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54-77-3 | 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE
CAS No: 54-77-3 Catalog No: AG00DENC MDL No:MFCD00011976
Product Description
Catalog Number:
AG00DENC
Chemical Name:
1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE
CAS Number:
54-77-3
Molecular Formula:
C12H19IN2
Molecular Weight:
318.1971
MDL Number:
MFCD00011976
IUPAC Name:
1,1-dimethyl-4-phenylpiperazin-1-ium;iodide
InChI:
InChI=1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI Key:
XFZJGFIKQCCLGK-UHFFFAOYSA-M
SMILES:
C[N+]1(C)CCN(CC1)c1ccccc1.[I-]
EC Number:
200-213-0
UNII:
X95H7DRX99
NSC Number:
89754
Properties
Complexity:
173
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
318.059g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
318.202g/mol
Monoisotopic Mass:
318.059g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Identification and mechanosensitivity of viscerofugal neurons. | Neuroscience 20121206 |
| Firing patterns and functional roles of different classes of spinal afferents in rectal nerves during colonic migrating motor complexes in mouse colon. | American journal of physiology. Gastrointestinal and liver physiology 20120801 |
| Early emergence of neural activity in the developing mouse enteric nervous system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111026 |
| α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension. | Basic & clinical pharmacology & toxicology 20111001 |
| Mutants of β-strand β3 and the loop B in the interface between α7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations. | Journal of neurochemistry 20110901 |
| Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig. | Peptides 20110901 |
| Synapse- and subtype-specific modulation of synaptic transmission by nicotinic acetylcholine receptors in the ventrobasal thalamus. | Neuroscience research 20110301 |
| Insulin/Insulin-like growth factor signaling controls non-Dauer developmental speed in the nematode Caenorhabditis elegans. | Genetics 20110101 |
| Colon-specific contractile responses to tetrodotoxin in the isolated mouse gastrointestinal tract. | Autonomic & autacoid pharmacology 20110101 |
| Activation of neuronal SST₁ and SST₂ receptors decreases neurogenic secretion in the guinea-pig jejunum. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101101 |
| Characterization of Ca2+ signaling pathways in mouse adrenal medullary chromaffin cells. | Journal of neurochemistry 20100301 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens. | European journal of pharmacology 20090815 |
| Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. | Anesthesiology 20090601 |
| Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus. | Regulatory peptides 20090410 |
| Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation. | The Journal of pharmacology and experimental therapeutics 20090401 |
| Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor A single channel pharmacological study. | Biochimica et biophysica acta 20090201 |
| Nongenomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells. | Endocrinology 20081001 |
| Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor. | Journal of neuroscience research 20081001 |
| Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors. | Acta pharmacologica Sinica 20080301 |
| Effects of nonylphenol on the calcium signal and catecholamine secretion coupled with nicotinic acetylcholine receptors in bovine adrenal chromaffin cells. | Toxicology 20080203 |
| Beta-adrenoceptor-mediated vasodilation of retinal blood vessels is reduced in streptozotocin-induced diabetic rats. | Vascular pharmacology 20080101 |
| Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla. | Journal of cardiology 20071201 |
| Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics. | Bioorganic & medicinal chemistry letters 20071115 |
| Non-charged amino acids from three different domains contribute to link agonist binding to channel gating in alpha7 nicotinic acetylcholine receptors. | Journal of neurochemistry 20071001 |
| Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla. | Archives of pharmacal research 20071001 |
| Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation. | British journal of pharmacology 20070601 |
| Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | Journal of leukocyte biology 20070501 |
| Nerve growth factor acutely potentiates synaptic transmission in vitro and induces dendritic growth in vivo on adult neurons in airway parasympathetic ganglia. | American journal of physiology. Lung cellular and molecular physiology 20070401 |
| The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function. | Development (Cambridge, England) 20070301 |
| Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine. | Neuroscience letters 20070208 |
| Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons. | American journal of physiology. Lung cellular and molecular physiology 20070101 |
| Real-time detection of dopamine released from a nerve model cell by an enzyme-catalyzed luminescence method and its application to drug assessment. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070101 |
| Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro. | Neuropharmacology 20061201 |
| Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. | British journal of pharmacology 20061201 |
| Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | American journal of physiology. Lung cellular and molecular physiology 20061001 |
| Inhibition by SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, of Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells. | Journal of pharmacological sciences 20060901 |
| Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans. | Development (Cambridge, England) 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine. | European journal of pharmacology 20060327 |
| Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. | Molecular pharmacology 20060301 |
| Arecoline inhibits catecholamine release from perfused rat adrenal gland. | Acta pharmacologica Sinica 20060101 |
| Measurement of Ca2+ entry using 45Ca2+. | Methods in molecular biology (Clifton, N.J.) 20060101 |
| Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells. | Journal of molecular neuroscience : MN 20060101 |
| Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus. | Journal of neurophysiology 20051201 |
| Carrier-mediated release of monoamines induced by the nicotinic acetylcholine receptor agonist DMPP. | Neuropharmacology 20050901 |
| Comparison of green tea extract and epigallocatechin gallate on secretion of catecholamines from the rabbit adrenal medulla. | Archives of pharmacal research 20050801 |
| Modulation of airway inflammation and resistance in mice by a nicotinic receptor agonist. | The European respiratory journal 20050701 |
| Opposing muscarinic and nicotinic modulation of hypoglossal motor output to genioglossus muscle in rats in vivo. | The Journal of physiology 20050615 |
| Effect of 1,1-dimethylphenyl 1,4-piperazinium on mouse tracheal smooth muscle responsiveness. | American journal of physiology. Lung cellular and molecular physiology 20050601 |
| Influence of naloxone on catecholamine release evoked by nicotinic receptor stimulation in the isolated rat adrenal gland. | Archives of pharmacal research 20050601 |
| Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells. | European journal of pharmacology 20050516 |
| Progesterone regulation of catecholamine secretion from chromaffin cells. | Brain research 20050510 |
| Rigid analogs of DMPP as probes for the nicotinic receptors. | Farmaco (Societa chimica italiana : 1989) 20050201 |
| Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats. | Neuroscience 20050101 |
| Prevention of diminished parasympathetic control of the heart in experimental heart failure. | American journal of physiology. Heart and circulatory physiology 20041001 |
| Generation of functionally competent single bovine adrenal chromaffin cells from cell aggregates using the neutral protease dispase. | Journal of neuroscience methods 20040830 |
| Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. | Brain research 20040827 |
| Differential effects of FK506 and cyclosporin A on catecholamine release from bovine adrenal chromaffin cells. | Autonomic & autacoid pharmacology 20040701 |
| Inhibitory effects of galanin on evoked [Ca2+]i responses in cultured myenteric neurons. | American journal of physiology. Gastrointestinal and liver physiology 20040601 |
| Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells. | The Journal of pharmacology and experimental therapeutics 20040501 |
| TNF-alpha hyperpolarizes membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurones. | Acta physiologica Scandinavica 20040501 |
| Mechanism of action of botulinum toxin on the internal anal sphincter. | The British journal of surgery 20040201 |
| Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland. | Autonomic neuroscience : basic & clinical 20040130 |
| Nicotinic stimulation modulates tyrosine hydroxylase mRNA half-life and protein binding to the 3'UTR in a manner that requires transcription. | Brain research. Molecular brain research 20040105 |
| Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. | Pharmacology 20040101 |
| Nicotinic activation of mesolimbic neurons assessed by rubidium efflux in rat accumbens and ventral tegmentum. | Neuro-Signals 20040101 |
| Presynaptic alpha-7 nicotinic acetylcholine receptors modulate excitatory synaptic transmission in hippocampal neurons. | Sheng li xue bao : [Acta physiologica Sinica] 20031225 |
| Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester. | Bioorganic & medicinal chemistry letters 20031215 |
| Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung. | American journal of physiology. Lung cellular and molecular physiology 20031201 |
| Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. | Molecular pharmacology 20031201 |
| Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists. | Brain research 20031114 |
| A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon. | The Journal of physiology 20030915 |
| GABAergic systems modulate nicotinic receptor-mediated seizures in mice. | The Journal of pharmacology and experimental therapeutics 20030901 |
| Cotinine inhibits catecholamine release evoked by cholinergic stimulation from the rat adrenal medulla. | Archives of pharmacal research 20030901 |
| Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells. | Neuroscience letters 20030612 |
| Catecholamine release from cultured bovine adrenal medullary chromaffin cells in the presence of 60-Hz magnetic fields. | Bioelectrochemistry (Amsterdam, Netherlands) 20030401 |
| Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells. | Journal of pharmacological sciences 20030301 |
| Muscularis mucosae contraction evokes colonic secretion via prostaglandin synthesis and nerve stimulation. | American journal of physiology. Gastrointestinal and liver physiology 20030201 |
| Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases. | Chemico-biological interactions 20030106 |
| Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum. | American journal of physiology. Gastrointestinal and liver physiology 20030101 |
| Adenosine-acetylcholine interactions at the rat carotid body. | Advances in experimental medicine and biology 20030101 |
| Intracellular calcium activity in isolated bovine adrenal chromaffin cells in the presence and absence of 60 Hz magnetic fields. | Bioelectromagnetics 20021201 |
| Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord. | The Journal of physiology 20021101 |
| Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord. | Neuropharmacology 20021101 |
| Inhibition of autonomic nerve-mediated inotropic responses in guinea pig atrium by bafilomycin A. | Synapse (New York, N.Y.) 20020901 |
| Inhibitory mechanism of bromocriptine on catecholamine release evoked by cholinergic stimulation and membrane depolarization from the rat adrenal medulla. | Archives of pharmacal research 20020801 |
| Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit. | The Journal of physiology 20020715 |
| Novel tacrine derivatives that block neuronal calcium channels. | Bioorganic & medicinal chemistry 20020601 |
| Electrophysiological effects of tachykinin agonists on sympathetic ganglia of spontaneously hypertensive rats. | Autonomic neuroscience : basic & clinical 20020418 |
| A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons. | Journal of neurophysiology 20020301 |
| Nicotinic excitation of rat hypoglossal motoneurons. | Neuroscience 20020101 |
| Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. | Journal of immunology (Baltimore, Md. : 1950) 20011201 |
| Functional nicotinic acetylcholine receptor expression in stem and progenitor cells of the early embryonic mouse cerebral cortex. | Developmental biology 20011201 |
| Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP). | Journal of medicinal chemistry 20011108 |
| Determinants of agonist binding affinity on neuronal nicotinic receptor beta subunits. | The Journal of pharmacology and experimental therapeutics 20011001 |
| Interrelationship between colonic muscularis mucosae activity and changes in transmucosal potential difference. | American journal of physiology. Gastrointestinal and liver physiology 20010801 |
| Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. | British journal of pharmacology 20010801 |
| Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum. | British journal of pharmacology 20010701 |
| Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. | The Journal of physiology 20010501 |
| Noncompetitive inhibition by camphor of nicotinic acetylcholine receptors. | Biochemical pharmacology 20010401 |
| Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta. | British journal of pharmacology 20010401 |
| Nitric oxide modulates evoked catecholamine release from canine adrenal medulla. | Neuroscience 20010101 |
| Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype. | Molecular pharmacology 20000801 |
| Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line. | Brain research 19990417 |
| Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant. | European journal of pharmacology 19990205 |
| Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells. | The Journal of pharmacology and experimental therapeutics 19980201 |
| Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. | Naunyn-Schmiedeberg's archives of pharmacology 19970501 |
| Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes. | European journal of pharmacology 19960815 |
| Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type. | Neuropharmacology 19830301 |
| Effects of nicergoline on the cardiovascular system of dogs and rats. | Journal of cardiovascular pharmacology 19810101 |
| Absence of sensitization to epinephrine-induced cardiac arrhythmia and fibrillation in dogs and cats anesthetized with CI 744. | American journal of veterinary research 19750501 |
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