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58-74-2

58-74-2 | Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-

CAS No: 58-74-2 Catalog No: AG00E8WB MDL No:MFCD00024138

Product Description

Catalog Number:
AG00E8WB
Chemical Name:
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-
CAS Number:
58-74-2
Molecular Formula:
C20H21NO4
Molecular Weight:
339.3850
MDL Number:
MFCD00024138
IUPAC Name:
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
InChI:
InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
InChI Key:
XQYZDYMELSJDRZ-UHFFFAOYSA-N
SMILES:
COc1ccc(cc1OC)Cc1nccc2c1cc(OC)c(c2)OC
EC Number:
200-397-2
UNII:
DAA13NKG2Q
NSC Number:
136630

Properties

Complexity:
407  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
339.147g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
339.391g/mol
Monoisotopic Mass:
339.147g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
49.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  

Literature

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Vasorelaxant effect of iloprost on isolated human internal mammary artery. Fundamental & clinical pharmacology 20070201
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Isometric contraction of microvascular pericytes from mouse brain parenchyma. Microvascular research 20070101
Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. International urology and nephrology 20070101
Different hemodynamic responses by color Doppler ultrasonography studies between sildenafil non-responders and responders. Asian journal of andrology 20070101
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Application of derivative, derivative ratio, and multivariate spectral analysis and thin-layer chomatography-densitometry for determination of a ternary mixture containing drotaverine hydrochloride, caffeine, and paracetamol. Journal of AOAC International 20070101
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Haemodynamic changes after intracisternal papaverine instillation during intracranial aneurysmal surgery. British journal of anaesthesia 20061201
Buffered papaverine facilitates passage of intratympanic dexamethasone to the inner ear. Acta oto-laryngologica 20061201
Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon. The Journal of physiology 20061015
[Analysis of 37 drugs in whole blood by HPLC after solid phase extraction]. Fa yi xue za zhi 20061015
Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurosurgical focus 20060915
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits. The journal of sexual medicine 20060901
Design, microwave-assisted synthesis, and spasmolytic activity of 2-(alkyloxyaryl)-1H-benzimidazole derivatives as constrained stilbene bioisosteres. Bioorganic & medicinal chemistry letters 20060815
A novel bronchial ring bioassay for the evaluation of small airway smooth muscle function in mice. American journal of physiology. Lung cellular and molecular physiology 20060801
Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis. Neuropharmacology 20060801
The significance of putative urinary markers of illicit heroin use after consumption of poppy seed products. Therapeutic drug monitoring 20060801
[Determination of papaverine in Qiangli Pipalu by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060801
In vivo X-ray angiography in the mouse brain using synchrotron radiation. Stroke 20060701
Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products. Journal of pharmaceutical and biomedical analysis 20060616
Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma. Journal of pharmaceutical and biomedical analysis 20060607
A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules. Chemical & pharmaceutical bulletin 20060601
Isoquinoline derivatives as potential acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters 20060415
Vasopressin as adjunct vasopressor for vasodilatory shock due to non-occlusive mesenteric ischemia. Der Anaesthesist 20060301
Long-term treatment with intracavernosal injections in diabetic men with erectile dysfunction. Asian journal of andrology 20060301
Interaction of papaverine with the enalapril-induced cough in guinea pig. Acta physiologica Hungarica 20060301
Assessment of renal flow and flow reserve in humans. Journal of the American College of Cardiology 20060207
Feasibility of vitrification as a storage method for tissue-engineered blood vessels. Tissue engineering 20060201
Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum. European journal of pharmacology 20060113
Effects of papaverine and glycerylnitrate-verapamil solution as topical and intraluminal vasodilators for internal thoracic artery. The Annals of thoracic surgery 20060101
Inhibitory effect of erythropoietin on contractility of human chorionic plate vessels. American journal of obstetrics and gynecology 20060101
Atmospheric pressure ionisation mass spectrometric fragmentation pathways of noscapine and papaverine revealed by multistage mass spectrometry and in-source deuterium labelling. Rapid communications in mass spectrometry : RCM 20060101
Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits. International journal of urology : official journal of the Japanese Urological Association 20060101
Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods. Journal of AOAC International 20060101
The hypoactive corpora cavernosa with degenerative erectile dysfunction: a new syndrome. BMC urology 20060101
Effect of phentolamine on the hyperemic response to adenosine in patients with microvascular disease. The American journal of cardiology 20051215
Colonic blood flow responses in experimental colitis: time course and underlying mechanisms. American journal of physiology. Gastrointestinal and liver physiology 20051201
Clinical and duplex US assessment of effects of sildenafil on cavernosal arteries of the penis: comparison with intracavernosal injection of vasoactive agents--initial experience. Radiology 20051201
Ionic liquid-based aqueous two-phase system, a sample pretreatment procedure prior to high-performance liquid chromatography of opium alkaloids. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105
Erectile dysfunction in spinal cord injury: a cost-utility analysis. Journal of rehabilitation medicine 20051101
C-type natriuretic peptide relaxes human coronary artery bypass grafts preconstricted by endothelin-1. The Annals of thoracic surgery 20051001
Intracavernous papaverine/phentolamine-induced priapism can be accurately predicted with color Doppler ultrasonography. Urology 20051001
HPLC and chemometric assisted spectrophotometric methods for simultaneous determination of diprophylline, phenobarbitone and papaverine hydrochloride. Farmaco (Societa chimica italiana : 1989) 20050901
Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage. Clinical radiology 20050901
[Analysis of two year heroin seizures in the Liege area]. Revue medicale de Liege 20050901
Transport properties and electroanalytical response characteristics of drotaverine ion-selective sensors. Analytical and bioanalytical chemistry 20050801
Principal opium alkaloids as possible biochemical markers for the source identification of Indian opium. Journal of separation science 20050801
The surgical treatment of Peyronie's disease: replacement of plaque by free autograft of buccal mucosa. European urology 20050701
Inhibitory mechanism of papaverine on carbachol-induced contraction in bovine trachea. Journal of pharmacological sciences 20050701
Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine. Neurosurgery clinics of North America 20050701
An efficient immunoaffinity chromatographic method for extraction and purification of papaverine from samples of pericarpium papaveris and food products. Journal of separation science 20050701
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. International journal of molecular medicine 20050601
In vitro viability of human cavernosal endothelial and fibroblastic cells after exposure to papaverine/phentolamine and prostaglandin E1. BJU international 20050601
Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601
Development of an indirect competitive ELISA for the determination of papaverine. Talanta 20050515
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry 20050505
[Effects of growth hormone supplementation on erectile function and expression of nNOS in aging rats]. Zhonghua nan ke xue = National journal of andrology 20050501
Use of a visual analog scale to assess pain of injection with intracavernous injection therapy. The journal of sexual medicine 20050501
PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats. The European journal of neuroscience 20050201
Small artery remodeling depends on tissue-type transglutaminase. Circulation research 20050107
Participation of ATP in nonadrenergic, noncholinergic relaxation of longitudinal muscle of wistar rat jejunum. Journal of pharmacological sciences 20050101
Arterial wall hyperplasia is increased in placental compared with myoendometrial radial uterine arteries from late-pregnant rats. American journal of obstetrics and gynecology 20050101
A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1. International journal of impotence research 20050101
Cutaneous temperature measurements in men with penile prostheses: a comparison study. International journal of impotence research 20050101
Evaluation of a progressive treatment program for erectile dysfunction in patients with diabetes mellitus. International journal of impotence research 20050101
Effectiveness of vardenafil versus papaverine in penile Doppler ultrasonography. Urologia internationalis 20050101
A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient? Drugs 20050101
[Extra- and intracellular mechanisms of changes in erythrocyte aggregation]. Fiziologiia cheloveka 20050101
[Sildenafil citrate in diagnosis of erectile dysfunction]. Urologiia (Moscow, Russia : 1999) 20050101
Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurocritical care 20050101
Embolic activity subsequent to injection of the internal mammary artery with papaverine hydrochloride. The heart surgery forum 20050101
Transdermal and topical pharmacotherapy for male sexual dysfunction. Expert opinion on drug delivery 20050101
Thin-layer chromatography-densitometry and liquid chromatography analysis of alkaloids in leaves of Papaver somniferum under stress conditions. Journal of AOAC International 20050101
Intracavernous sodium nitroprusside (SNP) versus papaverine/phentolamine in erectile dysfunction: a comparative study of short-term efficacy and side-effects. The journal of sexual medicine 20050101
Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine. The National medical journal of India 20050101
Overactive corpus cavernosum: a novel cause of erectile dysfunction. Andrologia 20041201
Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms. American journal of physiology. Heart and circulatory physiology 20041201
Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography. Urology 20041201
Erectile dysfunction in primary care. The Nurse practitioner 20041201
Microvessels of hamster buccal pouch under conditions of reduced systemic blood pressure. Bulletin of experimental biology and medicine 20041201
Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 20041101
Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041101
Intracavernous chlorpromazine versus phentolamine: a double-blind clinical comparative study. The journal of sexual medicine 20041101
Oral terbutaline in the management of pharmacologically induced prolonged erection. International journal of impotence research 20041001
Accelerating tissue expansion by application of topical papaverine cream. Plastic and reconstructive surgery 20041001
Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. European journal of pharmacology 20040924
Cytotoxicity of different intracavernous vasoactive drugs on cultured endothelial cells of human corpus cavernosum penis. Urology 20040901
Role of adenosine triphosphate-dependent potassium channels in canine penile erection. Urology 20040901
Contribution of increased minimal coronary resistance and attenuated vascular adaptive remodeling to myocardial ischemia in patients with systemic hypertension and ventricular hypertrophy. The American journal of cardiology 20040815
Evaluation of the rat bladder-derived relaxant factor by coaxial bioassay system. European journal of pharmacology 20040714
Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine. Arteriosclerosis, thrombosis, and vascular biology 20040701
Effects of melatonin on impaired neurogenic and endothelial relaxations by bacterial lipopolysaccharide in the mouse corpus cavernosum. Pharmacology 20040701
Effects of bupivacaine enantiomers and ropivacaine on vasorelaxation mediated by adenosine triphosphate-sensitive K(+) channels in the rat aorta. Anesthesiology 20040701
Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction. International journal of impotence research 20040601
[Differences in outcome in patients with poor grade subarachnoid hemorrhage (WFNS grade IV and V): according to the perioperative management against vasospasm]. No shinkei geka. Neurological surgery 20040601
Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension (Dallas, Tex. : 1979) 20040501
Penile vascular abnormalities observed long-term after surgical repair of penile fractures. International journal of urology : official journal of the Japanese Urological Association 20040501
[Combination of serotonergic agents resulted in severe adverse effects]. Lakartidningen 20040429
Clinical and sonographic assessment of the side effects of intracavernous injection of vasoactive substances. International journal of impotence research 20040401
Periarterial application of papaverine during laparoscopic donor nephrectomy improves early graft function after kidney transplantation in pigs. Surgical endoscopy 20040301
Synthesis and antispasmodic activity evaluation of bis-(papaverine) analogues. Chemical & pharmaceutical bulletin 20040301
Long-term intracavernous therapy responders can potentially switch to sildenafil citrate after radical prostatectomy. Urology 20040301
Tempol improves vascular function in the mesenteric vascular bed of senescent rats. Canadian journal of physiology and pharmacology 20040301
[Using prostaglandin inhibitor dicloberl in patients with ureteral calculi]. Likars'ka sprava 20040301
Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. The Biochemical journal 20040215
In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery. American journal of physiology. Heart and circulatory physiology 20040201
Tetra-mu-benzoato-kappa8O:O'-bis([1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline-kappaN]zinc(II)): the first crystal structure with papaverine as a ligand. Acta crystallographica. Section C, Crystal structure communications 20040201
The value of penile duplex in the prediction of intracavernous drug-induced priapism. International journal of impotence research 20040201
Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii. Journal of natural products 20040201
[Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat]. Zhonghua yi xue za zhi 20040117
Changes in renal blood flow reserve after angioplasty of renal artery stenosis in hypertensive patients. Kidney international 20040101
Drotaverine hydrochloride for augmentation of labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20040101
Intracavernous pharmacotherapy for erectile dysfunction. Endocrine 20040101
Bioavailability study of drotaverine from capsule and tablet preparations in healthy volunteers. Arzneimittel-Forschung 20040101
Papaverine, an opium alkaloid influences hepatic and pulmonary glutathione S-transferase activity and glutathione content in rats. European journal of drug metabolism and pharmacokinetics 20040101
Effect of intraurethral papaverine on penile erection in rats. International urology and nephrology 20040101
[New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis]. Klinicheskaia meditsina 20040101
[Genito-sexual dysfunction in patients with a medullary lesion]. Journal de la Societe de biologie 20040101
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation. Cellular signalling 20031201
Effect of nitric oxide synthase inhibitor (L-NAME) on substance P-induced vasodilatation in the dental pulp. International endodontic journal 20031201
Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting. The Journal of thoracic and cardiovascular surgery 20031201
Pulmonary artery vasoactivity in broiler and Leghorn chickens: an age profile. Poultry science 20031201
Retrospective analysis of our cases with sudden hearing loss. The Journal of otolaryngology 20031201
Impaired nitric oxide function in the basilar artery of the obese Zucker rat. Journal of cardiovascular pharmacology 20031001
Long-term efficacy and compliance of intracorporeal (IC) injection for erectile dysfunction following radical prostatectomy: SHIM (IIEF-5) analysis. International journal of impotence research 20031001
Priapism associated with concurrent use of phosphodiesterase inhibitor drugs and intracavernous injection therapy. International journal of impotence research 20031001
Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. American journal of respiratory cell and molecular biology 20030901
[Non-occlusive mesenteric ischemia]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20030901
Advancing age is associated with diminished vascular remodeling and impaired vasodilation in resistance coronary arteries. Coronary artery disease 20030901
Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions. Archiv der Pharmazie 20030901
The influence of periarterial papaverine application on intraoperative renal function and blood flow during laparoscopic donor nephrectomy in a pig model. Surgical endoscopy 20030801
Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year. BJU international 20030801
The effect of papaverine on acute opiate withdrawal in guinea pig ileum. Phytotherapy research : PTR 20030801
Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. The Journal of thoracic and cardiovascular surgery 20030801
The incidence and management of priapism in Western Australia: a 16 year audit. International journal of impotence research 20030801
Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of vascular smooth muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030701
The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. BJU international 20030701
Detrimental effects of papaverine on the human internal thoracic artery. The Journal of thoracic and cardiovascular surgery 20030701
Response by the corpuscles of Stannius to hypotensive stimuli in three divergent ray-finned fishes (Amia calva, Anguilla rostrata, and Catastomus commersoni): cardiovascular and morphological changes. General and comparative endocrinology 20030615
[Conservative treatment of erectile dysfunction]. Orvosi hetilap 20030601
[Comparing effect in the management of erectile dysfunction by using 2 sets of drugs of intracavernosal injection]. Zhonghua nan ke xue = National journal of andrology 20030601
In vivo visualization of subendocardial arteriolar response in renovascular hypertensive hearts. American journal of physiology. Heart and circulatory physiology 20030501
Determination of two ternary mixtures containing phenobarbitone by second derivative of the ratio spectrum-zero-crossing and HPLC methods. Farmaco (Societa chimica italiana : 1989) 20030501
Application of capillary zone electrophoresis in the separation and determination of the principal gum opium alkaloids. Electrophoresis 20030501
Intracoronary and intravenous adenosine 5'-triphosphate, adenosine, papaverine, and contrast medium to assess fractional flow reserve in humans. Circulation 20030415
A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats. Brain research bulletin 20030415
Pharmacological management of erectile dysfunction. BJU international 20030301
Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian journal of andrology 20030301
The effect of chronic renal failure on phosphodiesterase inhibitor-induced relaxation responses in rabbit cavernosal strips. European journal of pharmacology 20030221
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle. European journal of pharmacology 20030221
Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circulation research 20030207
Papaverine blocks hKv1.5 channel current and human atrial ultrarapid delayed rectifier K+ currents. The Journal of pharmacology and experimental therapeutics 20030201
Papaverine angioplasty to treat cerebral vasospasm following traumatic subarachnoid haemorrhage. Anaesthesia and intensive care 20030201
Inhibitory effects of etomidate and ketamine on adenosine triphosphate-sensitive potassium channel relaxation in canine pulmonary artery. Anesthesiology 20030101
Flow injection determination of papaverine based on its sensitizing effect on the chemiluminescence reaction of permanganate-sulfite. Analytical and bioanalytical chemistry 20030101
Comparative study of topical use of vasodilating solutions. Scandinavian journal of plastic and reconstructive surgery and hand surgery 20030101
[Pathogenetic substantiation of sinusoidal modulated currents phoresis of drugs in children with various forms of alopecia areata]. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20030101
Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis. Drugs under experimental and clinical research 20030101
[Influence of fertilizers on yield and yield components of opium from Papaver somniferum Linn]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20030101
The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle. International urology and nephrology 20030101
Functional role of inhibitory and excitatory nerves in the porcine lower urinary tract. European journal of pharmacology 20021205
Topical agents and erectile dysfunction: is there a place? Current urology reports 20021201
Chronological changes of the contractile mechanism in prolonged vasospasm after subarachnoid hemorrhage: from protein kinase C to protein tyrosine kinase. Neurosurgery 20021201
Facial nerve palsy after intracisternal papaverine application during aneurysm surgery--case report. Neurologia medico-chirurgica 20021201
Properties of unitary potentials recorded from myenteric interstitial cells of Cajal distributed in the guinea-pig gastric antrum. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20021201
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. British journal of pharmacology 20021101
Randomized controlled trial investigating the effect of transcervical papaverine and bupivacaine on postoperative analgesia following laparoscopic sterilization. European journal of anaesthesiology 20021101
Electrocardiographic toxicity in the guinea pig. Current protocols in pharmacology 20021101
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. American journal of physiology. Heart and circulatory physiology 20021001
Omeprazole-induced relaxation in rat aorta is partly dependent on endothelium. Pharmacological research 20021001
Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury. Journal of neurosurgery 20021001
Small intestinal submucosa as a tunica albuginea graft material. The Journal of urology 20020901
The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020901
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes. European journal of pharmacology 20020802
Diagnostic steps in the evaluation of patients with erectile dysfunction. The Journal of urology 20020801
Experience with intraplaque injection of verapamil for Peyronie's disease. The Journal of urology 20020801
[Determination of papaverine hydrochloride in skin and blood and the drug contents in pig skin]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020801
Skin reactivity to vasomotor agents in non-eosinophilic and eosinophilic non-allergic rhinitis. The Journal of laryngology and otology 20020701
Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa. Asian journal of andrology 20020601
Pharmacological aspects of erectile dysfunction. Japanese journal of pharmacology 20020601
[Current role of intracavernous therapy in the treatment of erectile dysfunction]. Archivos espanoles de urologia 20020601
[Simple preparation and evaluations of amide-octyl-bonded phase]. Se pu = Chinese journal of chromatography 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations. Journal of pharmaceutical and biomedical analysis 20020415
Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: sildenafil and papaverin generate inhibition. The Prostate 20020401
Periarterial papaverine application improves intraoperative kidney function during laparoscopic donor nephrectomy. The Journal of surgical research 20020401
(+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET. Nuclear medicine and biology 20020401
Oxidation and degradation products of papaverine. Part I: Gadamer and Schulemann's papaverinol synthesis revisited. Archiv der Pharmazie 20020401
[Safety profile of NO-SPA]. Orvosi hetilap 20020317
Experimental stereotactic gamma knife radiosurgery. Vascular contractility studies of the rat middle cerebral artery after chronic survival. Neurological research 20020301
Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations. Planta medica 20020301
Collecting and paramuscular venules in glandular mucosa of rat stomach. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20020301
Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect Beta-adrenoceptor-evoked response in the rat urinary bladder. Pharmacology 20020201
Intracavernous injections for erectile dysfunction in patients with cardiovascular diseases and failure or contraindications for sildenafil citrate. International journal of impotence research 20020201
Combination therapy for erectile dysfunction: a randomized, double blind, unblinded active-controlled, cross-over study of the pharmacodynamics and safety of combined oral formulations of apomorphine hydrochloride, phentolamine mesylate and papaverine hydrochloride in men with moderate to severe erectile dysfunction. International journal of impotence research 20020201
NO-steroids: potent anti-inflammatory drugs with bronchodilating activity in vitro. Biochemical and biophysical research communications 20020111
What nonresponse to intracavernous injection really indicates: a determination by quantitative analysis. The Journal of urology 20020101
Inward remodeling follows chronic vasoconstriction in isolated resistance arteries. Journal of vascular research 20020101
[Intradermal tests with vasomotor agents in chronic noninfectious rhinitis]. Vojnosanitetski pregled 20020101
1H-NMR assay of papaverine hydrochloride and formulations. Phytochemical analysis : PCA 20020101
[Acute ischemia of the hand in a drug addict after accidental intra-arterial injection]. Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera 20020101
[The mechanisms underlying the formation of systemic hemodynamic reactions: role of initial vessel tone and arterial pressure]. Izvestiia Akademii nauk. Seriia biologicheskaia 20020101
Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions. Acta poloniae pharmaceutica 20020101
[Comparative study of the relaxation mechanism in the smooth muscles of bronchi and pulmonary artery in rat]. Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101
Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO. British journal of pharmacology 20011201
Brief pretreatment of radial artery conduits with phenoxybenzamine prevents vasoconstriction long term. The Annals of thoracic surgery 20011201
Vasodilator pre-treatment of human radial arteries; comparison of effects of phenoxybenzamine vs papaverine on norepinephrine-induced contraction in vitro. European heart journal 20011201
Quantitative analysis of papaverine-mediated blood-brain barrier disruption in rats. Biochemical and biophysical research communications 20011130
Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. Bioorganic & medicinal chemistry 20011101
Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101
Diagnosis and treatment of nonocclusive mesenteric ischemia after open heart surgery. The Annals of thoracic surgery 20011101
[Preparation and evaluation of alkyl ether-bonded phase for reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography 20011101
Retention of ionizable compounds on HPLC. 8. Influence of mobile-phase pH change on the chromatographic retention of acids and bases during gradient elution. Analytical chemistry 20011015
Diabetic impotence treated by intracavernosal injections: high treatment compliance and increasing dosage of vaso-active drugs. European urology 20011001
Selective renal vasodilation and active renal artery perfusion improve renal function in dogs with acute heart failure. The Journal of pharmacology and experimental therapeutics 20010901
Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20010901
Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study. Urology 20010901
Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Journal of analytical toxicology 20010901
Intra-arterial papaverine-induced seizures: case report and review of the literature. Surgical neurology 20010901
Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N(1)-agmatine and synthetic analogues. Journal of medicinal chemistry 20010830
eNOS and prostanoid enzymes in lungs of newborn piglets with chronic aortopulmonary shunts. American journal of physiology. Lung cellular and molecular physiology 20010801
Systemic and topical drug administration in the pig ureter: effect of phosphodiesterase inhibitors alpha1, beta and beta2-adrenergic receptor agonists and antagonists on the frequency and amplitude of ureteral contractions. The Journal of urology 20010801
Chronic ethanol consumption impairs adrenoceptor- and purinoceptor-mediated relaxations of isolated rat detrusor smooth muscle. BJU international 20010801
The value of sildenafil as mode of stimulation in pharmaco-penile duplex ultrasonography. International journal of impotence research 20010801
[Erectile disorders: the reality]. Nederlands tijdschrift voor geneeskunde 20010721
Redox signaling of the arteriolar myogenic response. Circulation research 20010720
Intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: an observational study. Sao Paulo medical journal = Revista paulista de medicina 20010705
A new method for the evaluation of erectile dysfunction: sildenafil plus Doppler ultrasonography. The Journal of urology 20010701
Comparative evaluation of treatments for erectile dysfunction in patients with prostate cancer after radical retropubic prostatectomy. BJU international 20010701
Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. British journal of pharmacology 20010701
Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biological & pharmaceutical bulletin 20010701
Pharmacological evaluation of (+)-2- [123I]A-69024: a radioligand for in vivo studies of dopamine D1 receptors. Life sciences 20010629
Acute, nongenomic vasodilatory action of estradiol is attenuated by chronic estradiol treatment. Experimental biology and medicine (Maywood, N.J.) 20010601
Relaxing effects of Ligstrum purpurascens extract and purified acteoside in rat aortic rings. Planta medica 20010601
Intracavernous injections: still the gold standard for treatment of erectile dysfunction in elderly men. International journal of impotence research 20010601
Lead-cadmium interaction effect on the responsiveness of rat mesenteric vessels to norepinephrine and angiotensin II. Toxicology 20010521
Influence of endothelium in dose-dependent inhibition and potentiation by isoniazid of isosorbide dinitrate relaxation of rat aorta. Journal of cardiovascular pharmacology 20010501
Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation. The Journal of urology 20010501
Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors. Journal of the American College of Cardiology 20010501
Intracavernosal injection and intraurethral therapy for erectile dysfunction. The Urologic clinics of North America 20010501
[Response to intracavernous administration of 3 different drugs in the same group of patients with erectile dysfunction]. Archivos espanoles de urologia 20010501
Effect of intracarotid papaverine on human cerebral blood flow and vascular resistance during acute hemispheric arterial hypotension. Journal of neurosurgical anesthesiology 20010401
Phenoxybenzamine is more effective and less harmful than papaverine in the prevention of radial artery vasospasm. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010401
Sildenafil citrate for penile hemodynamic determination: an alternative to intracavernosal agents in Doppler ultrasound evaluation of erectile dysfunction. Urology 20010401
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Validation in dogs of a rapid digital angiographic technique to measure relative coronary blood flow during routine cardiac catheterization. The American journal of cardiology 19850101
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