-methylhydroxylamine;hydrochloride
InChI:
InChI=1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H
InChI Key:
XNXVOSBNFZWHBV-UHFFFAOYSA-N
SMILES:
CON.Cl
EC Number:
209-798-7
UNII:
203546OLMF
NSC Number:
3801
UN Number:
1759

Properties

Complexity:
4.8  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
83.014g/mol
Formal Charge:
0
Heavy Atom Count:
4  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
83.515g/mol
Monoisotopic Mass:
83.014g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
35.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors. The Journal of pharmacy and pharmacology 20120801
DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences. Bioorganic & medicinal chemistry 20120715
Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715
Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents. DNA repair 20120102
Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell death & disease 20120101
Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant. Drug metabolism and disposition: the biological fate of chemicals 20111001
Disproportionation of O-methylhydroxylamine catalyzed by aquapentacyanoferrate(II). Inorganic chemistry 20110919
DNA repair BER pathway inhibition increases cell death caused by oxidative DNA damage in Trypanosoma cruzi. Journal of cellular biochemistry 20110801
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro-oncology 20110501
Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110401
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair. Cancer research 20110315
Diphenylthiourea, a common rubber chemical, is bioactivated to potent skin sensitizers. Chemical research in toxicology 20110114
Accumulation of true single strand breaks and AP sites in base excision repair deficient cells. Mutation research 20101210
Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia. Leukemia 20101001
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. DNA repair 20091102
Nucleophile addition of reduced glutathione on 2-methyl-2-nitroso compound: a combined electron paramagnetic resonance spectroscopy and electrospray tandem mass spectrometry study. Journal of the American Society for Mass Spectrometry 20091101
Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair. Nuclear medicine and biology 20091101
Inhibitory properties of trapping agents: glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms. Drug metabolism letters 20090401
Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers. Clinical cancer research : an official journal of the American Association for Cancer Research 20090315
Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats. Autonomic & autacoid pharmacology 20090101
The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine. Journal of cellular biochemistry 20080901
[Effects of manumycin combined with methoxyamine on apoptosis in myeloid leukemia U937 cells]. Ai zheng = Aizheng = Chinese journal of cancer 20080801
Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance. Molecular pharmacology 20080701
Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst. Chemical communications (Cambridge, England) 20070421
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood 20070301
Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha. Clinical cancer research : an official journal of the American Association for Cancer Research 20070301
Role for DNA polymerase beta in response to ionizing radiation. DNA repair 20070204
Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. Clinical cancer research : an official journal of the American Association for Cancer Research 20070101
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Molecular aspects of medicine 20070101
A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1. Cell cycle (Georgetown, Tex.) 20061001
Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization. International journal of radiation oncology, biology, physics 20060801
Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence. Molecular cancer therapeutics 20060401
Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay. Mutation research 20051230
DNA repair inhibition: a selective tumour targeting strategy. Trends in molecular medicine 20051101
Development and validation of an HPLC-UV method for the analysis of methoxyamine using 4-(diethylamino)benzaldehyde as a derivatizing agent. Journal of pharmaceutical and biomedical analysis 20050915
Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. Leukemia 20050401
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Molecular cancer therapeutics 20040801
Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway. Current opinion in investigational drugs (London, England : 2000) 20040601
Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005
Role of MutSalpha in the recognition of iododeoxyuridine in DNA. Cancer research 20030901
Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. Cancer research 20030215
A new sensitive HPLC assay for methoxyamine and its analogs. Journal of pharmaceutical and biomedical analysis 20021015
Base excision repair as a therapeutic target in colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. DNA repair 20020429
[Biochemical diagnosis of pheochromocytoma and neuroblastomas]. Annales de biologie clinique 20020101
[Normal values of plasma methoxyamines in the setting of renal insufficiency and peri-operative stress. Consequences for the etiological diagnosis of hypertension]. Annales d'endocrinologie 20011101
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. Cancer research 20011015
Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity. Biochemistry 20010626
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutation research 20010510

Related Products

© 2019 Angene International Limited. All rights Reserved.