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53602-00-9 | 4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol
CAS No: 53602-00-9 Catalog No: AG00E3DK MDL No:
Product Description
Catalog Number:
AG00E3DK
Chemical Name:
4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol
CAS Number:
53602-00-9
IUPAC Name:
4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one
InChI:
InChI=1S/C6H8N2O2/c9-6-4-3-7-2-1-5(4)10-8-6/h7H,1-3H2,(H,8,9)
InChI Key:
SXXLKZCNJHJYFL-UHFFFAOYSA-N
Properties
Complexity:
210
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
140.059g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
140.142g/mol
Monoisotopic Mass:
140.059g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
50.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.9
Literature
| Title | Journal |
|---|---|
| The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. | British journal of pharmacology 20111201 |
| Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors. | The European journal of neuroscience 20110401 |
| Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. | The European journal of neuroscience 20090301 |
| Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080902 |
| Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep-wakefulness: role of delta-subunit containing extrasynaptic GABAA receptors. | Neuroscience 20080515 |
| Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. | Neuropharmacology 20040501 |
| Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters. | Neurochemistry international 20030101 |
| Prenatal protein malnutrition enhances stimulus control by CDP, but not a CDP/THIP combination in rats. | Pharmacology, biochemistry, and behavior 20021101 |
| Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs. | The Journal of pharmacology and experimental therapeutics 20020801 |
| Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain. | European journal of pharmacology 20010928 |
| Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. | The Journal of pharmacology and experimental therapeutics 20010501 |
| Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO. | Neuropharmacology 19830101 |
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