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Home > Indoles and Oxindole > 59-48-3
59-48-3 | Indolin-2-one
CAS No: 59-48-3 Catalog No: AG003R0B MDL No:MFCD00005711
Product Description
Catalog Number:
AG003R0B
Chemical Name:
Indolin-2-one
CAS Number:
59-48-3
Molecular Formula:
C8H7NO
Molecular Weight:
133.1473
MDL Number:
MFCD00005711
IUPAC Name:
1,3-dihydroindol-2-one
InChI:
InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)
InChI Key:
JYGFTBXVXVMTGB-UHFFFAOYSA-N
SMILES:
O=C1Cc2c(N1)cccc2
UNII:
0S9338U62H
NSC Number:
274863
Properties
Complexity:
155
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
133.053g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
133.15g/mol
Monoisotopic Mass:
133.053g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.2
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| Highly enantioselective catalytic benzoyloxylation of 3-aryloxindoles using chiral VAPOL calcium phosphate. | Angewandte Chemie (International ed. in English) 20110201 |
| Different biochemical correlates for different neuropsychiatric abnormalities in patients with cirrhosis. | Hepatology (Baltimore, Md.) 20110201 |
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| Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
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| Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors. | Bioinformation 20110101 |
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| Recent advances in molecular diagnosis of thyroid cancer. | Journal of thyroid research 20110101 |
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| Medullary thyroid carcinoma: molecular signaling pathways and emerging therapies. | Journal of thyroid research 20110101 |
| How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. | Journal of thyroid research 20110101 |
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| Differential inhibitor sensitivity between human kinases VRK1 and VRK2. | PloS one 20110101 |
| Investigation of the structure requirement for 5-HT₆ binding affinity of arylsulfonyl derivatives: a computational study. | International journal of molecular sciences 20110101 |
| Combined 3D-QSAR and docking modelling study on indolocarbazole series compounds as Tie-2 inhibitors. | International journal of molecular sciences 20110101 |
| Investigation on quantitative structure activity relationships and pharmacophore modeling of a series of mGluR2 antagonists. | International journal of molecular sciences 20110101 |
| A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates. | Scientia pharmaceutica 20110101 |
| The importance of being profiled: improving drug candidate safety and efficacy using ion channel profiling. | Frontiers in pharmacology 20110101 |
| In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors. | International journal of molecular sciences 20110101 |
| New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond. | Therapeutics and clinical risk management 20110101 |
| Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor. | International journal of molecular sciences 20110101 |
| Molecular-field-based three-dimensional similarity studies on quinoline-based CNS active agents. | ISRN pharmaceutics 20110101 |
| Synthesis, antimicrobial and antioxidant activity of some oxindoles. | Indian journal of pharmaceutical sciences 20110101 |
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| Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. | Bioorganic & medicinal chemistry letters 20101215 |
| Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201 |
| A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation. | European journal of medicinal chemistry 20101201 |
| 3-[2-(1H-Benzimidazol-2-ylsulfan-yl)eth-yl]-1,3-oxazolidin-2-one. | Acta crystallographica. Section E, Structure reports online 20101201 |
| Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives. | Journal of medicinal chemistry 20101125 |
| A myosin V inhibitor based on privileged chemical scaffolds. | Angewandte Chemie (International ed. in English) 20101102 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| 3'-Hy-droxy-methyl-1'-methyl-3'-nitro-4'-(o-tol-yl)spiro-[indoline-3,2'-pyrrolidin]-2-one. | Acta crystallographica. Section E, Structure reports online 20101101 |
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| Palladium-catalyzed tandem diperoxidation/C-H activation resulting in diperoxy-oxindole in air. | Organic letters 20101015 |
| Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. | Journal of medicinal chemistry 20101014 |
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| Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters. | Organic letters 20101001 |
| 4-(3-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20101001 |
| Methyl 3-[(1H-benzimidazol-1-yl)meth-yl]-1-methyl-4-(4-methyl-phen-yl)-2'-oxopyrrolidine-2-spiro-3'-1-benzimidazole-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20101001 |
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| Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates. | Chemical communications (Cambridge, England) 20100928 |
| The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists. | Bioorganic & medicinal chemistry letters 20100915 |
| A facile method for the synthesis of oxindole based quaternary alpha-aminonitriles via the Strecker reaction. | Organic & biomolecular chemistry 20100907 |
| Synthesis of selenophene derivatives as novel CHK1 inhibitors. | Bioorganic & medicinal chemistry letters 20100901 |
| 1-(2-Oxoindolin-3-yl-idene)-4-[2-(tri-fluoro-meth-yl)phen-yl]thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100901 |
| 1-(2-Oxoindolin-3-yl-idene)-4-[2-(trifluoro-meth-oxy)phen-yl]thio-semi-carbazide. | Acta crystallographica. Section E, Structure reports online 20100901 |
| 5'-Amino-2-oxo-2',3'-dihydro-spiro-[indoline-3,7'-thieno[3,2-b]pyran]-6'-carbonitrile 1',1'-dioxide. | Acta crystallographica. Section E, Structure reports online 20100901 |
| 3-[2-(5H-Indolo[2,3-b]quinoxalin-5-yl)eth-yl]-1,3-oxazolidin-2-one. | Acta crystallographica. Section E, Structure reports online 20100901 |
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| Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B. | Angewandte Chemie (International ed. in English) 20100809 |
| First C-H activation route to oxindoles using copper catalysis. | Organic letters 20100806 |
| Oxidative protein labeling in mass-spectrometry-based proteomics. | Analytical and bioanalytical chemistry 20100801 |
| Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. | Bioorganic & medicinal chemistry letters 20100801 |
| N'-(1-Allyl-2-oxoindolin-3-yl-idene)benzohydrazide. | Acta crystallographica. Section E, Structure reports online 20100801 |
| 2-Chloro-N-isopropyl-N-phenyl-acetamide. | Acta crystallographica. Section E, Structure reports online 20100801 |
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| Organocatalytic enantioselective hydroxymethylation of oxindoles with paraformaldehyde as C1 unit. | The Journal of organic chemistry 20100716 |
| Highly diastereo- and enantioselective Michael additions of 3-substituted oxindoles to maleimides catalyzed by chiral bifunctional thiourea-tertiary amine. | Organic letters 20100702 |
| Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors. | Bioorganic & medicinal chemistry 20100701 |
| 4-(2-Ethyl-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100701 |
| (Z)-2-(2-Isopropyl-5-methyl-phen-oxy)-N'-(2-oxoindolin-3-yl-idene)acetohydrazide. | Acta crystallographica. Section E, Structure reports online 20100701 |
| 4-(3-Iodo-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100701 |
| 1-[2-Oxo-5-(trifluoro-meth-oxy)indolin-3-yl-idene]-4-[4-(trifluoro-methyl)-phen-yl]thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100701 |
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| Highly enantioselective synthesis of 3-amino-2-oxindole derivatives: catalytic asymmetric alpha-amination of 3-substituted 2-oxindoles with a chiral scandium complex. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100611 |
| Oxidative dearomatization in the synthesis of erythrina, oxindole and hexahydropyrrolo[2,3-b]indole skeletons. | Chemical communications (Cambridge, England) 20100607 |
| Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to spiro[pyrrolidine-3,3'-oxindoles]. Total synthesis of (+/-)-coerulescine, (+/-)-horsfiline, (+/-)-elacomine, and (+/-)-6-deoxyelacomine. | The Journal of organic chemistry 20100604 |
| Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy. | The American journal of gastroenterology 20100601 |
| Xanthine oxidase/tyrosinase inhibiting, antioxidant, and antifungal oxindole alkaloids from Isatis costata. | Pharmaceutical biology 20100601 |
| 4-(3-Methoxy-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100601 |
| 4-(3-Nitro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100601 |
| (E,Z)-3-(3',5'-Dimethoxy-4'-hydroxy-benzylidene)-2-indolinone blocks mast cell degranulation. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100512 |
| Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids. | The Journal of organic chemistry 20100507 |
| Six-component reactions for the stereoselective synthesis of 3-arylidene-2-oxindoles via sequential one-pot Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition. | The Journal of organic chemistry 20100507 |
| Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer. | The oncologist 20100501 |
| 4-(2-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100501 |
| 4-(5-Chloro-2-methyl-phen-yl)-1-[2-oxo-5-(trifluoro-meth-oxy)indolin-3-yl-idene]thio-semicarbazide. | Acta crystallographica. Section E, Structure reports online 20100501 |
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| An efficient stereoselective synthesis of 3-spirocyclopentene- and 3-spiropyrazole-2-oxindoles via 1,3-dipolar cycloaddition reaction. | Chemical communications (Cambridge, England) 20100428 |
| Evolution of a strategy for total synthesis of the marine fungal alkaloid (+/-)-communesin F. | The Journal of organic chemistry 20100416 |
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| Catalytic asymmetric synthesis of 3-(alpha-hydroxy-beta-carbonyl) oxindoles by a Sc(III)-catalyzed direct aldol-type reaction. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100322 |
| Highly enantioselective intramolecular cyanoamidation: (+)-horsfiline, (-)-coerulescine, and (-)-esermethole. | Organic letters 20100305 |
| Predictive comparative QSAR modelling of (phenylpiperazinyl-alkyl) oxindoles as selective 5-HT1A antagonists by stepwise regression, PCRA, FA-MLR and PLS techniques. | European journal of medicinal chemistry 20100301 |
| Organocatalytic tandem reaction to construct six-membered spirocyclic oxindoles with multiple chiral centres through a formal [2+2+2] annulation. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100301 |
| 4'-(2,4-Dichloro-phen-yl)-1,1'-dimethyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione. | Acta crystallographica. Section E, Structure reports online 20100301 |
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| Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib. | Acta crystallographica. Section C, Crystal structure communications 20100201 |
| 5-Chloro-benzothia-zole-2-spiro-3'-indolin-2'-one. | Acta crystallographica. Section E, Structure reports online 20100201 |
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| Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line. | Molecular cancer 20100101 |
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| 1-Benzyl-4',5'-diphenyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione. | Acta crystallographica. Section E, Structure reports online 20090101 |
| (Z)-5-Fluoro-3-[(1H-pyrrol-2-yl)methyl-ene]indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20090101 |
| Catalytic enantioselective Meerwein-Eschenmoser Claisen rearrangement: asymmetric synthesis of allyl oxindoles. | Journal of the American Chemical Society 20081203 |
| Stereoselective synthesis of 3-alkylideneoxindoles by palladium-catalyzed cyclization reaction of 2-(alkynyl)aryl isocyanates with organoboron reagents. | Organic letters 20081106 |
| Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib. | British journal of cancer 20081104 |
| Synthesis and biological evaluation of diversely substituted indolin-2-ones. | European journal of medicinal chemistry 20081101 |
| Benzoxazinoid biosynthesis in dicot plants. | Phytochemistry 20081101 |
| (13)C, (15)N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from Cat's Claw (Uncaria tomentosa). | Solid state nuclear magnetic resonance 20081101 |
| (E)-5-Chloro-3-(2,6-dichloro-benzyl-idene)-indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20081101 |
| Rearrangement of spirocyclic oxindoles with lithium amide bases. | Organic letters 20081016 |
| Samarium(II)-mediated spirocyclization by intramolecular aryl radical addition onto an aromatic ring. | The Journal of organic chemistry 20080919 |
| Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments. | Organic letters 20080918 |
| Stereoselective oxidative rearrangement of 2-aryl tryptamine derivatives. | Organic letters 20080918 |
| Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. | Bioorganic & medicinal chemistry letters 20080915 |
| Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis. | Chemical communications (Cambridge, England) 20080914 |
| Combined 3D-QSAR modeling and molecular docking study on indolinone derivatives as inhibitors of 3-phosphoinositide-dependent protein kinase-1. | Journal of chemical information and modeling 20080901 |
| 1',5-Dinitro-2'-phenyl-2',3',5',6',7',7a'-hexa-hydro-spiro-[indoline-3,3'-1'H-pyrrolizin]-2-one. | Acta crystallographica. Section E, Structure reports online 20080901 |
| Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. | Journal of medicinal chemistry 20080828 |
| Intermolecular enolate heterocoupling: scope, mechanism, and application. | Journal of the American Chemical Society 20080827 |
| Organocatalytic stereoselective mannich reaction of 3-substituted oxindoles. | Organic letters 20080821 |
| Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation. | Organic letters 20080807 |
| 2'-Methyl-2'-nitro-1'-phenyl-2',3',5',6',7',7a'-hexa-hydro-spiro-[indoline-3,3'-1'H-pyrrolizin]-2-one. | Acta crystallographica. Section E, Structure reports online 20080801 |
| Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles. | Journal of the American Chemical Society 20080723 |
| Palladium-catalyzed C-H functionalization of N-arylpropiolamides with aryliodonium salts: selective synthesis of 3-(1-arylmethylene)oxindoles. | The Journal of organic chemistry 20080718 |
| Facile and general synthesis of quaternary 3-aminooxindoles. | Organic letters 20080703 |
| BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. | Cancer research 20080615 |
| Molecular docking/dynamics studies of Aurora A kinase inhibitors. | Journal of molecular graphics & modelling 20080601 |
| Synthesis of (2-oxoindolin-3-ylidene)methyl acetates involving a C-H functionalization process. | Organic letters 20080501 |
| Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays. | Proteomics 20080501 |
| 1-Allyl-3,3-diphenyl-indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20080501 |
| 1-Allyl-3,3-di-p-tolyl-indolin-2-one. | Acta crystallographica. Section E, Structure reports online 20080501 |
| (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists. | Journal of medicinal chemistry 20080424 |
| Palladium-catalyzed alpha-arylation of oxindoles. | Organic letters 20080403 |
| Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). | Journal of medicinal chemistry 20080327 |
| A new route to indolines by the Cu-catalyzed cyclization reaction of 2-ethynylanilines with sulfonyl azides. | Organic letters 20080320 |
| Fragment-based de novo ligand design by multiobjective evolutionary optimization. | Journal of chemical information and modeling 20080301 |
| 5'-Chloro-spiro-[1,3-dioxolane-2,3'-indolin]-2'-one: a potential anti-convulsant. | Acta crystallographica. Section E, Structure reports online 20080301 |
| Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid. | Organic letters 20080207 |
| 1'-Phenyl-6'-thia-cyclo-heptane-1-spiro-2'-perhydro-pyrrolizine-3'-spiro-3''-indoline-2,2''-dione. | Acta crystallographica. Section E, Structure reports online 20080201 |
| 4'-Amino-2,2''-dioxo-2,2'',3,3''-tetra-hydro-1H-indole-3-spiro-1'-cyclo-pent-3'-ene-2'-spiro-3''-1H-indole-3',5',5'-tricarbonitrile dihydrate. | Acta crystallographica. Section E, Structure reports online 20080201 |
| 1-Aminoindanes as novel motif with potential atypical antipsychotic properties. | Bioorganic & medicinal chemistry letters 20080115 |
| Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors. | Journal of medicinal chemistry 20080110 |
| (2E)-N-(2-iodo-4,6-dimethylphenyl)-2-methylbut-2-enamide. | Acta crystallographica. Section C, Crystal structure communications 20080101 |
| Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity. | Journal of inorganic biochemistry 20080101 |
| [Synthesis of 1-furfuryl-indolin-2-one derivatives and preliminary evaluation of their antitumor activities]. | Yao xue xue bao = Acta pharmaceutica Sinica 20080101 |
| Palladium-catalyzed tandem Heck reaction/C-H functionalization--preparation of spiro-indane-oxindoles. | Angewandte Chemie (International ed. in English) 20080101 |
| Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense. | PloS one 20080101 |
| Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium-catalyzed intramolecular C-H functionalization. | Beilstein journal of organic chemistry 20080101 |
| Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV. | Nucleic acids symposium series (2004) 20080101 |
| Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases. | Current chemical genomics 20080101 |
| Oxindolealanine in age-related human cataracts. | Experimental eye research 20071201 |
| Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles. | Journal of the American Chemical Society 20071128 |
| Potent oxindole based human beta3 adrenergic receptor agonists. | Bioorganic & medicinal chemistry letters 20071115 |
| Design, synthesis and pharmacological evaluation of HIV-1 reverse transcriptase inhibition of new indolin-2-ones. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20071101 |
| Enantioselective construction of spirocyclic oxindolic cyclopentanes by palladium-catalyzed trimethylenemethane-[3+2]-cycloaddition. | Journal of the American Chemical Society 20071017 |
| Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition. | Organic letters 20071011 |
| The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. | FEBS letters 20070918 |
| Substitution and cyclization reactions involving the quasi-antiaromatic 2H-indol-2-one ring system. | Organic letters 20070913 |
| Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) D. C. cell suspension cultures via oxidative burst. | Biotechnology and bioengineering 20070901 |
| Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand. | Bioorganic & medicinal chemistry 20070901 |
| Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety. | Bioorganic & medicinal chemistry letters 20070901 |
| 1'-Methylcyclooctane-1-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2,2''-dione and 1,1'-dimethylpiperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2'',4-dione. | Acta crystallographica. Section C, Crystal structure communications 20070901 |
| Palladium-catalyzed carbonylative annulation reaction of 2-(1-alkynyl)benzenamines: selective synthesis of 3-(halomethylene)indolin-2-ones. | Organic letters 20070816 |
| Sunitinib malate. | Cancer chemotherapy and pharmacology 20070801 |
| Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. | Bioorganic & medicinal chemistry letters 20070715 |
| Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. | Bioorganic & medicinal chemistry letters 20070715 |
| Straightforward stereoselective synthesis of spiro-epoxyoxindoles. | Organic letters 20070426 |
| Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20070401 |
| Synthesis and biological evaluation of 3-(substituted-benzylidene)-1,3-dihydro-indolin derivatives as human protein kinase CK2 and p60(c-Src) tyrosine kinase inhibitors. | Biological & pharmaceutical bulletin 20070401 |
| Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation. | The Journal of organic chemistry 20070330 |
| Isatinones A and B, new antifungal oxindole alkaloids from Isatis costata. | Molecules (Basel, Switzerland) 20070206 |
| Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS. | Planta medica 20070201 |
| c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. | British journal of cancer 20070129 |
| Acid-promoted cyclization reactions of tetrahydroindolinones. Model studies for possible application in a synthesis of selaginoidine. | The Journal of organic chemistry 20070119 |
| Structure-activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines. | Analytica chimica acta 20070109 |
| Simple and one-pot protocol for synthesis of indene-spiro-oxindoles involving tandem Prins and Friedel-Crafts reactions. | Organic letters 20070104 |
| Palladium-catalyzed enantioselective domino heck-cyanation sequence: development and application to the total synthesis of esermethole and physostigmine. | Chemistry (Weinheim an der Bergstrasse, Germany) 20070101 |
| Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives. | Acta pharmacologica Sinica 20070101 |
| 3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101 |
| A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles. | Journal of combinatorial chemistry 20070101 |
| Generation of FGF reporter transgenic zebrafish and their utility in chemical screens. | BMC developmental biology 20070101 |
| Cinchona-alkaloid-catalyzed enantioselective direct aldol-type reaction of oxindoles with ethyl trifluoropyruvate. | Angewandte Chemie (International ed. in English) 20070101 |
| Antiangiogenic agents: an update on small molecule VEGFR inhibitors. | Current medicinal chemistry 20070101 |
| Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. | Journal of neural transmission. Supplementum 20070101 |
| Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and beta-keto esters using DBFOX ligand. | Journal of the American Chemical Society 20061227 |
| In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. | Biochemistry 20061226 |
| Enantioselective arylation of 2-methylacetoacetates catalyzed by CuI/trans-4-hydroxy-L-proline at low reaction temperatures. | Journal of the American Chemical Society 20061220 |
| Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors. | Molecular cancer therapeutics 20061201 |
| Biophysical characterization of an indolinone inhibitor in the ATP-binding site of DNA gyrase. | Biochemical and biophysical research communications 20061103 |
| Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates. | The Journal of organic chemistry 20061027 |
| Heteroyohimbinoid type oxindole alkaloids from Mitragyna parvifolia. | Phytochemistry 20061001 |
| Acid-base catalysis of chiral Pd complexes: development of novel catalytic asymmetric reactions and their application to synthesis of drug candidates. | Chemical & pharmaceutical bulletin 20061001 |
| Paratunamides A-D, oxindole alkaloids from Cinnamodendron axillare. | Journal of natural products 20061001 |
| An efficient synthesis of a spirocyclic oxindole analogue. | Molecules (Basel, Switzerland) 20060914 |
| Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2. | The Journal of organic chemistry 20060818 |
| General strategy for the syntheses of corynanthe, tacaman, and oxindole alkaloids. | The Journal of organic chemistry 20060818 |
| Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1. | Biochemical pharmacology 20060814 |
| Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. | Journal of neuroscience research 20060801 |
| Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers. | Bioorganic & medicinal chemistry letters 20060701 |
| Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties. | European journal of medicinal chemistry 20060601 |
| Palladium asymmetric allylic alkylation of prochiral nucleophiles: horsfiline. | Organic letters 20060511 |
| Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2. | Bioorganic & medicinal chemistry letters 20060415 |
| Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I. | Bioorganic & medicinal chemistry letters 20060415 |
| Selective kinase inhibition by exploiting differential pathway sensitivity. | Chemistry & biology 20060401 |
| Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular Heck reaction. | The Journal of organic chemistry 20060331 |
| Highly diastereoselective one-pot synthesis of spirocyclic oxindoles through intramolecular Ullmann coupling and Claisen rearrangement. | Angewandte Chemie (International ed. in English) 20060327 |
| Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups. | Blood 20060301 |
| Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416. | Toxicology in vitro : an international journal published in association with BIBRA 20060301 |
| Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. | British journal of haematology 20060301 |
| A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. | Phytotherapy research : PTR 20060301 |
| Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686. | Combinatorial chemistry & high throughput screening 20060301 |
| Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. | Chemical research in toxicology 20060301 |
| Synthesis of the putative structure of fistulosin using the ruthenium-catalyzed cycloisomerization of diene. | The Journal of organic chemistry 20060203 |
| A new chemical tool for exploring the physiological function of the PDE2 isozyme. | Bioorganic & medicinal chemistry letters 20060115 |
| The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. | BMC complementary and alternative medicine 20060101 |
| Synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1H-indole-2-ones and investigation of their structure-activity relationships. | Arzneimittel-Forschung 20060101 |
| Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40). | Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101 |
| Oxindole synthesis through intramolecular nucleophilic addition of vinylpalladiums to aryl isocyanates. | Angewandte Chemie (International ed. in English) 20051202 |
| In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors. | Bioorganic & medicinal chemistry letters 20051201 |
| Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor. | Bioorganic & medicinal chemistry letters 20051115 |
| Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach. | European journal of medicinal chemistry 20051101 |
| Inflammation 2005 - Seventh World Congress. Highlights I. | IDrugs : the investigational drugs journal 20051001 |
| Rapid access to the Welwitindolinone alkaloid skeleton by cyclization of indolecarboxaldehyde substituted cyclohexanones. | Organic letters 20050915 |
| Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. | Evidence-based complementary and alternative medicine : eCAM 20050901 |
| Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis. | Journal of medicinal chemistry 20050825 |
| Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions. | The Journal of organic chemistry 20050819 |
| SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists. | Bioorganic & medicinal chemistry letters 20050801 |
| Catalytic enantioselective fluorination of oxindoles. | Journal of the American Chemical Society 20050727 |
| Identification of degradation products of diclofenac by electrospray ion trap mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20050715 |
| Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies. | European journal of pharmacology 20050711 |
| Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives. | Biopolymers 20050701 |
| Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis. | Journal of cellular biochemistry 20050701 |
| Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa. | Pharmacology, biochemistry, and behavior 20050701 |
| Nitrated and oxidized products of a single tryptophan residue in human Cu,Zn-superoxide dismutase treated with either peroxynitrite-carbon dioxide or myeloperoxidase-hydrogen peroxide-nitrite. | Journal of biochemistry 20050701 |
| TiCl4 catalyzed tandem construction of C-C and C-O bonds: a simple and one-pot atom-economical stereoselective synthesis of spiro-oxindoles. | Chemical communications (Cambridge, England) 20050528 |
| Identification of natural dyes used in works of art by pyrolysis-gas chromatography/mass spectrometry combined with in situ trimethylsilylation. | Analytical and bioanalytical chemistry 20050501 |
| Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor. | Proteomics 20050401 |
| Structure-activity relationships of the oxindole growth hormone secretagogues. | Bioorganic & medicinal chemistry letters 20050401 |
| AG-041R, a novel indoline-2-one derivative, stimulates chondrogenesis in a bipotent chondroprogenitor cell line CL-1. | Osteoarthritis and cartilage 20050401 |
| A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth. | Molecular cancer therapeutics 20050401 |
| Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. | Journal of immunology (Baltimore, Md. : 1950) 20050301 |
| Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C. | Organic letters 20050217 |
| An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid. | Journal of ethnopharmacology 20050115 |
| HPLC quantification of uncarine D and the anti-plasmodial activity of alkaloids from leaves of Mitragyna inermis (Willd.) O. Kuntze. | Phytochemical analysis : PCA 20050101 |
| Recent developments on KCNQ potassium channel openers. | Current medicinal chemistry 20050101 |
| Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. | Toxicological reviews 20050101 |
| Genotoxic and cytotoxic studies of beta-sitosterol and pteropodine in mouse. | Journal of biomedicine & biotechnology 20050101 |
| Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. | Journal of inflammation (London, England) 20050101 |
| Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: synthesis of 3-allyl-3-aryl oxindoles. | Angewandte Chemie (International ed. in English) 20041227 |
| MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. | International journal of cancer 20041220 |
| Identification of indigoid dyes in natural organic pigments used in historical art objects by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry. | Journal of mass spectrometry : JMS 20041201 |
| A Lewis acid-promoted cyclization of ethenetricarboxylate derivative aromatic compounds. Novel syntheses of oxindoles and benzofuranones via Friedel-Crafts intramolecular Michael addition. | Organic & biomolecular chemistry 20041107 |
| Methanol extracts of Hamelia patens containing oxindole alkaloids relax KCl-induced contraction in rat myometrium. | Biological & pharmaceutical bulletin 20041001 |
| 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. | Journal of experimental therapeutics & oncology 20041001 |
| One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formation of a small oxindole library. | Organic letters 20040930 |
| Tissue distribution of molidone in a multidrug overdose. | Journal of analytical toxicology 20040901 |
| New spirocyclic oxindole synthesis based on a hetero Claisen rearrangement. | Organic letters 20040708 |
| Electroorganic synthesis using a fluoride ion mediator under ultrasonic irradiation: synthesis of oxindole and 3-oxotetrahydroisoquinoline derivatives. | Organic letters 20040708 |
| Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma. | Journal of the National Cancer Institute 20040707 |
| Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton. | Chemical communications (Cambridge, England) 20040521 |
| Novel pyrrole-containing progesterone receptor modulators. | Bioorganic & medicinal chemistry letters 20040503 |
| Substituted E-3-(2-Chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity. | Bioorganic & medicinal chemistry 20040301 |
| Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells. | Die Pharmazie 20040301 |
| A new series of potent oxindole inhibitors of CDK2. | Bioorganic & medicinal chemistry letters 20040223 |
| Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. | Bioorganic & medicinal chemistry letters 20040223 |
| A holistic passive integrative sampling approach for assessing the presence and potential impacts of waterborne environmental contaminants. | Chemosphere 20040201 |
| Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase. | Bioorganic & medicinal chemistry letters 20040105 |
| Characterisation of natural indigo and shellfish purple by mass spectrometric techniques. | Rapid communications in mass spectrometry : RCM 20040101 |
| [Effects of 3-substituted aryl oxindole(PH II-7) on cell cycle of tumor cells]. | Yao xue xue bao = Acta pharmaceutica Sinica 20031101 |
| New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.). | Chemical & pharmaceutical bulletin 20031001 |
| Mapping the kinase domain of Janus Kinase 3. | Bioorganic & medicinal chemistry letters 20030915 |
| Inactivation of Ret/Ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1. | Cellular and molecular life sciences : CMLS 20030701 |
| Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid. | Organic letters 20030612 |
| Potential inhibitors of angiogenesis. Part I: 3-(imidazol-4(5)-ylmethylene)indolin-2-ones. | Journal of enzyme inhibition and medicinal chemistry 20030601 |
| SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. | Molecular cancer therapeutics 20030501 |
| Synthesis of potent oxindole CDK2 inhibitors. | Bioorganic & medicinal chemistry 20030417 |
| Enantioselective fluorination mediated by N-fluoroammonium salts of cinchona alkaloids: first enantioselective synthesis of BMS-204352 (MaxiPost). | The Journal of organic chemistry 20030321 |
| A short diastereoselective synthesis of the putative alkaloid jamtine, using a tandem pummerer/mannich cyclization sequence. | The Journal of organic chemistry 20030207 |
| AG-041R stimulates cartilage matrix synthesis without promoting terminal differentiation in rat articular chondrocytes. | Osteoarthritis and cartilage 20030201 |
| Gelsemine: a thought-provoking target for total synthesis. | Angewandte Chemie (International ed. in English) 20030103 |
| Reactions of the ionized enol tautomer of acetanilide: elimination of HNCO via a novel rearrangement. | European journal of mass spectrometry (Chichester, England) 20030101 |
| RET/PTC oncoproteins: molecular targets of new drugs. | Tumori 20030101 |
| Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine. | Organic letters 20021128 |
| SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. | Blood 20021015 |
| Further insights into the reaction of melatonin with hydroxyl radical. | Bioorganic chemistry 20021001 |
| Enantioselective total synthesis of quadrigemine C and psycholeine. | Journal of the American Chemical Society 20020807 |
| Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. | Blood 20020715 |
| Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors. | Bioorganic & medicinal chemistry letters 20020617 |
| Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20020501 |
| Densitometric determination of diclofenac, 1-(2,6-dichlorophenyl)indolin-2-one and indolin-2-one in pharmaceutical preparations and model solutions. | Journal of pharmaceutical and biomedical analysis 20020415 |
| The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels. | Bioorganic & medicinal chemistry letters 20020408 |
| Rational determination of transfer free energies of small drugs across the water-oil interface. | Journal of medicinal chemistry 20020103 |
| Relationship between structures of substituted indolic compounds and their degradation by marine anaerobic microorganisms. | Marine pollution bulletin 20020101 |
| Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. | Progress in brain research 20020101 |
| Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. | Angiogenesis 20020101 |
| Oxindole derivatives as orally active potent growth hormone secretagogues. | Journal of medicinal chemistry 20011220 |
| Azomethine ylide cycloaddition/reductive heterocyclization approach to oxindole alkaloids: asymmetric synthesis of (-)-horsfiline. | The Journal of organic chemistry 20011214 |
| Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686. | The Journal of endocrinology 20011201 |
| Why are the terpenoid indole alkaloids of type I homochiral? | Chirality 20010801 |
| Investigation of Uña De Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa. | Phytochemistry 20010701 |
| Improved method for the determination of oxindole alkaloids in Uncaria tomentosa by high performance liquid chromatography. | Planta medica 20010701 |
| Synthesis, absolute configuration, and enantiomeric enrichment of a cruciferous oxindole phytoalexin, (S)-(-)-spirobrassinin, and its oxazoline analog. | The Journal of organic chemistry 20010601 |
| Improved catalysts for the palladium-catalyzed synthesis of oxindoles by amide alpha-arylation. Rate acceleration, use of aryl chloride substrates, and a new carbene ligand for asymmetric transformations. | The Journal of organic chemistry 20010518 |
| Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity. | Bioorganic & medicinal chemistry letters 20010507 |
| Diclofenac sodium injection sterilized by autoclave and the occurrence of cyclic reaction producing a small amount of impurity. | Journal of pharmaceutical sciences 20010501 |
| Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells. | Cancer research 20010501 |
| AG-041R, a novel indoline-2-one derivative, induces systemic cartilage hyperplasia in rats. | European journal of pharmacology 20010427 |
| Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E. | Acta crystallographica. Section C, Crystal structure communications 20010401 |
| Weekly dosing with the platelet-derived growth factor receptor tyrosine kinase inhibitor SU9518 significantly inhibits arterial stenosis. | Circulation research 20010330 |
| Novel oxindole derivatives and their biological activity. | Folia microbiologica 20010101 |
| Crystal structure of a conformation-selective casein kinase-1 inhibitor. | The Journal of biological chemistry 20000630 |
| Characterization of novel inhibitors of cyclin-dependent kinases. | Biochemical and biophysical research communications 19990714 |
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