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54-21-7 | Sodium 2-hydroxybenzoate
CAS No: 54-21-7 Catalog No: AG003UE1 MDL No:MFCD00002440
Product Description
Catalog Number:
AG003UE1
Chemical Name:
Sodium 2-hydroxybenzoate
CAS Number:
54-21-7
Molecular Formula:
C7H5NaO3
Molecular Weight:
160.1026
MDL Number:
MFCD00002440
IUPAC Name:
sodium;2-hydroxybenzoate
InChI:
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI Key:
ABBQHOQBGMUPJH-UHFFFAOYSA-M
SMILES:
[O-]C(=O)c1ccccc1O.[Na+]
UNII:
WIQ1H85SYP
Properties
Complexity:
138
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
160.014g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
160.104g/mol
Monoisotopic Mass:
160.014g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
60.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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| Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs. | Cell cycle (Georgetown, Tex.) 20040701 |
| Effects of salicylate on voltage-gated sodium channels in rat inferior colliculus neurons. | Hearing research 20040701 |
| Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles. | Journal of controlled release : official journal of the Controlled Release Society 20040618 |
| Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons. | Journal of veterinary pharmacology and therapeutics 20040401 |
| Oral vaccination of African catfish with Vibrio anguillarum O2: effect on antigen uptake and immune response by absorption enhancers in lag time coated pellets. | Fish & shellfish immunology 20040301 |
| Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms. | International journal of pharmaceutics 20040301 |
| Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases. | Neuroscience letters 20040212 |
| Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. | Molecular pharmacology 20040201 |
| Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. | Immunopharmacology and immunotoxicology 20040201 |
| Enhanced ileal absorption of a hydrophilic macromolecule, pentosan polysulfate sodium (PPS). | Journal of biomaterials science. Polymer edition 20040101 |
| The effects of water supplementation with vitamin E and sodium salicylate (Uni-Sol) on the resistance of turkeys to Escherichia coli respiratory infection. | Avian diseases 20040101 |
| Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus. | Experimental brain research 20031201 |
| PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress. | Microbiology (Reading, England) 20031201 |
| Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method. | AAPS PharmSciTech 20031201 |
| Facilitation of iontophoretic drug delivery through intact and caries-affected dentine. | International endodontic journal 20031001 |
| Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. | Journal of thrombosis and haemostasis : JTH 20031001 |
| Evaluation of anhydride oligomers within polymer microsphere blends and their impact on bioadhesion and drug delivery in vitro. | Biomaterials 20030901 |
| Auditory nerve fibre responses to salicylate revisited. | Hearing research 20030901 |
| [The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate]. | Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20030901 |
| A high performance liquid chromatography method for determination of gas-phase hydrogen peroxide in ambient air using Fenton's chemistry. | Chemosphere 20030801 |
| Sodium salicylate induces apoptosis in HCT116 colorectal cancer cells through activation of p38MAPK. | International journal of oncology 20030801 |
| Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells. | European journal of biochemistry 20030801 |
| Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival. | Blood 20030701 |
| Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes. | Archives of pharmacal research 20030701 |
| A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus. | Hearing research 20030601 |
| Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. | Seminars in vascular medicine 20030501 |
| Expression of NF-kappaB in epidermis and the relationship between NF-kappaB activation and inhibition of keratinocyte growth. | The British journal of dermatology 20030401 |
| Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle. | The Journal of pharmacy and pharmacology 20030401 |
| Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. | Brain research 20030321 |
| Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis. | Free radical biology & medicine 20030215 |
| Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. | The Journal of pharmacology and experimental therapeutics 20030201 |
| Urate transport via human PAH transporter hOAT1 and its gene structure. | Kidney international 20030101 |
| Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030101 |
| Intraperitoneal administration of salicylate dose-dependently prevents stress-induced ulcer formation in rats. | Polish journal of pharmacology 20030101 |
| Isolation and characterisation of new Planococcus sp. strain able for aromatic hydrocarbons degradation. | Acta microbiologica Polonica 20030101 |
| Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens. | Journal of veterinary pharmacology and therapeutics 20021201 |
| Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20021201 |
| Effects of nimodipine on salicylate ototoxicity. | The Annals of otology, rhinology, and laryngology 20021201 |
| Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells. | The Journal of pharmacy and pharmacology 20021201 |
| [Effects of salicylate on the capillary permeability of inner ear in guinea pigs]. | Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20021201 |
| Attenuation of iminodipropionitrile induced behavioral syndrome by sodium salicylate in rats. | Pharmacology, biochemistry, and behavior 20021001 |
| Enhancement effects of double-chained cationic surfactants of n-dimethyldialkylammoniums on permeability of salicylate through guinea pig dorsal skin. | Chemical & pharmaceutical bulletin 20021001 |
| Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate. | Journal of molecular medicine (Berlin, Germany) 20021001 |
| The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus. | International journal of antimicrobial agents 20020901 |
| Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs. | The Journal of general virology 20020801 |
| Anti-inflammatory effects of aspirin and sodium salicylate. | European journal of pharmacology 20020628 |
| Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer. | Journal of controlled release : official journal of the Controlled Release Society 20020617 |
| Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat. | The Journal of pharmacology and experimental therapeutics 20020601 |
| Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. | Diabetes 20020601 |
| Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils. | Clinical and experimental immunology 20020601 |
| Differential cytostatic effect of sodium salicylate in human colorectal cancers using an individualized histoculture system. | Cancer chemotherapy and pharmacology 20020601 |
| Sodium salicylate-triggered apoptosis in HL-60 cells depends on caspase-8 activation. | International journal of hematology 20020501 |
| Effect of bioadhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether, and method of preparation on the relative hypoglycemia produced by insulin enteric-coated capsules in diabetic beagle dogs. | Drug development and industrial pharmacy 20020501 |
| Oral delivery of insulin from enteric-coated capsules containing sodium salicylate: effect on relative hypoglycemia of diabetic beagle dogs. | International journal of pharmaceutics 20020426 |
| Selective inhibition of STAT3 phosphorylation by sodium salicylate in cardiac fibroblasts. | Biochemical pharmacology 20020401 |
| Inhibition of p-cresol on aerobic biodegradation of carbazole, and sodium salicylate by Pseudomonas putida. | Water research 20020401 |
| NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. | Biochemical and biophysical research communications 20020308 |
| Aspirin and salicylates inhibit the IL-4- and IL-13-induced activation of STAT6. | Journal of immunology (Baltimore, Md. : 1950) 20020201 |
| Iron (III) attenuates hydroxyl radical generation accompanying non-enzymatic oxidation of noradrenaline in the rat heart. | Naunyn-Schmiedeberg's archives of pharmacology 20020201 |
| [Effects of sodium salicylate and extracellular K(+) on outward potassium current and resting potential of outer hair cell isolated from guinea pig cochlea]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020201 |
| Targeting of salicylate to skin and muscle following topical injections in rats. | International journal of pharmaceutics 20020114 |
| Interaction of cyclooxygenase-2 inhibitors and salicylate in gastric mucosal damage. | European journal of pharmacology 20020102 |
| NF-kappa B DNA-binding activity in embryos responding to a teratogen, cyclophosphamide. | BMC developmental biology 20020101 |
| Effect of bio-adhesive polymers, sodium salicylate, polyoxyethylene-9-lauryl ether and method of preparation on the relative hypoglycemia produced by insulin enteric coated capsules in diabetic beagle dogs. | Bollettino chimico farmaceutico 20020101 |
| A comparison of biodegradation of phenol and homologous compounds by Pseudomonas vesicularis and Staphylococcus sciuri strains. | Acta microbiologica Polonica 20020101 |
| Sodium salicylate enhances the expression of cyclooxygenase-2 in endotoxin-stimulated human mononuclear cells. | European journal of pharmacology 20011214 |
| Sodium salicylate inhibits prostaglandin formation without affecting the induction of cyclooxygenase-2 by bacterial lipopolysaccharide in vivo. | The Journal of pharmacology and experimental therapeutics 20011201 |
| Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents. | Photochemistry and photobiology 20011201 |
| Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101 |
| Relative hypoglycemic effect of insulin suppositories in diabetic beagle dogs: optimization of various concentrations of sodium salicylate and polyoxyethylene-9-lauryl ether. | Biological & pharmaceutical bulletin 20011101 |
| Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. | Cancer research 20011015 |
| Effect of salicylate and short-term sound exposure on extracochlear electrically-evoked otoacoustic emissions. | Acta oto-laryngologica 20011001 |
| [Structural and functional changes in sympathetic ganglia following endotoxin and alpha1-antitrypsin exposure]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011001 |
| [Changes in the afferent activity of the vagus nerve and the rectal temperature in rats following Escherichia coli endotoxin administration]. | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011001 |
| Effect of media composition on yield values of bacteria growing on binary and ternary substrate mixtures in continuous culture. | Biotechnology and bioengineering 20010905 |
| Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. | Science (New York, N.Y.) 20010831 |
| The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. | Blood 20010815 |
| FT-Raman, FT-IR and surface enhanced Raman scattering spectra of sodium salicylate. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010701 |
| Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. | The Journal of biological chemistry 20010601 |
| Acanthoamoeba attachment to contact lenses. | Ophthalmology 20010501 |
| Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes. | Molecular pharmacology 20010401 |
| Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism. | Journal of immunology (Baltimore, Md. : 1950) 20010115 |
| Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis. | Free radical biology & medicine 20010115 |
| The possibility of achieving an interactive mixture with high dose homogeneity containing an extremely low proportion of a micronised drug. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010101 |
| Increases in the mutation frequency at which fusidic acid-resistant Staphylococcus aureus arise with salicylate. | Journal of medical microbiology 20010101 |
| Quantitative analysis of hydroxyl radicals in the anterior optic nerve of the cat following transient ischemia. | Ophthalmic surgery and lasers 20010101 |
| Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells. | Anticancer research 20010101 |
| Preparation of regular sized Ca-alginate microspheres using membrane emulsification method. | Journal of microencapsulation 20010101 |
| Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. | The Journal of biological chemistry 20001208 |
| Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates. | Biochemical and biophysical research communications 20000616 |
| Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. | Neuroscience letters 20000114 |
| Sulindac inhibits activation of the NF-kappaB pathway. | The Journal of biological chemistry 19990917 |
| Sodium salicylate inhibits macrophage TNF-alpha production and alters MAPK activation. | The Journal of surgical research 19990615 |
| Induction of stromelysin gene expression by tumor necrosis factor alpha is inhibited by dexamethasone, salicylate, and N-acetylcysteine in synovial fibroblasts. | The Journal of pharmacology and experimental therapeutics 19990601 |
| Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. | Cytokine 19990501 |
| Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. | Proceedings of the National Academy of Sciences of the United States of America 19990427 |
| Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. | Blood 19990401 |
| Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. | Blood 19980815 |
| Induction of the DNA-binding and transcriptional activities of heat shock factor 1 is uncoupled in Xenopus oocytes. | Biochimica et biophysica acta 19980312 |
| Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. | Molecular pharmacology 19970901 |
| Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures. | The European journal of neuroscience 19960901 |
| Inhibition of NF-kappa B by sodium salicylate and aspirin. | Science (New York, N.Y.) 19940812 |
| Sodium salicylate sensitivity in an asthmatic patient with aspirin sensitivity. | Journal of Korean medical science 19910601 |
| Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats. | Brain research 19881018 |
| Temporary hearing loss induced by combinations of intense sounds and nonsteroidal anti-inflammatory drugs. | American journal of otolaryngology 19840101 |
| Therapeutic attempts in infants with nonketotic hyperglycinaemia. | Journal of mental deficiency research 19810301 |
| Effect of myocardial ischaemia and antilipolytic agents on lipolysis and fatty acid metabolism in the in situ dog heart. | Scandinavian journal of clinical and laboratory investigation 19791001 |
| Comparative nephrotoxicity of aspirin and phenacetin derivatives. | British medical journal 19711127 |
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