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Home > Nitro Compounds > 56577-02-7
56577-02-7 | S-nitroso-N-acetylcysteine
CAS No: 56577-02-7 Catalog No: AG00F0FR MDL No:
Product Description
Catalog Number:
AG00F0FR
Chemical Name:
S-nitroso-N-acetylcysteine
CAS Number:
56577-02-7
IUPAC Name:
(2R)-2-acetamido-3-nitrososulfanylpropanoic acid
InChI:
InChI=1S/C5H8N2O4S/c1-3(8)6-4(5(9)10)2-12-7-11/h4H,2H2,1H3,(H,6,8)(H,9,10)/t4-/m0/s1
InChI Key:
QTJKCQPXTOYYHJ-BYPYZUCNSA-N
UNII:
OZ9124L8ZV
Properties
Complexity:
196
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
192.02g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
192.189g/mol
Monoisotopic Mass:
192.02g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
121A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.9
Literature
| Title | Journal |
|---|---|
| A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response. | Nitric oxide : biology and chemistry 20121015 |
| Increased stability of S-nitrosothiol solutions via pH modulations. | Free radical research 20120201 |
| Relationship between ischemia/reperfusion injury and the stimulus of fibrogenesis in an experimental model: comparison among different preservation solutions. | Transplantation proceedings 20111201 |
| S-Nitroso-N-acetylcysteine induces de-differentiation of activated hepatic stellate cells and promotes antifibrotic effects in vitro. | Nitric oxide : biology and chemistry 20111030 |
| Kinetics and mechanism of S-nitrosothiol acid-catalyzed hydrolysis: sulfur activation promotes facile NO+ release. | The journal of physical chemistry. B 20110331 |
| Nanocarriers for nitric oxide delivery. | Journal of drug delivery 20110101 |
| S-nitroso-N-acetylcysteine: a promising drug for early ischemia/reperfusion injury in rat liver. | Transplantation proceedings 20101201 |
| Nitrosation of N-methyl derivatives of uric acid and their transnitrosation ability to N-acetylcysteine. | Chemical & pharmaceutical bulletin 20100901 |
| S-nitroso-N-acetylcysteine ameliorates ischemia-reperfusion injury in the steatotic liver. | Clinics (Sao Paulo, Brazil) 20100701 |
| S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats. | Journal of molecular medicine (Berlin, Germany) 20100401 |
| In vitro amoebicidal activity of S-nitrosoglutathione and S-nitroso-N-acetylcysteine against trophozoites of Acanthamoeba castellanii. | The Journal of antimicrobial chemotherapy 20100301 |
| Comparative antilipidemic effect of N-acetylcysteine and sesame oil administration in diet-induced hypercholesterolemic mice. | Lipids in health and disease 20100101 |
| N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease. | Hepatitis monthly 20100101 |
| Effects of uric acid on nitrosation of N-acetylcysteine by diethylamine NONOate and N-acetyl-N-nitrosotryptophan. | Chemical & pharmaceutical bulletin 20090701 |
| Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment. | Journal of the American College of Nutrition 20080401 |
| S-nitroso-N-acetylcysteine (SNAC) prevents myocardial alterations in hypercholesterolemic LDL receptor knockout mice by antiinflammatory action. | Journal of cardiovascular pharmacology 20080101 |
| S-nitrosothiols signal hypoxia-mimetic vascular pathology. | The Journal of clinical investigation 20070904 |
| Modulation of hepatic microsomal triglyceride transfer protein (MTP) induced by S-nitroso-N-acetylcysteine in ob/ob mice. | Biochemical pharmacology 20070715 |
| Effect of Some nitrosative agents on the growth of vgb-bearing Enterobacter aerogenes strains. | Current microbiology 20070701 |
| Leishmanicidal activity of primary S-nitrosothiols against Leishmania major and Leishmania amazonensis: implications for the treatment of cutaneous leishmaniasis. | Nitric oxide : biology and chemistry 20061101 |
| Hepatic gene expression profile associated with non-alcoholic steatohepatitis protection by S-nitroso-N-acetylcysteine in ob/ob mice. | Journal of hepatology 20061101 |
| Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats. | World journal of gastroenterology 20060328 |
| Antiatherogenic effects of S-nitroso-N-acetylcysteine in hypercholesterolemic LDL receptor knockout mice. | Nitric oxide : biology and chemistry 20060201 |
| Direct detection of S-nitrosothiols using planar amperometric nitric oxide sensor modified with polymeric films containing catalytic copper species. | Analytical chemistry 20050601 |
| The effects of exogenous nitric oxide donor on motor functional recovery of reperfused peripheral nerve. | The Journal of hand surgery 20050501 |
| Synthesis, characterization, and controlled nitric oxide release from S-nitrosothiol-derivatized fumed silica polymer filler particles. | Journal of biomedical materials research. Part A 20050315 |
| Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle. | Microsurgery 20050101 |
| Topically applied S-nitrosothiol-containing hydrogels as experimental and pharmacological nitric oxide donors in human skin. | The British journal of dermatology 20041101 |
| The role of a formaldehyde dehydrogenase-glutathione pathway in protein S-nitrosation in mammalian cells. | Nitric oxide : biology and chemistry 20031101 |
| S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries. | The Journal of pharmacology and experimental therapeutics 20031001 |
| Thermal and photochemical nitric oxide release from S-nitrosothiols incorporated in Pluronic F127 gel: potential uses for local and controlled nitric oxide release. | Biomaterials 20030901 |
| Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030501 |
| Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro. | Urology 20030201 |
| A putative role for S-nitrosoglutathione as the source of nitric oxide in photorelaxation of the mouse gastric fundus. | European journal of pharmacology 20020830 |
| Characterization of the hypotensive effect of S-nitroso-N-acetylcysteine in normotensive and hypertensive conscious rats. | Nitric oxide : biology and chemistry 20020801 |
| Properties of selected S-nitrosothiols compared to nitrosylated WR-1065. | Radiation research 20020501 |
| Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides. | Biochemical pharmacology 20011101 |
| Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide. | American journal of physiology. Renal physiology 20010901 |
| The relaxation induced by S-nitroso-glutathione and S-nitroso-N-acetylcysteine in rat aorta is not related to nitric oxide production. | The Journal of pharmacology and experimental therapeutics 20010801 |
| Nitric oxide synthase expression and effects of nitric oxide modulation on contractility of rat extraocular muscle. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010801 |
| Sulfur-to-nitrogen transnitrosation: transfer of nitric oxide from S-nitroso compounds to diethanolamine and the role of intermediate sulfur-to-sulfur transnitrosation. | Toxicology 20010621 |
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